DDT (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''D-dopachrome decarboxylase''' is an [[enzyme]] that in humans is encoded by the ''DDT'' [[gene]].<ref name="pmid9480844">{{cite journal | vauthors = Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M | title = Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation | journal = Biochem Biophys Res Commun | volume = 243 | issue = 2 | pages = 538–44 |date=Mar 1998 | pmid = 9480844 | pmc =  | doi = 10.1006/bbrc.1998.8123 }}</ref><ref name="pmid9729470">{{cite journal | vauthors = Coggan M, Whitbread L, Whittington A, Board P | title = Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex | series = 334 | journal = Biochem J | volume = ( Pt 3) | issue =  | pages = 617–23 |date=Nov 1998 | pmid = 9729470 | pmc = 1219731 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDT D-dopachrome tautomerase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1652| accessdate = }}</ref>
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D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the [[macrophage migration inhibitory factor]] (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_DDT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dpt.
| PDB = {{PDB2|1dpt}}
| Name = D-dopachrome tautomerase
| HGNCid = 2732
| Symbol = DDT
| AltSymbols =;
| OMIM = 602750
| ECnumber = 
| Homologene = 1038
| MGIid = 1298381
| GeneAtlas_image1 = PBB_GE_DDT_202929_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004167 |text = dopachrome isomerase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1652
    | Hs_Ensembl = ENSG00000099977
    | Hs_RefseqProtein = NP_001346
    | Hs_RefseqmRNA = NM_001355
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 22643562
    | Hs_GenLoc_end = 22652019
    | Hs_Uniprot = P30046
    | Mm_EntrezGene = 13202
    | Mm_Ensembl = ENSMUSG00000001666
    | Mm_RefseqmRNA = NM_010027
    | Mm_RefseqProtein = NP_034157
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 75214942
    | Mm_GenLoc_end = 75217083
    | Mm_Uniprot = Q3UNI8
  }}
}}
'''D-dopachrome tautomerase''', also known as '''DDT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDT D-dopachrome tautomerase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1652| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
* [[Macrophage migration inhibitory factor domain]]
| section_title =  
| summary_text = D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.<ref name="entrez">{{cite web | title = Entrez Gene: DDT D-dopachrome tautomerase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1652| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Hochstrasser DF, Frutiger S, Paquet N |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=10.1002/elps.11501301201 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Odh G, Hindemith A, Rosengren AM |title=Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 619–24 |year= 1994 |pmid= 8267597 |doi= 10.1006/bbrc.1993.2524 |display-authors=etal}}
*{{cite journal  | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi=  }}
*{{cite journal  | vauthors=Esumi N, Budarf M, Ciccarelli L |title=Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. |journal=Mamm. Genome |volume=9 |issue= 9 |pages= 753–7 |year= 1999 |pmid= 9716662 |doi=10.1007/s003359900858 |display-authors=etal}}
*{{cite journal  | author=Odh G, Hindemith A, Rosengren AM, ''et al.'' |title=Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 619-24 |year= 1994 |pmid= 8267597 |doi= 10.1006/bbrc.1993.2524 }}
*{{cite journal  | vauthors=Sugimoto H, Taniguchi M, Nakagawa A |title=Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. |journal=Biochemistry |volume=38 |issue= 11 |pages= 3268–79 |year= 1999 |pmid= 10079069 |doi= 10.1021/bi982184o |display-authors=etal}}
*{{cite journal  | author=Nishihira J, Fujinaga M, Kuriyama T, ''et al.'' |title=Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 538-44 |year= 1998 |pmid= 9480844 |doi= 10.1006/bbrc.1998.8123 }}
*{{cite journal  | vauthors=Dunham I, Shimizu N, Roe BA |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |display-authors=etal}}
*{{cite journal  | author=Esumi N, Budarf M, Ciccarelli L, ''et al.'' |title=Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. |journal=Mamm. Genome |volume=9 |issue= 9 |pages= 753-7 |year= 1999 |pmid= 9716662 |doi= }}
*{{cite journal  | vauthors=Lubetsky JB, Dios A, Han J |title=The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24976–82 |year= 2002 |pmid= 11997397 |doi= 10.1074/jbc.M203220200 |display-authors=etal}}
*{{cite journal  | author=Coggan M, Whitbread L, Whittington A, Board P |title=Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. |journal=Biochem. J. |volume=334 ( Pt 3) |issue= |pages= 617-23 |year= 1998 |pmid= 9729470 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Sugimoto H, Taniguchi M, Nakagawa A, ''et al.'' |title=Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. |journal=Biochemistry |volume=38 |issue= 11 |pages= 3268-79 |year= 1999 |pmid= 10079069 |doi= 10.1021/bi982184o }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | vauthors=Sonesson B, Rosengren E, Hansson AS, Hansson C |title=UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. |journal=Exp. Dermatol. |volume=12 |issue= 3 |pages= 278–82 |year= 2004 |pmid= 12823441 |doi=10.1034/j.1600-0625.2003.120307.x }}
*{{cite journal  | author=Lubetsky JB, Dios A, Han J, ''et al.'' |title=The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24976-82 |year= 2002 |pmid= 11997397 |doi= 10.1074/jbc.M203220200 }}
*{{cite journal  | vauthors=Collins JE, Wright CL, Edwards CA |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Sonesson B, Rosengren E, Hansson AS, Hansson C |title=UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. |journal=Exp. Dermatol. |volume=12 |issue= 3 |pages= 278-82 |year= 2004 |pmid= 12823441 |doi=  }}
*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1652}}


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{{gene-22-stub}}
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Latest revision as of 18:18, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.[1][2][3]

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the macrophage migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.[3]

See also

References

  1. ↑ Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M (Mar 1998). "Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation". Biochem Biophys Res Commun. 243 (2): 538–44. doi:10.1006/bbrc.1998.8123. PMID 9480844.
  2. ↑ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334. ( Pt 3): 617–23. PMC 1219731. PMID 9729470.
  3. ↑ 3.0 3.1 "Entrez Gene: DDT D-dopachrome tautomerase".

Further reading


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