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| | '''Protein DGCR14''' is a [[protein]] that in humans is encoded by the ''DGCR14'' [[gene]].<ref name="pmid8776594">{{cite journal | vauthors = Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML | title = A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11 | journal = Hum Mol Genet | volume = 5 | issue = 6 | pages = 789–800 |date=Dec 1996 | pmid = 8776594 | pmc = | doi =10.1093/hmg/5.6.789 }}</ref><ref name="pmid9063747">{{cite journal | vauthors = Gong W, Emanuel BS, Galili N, Kim DH, Roe B, Driscoll DA, Budarf ML | title = Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region | journal = Hum Mol Genet | volume = 6 | issue = 2 | pages = 267–276 |date=Aug 1997 | pmid = 9063747 | pmc = | doi =10.1093/hmg/6.2.267 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DGCR14 DiGeorge syndrome critical region gene 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8220| accessdate = }}</ref> | ||
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| summary_text = This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.<ref name="entrez" | | summary_text = This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | author=Rizzu P | *{{cite journal | author=Rizzu P |title=Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans |journal=Mamm. Genome |volume=7 |issue= 9 |pages= 639–643 |year= 1996 |pmid= 8703114 |doi=10.1007/s003359900197 |name-list-format=vanc| author2=Lindsay EA | author3=Taylor C | display-authors=3 | last4=o’Donnell | first4=H. | last5=Levy | first5=A. | last6=Scambler | first6=P. | last7=Baldini | first7=A. }} | ||
*{{cite journal | author=Lindsay EA |title=A transcription map in the CATCH22 critical region: identification, mapping, and ordering of four novel transcripts expressed in heart |journal=Genomics |volume=32 |issue= 1 |pages= 104–112 |year= 1996 |pmid= 8786095 |doi= 10.1006/geno.1996.0082 |name-list-format=vanc| author2=Rizzu P | author3=Antonacci R | display-authors=3 | last4=Jurecic | first4=V | last5=Delmas-Mata | first5=J | last6=Lee | first6=CC | last7=Kim | first7=UJ | last8=Scambler | first8=PJ | last9=Baldini | first9=A }} | |||
*{{cite journal | author=Lindsay EA | *{{cite journal | vauthors=Botta A, Lindsay EA, Jurecic V, Baldini A |title=Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation |journal=Mamm. Genome |volume=8 |issue= 12 |pages= 890–895 |year= 1998 |pmid= 9383280 |doi=10.1007/s003359900606 }} | ||
*{{cite journal | author=Puech A |title=Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14608–14613 |year= 1998 |pmid= 9405660 |doi=10.1073/pnas.94.26.14608 | pmc=25069 |name-list-format=vanc| author2=Saint-Jore B | author3=Funke B | display-authors=3 | last4=Gilbert | first4=DJ | last5=Sirotkin | first5=H | last6=Copeland | first6=NG | last7=Jenkins | first7=NA | last8=Kucherlapati | first8=R | last9=Morrow | first9=B }} | |||
*{{cite journal | | *{{cite journal | vauthors=Lindsay EA, Harvey EL, Scambler PJ, Baldini A |title=ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 629–635 |year= 1998 |pmid= 9499415 |doi=10.1093/hmg/7.4.629 }} | ||
*{{cite journal | author=Puech A | *{{cite journal | vauthors=Taricani L, Tejada ML, Young PG |title=The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10562–10572 |year= 2002 |pmid= 11751918 |doi= 10.1074/jbc.M110686200 }} | ||
*{{cite journal | | *{{cite journal | author=Tchernev VT |title=The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins |journal=Mol. Med. |volume=8 |issue= 1 |pages= 56–64 |year= 2002 |pmid= 11984006 |doi= | pmc=2039936 |name-list-format=vanc| author2=Mansfield TA | author3=Giot L | display-authors=3 | last4=Kumar | first4=AM | last5=Nandabalan | first5=K | last6=Li | first6=Y | last7=Mishra | first7=VS | last8=Detter | first8=JC | last9=Rothberg | first9=JM }} | ||
*{{cite journal | | *{{cite journal | author=Jurica MS |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–439 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 |name-list-format=vanc| author2=Licklider LJ | author3=Gygi SR | display-authors=3 | last4=Grigorieff | first4=Nikolaus | last5=Moore | first5=Melissa J. }} | ||
*{{cite journal | author=Tchernev VT | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Jurica MS | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Strausberg RL | *{{cite journal | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |name-list-format=vanc| author2=Wright CL | author3=Edwards CA | display-authors=3 | last4=Davis | first4=Matthew P | last5=Grinham | first5=James A | last6=Cole | first6=Charlotte G | last7=Goward | first7=Melanie E | last8=Aguado | first8=Begoña | last9=Mallya | first9=Meera }} | ||
*{{cite journal | author=Ota T | *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Collins JE | *{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–648 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias }} | ||
*{{cite journal | author=Gerhard DS | |||
*{{cite journal | author=Olsen JV | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{gene-22-stub}} | {{gene-22-stub}} | ||
Latest revision as of 18:24, 30 August 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
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Protein DGCR14 is a protein that in humans is encoded by the DGCR14 gene.[1][2][3]
This gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of 22q11.2. The encoded protein may be a component of C complex spliceosomes, and the orthologous protein in the mouse localizes to the nucleus.[3]
References
- ↑ Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe B, Budarf ML (Dec 1996). "A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11". Hum Mol Genet. 5 (6): 789–800. doi:10.1093/hmg/5.6.789. PMID 8776594.
- ↑ Gong W, Emanuel BS, Galili N, Kim DH, Roe B, Driscoll DA, Budarf ML (Aug 1997). "Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region". Hum Mol Genet. 6 (2): 267–276. doi:10.1093/hmg/6.2.267. PMID 9063747.
- ↑ 3.0 3.1 "Entrez Gene: DGCR14 DiGeorge syndrome critical region gene 14".
Further reading
- Rizzu P, Lindsay EA, Taylor C, et al. (1996). "Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans". Mamm. Genome. 7 (9): 639–643. doi:10.1007/s003359900197. PMID 8703114.
- Lindsay EA, Rizzu P, Antonacci R, et al. (1996). "A transcription map in the CATCH22 critical region: identification, mapping, and ordering of four novel transcripts expressed in heart". Genomics. 32 (1): 104–112. doi:10.1006/geno.1996.0082. PMID 8786095.
- Botta A, Lindsay EA, Jurecic V, Baldini A (1998). "Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation". Mamm. Genome. 8 (12): 890–895. doi:10.1007/s003359900606. PMID 9383280.
- Puech A, Saint-Jore B, Funke B, et al. (1998). "Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14608–14613. doi:10.1073/pnas.94.26.14608. PMC 25069. PMID 9405660.
- Lindsay EA, Harvey EL, Scambler PJ, Baldini A (1998). "ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene". Hum. Mol. Genet. 7 (4): 629–635. doi:10.1093/hmg/7.4.629. PMID 9499415.
- Taricani L, Tejada ML, Young PG (2002). "The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein". J. Biol. Chem. 277 (12): 10562–10572. doi:10.1074/jbc.M110686200. PMID 11751918.
- Tchernev VT, Mansfield TA, Giot L, et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. PMC 2039936. PMID 11984006.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–439. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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