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{{Infobox gene}}
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'''Claudin-2''' is a [[protein]] that in humans is encoded by the ''CLDN2'' [[gene]].<ref name="pmid9892664">{{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 2 | pages = 511–6 |date=March 1999 | pmid = 9892664 | pmc = 15167 | doi =10.1073/pnas.96.2.511 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLDN2 claudin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = }}</ref> It belongs to the group of [[claudin]]s.
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Claudin 2
| HGNCid = 2041
| Symbol = CLDN2
| AltSymbols =;
| OMIM = 300520
| ECnumber = 
| Homologene = 9621
| MGIid = 1276110
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0016338 |text = calcium-independent cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9075
    | Hs_Ensembl = ENSG00000165376
    | Hs_RefseqProtein = NP_065117
    | Hs_RefseqmRNA = NM_020384
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 106030050
    | Hs_GenLoc_end = 106060747
    | Hs_Uniprot = P57739
    | Mm_EntrezGene = 12738
    | Mm_Ensembl = ENSMUSG00000047230
    | Mm_RefseqmRNA = NM_016675
    | Mm_RefseqProtein = NP_057884
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 135147192
    | Mm_GenLoc_end = 135157748
    | Mm_Uniprot = O88552
  }}
}}
'''Claudin 2''', also known as '''CLDN2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLDN2 claudin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = }}</ref>


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{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CLDN2 claudin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = }}</ref>
| summary_text = Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
== Function ==
{{reflist|2}}
Claudin-2 is expressed in [[Cation#Anions and cations|cation]]-leaky [[Epithelium|epithelia]] such as that of the [[kidney]] [[Proximal convoluted tubule|proximal tubule]].<ref>{{cite journal
==Further reading==
| last1 = Muto | first1 = S.
| last2 = Hata | first2 = M.
| last3 = Taniguchi | first3 = J.
| last4 = Tsuruoka | first4 = S.
| last5 = Moriwaki | first5 = K.
| last6 = Saitou | first6 = M.
| last7 = Furuse | first7 = K.
| last8 = Sasaki | first8 = H.
| last9 = Fujimura | first9 = A.
| doi = 10.1073/pnas.0912901107
| last10 = Imai | first10 = M.
| last11 = Kusano | first11 = E.
| last12 = Tsukita | first12 = S.
| last13 = Furuse | first13 = M.
| title = Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules
| journal = Proceedings of the National Academy of Sciences
| volume = 107
| issue = 17
| pages = 8011–8016
| year = 2010
| pmid = 20385797
| pmc =2867900
}}</ref> Mice that are [[Knockout mouse|deficient]] in claudin-2 have reduced [[reabsorption]] of [[Sodium#Sodium in humans|Na]]<sup>+</sup> in the proximal tubule, consistent with a role in [[paracellular transport]].
Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.<ref>{{cite journal|pmid=12432083|year=2002|author1=Amasheh|first1=S|title=Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells|journal=Journal of Cell Science|volume=115|issue=Pt 24|pages=4969–76|last2=Meiri|first2=N|last3=Gitter|first3=A. H.|last4=Schöneberg|first4=T|last5=Mankertz|first5=J|last6=Schulzke|first6=J. D.|last7=Fromm|first7=M|doi=10.1242/jcs.00165}}</ref>
Furthermore, claudin-2 has been shown to form paracellular channels for water.<ref>{{cite journal
| last1 = Rosenthal | first1 = R.
| last2 = Milatz | first2 = S.
| last3 = Krug | first3 = S. M.
| last4 = Oelrich | first4 = B.
| last5 = Schulzke | first5 = J. -D.
| last6 = Amasheh | first6 = S.
| last7 = Gunzel | first7 = D.
| last8 = Fromm | first8 = M.
| doi = 10.1242/jcs.060665
| title = Claudin-2, a component of the tight junction, forms a paracellular water channel
| journal = Journal of Cell Science
| volume = 123
| issue = 11
| pages = 1913–1921
| year = 2010
| pmid = 20460438
| pmc =
}}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CLDN2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB Further reading
| citations =  
| citations =  
*{{cite journal  | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57-76 |year= 2000 |pmid= 10690502 |doi=  }}
*{{cite journal  | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 }}
*{{cite journal  | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93-8 |year= 2001 |pmid= 11247307 |doi=  }}
*{{cite journal  | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x }}
*{{cite journal  | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285-93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
*{{cite journal  | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
*{{cite journal  | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531-6 |year= 2003 |pmid= 12231346 |doi=  }}
*{{cite journal  | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
*{{cite journal  | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1-44 |year= 2003 |pmid= 12475568 |doi=  }}
*{{cite journal  | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 }}
*{{cite journal  | author=Furuse M, Fujita K, Hiiragi T, ''et al.'' |title=Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1539-50 |year= 1998 |pmid= 9647647 |doi= }}
*{{cite journal  | vauthors=Furuse M, Fujita K, Hiiragi T |title=Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1539–50 |year= 1998 |pmid= 9647647 |doi=10.1083/jcb.141.7.1539  | pmc=2132999  |display-authors=etal}}
*{{cite journal  | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511-6 |year= 1999 |pmid= 9892664 |doi= }}
*{{cite journal  | vauthors=Itoh M, Furuse M, Morita K |title=Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=10.1083/jcb.147.6.1351  | pmc=2168087 |display-authors=etal}}
*{{cite journal  | author=Itoh M, Furuse M, Morita K, ''et al.'' |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351-63 |year= 2000 |pmid= 10601346 |doi=  }}
*{{cite journal  | vauthors=Sakaguchi T, Gu X, Golden HM |title=Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21361–70 |year= 2002 |pmid= 11934881 |doi= 10.1074/jbc.M110261200 |display-authors=etal}}
*{{cite journal  | author=Sakaguchi T, Gu X, Golden HM, ''et al.'' |title=Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21361-70 |year= 2002 |pmid= 11934881 |doi= 10.1074/jbc.M110261200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346–54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002 }}
*{{cite journal  | author=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346-54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Mankertz J, Hillenbrand B, Tavalali S |title=Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 4 |pages= 1001–7 |year= 2004 |pmid= 14751232 |doi=10.1016/j.bbrc.2003.12.185 |display-authors=etal}}
*{{cite journal  | author=Mankertz J, Hillenbrand B, Tavalali S, ''et al.'' |title=Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 4 |pages= 1001-7 |year= 2004 |pmid= 14751232 |doi=  }}
*{{cite journal  | vauthors=Yamauchi K, Rai T, Kobayashi K |title=Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4690–4 |year= 2004 |pmid= 15070779 |doi= 10.1073/pnas.0306924101 | pmc=384808 |display-authors=etal}}
*{{cite journal  | author=Yamauchi K, Rai T, Kobayashi K, ''et al.'' |title=Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4690-4 |year= 2004 |pmid= 15070779 |doi= 10.1073/pnas.0306924101 }}
*{{cite journal  | vauthors=Escaffit F, Boudreau F, Beaulieu JF |title=Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 15–26 |year= 2005 |pmid= 15389642 |doi= 10.1002/jcp.20189 }}
*{{cite journal  | author=Escaffit F, Boudreau F, Beaulieu JF |title=Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 15-26 |year= 2005 |pmid= 15389642 |doi= 10.1002/jcp.20189 }}
}}
}}
* {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 }}
{{refend}}
{{refend}}


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Revision as of 03:03, 15 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[1][2] It belongs to the group of claudins.

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][2]

Function

Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[3] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[4] Furthermore, claudin-2 has been shown to form paracellular channels for water.[5]

References

  1. ↑ Morita K, Furuse M, Fujimoto K, Tsukita S (March 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc Natl Acad Sci U S A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
  2. ↑ 2.0 2.1 "Entrez Gene: CLDN2 claudin 2".
  3. ↑ Muto, S.; Hata, M.; Taniguchi, J.; Tsuruoka, S.; Moriwaki, K.; Saitou, M.; Furuse, K.; Sasaki, H.; Fujimura, A.; Imai, M.; Kusano, E.; Tsukita, S.; Furuse, M. (2010). "Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules". Proceedings of the National Academy of Sciences. 107 (17): 8011–8016. doi:10.1073/pnas.0912901107. PMC 2867900. PMID 20385797.
  4. ↑ Amasheh, S; Meiri, N; Gitter, A. H.; Schöneberg, T; Mankertz, J; Schulzke, J. D.; Fromm, M (2002). "Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells". Journal of Cell Science. 115 (Pt 24): 4969–76. doi:10.1242/jcs.00165. PMID 12432083.
  5. ↑ Rosenthal, R.; Milatz, S.; Krug, S. M.; Oelrich, B.; Schulzke, J. -D.; Amasheh, S.; Gunzel, D.; Fromm, M. (2010). "Claudin-2, a component of the tight junction, forms a paracellular water channel". Journal of Cell Science. 123 (11): 1913–1921. doi:10.1242/jcs.060665. PMID 20460438.

External links

Further reading



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