DDEF1: Difference between revisions

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Revision as of 18:18, 30 August 2017

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene.^[1]^[2]

Interactions

DDEF1 has been shown to interact with Src.^[3]

References

↑ Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol Cell Biol. 18 (12): 7038–51. PMC 109286. PMID 9819391.
↑ "Entrez Gene: DDEF1 development and differentiation enhancing factor 1".
↑ Brown, M T; Andrade J; Radhakrishna H; Donaldson J G; Cooper J A; Randazzo P A (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol. Cell. Biol. UNITED STATES. 18 (12): 7038–51. ISSN 0270-7306. PMC 109286. PMID 9819391.

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Furman C, Short SM, Subramanian RR, et al. (2002). "DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism". J. Biol. Chem. 277 (10): 7962–9. doi:10.1074/jbc.M109149200. PMID 11773070.
Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Liu Y, Loijens JC, Martin KH, et al. (2002). "The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly". Mol. Biol. Cell. 13 (6): 2147–56. doi:10.1091/mbc.E02-01-0018. PMC 117631. PMID 12058076.
Oshiro T, Koyama S, Sugiyama S, et al. (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41): 38618–26. doi:10.1074/jbc.M203453200. PMID 12149250.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Oda A, Wada I, Miura K, et al. (2003). "CrkL directs ASAP1 to peripheral focal adhesions". J. Biol. Chem. 278 (8): 6456–60. doi:10.1074/jbc.M210817200. PMID 12522101.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134. PMID 15719014.
Ehlers JP, Worley L, Onken MD, Harbour JW (2005). "DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma". Clin. Cancer Res. 11 (10): 3609–13. doi:10.1158/1078-0432.CCR-04-1941. PMID 15897555.
Che MM, Boja ES, Yoon HY, et al. (2005). "Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains". Cell. Signal. 17 (10): 1276–88. doi:10.1016/j.cellsig.2005.01.007. PMID 16038802.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Hashimoto S, Hirose M, Hashimoto A, et al. (2006). "Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 7036–41. doi:10.1073/pnas.0509166103. PMC 1459014. PMID 16636290.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid9819391-1] Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol Cell Biol. 18 (12): 7038–51. PMC 109286. PMID 9819391.

[entrez-2] "Entrez Gene: DDEF1 development and differentiation enhancing factor 1".

[autogenerated1-3] Brown, M T; Andrade J; Radhakrishna H; Donaldson J G; Cooper J A; Randazzo P A (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol. Cell. Biol. UNITED STATES. 18 (12): 7038–51. ISSN 0270-7306. PMC 109286. PMID 9819391.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''ASAP1'' [[gene]].<ref name="pmid9819391">{{cite journal | vauthors = Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA | title = ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src | journal = Mol Cell Biol | volume = 18 | issue = 12 | pages = 7038–51 |date=Dec 1998 | pmid = 9819391 | pmc = 109286 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDEF1 development and differentiation enhancing factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50807| accessdate = }}</ref>
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- | image = PBB_Protein_DDEF1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2da0.
- | PDB = {{PDB2|2da0}}
- | Name = Development and differentiation enhancing factor 1
- | HGNCid = 2720
- | Symbol = DDEF1
- | AltSymbols =; PAP; AMAP1; ASAP1; KIAA1249; PAG2; ZG14P
- | OMIM = 605953
- | ECnumber =
- | Homologene = 7684
- | MGIid = 1342335
- | GeneAtlas_image1 = PBB_GE_DDEF1_221039_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 50807
-    | Hs_Ensembl = ENSG00000153317
-    | Hs_RefseqProtein = NP_060952
-    | Hs_RefseqmRNA = NM_018482
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 8
-    | Hs_GenLoc_start = 131133535
-    | Hs_GenLoc_end = 131483399
-    | Hs_Uniprot = Q9ULH1
-    | Mm_EntrezGene = 13196
-    | Mm_Ensembl = ENSMUSG00000022377
-    | Mm_RefseqmRNA = XM_976874
-    | Mm_RefseqProtein = XP_981968
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 63918209
-    | Mm_GenLoc_end = 64212592
-    | Mm_Uniprot = Q3TXY1
-  }}
-}}
-'''Development and differentiation enhancing factor 1''', also known as '''DDEF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDEF1 development and differentiation enhancing factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50807| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
 | summary_text =
 }}
+==Interactions==
+DDEF1 has been shown to [[Protein-protein interaction|interact]] with [[Src (gene)|Src]].<ref name=autogenerated1>{{cite journal |last=Brown |first=M T |author2=Andrade J |author3=Radhakrishna H |author4=Donaldson J G |author5=Cooper J A |author6=Randazzo P A  |date=Dec 1998 |title=ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src |journal=Mol. Cell. Biol. |volume=18 |issue=12 |pages=7038–51 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9819391 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109286 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Brown MT, Andrade J, Radhakrishna H, ''et al.'' |title=ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7038-51 |year= 1998 |pmid= 9819391 |doi=  }}
+*{{cite journal  | vauthors=Nagase T, Ishikawa K, Kikuno R |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337  |display-authors=etal}}
-*{{cite journal  | author=Nagase T, Ishikawa K, Kikuno R, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337-45 |year= 2000 |pmid= 10574462 |doi=  }}
+*{{cite journal  | vauthors=Furman C, Short SM, Subramanian RR |title=DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7962–9 |year= 2002 |pmid= 11773070 |doi= 10.1074/jbc.M109149200 |display-authors=etal}}
-*{{cite journal  | author=Furman C, Short SM, Subramanian RR, ''et al.'' |title=DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7962-9 |year= 2002 |pmid= 11773070 |doi= 10.1074/jbc.M109149200 }}
+*{{cite journal  | vauthors=Scott MP, Zappacosta F, Kim EY |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 |display-authors=etal}}
-*{{cite journal  | author=Scott MP, Zappacosta F, Kim EY, ''et al.'' |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238-46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200 }}
+*{{cite journal  | vauthors=Liu Y, Loijens JC, Martin KH |title=The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. |journal=Mol. Biol. Cell |volume=13 |issue= 6 |pages= 2147–56 |year= 2002 |pmid= 12058076 |doi= 10.1091/mbc.E02-01-0018  | pmc=117631 |display-authors=etal}}
-*{{cite journal  | author=Liu Y, Loijens JC, Martin KH, ''et al.'' |title=The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. |journal=Mol. Biol. Cell |volume=13 |issue= 6 |pages= 2147-56 |year= 2002 |pmid= 12058076 |doi= 10.1091/mbc.E02-01-0018 }}
+*{{cite journal  | vauthors=Oshiro T, Koyama S, Sugiyama S |title=Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38618–26 |year= 2002 |pmid= 12149250 |doi= 10.1074/jbc.M203453200 |display-authors=etal}}
-*{{cite journal  | author=Oshiro T, Koyama S, Sugiyama S, ''et al.'' |title=Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38618-26 |year= 2002 |pmid= 12149250 |doi= 10.1074/jbc.M203453200 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Oda A, Wada I, Miura K |title=CrkL directs ASAP1 to peripheral focal adhesions. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6456–60 |year= 2003 |pmid= 12522101 |doi= 10.1074/jbc.M210817200 |display-authors=etal}}
-*{{cite journal  | author=Oda A, Wada I, Miura K, ''et al.'' |title=CrkL directs ASAP1 to peripheral focal adhesions. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6456-60 |year= 2003 |pmid= 12522101 |doi= 10.1074/jbc.M210817200 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Onodera Y, Hashimoto S, Hashimoto A |title=Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. |journal=EMBO J. |volume=24 |issue= 5 |pages= 963–73 |year= 2005 |pmid= 15719014 |doi= 10.1038/sj.emboj.7600588  | pmc=554134 |display-authors=etal}}
-*{{cite journal  | author=Onodera Y, Hashimoto S, Hashimoto A, ''et al.'' |title=Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. |journal=EMBO J. |volume=24 |issue= 5 |pages= 963-73 |year= 2005 |pmid= 15719014 |doi= 10.1038/sj.emboj.7600588 }}
+*{{cite journal  | vauthors=Ehlers JP, Worley L, Onken MD, Harbour JW |title=DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma. |journal=Clin. Cancer Res. |volume=11 |issue= 10 |pages= 3609–13 |year= 2005 |pmid= 15897555 |doi= 10.1158/1078-0432.CCR-04-1941 }}
-*{{cite journal  | author=Ehlers JP, Worley L, Onken MD, Harbour JW |title=DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma. |journal=Clin. Cancer Res. |volume=11 |issue= 10 |pages= 3609-13 |year= 2005 |pmid= 15897555 |doi= 10.1158/1078-0432.CCR-04-1941 }}
+*{{cite journal  | vauthors=Che MM, Boja ES, Yoon HY |title=Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. |journal=Cell. Signal. |volume=17 |issue= 10 |pages= 1276–88 |year= 2005 |pmid= 16038802 |doi= 10.1016/j.cellsig.2005.01.007 |display-authors=etal}}
-*{{cite journal  | author=Che MM, Boja ES, Yoon HY, ''et al.'' |title=Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. |journal=Cell. Signal. |volume=17 |issue= 10 |pages= 1276-88 |year= 2005 |pmid= 16038802 |doi= 10.1016/j.cellsig.2005.01.007 }}
+*{{cite journal  | vauthors=Nusbaum C, Mikkelsen TS, Zody MC |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 |display-authors=etal}}
-*{{cite journal  | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331-5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
+*{{cite journal  | vauthors=Hashimoto S, Hirose M, Hashimoto A |title=Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 18 |pages= 7036–41 |year= 2006 |pmid= 16636290 |doi= 10.1073/pnas.0509166103  | pmc=1459014 |display-authors=etal}}
-*{{cite journal  | author=Hashimoto S, Hirose M, Hashimoto A, ''et al.'' |title=Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 18 |pages= 7036-41 |year= 2006 |pmid= 16636290 |doi= 10.1073/pnas.0509166103 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=50807}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-8-stub}}
-{{WikiDoc Sources}}

DDEF1: Difference between revisions

Revision as of 18:18, 30 August 2017

Interactions

References

Further reading

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