COP9 signalosome complex subunit 3: Difference between revisions

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{{Infobox_gene}}
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'''COP9 signalosome complex subunit 3''' is a [[protein]] that in humans is encoded by the ''COPS3'' [[gene]].<ref name="pmid9535219">{{cite journal | vauthors = Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W | title = A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | journal = FASEB J | volume = 12 | issue = 6 | pages = 469–78 |date=Apr 1998 | pmid = 9535219 | pmc =  | doi = }}</ref><ref name="pmid10191102">{{cite journal | vauthors = Potocki L, Chen KS, Lupski JR | title = Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2 | journal = Genomics | volume = 57 | issue = 1 | pages = 180–2 |date=Jun 1999 | pmid = 10191102 | pmc =  | doi = 10.1006/geno.1998.5748 }}</ref><ref name="entrez"/> It encodes a subunit of the [[COP9 signalosome]].
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
| HGNCid = 2239
| Symbol = COPS3
| AltSymbols =; SGN3
| OMIM = 604665
| ECnumber = 
| Homologene = 2710
| MGIid = 1349409
| GeneAtlas_image1 = PBB_GE_COPS3_202078_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008180 |text = signalosome}}
  | Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009416 |text = response to light stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8533
    | Hs_Ensembl = ENSG00000141030
    | Hs_RefseqProtein = NP_003644
    | Hs_RefseqmRNA = NM_003653
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 17090876
    | Hs_GenLoc_end = 17125339
    | Hs_Uniprot = Q9UNS2
    | Mm_EntrezGene = 26572
    | Mm_Ensembl = ENSMUSG00000019373
    | Mm_RefseqmRNA = NM_011991
    | Mm_RefseqProtein = NP_036121
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 59633992
    | Mm_GenLoc_end = 59655962
    | Mm_Uniprot = Q3TEA5
  }}
}}
'''COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)''', also known as '''COPS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533| accessdate = }}</ref>


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| section_title =  
| summary_text = The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533| accessdate = }}</ref>
| summary_text = The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533| accessdate = }}</ref>
}}
}}
== See also ==
*[[Signalosome]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|COPS3}}
* {{UCSC gene info|CSN3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029-33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
*{{cite journal  | vauthors=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029–33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
*{{cite journal  | author=van Dartel M, Hulsebos TJ |title=Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. |journal=Cancer Genet. Cytogenet. |volume=153 |issue= 1 |pages= 77-80 |year= 2004 |pmid= 15325100 |doi= 10.1016/j.cancergencyto.2004.03.007 }}
*{{cite journal  | vauthors=van Dartel M, Hulsebos TJ |title=Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. |journal=Cancer Genet. Cytogenet. |volume=153 |issue= 1 |pages= 77–80 |year= 2004 |pmid= 15325100 |doi= 10.1016/j.cancergencyto.2004.03.007 }}
*{{cite journal  | author=Seeger M, Kraft R, Ferrell K, ''et al.'' |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. |journal=FASEB J. |volume=12 |issue= 6 |pages= 469-78 |year= 1998 |pmid= 9535219 |doi= }}
*{{cite journal  | vauthors=Wei N, Tsuge T, Serino G |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919–22 |year= 1998 |pmid= 9707402 |doi=10.1016/S0960-9822(07)00372-7  |display-authors=etal}}
*{{cite journal  | author=Wei N, Tsuge T, Serino G, ''et al.'' |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919-22 |year= 1998 |pmid= 9707402 |doi= }}
*{{cite journal  | vauthors=Bianchi E, Denti S, Granata A |title=Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. |journal=Nature |volume=404 |issue= 6778 |pages= 617–21 |year= 2000 |pmid= 10766246 |doi= 10.1038/35007098 |display-authors=etal}}
*{{cite journal  | author=Potocki L, Chen KS, Lupski JR |title=Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. |journal=Genomics |volume=57 |issue= 1 |pages= 180-2 |year= 1999 |pmid= 10191102 |doi= 10.1006/geno.1998.5748 }}
*{{cite journal  | vauthors=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }}
*{{cite journal  | author=Bianchi E, Denti S, Granata A, ''et al.'' |title=Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. |journal=Nature |volume=404 |issue= 6778 |pages= 617-21 |year= 2000 |pmid= 10766246 |doi= 10.1038/35007098 }}
*{{cite journal  | vauthors=Bech-Otschir D, Kraft R, Huang X |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630–9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630  | pmc=145508 |display-authors=etal}}
*{{cite journal  | author=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1-9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }}
*{{cite journal  | vauthors=Lyapina S, Cope G, Shevchenko A |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 |display-authors=etal}}
*{{cite journal  | author=Bech-Otschir D, Kraft R, Huang X, ''et al.'' |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630-9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630 }}
*{{cite journal  | vauthors=Hong X, Xu L, Li X |title=CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation |journal=FEBS Lett. |volume=499 |issue= 1–2 |pages= 133–6 |year= 2001 |pmid= 11418127 |doi=10.1016/S0014-5793(01)02535-2  |display-authors=etal}}
*{{cite journal  | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
*{{cite journal  | vauthors=Bi W, Yan J, Stankiewicz P |title=Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702  | pmc=186594 |display-authors=etal}}
*{{cite journal  | author=Hong X, Xu L, Li X, ''et al.'' |title=CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation. |journal=FEBS Lett. |volume=499 |issue= 1-2 |pages= 133-6 |year= 2001 |pmid= 11418127 |doi= }}
*{{cite journal  | vauthors=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome |journal=FEBS Lett. |volume=527 |issue= 1–3 |pages= 15–21 |year= 2002 |pmid= 12220626 |doi=10.1016/S0014-5793(02)03147-2  }}
*{{cite journal  | author=Bi W, Yan J, Stankiewicz P, ''et al.'' |title=Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. |journal=Genome Res. |volume=12 |issue= 5 |pages= 713-28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 15-21 |year= 2002 |pmid= 12220626 |doi=  }}
*{{cite journal  | vauthors=Petersen HH, Hilpert J, Militz D |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule |journal=J. Cell Sci. |volume=116 |issue= Pt 3 |pages= 453–61 |year= 2003 |pmid= 12508107 |doi=10.1242/jcs.00243 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Serino G, Su H, Peng Z |title=Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex |journal=Plant Cell |volume=15 |issue= 3 |pages= 719–31 |year= 2003 |pmid= 12615944 |doi=10.1105/tpc.009092  | pmc=150025  |display-authors=etal}}
*{{cite journal  | author=Petersen HH, Hilpert J, Militz D, ''et al.'' |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. |journal=J. Cell. Sci. |volume=116 |issue= Pt 3 |pages= 453-61 |year= 2003 |pmid= 12508107 |doi= }}
*{{cite journal  | vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3  }}
*{{cite journal  | author=Serino G, Su H, Peng Z, ''et al.'' |title=Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. |journal=Plant Cell |volume=15 |issue= 3 |pages= 719-31 |year= 2003 |pmid= 12615944 |doi=  }}
*{{cite journal  | vauthors=Uhle S, Medalia O, Waldron R |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302–12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 | pmc=151059 |display-authors=etal}}
*{{cite journal  | author=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112-25 |year= 2003 |pmid= 12620389 |doi= }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Uhle S, Medalia O, Waldron R, ''et al.'' |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302-12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 }}
*{{cite journal  | vauthors=Groisman R, Polanowska J, Kuraoka I |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage |journal=Cell |volume=113 |issue= 3 |pages= 357–67 |year= 2003 |pmid= 12732143 |doi=10.1016/S0092-8674(03)00316-7  |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Henriksen J, Aagesen TH, Maelandsmo GM |title=Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation |journal=Oncogene |volume=22 |issue= 34 |pages= 5358–61 |year= 2003 |pmid= 12917637 |doi= 10.1038/sj.onc.1206671 |display-authors=etal}}
*{{cite journal  | author=Groisman R, Polanowska J, Kuraoka I, ''et al.'' |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. |journal=Cell |volume=113 |issue= 3 |pages= 357-67 |year= 2003 |pmid= 12732143 |doi=  }}
*{{cite journal  | author=Henriksen J, Aagesen TH, Maelandsmo GM, ''et al.'' |title=Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. |journal=Oncogene |volume=22 |issue= 34 |pages= 5358-61 |year= 2003 |pmid= 12917637 |doi= 10.1038/sj.onc.1206671 }}
}}
}}
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{{refend}}


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Latest revision as of 19:36, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[1][2][3] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[3]

See also

References

  1. ↑ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
  2. ↑ Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
  3. ↑ 3.0 3.1 "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

External links

Further reading



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