CSTF2: Difference between revisions

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{{Infobox_gene}}
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'''Cleavage stimulation factor 64 kDa subunit''' is a [[protein]] that in humans is encoded by the ''CSTF2'' [[gene]].<ref name="pmid1741396">{{cite journal | vauthors = Takagaki Y, MacDonald CC, Shenk T, Manley JL | title = The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 4 | pages = 1403–7 |date=March 1992 | pmid = 1741396 | pmc = 48459 | doi =10.1073/pnas.89.4.1403 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CSTF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p1t.
| PDB = {{PDB2|1p1t}}, {{PDB2|2j8p}}
| Name = Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
| HGNCid = 2484
| Symbol = CSTF2
| AltSymbols =; CstF-64
| OMIM = 600368
| ECnumber = 
| Homologene = 80171
| MGIid = 1343054
| GeneAtlas_image1 = PBB_GE_CSTF2_204459_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GNF_GO|id=GO:0006379 |text = mRNA cleavage}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1478
    | Hs_Ensembl = ENSG00000101811
    | Hs_RefseqProtein = NP_001316
    | Hs_RefseqmRNA = NM_001325
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 99962004
    | Hs_GenLoc_end = 99982577
    | Hs_Uniprot = P33240
    | Mm_EntrezGene = 108062
    | Mm_Ensembl = ENSMUSG00000031256
    | Mm_RefseqmRNA = NM_133196
    | Mm_RefseqProtein = NP_573459
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 129405699
    | Mm_GenLoc_end = 129433171
    | Mm_Uniprot = Q8BIQ5
  }}
}}
'''Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa''', also known as '''CSTF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.<ref name="entrez">{{cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = }}</ref>
| summary_text = This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.<ref name="entrez"/>
}}
}}
==Interactions==
CSTF2 has been shown to [[Protein-protein interaction|interact]] with [[CSTF3]],<ref name=pmid10669729>{{cite journal |last=Takagaki |first=Y |author2=Manley J L |date=March 2000  |title=Complex protein interactions within the human polyadenylation machinery identify a novel component |journal=Mol. Cell. Biol. |volume=20 |issue=5 |pages=1515–25 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10669729 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.5.1515-1525.2000 |pmc=85326 }}</ref> [[SUB1]],<ref name=pmid11389848>{{cite journal |last=Calvo |first=O |author2=Manley J L |date=May 2001 |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination |journal=Mol. Cell |volume=7 |issue=5 |pages=1013–23 |publisher= |location = United States| issn = 1097-2765| pmid = 11389848 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(01)00236-2 }}</ref> [[SYMPK]],<ref name=pmid10669729/> [[BARD1]]<ref name=pmid11257228>{{cite journal |last=Kleiman |first=F E |author2=Manley J L |date=March 2001  |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression |journal=Cell |volume=104 |issue=5 |pages=743–53 |publisher= |location = United States| issn = 0092-8674| pmid = 11257228 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(01)00270-7 }}</ref><ref name=pmid10477523>{{cite journal |last=Kleiman |first=F E |author2=Manley J L |date=September 1999  |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=[[Science (journal)|Science]] |volume=285 |issue=5433 |pages=1576–9 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 10477523 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1126/science.285.5433.1576 }}</ref> and [[BRCA1]].<ref name=pmid11257228/><ref name=pmid10477523/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CSTF2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471-4 |year= 1992 |pmid= 1358884 |doi=  }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue. |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471–4 |year= 1992 |pmid= 1358884 |doi=  }}
*{{cite journal  | author=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403-7 |year= 1992 |pmid= 1741396 |doi=  }}
*{{cite journal  | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672 }}
*{{cite journal  | author=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672-83 |year= 1995 |pmid= 7590244 |doi= }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 }}
*{{cite journal  | author=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. |journal=Nature |volume=372 |issue= 6505 |pages= 471-4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 }}
*{{cite journal  | vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107  }}
*{{cite journal  | author=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107-13 |year= 1996 |pmid= 8626397 |doi=  }}
*{{cite journal  | vauthors=Schul W, Groenhout B, Koberna K |title=The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. |journal=EMBO J. |volume=15 |issue= 11 |pages= 2883–92 |year= 1996 |pmid= 8654386 |doi=  | pmc=450226  |display-authors=etal}}
*{{cite journal  | author=Schul W, Groenhout B, Koberna K, ''et al.'' |title=The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA. |journal=EMBO J. |volume=15 |issue= 11 |pages= 2883-92 |year= 1996 |pmid= 8654386 |doi=  }}
*{{cite journal  | vauthors=Takagaki Y, Seipelt RL, Peterson ML, Manley JL |title=The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. |journal=Cell |volume=87 |issue= 5 |pages= 941–52 |year= 1997 |pmid= 8945520 |doi=10.1016/S0092-8674(00)82000-0 }}
*{{cite journal  | author=Takagaki Y, Seipelt RL, Peterson ML, Manley JL |title=The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. |journal=Cell |volume=87 |issue= 5 |pages= 941-52 |year= 1997 |pmid= 8945520 |doi=  }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=RNA recognition by the human polyadenylation factor CstF. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3907–14 |year= 1997 |pmid= 9199325 |doi= | pmc=232243 }}
*{{cite journal  | author=Takagaki Y, Manley JL |title=RNA recognition by the human polyadenylation factor CstF. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3907-14 |year= 1997 |pmid= 9199325 |doi= }}
*{{cite journal  | vauthors=Martincic K, Campbell R, Edwalds-Gilbert G |title=Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11095–100 |year= 1998 |pmid= 9736695 |doi=10.1073/pnas.95.19.11095  | pmc=21601  |display-authors=etal}}
*{{cite journal  | author=Martincic K, Campbell R, Edwalds-Gilbert G, ''et al.'' |title=Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11095-100 |year= 1998 |pmid= 9736695 |doi= }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 761–71 |year= 1999 |pmid= 9885564 |doi=10.1016/S1097-2765(00)80291-9  }}
*{{cite journal  | author=Takagaki Y, Manley JL |title=Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 761-71 |year= 1999 |pmid= 9885564 |doi=  }}
*{{cite journal  | vauthors=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=10.1126/science.285.5433.1576 }}
*{{cite journal  | author=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. |journal=Science |volume=285 |issue= 5433 |pages= 1576-9 |year= 1999 |pmid= 10477523 |doi=  }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000  | pmc=85326 }}
*{{cite journal  | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515-25 |year= 2000 |pmid= 10669729 |doi= }}
*{{cite journal  | vauthors=Dass B, McMahon KW, Jenkins NA |title=The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8044–50 |year= 2001 |pmid= 11113135 |doi= 10.1074/jbc.M009091200 |display-authors=etal}}
*{{cite journal  | author=Dass B, McMahon KW, Jenkins NA, ''et al.'' |title=The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8044-50 |year= 2001 |pmid= 11113135 |doi= 10.1074/jbc.M009091200 }}
*{{cite journal  | vauthors=Kleiman FE, Manley JL |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. |journal=Cell |volume=104 |issue= 5 |pages= 743–53 |year= 2001 |pmid= 11257228 |doi=10.1016/S0092-8674(01)00270-7  }}
*{{cite journal  | author=Kleiman FE, Manley JL |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. |journal=Cell |volume=104 |issue= 5 |pages= 743-53 |year= 2001 |pmid= 11257228 |doi=  }}
*{{cite journal  | vauthors=Calvo O, Manley JL |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 1013–23 |year= 2001 |pmid= 11389848 |doi=10.1016/S1097-2765(01)00236-2 }}
*{{cite journal  | author=Calvo O, Manley JL |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 1013-23 |year= 2001 |pmid= 11389848 |doi=  }}
*{{cite journal  | vauthors=Bléoo S, Sun X, Hendzel MJ |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046–59 |year= 2002 |pmid= 11598190 |doi=  10.1091/mbc.12.10.3046| pmc=60154  |display-authors=etal}}
*{{cite journal  | author=Bléoo S, Sun X, Hendzel MJ, ''et al.'' |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046-59 |year= 2002 |pmid= 11598190 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Pérez Cañadillas JM, Varani G |title=Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2821–30 |year= 2003 |pmid= 12773396 |doi= 10.1093/emboj/cdg259  | pmc=156756 }}
*{{cite journal  | author=Pérez Cañadillas JM, Varani G |title=Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2821-30 |year= 2003 |pmid= 12773396 |doi= 10.1093/emboj/cdg259 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Xing H, Mayhew CN, Cullen KE |title=HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10551–5 |year= 2004 |pmid= 14707147 |doi= 10.1074/jbc.M311719200 |display-authors=etal}}
*{{cite journal  | author=Xing H, Mayhew CN, Cullen KE, ''et al.'' |title=HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10551-5 |year= 2004 |pmid= 14707147 |doi= 10.1074/jbc.M311719200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1478}}
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Revision as of 10:08, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[1][2]

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[2]

Interactions

CSTF2 has been shown to interact with CSTF3,[3] SUB1,[4] SYMPK,[3] BARD1[5][6] and BRCA1.[5][6]

References

  1. ↑ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
  2. ↑ 2.0 2.1 "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".
  3. ↑ 3.0 3.1 Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. UNITED STATES. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729.
  4. ↑ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. United States. 7 (5): 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848.
  5. ↑ 5.0 5.1 Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. United States. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228.
  6. ↑ 6.0 6.1 Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. UNITED STATES. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.

External links

Further reading



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