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{{Infobox_gene}}
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'''ATP-dependent RNA helicase DDX1''' is an [[enzyme]] that in humans is encoded by the ''DDX1'' [[gene]].<ref name="pmid1552844">{{cite journal | vauthors = Schmid SR, Linder P | title = D-E-A-D protein family of putative RNA helicases | journal = Mol Microbiol | volume = 6 | issue = 3 | pages = 283–292 |date=Apr 1992 | pmid = 1552844 | pmc =  | doi =10.1111/j.1365-2958.1992.tb01470.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1653| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
| HGNCid = 2734
| Symbol = DDX1
| AltSymbols =; DBP-RB; UKVH5d
| OMIM = 601257
| ECnumber =
| Homologene = 3627
| MGIid = 2144727
  | GeneAtlas_image1 = PBB_GE_DDX1_201241_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0004618 |text = phosphoglycerate kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
  | Process = {{GNF_GO|id=GO:0000245 |text = spliceosome assembly}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1653
    | Hs_Ensembl = ENSG00000079785
    | Hs_RefseqProtein = NP_004930
    | Hs_RefseqmRNA = NM_004939
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 15648753
    | Hs_GenLoc_end = 15688676
    | Hs_Uniprot = Q92499
    | Mm_EntrezGene = 104721
    | Mm_Ensembl = ENSMUSG00000037149
    | Mm_RefseqmRNA = NM_134040
    | Mm_RefseqProtein = NP_598801
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 13245295
    | Mm_GenLoc_end = 13275162
    | Mm_Uniprot = Q3V1Z7
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 1''', also known as '''DDX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1653| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.<ref name="entrez">{{cite web | title = Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1653| accessdate = }}</ref>
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.<ref name="entrez" />
}}
}}
==Interactions==
DDX1 has been shown to [[Protein-protein interaction|interact]] with [[HNRPK]].<ref name=pmid12183465>{{cite journal |last=Chen |first=Hui-Chin |author2=Lin Wei-Chin |author3=Tsay Yeou-Guang |author4=Lee Sheng-Chung |author5=Chang Ching-Jin  |date=Oct 2002 |title=An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K |journal=J. Biol. Chem. |volume=277 |issue=43 |pages=40403–40409 |publisher= |location = United States| issn = 0021-9258| pmid = 12183465 |doi = 10.1074/jbc.M206981200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schmid SR, Linder P |title=D-E-A-D protein family of putative RNA helicases. |journal=Mol. Microbiol. |volume=6 |issue= 3 |pages= 283-91 |year= 1992 |pmid= 1552844 |doi= }}
*{{cite journal  | author=Li L |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions |journal=Cell Res. |volume=15 |issue= 11–12 |pages= 923–934 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 |name-list-format=vanc| author2=Li HS | author3=Pauza CD | display-authors=3  | last4=Bukrinsky  | first4=Michael  | last5=Zhao  | first5=Richard Y }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
*{{cite journal  | vauthors=Godbout R, Squire J |title=Amplification of a DEAD box protein gene in retinoblastoma cell lines |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7578–7582 |year= 1993 |pmid= 7689221 |doi=10.1073/pnas.90.16.7578  | pmc=47185 }}
*{{cite journal  | author=Godbout R, Squire J |title=Amplification of a DEAD box protein gene in retinoblastoma cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7578-82 |year= 1993 |pmid= 7689221 |doi=  }}
*{{cite journal  | author=Kitajima Y |title=A novel human homologue of a dead-box RNA helicase family |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 748–754 |year= 1994 |pmid= 8135819 |doi=10.1006/bbrc.1994.1292 |name-list-format=vanc| author2=Yatsuki H  | author3=Zhang R  | display-authors=3  | last4=Matsuhashi  | first4=S  | last5=Hori  | first5=K }}
*{{cite journal  | author=Kitajima Y, Yatsuki H, Zhang R, ''et al.'' |title=A novel human homologue of a dead-box RNA helicase family. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 748-54 |year= 1994 |pmid= 8135819 |doi=  }}
*{{cite journal  | author=Akiyama K |title=Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 4 |pages= 563–8 |year= 1999 |pmid= 10319407 |doi=  10.1080/15216549900201603|name-list-format=vanc| author2=Akao Y  | author3=Yokoyama M  | display-authors=3 | last4=Nakagawa  | first4=Y  | last5=Noguchi  | first5=T  | last6=Yagi  | first6=K  | last7=Nishi  | first7=Y }}
*{{cite journal  | author=Akiyama K, Akao Y, Yokoyama M, ''et al.'' |title=Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines. |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 4 |pages= 563-8 |year= 1999 |pmid= 10319407 |doi=  }}
*{{cite journal  | author=Golembowski S |title=Clonal evolution in a primary cutaneous follicle center B cell lymphoma revealed by single cell analysis in sequential biopsies |journal=Immunobiology |volume=201 |issue= 5 |pages= 631–44 |year= 2000 |pmid= 10834319 |doi=  10.1016/s0171-2985(00)80080-7|name-list-format=vanc| author2=Gellrich S  | author3=von Zimmermann M  | display-authors=3  | last4=Rutz  | first4=S  | last5=Lippert  | first5=S  | last6=Audring  | first6=H  | last7=Lorenz  | first7=P  | last8=Sterry  | first8=W  | last9=Jahn  | first9=S  }}
*{{cite journal  | author=Golembowski S, Gellrich S, von Zimmermann M, ''et al.'' |title=Clonal evolution in a primary cutaneous follicle center B cell lymphoma revealed by single cell analysis in sequential biopsies. |journal=Immunobiology |volume=201 |issue= 5 |pages= 631-44 |year= 2000 |pmid= 10834319 |doi=  }}
*{{cite journal  | author=Bléoo S |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046–59 |year= 2002 |pmid= 11598190 |doi= 10.1091/mbc.12.10.3046| pmc=60154 |name-list-format=vanc| author2=Sun X  | author3=Hendzel MJ  | display-authors=3  | last4=Rowe  | first4=JM  | last5=Packer  | first5=M  | last6=Godbout  | first6=R  }}
*{{cite journal  | author=Bléoo S, Sun X, Hendzel MJ, ''et al.'' |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046-59 |year= 2002 |pmid= 11598190 |doi=  }}
*{{cite journal  | author=Andersen JS |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  |name-list-format=vanc| author2=Lyon CE | author3=Fox AH  | display-authors=3  | last4=Leung  | first4=Anthony K.L. | last5=Lam  | first5=Yun Wah  | last6=Steen  | first6=Hanno | last7=Mann  | first7=Matthias  | last8=Lamond  | first8=Angus I. }}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | author=Chen HC |title=An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40403–40409 |year= 2002 |pmid= 12183465 |doi= 10.1074/jbc.M206981200 |name-list-format=vanc| author2=Lin WC  | author3=Tsay YG  | display-authors=3  | last4=Lee  | first4=SC  | last5=Chang  | first5=CJ }}
*{{cite journal  | author=Chen HC, Lin WC, Tsay YG, ''et al.'' |title=An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40403-9 |year= 2002 |pmid= 12183465 |doi= 10.1074/jbc.M206981200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Fang J |title=A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev |journal=Virology |volume=330 |issue= 2 |pages= 471–480 |year= 2005 |pmid= 15567440 |doi= 10.1016/j.virol.2004.09.039  |name-list-format=vanc| author2=Kubota S  | author3=Yang B  | display-authors=3  | last4=Zhou  | first4=N  | last5=Zhang  | first5=H  | last6=Godbout  | first6=R  | last7=Pomerantz  | first7=R }}
*{{cite journal  | author=Fang J, Kubota S, Yang B, ''et al.'' |title=A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev. |journal=Virology |volume=330 |issue= 2 |pages= 471-80 |year= 2005 |pmid= 15567440 |doi= 10.1016/j.virol.2004.09.039 }}
*{{cite journal  | vauthors=Krishnan V, Zeichner SL |title=Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication |journal=Retrovirology |volume=1 |issue=  |pages= 42 |year= 2006 |pmid= 15588285 |doi= 10.1186/1742-4690-1-42  | pmc=543576 }}
*{{cite journal | author=Krishnan V, Zeichner SL |title=Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication. |journal=Retrovirology |volume=1 |issue=  |pages= 42 |year= 2006 |pmid= 15588285 |doi= 10.1186/1742-4690-1-42 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Fang J |title=The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes |journal=Virology |volume=336 |issue= 2 |pages= 299–307 |year= 2005 |pmid= 15892970 |doi= 10.1016/j.virol.2005.03.017  |name-list-format=vanc| author2=Acheampong E  | author3=Dave R  | display-authors=3  | last4=Wang  | first4=F  | last5=Mukhtar  | first5=M  | last6=Pomerantz  | first6=R }}
*{{cite journal | author=Fang J, Acheampong E, Dave R, ''et al.'' |title=The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes. |journal=Virology |volume=336 |issue= 2 |pages= 299-307 |year= 2005 |pmid= 15892970 |doi= 10.1016/j.virol.2005.03.017 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kaneko S |title=Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma |journal=J. Cancer Res. Clin. Oncol. |volume=133 |issue= 3 |pages= 185–192 |year= 2007 |pmid= 17028906 |doi= 10.1007/s00432-006-0156-y  |name-list-format=vanc| author2=Ohira M  | author3=Nakamura Y  | display-authors=3  | last4=Isogai  | first4=Eriko  | last5=Nakagawara  | first5=Akira  | last6=Kaneko  | first6=Michio }}
*{{cite journal | author=Kaneko S, Ohira M, Nakamura Y, ''et al.'' |title=Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma. |journal=J. Cancer Res. Clin. Oncol. |volume=133 |issue= 3 |pages= 185-92 |year= 2007 |pmid= 17028906 |doi= 10.1007/s00432-006-0156-y }}
*{{cite journal  | vauthors=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells |journal=Mol. Cell. Proteomics |volume=6 |issue= 4 |pages= 575–588 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575-88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:18, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.[2]

Interactions

DDX1 has been shown to interact with HNRPK.[3]

References

  1. ↑ Schmid SR, Linder P (Apr 1992). "D-E-A-D protein family of putative RNA helicases". Mol Microbiol. 6 (3): 283–292. doi:10.1111/j.1365-2958.1992.tb01470.x. PMID 1552844.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1".
  3. ↑ Chen, Hui-Chin; Lin Wei-Chin; Tsay Yeou-Guang; Lee Sheng-Chung; Chang Ching-Jin (Oct 2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K". J. Biol. Chem. United States. 277 (43): 40403–40409. doi:10.1074/jbc.M206981200. ISSN 0021-9258. PMID 12183465.

Further reading



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