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{{ | '''Bifunctional coenzyme A synthase''' is an [[enzyme]] that in humans is encoded by the ''COASY'' [[gene]].<ref name="pmid11923312">{{cite journal | vauthors = Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A | title = Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics | journal = J Biol Chem | volume = 277 | issue = 24 | pages = 21431–9 |date=Jun 2002 | pmid = 11923312 | pmc = | doi = 10.1074/jbc.M201708200 }}</ref><ref name="pmid11980892">{{cite journal | vauthors = Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT | title = Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis | journal = J Biol Chem | volume = 277 | issue = 25 | pages = 22107–10 |date=Jun 2002 | pmid = 11980892 | pmc = | doi = 10.1074/jbc.C200195200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COASY Coenzyme A synthase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80347| accessdate = }}</ref> | ||
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==Interactions== | |||
COASY has been shown to [[Protein-protein interaction|interact]] with [[P70-S6 Kinase 1]].<ref name=pmid15589845>{{cite journal |last=Nemazanyy |first=Ivan |author2=Panasyuk Ganna |author3=Zhyvoloup Alexander |author4=Panayotou George |author5=Gout Ivan T |author6=Filonenko Valeriy |date=Dec 2004 |title=Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism |journal=FEBS Lett. |volume=578 |issue=3 |pages=357–62 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 15589845 |doi = 10.1016/j.febslet.2004.10.091 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
In 2009, COASY has also been implicated in [[PI3K|PI3K signaling]], as it was shown to interact with a regulatory subunit of PI3K.<ref name=pmid19482007>{{cite journal |last=Breus |first=Oksana |author2=Panasyuk G|author3=Gout IT|author4=Filonenko V|author5=Nemazanyy I |date=May 2009 |title=CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway. |journal=Biochem Biophys Res Commun |volume=385 |issue=4 |pages=581–5 |publisher= |location = | issn = | pmid = 19482007 |doi = 10.1016/j.bbrc.2009.05.102 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|COASY}} | |||
* {{UCSC gene info|PPAT}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Montagna M, Serova O, Sylla BS |title=A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase |journal=Hum. Genet. |volume=96 |issue= 5 |pages= 532–8 |year= 1996 |pmid= 8529999 |doi= 10.1007/bf00197407|display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} | ||
*{{cite journal | vauthors=Aghajanian S, Worrall DM |title=Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase) |journal=Biochem. J. |volume=365 |issue= Pt 1 |pages= 13–8 |year= 2002 |pmid= 11994049 |doi= 10.1042/BJ20020569 | pmc=1222654 }} | |||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Zhyvoloup A, Nemazanyy I, Panasyuk G |title=Subcellular localization and regulation of coenzyme A synthase |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 50316–21 |year= 2004 |pmid= 14514684 |doi= 10.1074/jbc.M307763200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nemazanyy I, Panasyuk G, Zhyvoloup A |title=Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism |journal=FEBS Lett. |volume=578 |issue= 3 |pages= 357–62 |year= 2005 |pmid= 15589845 |doi= 10.1016/j.febslet.2004.10.091 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nemazanyy I, Panasyuk G, Breus O |title=Identification of a novel CoA synthase isoform, which is primarily expressed in the brain |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 4 |pages= 995–1000 |year= 2006 |pmid= 16460672 |doi= 10.1016/j.bbrc.2006.01.051 |display-authors=etal}} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Revision as of 02:38, 25 October 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.[1][2][3]
Interactions
COASY has been shown to interact with P70-S6 Kinase 1.[4] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.[5]
References
- ↑ Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A (Jun 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". J Biol Chem. 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312.
- ↑ Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (Jun 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". J Biol Chem. 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892.
- ↑ "Entrez Gene: COASY Coenzyme A synthase".
- ↑ Nemazanyy, Ivan; Panasyuk Ganna; Zhyvoloup Alexander; Panayotou George; Gout Ivan T; Filonenko Valeriy (Dec 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. Netherlands. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. ISSN 0014-5793. PMID 15589845.
- ↑ Breus, Oksana; Panasyuk G; Gout IT; Filonenko V; Nemazanyy I (May 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway". Biochem Biophys Res Commun. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007.
External links
- Human COASY genome location and COASY gene details page in the UCSC Genome Browser.
- Human PPAT genome location and PPAT gene details page in the UCSC Genome Browser.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Montagna M, Serova O, Sylla BS, et al. (1996). "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase". Hum. Genet. 96 (5): 532–8. doi:10.1007/bf00197407. PMID 8529999.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Aghajanian S, Worrall DM (2002). "Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)". Biochem. J. 365 (Pt 1): 13–8. doi:10.1042/BJ20020569. PMC 1222654. PMID 11994049.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhyvoloup A, Nemazanyy I, Panasyuk G, et al. (2004). "Subcellular localization and regulation of coenzyme A synthase". J. Biol. Chem. 278 (50): 50316–21. doi:10.1074/jbc.M307763200. PMID 14514684.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Nemazanyy I, Panasyuk G, Zhyvoloup A, et al. (2005). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nemazanyy I, Panasyuk G, Breus O, et al. (2006). "Identification of a novel CoA synthase isoform, which is primarily expressed in the brain". Biochem. Biophys. Res. Commun. 341 (4): 995–1000. doi:10.1016/j.bbrc.2006.01.051. PMID 16460672.
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