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{{Infobox_gene}}
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'''Delta-like 4''' is a [[protein]] that in humans is encoded by the ''DLL4'' [[gene]].<ref name="pmid10837024">{{cite journal | vauthors = Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL | title = Dll4, a novel Notch ligand expressed in arterial endothelium | journal = Genes Dev | volume = 14 | issue = 11 | pages = 1313–8 |date=Jul 2000 | pmid = 10837024 | pmc = 316657 | doi = 10.1101/gad.14.11.1313 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Delta-like 4 (Drosophila)
| HGNCid = 2910
| Symbol = DLL4
| AltSymbols =; MGC126344; hdelta2
| OMIM = 605185
| ECnumber = 
| Homologene = 10411
| MGIid = 1859388
| GeneAtlas_image1 = PBB_GE_DLL4_gnf1h00322_at_tn.png
| Function = {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}  
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54567
    | Hs_Ensembl = ENSG00000128917
    | Hs_RefseqProtein = NP_061947
    | Hs_RefseqmRNA = NM_019074
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 39009159
    | Hs_GenLoc_end = 39017019
    | Hs_Uniprot = Q9NR61
    | Mm_EntrezGene = 54485
    | Mm_Ensembl = ENSMUSG00000027314
    | Mm_RefseqmRNA = NM_019454
    | Mm_RefseqProtein = NP_062327
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 119017225
    | Mm_GenLoc_end = 119027403
    | Mm_Uniprot = Q9DBU9
  }}
}}
'''Delta-like 4 (Drosophila)''', also known as '''DLL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.<ref name="entrez">{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567| accessdate = }}</ref>
| summary_text = This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Shutter JR, Scully S, Fan W, ''et al.'' |title=Dll4, a novel Notch ligand expressed in arterial endothelium. |journal=Genes Dev. |volume=14 |issue= 11 |pages= 1313-8 |year= 2000 |pmid= 10837024 |doi=  }}
*{{cite journal  | vauthors=Yoneya T, Tahara T, Nagao K |title=Molecular cloning of delta-4, a new mouse and human Notch ligand. |journal=J. Biochem. |volume=129 |issue= 1 |pages= 27–34 |year= 2001 |pmid= 11134954 |doi=  10.1093/oxfordjournals.jbchem.a002832|display-authors=etal}}
*{{cite journal  | author=Yoneya T, Tahara T, Nagao K, ''et al.'' |title=Molecular cloning of delta-4, a new mouse and human Notch ligand. |journal=J. Biochem. |volume=129 |issue= 1 |pages= 27-34 |year= 2001 |pmid= 11134954 |doi=  }}
*{{cite journal  | vauthors=Yan XQ, Sarmiento U, Sun Y |title=A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. |journal=Blood |volume=98 |issue= 13 |pages= 3793–9 |year= 2002 |pmid= 11739188 |doi=10.1182/blood.V98.13.3793 |display-authors=etal}}
*{{cite journal  | author=Yan XQ, Sarmiento U, Sun Y, ''et al.'' |title=A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. |journal=Blood |volume=98 |issue= 13 |pages= 3793-9 |year= 2002 |pmid= 11739188 |doi= }}
*{{cite journal  | vauthors=Mailhos C, Modlich U, Lewis J |title=Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. |journal=Differentiation |volume=69 |issue= 2–3 |pages= 135–44 |year= 2002 |pmid= 11798067 |doi=10.1046/j.1432-0436.2001.690207.x  |display-authors=etal}}
*{{cite journal  | author=Mailhos C, Modlich U, Lewis J, ''et al.'' |title=Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. |journal=Differentiation |volume=69 |issue= 2-3 |pages= 135-44 |year= 2002 |pmid= 11798067 |doi=  }}
*{{cite journal  | vauthors=Dorsch M, Zheng G, Yowe D |title=Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease |journal=Blood |volume=100 |issue= 6 |pages= 2046–55 |year= 2002 |pmid= 12200365 |doi=  |display-authors=etal}}
*{{cite journal  | author=Dorsch M, Zheng G, Yowe D, ''et al.'' |title=Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. |journal=Blood |volume=100 |issue= 6 |pages= 2046-55 |year= 2002 |pmid= 12200365 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Liu ZJ, Shirakawa T, Li Y |title=Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 14–25 |year= 2003 |pmid= 12482957 |doi=10.1128/MCB.23.1.14-25.2003  | pmc=140667  |display-authors=etal}}
*{{cite journal  | author=Liu ZJ, Shirakawa T, Li Y, ''et al.'' |title=Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 14-25 |year= 2003 |pmid= 12482957 |doi=  }}
*{{cite journal  | vauthors=Tohda S, Murata-Ohsawa M, Sakano S, Nara N |title=Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines |journal=Int. J. Oncol. |volume=22 |issue= 5 |pages= 1073–9 |year= 2003 |pmid= 12684674 |doi=  10.3892/ijo.22.5.1073}}
*{{cite journal  | author=Tohda S, Murata-Ohsawa M, Sakano S, Nara N |title=Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. |journal=Int. J. Oncol. |volume=22 |issue= 5 |pages= 1073-9 |year= 2003 |pmid= 12684674 |doi=  }}
*{{cite journal  | vauthors=Shawber CJ, Das I, Francisco E, Kitajewski J |title=Notch signaling in primary endothelial cells |journal=Ann. N. Y. Acad. Sci. |volume=995 |issue= |pages= 162–70 |year= 2003 |pmid= 12814948 |doi=10.1111/j.1749-6632.2003.tb03219.x }}
*{{cite journal  | author=Shawber CJ, Das I, Francisco E, Kitajewski J |title=Notch signaling in primary endothelial cells. |journal=Ann. N. Y. Acad. Sci. |volume=995 |issue= |pages= 162-70 |year= 2003 |pmid= 12814948 |doi=  }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Lauret E, Catelain C, Titeux M |title=Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential |journal=Leukemia |volume=18 |issue= 4 |pages= 788–97 |year= 2004 |pmid= 14990974 |doi= 10.1038/sj.leu.2403288 |display-authors=etal}}
*{{cite journal  | author=Lauret E, Catelain C, Titeux M, ''et al.'' |title=Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential. |journal=Leukemia |volume=18 |issue= 4 |pages= 788-97 |year= 2004 |pmid= 14990974 |doi= 10.1038/sj.leu.2403288 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=McKeane DP, Meyer J, Dobrin SE |title=No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families |journal=[[Schizophrenia Research]] |volume=75 |issue= 1 |pages= 1–3 |year= 2005 |pmid= 15820317 |doi= 10.1016/j.schres.2004.07.017 |display-authors=etal}}
*{{cite journal  | author=McKeane DP, Meyer J, Dobrin SE, ''et al.'' |title=No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families. |journal=[[Schizophrenia Research]] |volume=75 |issue= 1 |pages= 1-3 |year= 2005 |pmid= 15820317 |doi= 10.1016/j.schres.2004.07.017 }}
*{{cite journal  | vauthors=Patel NS, Li JL, Generali D |title=Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function |journal=Cancer Res. |volume=65 |issue= 19 |pages= 8690–7 |year= 2005 |pmid= 16204037 |doi= 10.1158/0008-5472.CAN-05-1208 |display-authors=etal}}
*{{cite journal  | author=Patel NS, Li JL, Generali D, ''et al.'' |title=Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. |journal=Cancer Res. |volume=65 |issue= 19 |pages= 8690-7 |year= 2005 |pmid= 16204037 |doi= 10.1158/0008-5472.CAN-05-1208 }}
*{{cite journal  | vauthors=Patel NS, Dobbie MS, Rochester M |title=Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer |journal=Clin. Cancer Res. |volume=12 |issue= 16 |pages= 4836–44 |year= 2006 |pmid= 16914569 |doi= 10.1158/1078-0432.CCR-06-0285 |display-authors=etal}}
*{{cite journal  | author=Patel NS, Dobbie MS, Rochester M, ''et al.'' |title=Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. |journal=Clin. Cancer Res. |volume=12 |issue= 16 |pages= 4836-44 |year= 2006 |pmid= 16914569 |doi= 10.1158/1078-0432.CCR-06-0285 }}
*{{cite journal  | vauthors=Lefort N, Benne C, Lelièvre JD |title=Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells |journal=Exp. Hematol. |volume=34 |issue= 12 |pages= 1720–9 |year= 2007 |pmid= 17157169 |doi= 10.1016/j.exphem.2006.08.007 |display-authors=etal}}
*{{cite journal  | author=Lefort N, Benne C, Lelièvre JD, ''et al.'' |title=Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells. |journal=Exp. Hematol. |volume=34 |issue= 12 |pages= 1720-9 |year= 2007 |pmid= 17157169 |doi= 10.1016/j.exphem.2006.08.007 }}
*{{cite journal  | vauthors=Fung E, Tang SM, Canner JP |title=Delta-like 4 induces notch signaling in macrophages: implications for inflammation |journal=Circulation |volume=115 |issue= 23 |pages= 2948–56 |year= 2007 |pmid= 17533181 |doi= 10.1161/CIRCULATIONAHA.106.675462 |display-authors=etal}}
*{{cite journal  | author=Fung E, Tang SM, Canner JP, ''et al.'' |title=Delta-like 4 induces notch signaling in macrophages: implications for inflammation. |journal=Circulation |volume=115 |issue= 23 |pages= 2948-56 |year= 2007 |pmid= 17533181 |doi= 10.1161/CIRCULATIONAHA.106.675462 }}
*{{cite journal  | vauthors=Hodkinson PS, Elliott PA, Lad Y |title=Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras |journal=J. Biol. Chem. |volume=282 |issue= 39 |pages= 28991–9001 |year= 2007 |pmid= 17664272 |doi= 10.1074/jbc.M703601200 |display-authors=etal}}
*{{cite journal  | author=Hodkinson PS, Elliott PA, Lad Y, ''et al.'' |title=Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras. |journal=J. Biol. Chem. |volume=282 |issue= 39 |pages= 28991-9001 |year= 2007 |pmid= 17664272 |doi= 10.1074/jbc.M703601200 }}
*{{cite journal  | vauthors=Zang S, ((Ji Ch)), Qu X |title=A study on Notch signaling in human breast cancer |journal=Neoplasma |volume=54 |issue= 4 |pages= 304–10 |year= 2007 |pmid= 17822320 |doi=  |display-authors=etal}}
*{{cite journal | author=Zang S, Ji Ch, Qu X, ''et al.'' |title=A study on Notch signaling in human breast cancer. |journal=Neoplasma |volume=54 |issue= 4 |pages= 304-10 |year= 2007 |pmid= 17822320 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{Notch signaling pathway}}
 
 
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Revision as of 18:32, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.[1][2]

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[2]

References

  1. ↑ Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL (Jul 2000). "Dll4, a novel Notch ligand expressed in arterial endothelium". Genes Dev. 14 (11): 1313–8. doi:10.1101/gad.14.11.1313. PMC 316657. PMID 10837024.
  2. ↑ 2.0 2.1 "Entrez Gene: DLL4 delta-like 4 (Drosophila)".

Further reading



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