DDX10: Difference between revisions

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'''Probable ATP-dependent RNA helicase DDX10''' is an [[enzyme]] that in humans is encoded by the ''DDX10'' [[gene]].<ref name="pmid8660968">{{cite journal | vauthors = Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G | title = A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23 | journal = Genomics | volume = 33 | issue = 2 | pages = 199–206 |date=Jan 1997 | pmid = 8660968 | pmc =  | doi = 10.1006/geno.1996.0184 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1662| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_DDX10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2pl3.
| PDB = {{PDB2|2pl3}}
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
| HGNCid = 2735
| Symbol = DDX10
| AltSymbols =; HRH-J8
| OMIM = 601235
| ECnumber = 
| Homologene = 20922
| MGIid = 1924841
| GeneAtlas_image1 = PBB_GE_DDX10_204977_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1662
    | Hs_Ensembl = ENSG00000178105
    | Hs_RefseqProtein = NP_004389
    | Hs_RefseqmRNA = NM_004398
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 108041014
    | Hs_GenLoc_end = 108316866
    | Hs_Uniprot = Q13206
    | Mm_EntrezGene = 77591
    | Mm_Ensembl = ENSMUSG00000053289
    | Mm_RefseqmRNA = XM_001002864
    | Mm_RefseqProtein = XP_001002864
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 52861036
    | Mm_GenLoc_end = 53010486
    | Mm_Uniprot = Q3TKX5
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 10''', also known as '''DDX10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1662| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.<ref name="entrez">{{cite web | title = Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1662| accessdate = }}</ref>
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Wang SC, Lien HC, Xia W, ''et al.'' |title=Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. |journal=Cancer Cell |volume=6 |issue= 3 |pages= 251-61 |year= 2004 |pmid= 15380516 |doi= 10.1016/j.ccr.2004.07.012 }}
*{{cite journal  | vauthors=Wang SC, Lien HC, Xia W |title=Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. |journal=Cancer Cell |volume=6 |issue= 3 |pages= 251–61 |year= 2004 |pmid= 15380516 |doi= 10.1016/j.ccr.2004.07.012 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}}
*{{cite journal  | author=Nakao K, Nishino M, Takeuchi K, ''et al.'' |title=Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. |journal=Intern. Med. |volume=39 |issue= 5 |pages= 412-5 |year= 2000 |pmid= 10830185 |doi=  }}
*{{cite journal  | vauthors=Nakao K, Nishino M, Takeuchi K |title=Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. |journal=Intern. Med. |volume=39 |issue= 5 |pages= 412–5 |year= 2000 |pmid= 10830185 |doi=10.2169/internalmedicine.39.412 |display-authors=etal}}
*{{cite journal  | author=Zuber J, Tchernitsa OI, Hinzmann B, ''et al.'' |title=A genome-wide survey of RAS transformation targets. |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144-52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799 }}
*{{cite journal  | vauthors=Zuber J, Tchernitsa OI, Hinzmann B |title=A genome-wide survey of RAS transformation targets. |journal=Nat. Genet. |volume=24 |issue= 2 |pages= 144–52 |year= 2000 |pmid= 10655059 |doi= 10.1038/72799 |display-authors=etal}}
*{{cite journal  | author=Ikeda T, Ikeda K, Sasaki K, ''et al.'' |title=The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. |journal=Int. J. Hematol. |volume=69 |issue= 3 |pages= 160-4 |year= 1999 |pmid= 10222653 |doi=  }}
*{{cite journal  | vauthors=Ikeda T, Ikeda K, Sasaki K |title=The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. |journal=Int. J. Hematol. |volume=69 |issue= 3 |pages= 160–4 |year= 1999 |pmid= 10222653 |doi=  |display-authors=etal}}
*{{cite journal  | author=Liang WQ, Clark JA, Fournier MJ |title=The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 4124-32 |year= 1997 |pmid= 9199348 |doi=  }}
*{{cite journal  | vauthors=Liang WQ, Clark JA, Fournier MJ |title=The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 4124–32 |year= 1997 |pmid= 9199348 |doi= | pmc=232266 }}
*{{cite journal  | author=Arai Y, Hosoda F, Kobayashi H, ''et al.'' |title=The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. |journal=Blood |volume=89 |issue= 11 |pages= 3936-44 |year= 1997 |pmid= 9166830 |doi=  }}
*{{cite journal  | vauthors=Arai Y, Hosoda F, Kobayashi H |title=The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. |journal=Blood |volume=89 |issue= 11 |pages= 3936–44 |year= 1997 |pmid= 9166830 |doi=  |display-authors=etal}}
*{{cite journal  | author=Savitsky K, Ziv Y, Bar-Shira A, ''et al.'' |title=A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. |journal=Genomics |volume=33 |issue= 2 |pages= 199-206 |year= 1997 |pmid= 8660968 |doi= 10.1006/geno.1996.0184 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1662}}
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Revision as of 18:18, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.[2]

References

  1. ↑ Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics. 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID 8660968.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10".

Further reading



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