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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Deoxyguanosine kinase, mitochondrial''' is an [[enzyme]] that in humans is encoded by the ''DGUOK'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DGUOK deoxyguanosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1716| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DGUOK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ocp.
| PDB = {{PDB2|2ocp}}
| Name = Deoxyguanosine kinase
| HGNCid = 2858
| Symbol = DGUOK
| AltSymbols =; dGK
| OMIM = 601465
| ECnumber = 
| Homologene = 8456
| MGIid = 1351602
| GeneAtlas_image1 = PBB_GE_DGUOK_203816_at_tn.png
| GeneAtlas_image2 = PBB_GE_DGUOK_209549_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004138 |text = deoxyguanosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016773 |text = phosphotransferase activity, alcohol group as acceptor}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0008617 |text = guanosine metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1716
    | Hs_Ensembl = ENSG00000114956
    | Hs_RefseqProtein = NP_550438
    | Hs_RefseqmRNA = NM_080916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 74007461
    | Hs_GenLoc_end = 74039596
    | Hs_Uniprot = Q16854
    | Mm_EntrezGene = 27369
    | Mm_Ensembl = ENSMUSG00000014554
    | Mm_RefseqmRNA = NM_013764
    | Mm_RefseqProtein = NP_038792
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 83445877
    | Mm_GenLoc_end = 83472627
    | Mm_Uniprot = Q504N4
  }}
}}
'''Deoxyguanosine kinase''', also known as '''DGUOK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DGUOK deoxyguanosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1716| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In mammalian cells, the [[phosphorylation]] of purine [[deoxyribonucleoside]]s is mediated predominantly by two [[deoxynucleoside kinase|deoxyribonucleoside kinases]], cytosolic [[deoxycytidine kinase]] and mitochondrial [[deoxyguanosine kinase]]. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the [[mitochondrial]] matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. [[Alternative splicing|Alternative splice]] variants encoding different protein isoforms have been described for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DGUOK deoxyguanosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1716| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Johansson M, Karlsson A | title = Cloning and expression of human deoxyguanosine kinase cDNA | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 14 | pages = 7258–62 | year = 1996 | pmid = 8692979 | pmc = 38970 | doi = 10.1073/pnas.93.14.7258 }}
| citations =
* {{cite journal | vauthors = Wang L, Hellman U, Eriksson S | title = Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA | journal = FEBS Lett. | volume = 390 | issue = 1 | pages = 39–43 | year = 1996 | pmid = 8706825 | doi = 10.1016/0014-5793(96)00623-0 }}
*{{cite journal | author=Johansson M, Karlsson A |title=Cloning and expression of human deoxyguanosine kinase cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7258-62 |year= 1996 |pmid= 8692979 |doi= }}
* {{cite journal | vauthors = Johansson M, Bajalica-Lagercrantz S, Lagercrantz J, Karlsson A | title = Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13 | journal = Genomics | volume = 38 | issue = 3 | pages = 450–1 | year = 1997 | pmid = 8975728 | doi = 10.1006/geno.1996.0654 }}
*{{cite journal | author=Wang L, Hellman U, Eriksson S |title=Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA. |journal=FEBS Lett. |volume=390 |issue= 1 |pages= 39-43 |year= 1996 |pmid= 8706825 |doi= }}
* {{cite journal | vauthors = Jüllig M, Eriksson S | title = Mitochondrial and submitochondrial localization of human deoxyguanosine kinase | journal = Eur. J. Biochem. | volume = 267 | issue = 17 | pages = 5466–72 | year = 2000 | pmid = 10951205 | doi = 10.1046/j.1432-1327.2000.01607.x }}
*{{cite journal | author=Johansson M, Bajalica-Lagercrantz S, Lagercrantz J, Karlsson A |title=Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13. |journal=Genomics |volume=38 |issue= 3 |pages= 450-1 |year= 1997 |pmid= 8975728 |doi= 10.1006/geno.1996.0654 }}
* {{cite journal | vauthors = Jüllig M, Eriksson S | title = Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24000–4 | year = 2001 | pmid = 11294860 | doi = 10.1074/jbc.M100435200 }}
*{{cite journal | author=Jüllig M, Eriksson S |title=Mitochondrial and submitochondrial localization of human deoxyguanosine kinase. |journal=Eur. J. Biochem. |volume=267 |issue= 17 |pages= 5466-72 |year= 2000 |pmid= 10951205 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S | title = Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes | journal = Genome Res. | volume = 11 | issue = 5 | pages = 677–84 | year = 2001 | pmid = 11337467 | pmc = 311086 | doi = 10.1101/gr.164001 }}
*{{cite journal | author=Jüllig M, Eriksson S |title=Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24000-4 |year= 2001 |pmid= 11294860 |doi= 10.1074/jbc.M100435200 }}
* {{cite journal | vauthors = Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H | title = Structural basis for substrate specificities of cellular deoxyribonucleoside kinases | journal = Nat. Struct. Biol. | volume = 8 | issue = 7 | pages = 616–20 | year = 2001 | pmid = 11427893 | doi = 10.1038/89661 }}
*{{cite journal | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
* {{cite journal | vauthors = Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y, Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N | title = The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA | journal = Nat. Genet. | volume = 29 | issue = 3 | pages = 337–41 | year = 2001 | pmid = 11687800 | doi = 10.1038/ng746 }}
*{{cite journal | author=Johansson K, Ramaswamy S, Ljungcrantz C, ''et al.'' |title=Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. |journal=Nat. Struct. Biol. |volume=8 |issue= 7 |pages= 616-20 |year= 2001 |pmid= 11427893 |doi= 10.1038/89661 }}
* {{cite journal | vauthors = Lotfi K, Månsson E, Peterson C, Eriksson S, Albertioni F | title = Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 5 | pages = 1489–96 | year = 2002 | pmid = 12054684 | doi = 10.1016/S0006-291X(02)00415-1 }}
*{{cite journal | author=Mandel H, Szargel R, Labay V, ''et al.'' |title=The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. |journal=Nat. Genet. |volume=29 |issue= 3 |pages= 337-41 |year= 2001 |pmid= 11687800 |doi= 10.1038/ng746 }}
* {{cite journal | vauthors = Salviati L, Sacconi S, Mancuso M, Otaegui D, Camaño P, Marina A, Rabinowitz S, Shiffman R, Thompson K, Wilson CM, Feigenbaum A, Naini AB, Hirano M, Bonilla E, DiMauro S, Vu TH | title = Mitochondrial DNA depletion and dGK gene mutations | journal = Ann. Neurol. | volume = 52 | issue = 3 | pages = 311–7 | year = 2002 | pmid = 12205643 | doi = 10.1002/ana.10284 }}
*{{cite journal | author=Lotfi K, Månsson E, Peterson C, ''et al.'' |title=Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 5 |pages= 1489-96 |year= 2002 |pmid= 12054684 |doi= 10.1016/S0006-291X(02)00415-1 }}
* {{cite journal | vauthors = Taanman JW, Kateeb I, Muntau AC, Jaksch M, Cohen N, Mandel H | title = A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA | journal = Ann. Neurol. | volume = 52 | issue = 2 | pages = 237–9 | year = 2002 | pmid = 12210798 | doi = 10.1002/ana.10247 }}
*{{cite journal | author=Salviati L, Sacconi S, Mancuso M, ''et al.'' |title=Mitochondrial DNA depletion and dGK gene mutations. |journal=Ann. Neurol. |volume=52 |issue= 3 |pages= 311-7 |year= 2002 |pmid= 12205643 |doi= 10.1002/ana.10284 }}
* {{cite journal | vauthors = Krawiec K, Kierdaszuk B, Shugar D | title = Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases | journal = Biochem. Biophys. Res. Commun. | volume = 301 | issue = 1 | pages = 192–7 | year = 2003 | pmid = 12535661 | doi = 10.1016/S0006-291X(02)03007-3 }}
*{{cite journal | author=Taanman JW, Kateeb I, Muntau AC, ''et al.'' |title=A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA. |journal=Ann. Neurol. |volume=52 |issue= 2 |pages= 237-9 |year= 2002 |pmid= 12210798 |doi= 10.1002/ana.10247 }}
* {{cite journal | vauthors = Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S | title = Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes | journal = Mol. Genet. Metab. | volume = 84 | issue = 1 | pages = 75–82 | year = 2005 | pmid = 15639197 | doi = 10.1016/j.ymgme.2004.09.005 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mancuso M, Ferraris S, Pancrudo J, Feigenbaum A, Raiman J, Christodoulou J, Thorburn DR, DiMauro S | title = New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome | journal = Arch. Neurol. | volume = 62 | issue = 5 | pages = 745–7 | year = 2005 | pmid = 15883261 | doi = 10.1001/archneur.62.5.745 }}
*{{cite journal | author=Krawiec K, Kierdaszuk B, Shugar D |title=Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 192-7 |year= 2003 |pmid= 12535661 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Fyrberg A, Mirzaee S, Lotfi K | title = Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells | journal = Nucleosides Nucleotides Nucleic Acids | volume = 25 | issue = 9–11 | pages = 1201–4 | year = 2007 | pmid = 17065091 | doi = 10.1080/15257770600894386 }}
*{{cite journal | author=Wang L, Limongelli A, Vila MR, ''et al.'' |title=Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. |journal=Mol. Genet. Metab. |volume=84 |issue= 1 |pages= 75-82 |year= 2005 |pmid= 15639197 |doi= 10.1016/j.ymgme.2004.09.005 }}
* {{cite journal | vauthors = Mousson de Camaret B, Taanman JW, Padet S, Chassagne M, Mayençon M, Clerc-Renaud P, Mandon G, Zabot MT, Lachaux A, Bozon D | title = Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion | journal = Biochem. J. | volume = 402 | issue = 2 | pages = 377–85 | year = 2007 | pmid = 17073823 | pmc = 1798436 | doi = 10.1042/BJ20060705 }}
*{{cite journal | author=Mancuso M, Ferraris S, Pancrudo J, ''et al.'' |title=New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome. |journal=Arch. Neurol. |volume=62 |issue= 5 |pages= 745-7 |year= 2005 |pmid= 15883261 |doi= 10.1001/archneur.62.5.745 }}
* {{cite journal | vauthors = Franco M, Johansson M, Karlsson A | title = Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells | journal = Exp. Cell Res. | volume = 313 | issue = 12 | pages = 2687–94 | year = 2007 | pmid = 17490647 | doi = 10.1016/j.yexcr.2007.04.003 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Fyrberg A, Mirzaee S, Lotfi K |title=Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells. |journal=Nucleosides Nucleotides Nucleic Acids |volume=25 |issue= 9-11 |pages= 1201-4 |year= 2007 |pmid= 17065091 |doi= 10.1080/15257770600894386 }}
*{{cite journal  | author=Mousson de Camaret B, Taanman JW, Padet S, ''et al.'' |title=Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion. |journal=Biochem. J. |volume=402 |issue= 2 |pages= 377-85 |year= 2007 |pmid= 17073823 |doi= 10.1042/BJ20060705 }}
*{{cite journal | author=Franco M, Johansson M, Karlsson A |title=Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells. |journal=Exp. Cell Res. |volume=313 |issue= 12 |pages= 2687-94 |year= 2007 |pmid= 17490647 |doi= 10.1016/j.yexcr.2007.04.003 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
*[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=dguok-mtddepl  GeneReview/NIH/UW entry on DGUOK-Related Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form]
 
{{PDB Gallery|geneid=1716}}
 
 
{{gene-2-stub}}

Revision as of 18:25, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.[1]

Function

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DGUOK deoxyguanosine kinase".

Further reading

  • Johansson M, Karlsson A (1996). "Cloning and expression of human deoxyguanosine kinase cDNA". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7258–62. doi:10.1073/pnas.93.14.7258. PMC 38970. PMID 8692979.
  • Wang L, Hellman U, Eriksson S (1996). "Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA". FEBS Lett. 390 (1): 39–43. doi:10.1016/0014-5793(96)00623-0. PMID 8706825.
  • Johansson M, Bajalica-Lagercrantz S, Lagercrantz J, Karlsson A (1997). "Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13". Genomics. 38 (3): 450–1. doi:10.1006/geno.1996.0654. PMID 8975728.
  • Jüllig M, Eriksson S (2000). "Mitochondrial and submitochondrial localization of human deoxyguanosine kinase". Eur. J. Biochem. 267 (17): 5466–72. doi:10.1046/j.1432-1327.2000.01607.x. PMID 10951205.
  • Jüllig M, Eriksson S (2001). "Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase". J. Biol. Chem. 276 (26): 24000–4. doi:10.1074/jbc.M100435200. PMID 11294860.
  • Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467.
  • Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H (2001). "Structural basis for substrate specificities of cellular deoxyribonucleoside kinases". Nat. Struct. Biol. 8 (7): 616–20. doi:10.1038/89661. PMID 11427893.
  • Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y, Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N (2001). "The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA". Nat. Genet. 29 (3): 337–41. doi:10.1038/ng746. PMID 11687800.
  • Lotfi K, Månsson E, Peterson C, Eriksson S, Albertioni F (2002). "Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity". Biochem. Biophys. Res. Commun. 293 (5): 1489–96. doi:10.1016/S0006-291X(02)00415-1. PMID 12054684.
  • Salviati L, Sacconi S, Mancuso M, Otaegui D, Camaño P, Marina A, Rabinowitz S, Shiffman R, Thompson K, Wilson CM, Feigenbaum A, Naini AB, Hirano M, Bonilla E, DiMauro S, Vu TH (2002). "Mitochondrial DNA depletion and dGK gene mutations". Ann. Neurol. 52 (3): 311–7. doi:10.1002/ana.10284. PMID 12205643.
  • Taanman JW, Kateeb I, Muntau AC, Jaksch M, Cohen N, Mandel H (2002). "A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA". Ann. Neurol. 52 (2): 237–9. doi:10.1002/ana.10247. PMID 12210798.
  • Krawiec K, Kierdaszuk B, Shugar D (2003). "Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases". Biochem. Biophys. Res. Commun. 301 (1): 192–7. doi:10.1016/S0006-291X(02)03007-3. PMID 12535661.
  • Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S (2005). "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes". Mol. Genet. Metab. 84 (1): 75–82. doi:10.1016/j.ymgme.2004.09.005. PMID 15639197.
  • Mancuso M, Ferraris S, Pancrudo J, Feigenbaum A, Raiman J, Christodoulou J, Thorburn DR, DiMauro S (2005). "New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome". Arch. Neurol. 62 (5): 745–7. doi:10.1001/archneur.62.5.745. PMID 15883261.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Fyrberg A, Mirzaee S, Lotfi K (2007). "Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells". Nucleosides Nucleotides Nucleic Acids. 25 (9–11): 1201–4. doi:10.1080/15257770600894386. PMID 17065091.
  • Mousson de Camaret B, Taanman JW, Padet S, Chassagne M, Mayençon M, Clerc-Renaud P, Mandon G, Zabot MT, Lachaux A, Bozon D (2007). "Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion". Biochem. J. 402 (2): 377–85. doi:10.1042/BJ20060705. PMC 1798436. PMID 17073823.
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External links


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