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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''N-acylneuraminate cytidylyltransferase''' is an [[enzyme]] that in humans is encoded by the ''CMAS'' [[gene]].<ref name="pmid8889549">{{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | pmc =  | doi = 10.1101/gr.6.9.807 }}</ref><ref name="pmid7566098">{{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | date = September 1995 | pmid = 7566098 | pmc =  | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55907| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CMAS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qwj.
| PDB = {{PDB2|1qwj}}
| Name = Cytidine monophosphate N-acetylneuraminic acid synthetase
| HGNCid = 18290
| Symbol = CMAS
| AltSymbols =;
| OMIM = 603316
| ECnumber = 
| Homologene = 7670
| MGIid = 1337124
| GeneAtlas_image1 = PBB_GE_CMAS_218111_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008781 |text = N-acylneuraminate cytidylyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0009103 |text = lipopolysaccharide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55907
    | Hs_Ensembl = ENSG00000111726
    | Hs_RefseqProtein = NP_061156
    | Hs_RefseqmRNA = NM_018686
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 22090426
    | Hs_GenLoc_end = 22109869
    | Hs_Uniprot = Q8NFW8
    | Mm_EntrezGene = 12764
    | Mm_Ensembl = ENSMUSG00000030282
    | Mm_RefseqmRNA = NM_009908
    | Mm_RefseqProtein = NP_034038
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 142713979
    | Mm_GenLoc_end = 142732929
    | Mm_Uniprot = Q99KK2
  }}
}}
'''Cytidine monophosphate N-acetylneuraminic acid synthetase''', also known as '''CMAS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55907| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The enzyme encoded by this gene catalyzes the activation of [[Neu5Ac]] to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of [[sialic acid]]. Sialic acids of cell surface [[glycoprotein]]s and [[glycolipid]]s play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.<ref name="entrez">{{cite web | title = Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55907| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== External links ==
* {{UCSC gene info|CMAS}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Münster AK, Eckhardt M, Potvin B, Mühlenhoff M, Stanley P, Gerardy-Schahn R | title = Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 16 | pages = 9140–5 | date = August 1998 | pmid = 9689047 | pmc = 21305 | doi = 10.1073/pnas.95.16.9140 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Angata T, Varki NM, Varki A | title = A second uniquely human mutation affecting sialic acid biology | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 40282–7 | date = October 2001 | pmid = 11546777 | doi = 10.1074/jbc.M105926200 }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ | title = Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells | journal = Glycoconjugate Journal | volume = 18 | issue = 3 | pages = 205–13 | date = March 2001 | pmid = 11602804 | doi = 10.1023/A:1012452705349 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Munster AK, Weinhold B, Gotza B, Muhlenhoff M, Frosch M, Gerardy-Schahn R | title = Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19688–96 | date = May 2002 | pmid = 11893746 | doi = 10.1074/jbc.M201093200 }}
*{{cite journal | author=Münster AK, Eckhardt M, Potvin B, ''et al.'' |title=Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9140-5 |year= 1998 |pmid= 9689047 |doi= }}
* {{cite journal | vauthors = Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER | title = NotI flanking sequences: a tool for gene discovery and verification of the human genome | journal = Nucleic Acids Research | volume = 30 | issue = 14 | pages = 3163–70 | date = July 2002 | pmid = 12136098 | pmc = 135748 | doi = 10.1093/nar/gkf428 }}
*{{cite journal | author=Angata T, Varki NM, Varki A |title=A second uniquely human mutation affecting sialic acid biology. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40282-7 |year= 2001 |pmid= 11546777 |doi= 10.1074/jbc.M105926200 }}
*{{cite journal | author=Lawrence SM, Huddleston KA, Tomiya N, ''et al.'' |title=Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. |journal=Glycoconj. J. |volume=18 |issue= 3 |pages= 205-13 |year= 2002 |pmid= 11602804 |doi= }}
*{{cite journal | author=Munster AK, Weinhold B, Gotza B, ''et al.'' |title=Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19688-96 |year= 2002 |pmid= 11893746 |doi= 10.1074/jbc.M201093200 }}
*{{cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, ''et al.'' |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163-70 |year= 2002 |pmid= 12136098 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=55907}}
[[Category:Enzymes]]


{{protein-stub}}
{{gene-12-stub}}
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Latest revision as of 09:51, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

N-acylneuraminate cytidylyltransferase is an enzyme that in humans is encoded by the CMAS gene.[1][2][3]

Function

The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.[3]

References

  1. ↑ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  2. ↑ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  3. ↑ 3.0 3.1 "Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase".

External links

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=CMAS_(gene)&oldid=1415902"