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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cullin-2''' is a [[protein]] that in humans is encoded by the ''CUL2'' [[gene]].<ref name="pmid8681378">{{cite journal | vauthors = Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM | title = cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family | journal = Cell | volume = 85 | issue = 6 | pages = 829–39 | date = Aug 1996 | pmid = 8681378 | pmc =  | doi = 10.1016/S0092-8674(00)81267-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CUL2 cullin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8453| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Cullin 2
| HGNCid = 2552
| Symbol = CUL2
| AltSymbols =; MGC131970
| OMIM = 603135
| ECnumber = 
| Homologene = 2662
| MGIid = 1918995
| GeneAtlas_image1 = PBB_GE_CUL2_203078_at_tn.png
| GeneAtlas_image2 = PBB_GE_CUL2_203079_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8453
    | Hs_Ensembl = ENSG00000108094
    | Hs_RefseqProtein = NP_003582
    | Hs_RefseqmRNA = NM_003591
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 35337485
    | Hs_GenLoc_end = 35419576
    | Hs_Uniprot = Q13617
    | Mm_EntrezGene = 71745
    | Mm_Ensembl = ENSMUSG00000024231
    | Mm_RefseqmRNA = NM_029402
    | Mm_RefseqProtein = NP_083678
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 3383029
    | Mm_GenLoc_end = 3436372
    | Mm_Uniprot = Q571A2
  }}
}}
'''Cullin 2''', also known as '''CUL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CUL2 cullin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8453| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CUL2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CAND1]],<ref name = pmid18173839/><ref name = pmid12609982>{{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15905–10 | date = May 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }}</ref>
| summary_text =  
* [[DCUN1D1]],<ref name = pmid18826954>{{cite journal | vauthors = Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B | title = SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation | journal = J. Biol. Chem. | volume = 283 | issue = 48 | pages = 33211–20 | date = Nov 2008 | pmid = 18826954 | pmc = 2586271 | doi = 10.1074/jbc.M804440200 }}</ref>
}}
* [[RBX1]],<ref name = pmid12481031>{{cite journal | vauthors = Dias DC, Dolios G, Wang R, Pan ZQ | title = CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16601–6 | date = Dec 2002 | pmid = 12481031 | pmc = 139190 | doi = 10.1073/pnas.252646399 }}</ref><ref name = pmid10230407>{{cite journal | vauthors = Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol. Cell | volume = 3 | issue = 4 | pages = 535–41 | date = Apr 1999 | pmid = 10230407 | doi =  10.1016/s1097-2765(00)80482-7}}</ref>
* [[SAP130]],<ref name = pmid18173839>{{cite journal | vauthors = Menon S, Tsuge T, Dohmae N, Takio K, Wei N | title = Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome | journal = BMC Biochem. | volume = 9 | issue = | pages = 1 | pmid = 18173839 | pmc = 2265268 | doi = 10.1186/1471-2091-9-1 }}</ref>  
* [[TCEB2]]<ref name = pmid18173839/><ref name = pmid11384984>{{cite journal | vauthors = Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW | title = Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29748–53 | date = Aug 2001 | pmid = 11384984 | doi = 10.1074/jbc.M103093200 }}</ref>  and
* [[Von Hippel-Lindau tumor suppressor]].<ref name = pmid18173839/><ref name = pmid11384984/><ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue =  | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = pmid10587522>{{cite journal | vauthors = Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG | title = Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein | journal = J. Clin. Invest. | volume = 104 | issue = 11 | pages = 1583–91 | date = Dec 1999 | pmid = 10587522 | pmc = 481054 | doi = 10.1172/JCI8161 }}</ref><ref name = pmid19030229>{{cite journal | vauthors = Hacker KE, Lee CM, Rathmell WK | title = VHL type 2B mutations retain VBC complex form and function | journal = PLoS ONE | volume = 3 | issue = 11 | pages = e3801 | pmid = 19030229 | pmc = 2583047 | doi = 10.1371/journal.pone.0003801 | editor1-last = Zhang | editor1-first = Baohong }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|CUL2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG | title = Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C | journal = Science | volume = 269 | issue = 5229 | pages = 1444–6 | year = 1995 | pmid = 7660130 | doi = 10.1126/science.7660130 }}
| citations =
* {{cite journal | vauthors = Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD | title = The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 6 | pages = 2156–61 | year = 1997 | pmid = 9122164 | pmc = 20057 | doi = 10.1073/pnas.94.6.2156 }}
*{{cite journal | author=Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG |title=Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. |journal=Science |volume=269 |issue= 5229 |pages= 1444-6 |year= 1995 |pmid= 7660130 |doi= }}
* {{cite journal | vauthors = Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG | title = Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2 | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 732–41 | year = 1998 | pmid = 9447969 | pmc = 108784 | doi =  }}
*{{cite journal | author=Kipreos ET, Lander LE, Wing JP, ''et al.'' |title=cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. |journal=Cell |volume=85 |issue= 6 |pages= 829-39 |year= 1996 |pmid= 8681378 |doi= }}
* {{cite journal | vauthors = Wada H, Yeh ET, Kamitani T | title = Identification of NEDD8-conjugation site in human cullin-2 | journal = Biochem. Biophys. Res. Commun. | volume = 257 | issue = 1 | pages = 100–5 | year = 1999 | pmid = 10092517 | doi = 10.1006/bbrc.1999.0339 }}
*{{cite journal | author=Pause A, Lee S, Worrell RA, ''et al.'' |title=The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2156-61 |year= 1997 |pmid= 9122164 |doi=  }}
* {{cite journal | vauthors = Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol. Cell | volume = 3 | issue = 4 | pages = 535–41 | year = 1999 | pmid = 10230407 | doi = 10.1016/S1097-2765(00)80482-7 }}
*{{cite journal | author=Lonergan KM, Iliopoulos O, Ohh M, ''et al.'' |title=Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 732-41 |year= 1998 |pmid= 9447969 |doi= }}
* {{cite journal | vauthors = Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD | title = Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9533–8 | year = 1999 | pmid = 10449727 | pmc = 22243 | doi = 10.1073/pnas.96.17.9533 }}
*{{cite journal | author=Wada H, Yeh ET, Kamitani T |title=Identification of NEDD8-conjugation site in human cullin-2. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 1 |pages= 100-5 |year= 1999 |pmid= 10092517 |doi= 10.1006/bbrc.1999.0339 }}
* {{cite journal | vauthors = Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A | title = Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 22 | pages = 12436–41 | year = 1999 | pmid = 10535940 | pmc = 22941 | doi = 10.1073/pnas.96.22.12436 }}
*{{cite journal | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535-41 |year= 1999 |pmid= 10230407 |doi= }}
* {{cite journal | vauthors = Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K | title = Covalent modification of all members of human cullin family proteins by NEDD8 | journal = Oncogene | volume = 18 | issue = 48 | pages = 6829–34 | year = 2000 | pmid = 10597293 | doi = 10.1038/sj.onc.1203093 }}
*{{cite journal | author=Pause A, Peterson B, Schaffar G, ''et al.'' |title=Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 17 |pages= 9533-8 |year= 1999 |pmid= 10449727 |doi= }}
* {{cite journal | vauthors = Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW | title = Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 19 | pages = 10430–5 | year = 2000 | pmid = 10973499 | pmc = 27041 | doi = 10.1073/pnas.190332597 }}
*{{cite journal | author=Iwai K, Yamanaka K, Kamura T, ''et al.'' |title=Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 22 |pages= 12436-41 |year= 1999 |pmid= 10535940 |doi= }}
* {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | year = 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }}
*{{cite journal | author=Hori T, Osaka F, Chiba T, ''et al.'' |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829-34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093 }}
* {{cite journal | vauthors = Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW | title = Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29748–53 | year = 2001 | pmid = 11384984 | doi = 10.1074/jbc.M103093200 }}
*{{cite journal | author=Kamura T, Sato S, Iwai K, ''et al.'' |title=Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10430-5 |year= 2000 |pmid= 10973499 |doi= 10.1073/pnas.190332597 }}
* {{cite journal | vauthors = Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG | title = An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells | journal = EMBO Rep. | volume = 3 | issue = 2 | pages = 177–82 | year = 2002 | pmid = 11818338 | pmc = 1083969 | doi = 10.1093/embo-reports/kvf028 }}
*{{cite journal | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
* {{cite journal | vauthors = Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP | title = Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling | journal = Science | volume = 296 | issue = 5574 | pages = 1886–9 | year = 2002 | pmid = 12004076 | doi = 10.1126/science.1073440 }}
*{{cite journal | author=Kamura T, Burian D, Yan Q, ''et al.'' |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748-53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200 }}
* {{cite journal | vauthors = Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC | title = Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 16 | pages = 10353–8 | year = 2002 | pmid = 12149480 | pmc = 124918 | doi = 10.1073/pnas.162424199 }}
*{{cite journal | author=Ohh M, Kim WY, Moslehi JJ, ''et al.'' |title=An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. |journal=EMBO Rep. |volume=3 |issue= 2 |pages= 177-82 |year= 2002 |pmid= 11818338 |doi= 10.1093/embo-reports/kvf028 }}
* {{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15905–10 | year = 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }}
*{{cite journal | author=Min JH, Yang H, Ivan M, ''et al.'' |title=Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. |journal=Science |volume=296 |issue= 5574 |pages= 1886-9 |year= 2002 |pmid= 12004076 |doi= 10.1126/science.1073440 }}
* {{cite journal | vauthors = Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW | title = Identification of Elongin C and Skp1 sequences that determine Cullin selection | journal = J. Biol. Chem. | volume = 279 | issue = 41 | pages = 43019–26 | year = 2004 | pmid = 15280393 | doi = 10.1074/jbc.M408018200 }}
*{{cite journal | author=Brower CS, Sato S, Tomomori-Sato C, ''et al.'' |title=Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10353-8 |year= 2002 |pmid= 12149480 |doi= 10.1073/pnas.162424199 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Min KW, Hwang JW, Lee JS, ''et al.'' |title=TIP120A associates with cullins and modulates ubiquitin ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15905-10 |year= 2003 |pmid= 12609982 |doi= 10.1074/jbc.M213070200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | author=Yan Q, Kamura T, Cai Y, ''et al.'' |title=Identification of Elongin C and Skp1 sequences that determine Cullin selection. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43019-26 |year= 2004 |pmid= 15280393 |doi= 10.1074/jbc.M408018200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-10-stub}}

Latest revision as of 10:11, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cullin-2 is a protein that in humans is encoded by the CUL2 gene.[1][2]

Interactions

CUL2 has been shown to interact with:

References

  1. ↑ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378.
  2. ↑ "Entrez Gene: CUL2 cullin 2".
  3. ↑ 3.0 3.1 3.2 3.3 Menon S, Tsuge T, Dohmae N, Takio K, Wei N. "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.
  4. ↑ Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
  5. ↑ Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.
  6. ↑ Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  7. ↑ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/s1097-2765(00)80482-7. PMID 10230407.
  8. ↑ 8.0 8.1 Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (Aug 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
  9. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  10. ↑ Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC 481054. PMID 10587522.
  11. ↑ Hacker KE, Lee CM, Rathmell WK. Zhang B, ed. "VHL type 2B mutations retain VBC complex form and function". PLoS ONE. 3 (11): e3801. doi:10.1371/journal.pone.0003801. PMC 2583047. PMID 19030229.

External links

Further reading


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