DNMT3B: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''DNA (cytosine-5-)-methyltransferase 3 beta''', also known as '''DNMT3B''', is a protein associated with [[immunodeficiency, centromere instability and facial anomalies syndrome]].
| update_page = yes
 
| require_manual_inspection = no
== Function ==
| update_protein_box = yes
 
| update_summary = yes
CpG methylation is an [[epigenetics|epigenetic]] modification that is important for [[embryonic development]], [[Genomic imprinting|imprinting]], and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a [[DNA methyltransferase]] which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the [[ICF syndrome|immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome]]. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1789| accessdate = }}</ref>
| update_citations = yes
 
}}
== Interactions ==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DNMT3B has been shown to [[Protein-protein interaction|interact]] with:
{{GNF_Protein_box
{{div col|colwidth=20em}}
| image = PBB_Protein_DNMT3B_image.jpg
* [[CBX5 (gene)|CBX5]],<ref name = pmid12867029>{{cite journal | date = Jul 2003 | vauthors = Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH | title = Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin | journal = Curr. Biol. | volume = 13 | issue = 14 | pages = 1192–200 | pmid = 12867029 | doi = 10.1016/s0960-9822(03)00432-9}}</ref>
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1khc.
* [[DNMT1]],<ref name = pmid12867029/><ref name = pmid12145218>{{cite journal | date = Aug 2002 | vauthors = Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S | title = Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases | journal = EMBO J. | volume = 21 | issue = 15 | pages = 4183–95 | pmid = 12145218 | pmc = 126147 | doi = 10.1093/emboj/cdf401}}</ref>
| PDB = {{PDB2|1khc}}
* [[DNMT3A]],<ref name = pmid12867029/><ref name = pmid12145218/><ref name = pmid14752048>{{cite journal | vauthors = Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD | title = Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription | journal = Nucleic Acids Res. | volume = 32 | issue = 2 | pages = 598–610 | pmid = 14752048 | pmc = 373322 | doi = 10.1093/nar/gkh195 }}</ref>
| Name = DNA (cytosine-5-)-methyltransferase 3 beta
* [[KIF4A]],<ref name = pmid15148359>{{cite journal | vauthors = Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD | title = Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery | journal = Nucleic Acids Res. | volume = 32 | issue = 9 | pages = 2716–29 | pmid = 15148359 | pmc = 419596 | doi = 10.1093/nar/gkh589 }}</ref>
| HGNCid = 2979
* [[NCAPG]],<ref name = pmid15148359/>
| Symbol = DNMT3B
* [[SMC2]],<ref name = pmid15148359/>
| AltSymbols =; ICF; M.HsaIIIB
* [[Small ubiquitin-related modifier 1|SUMO1]]<ref name = pmid11735126>{{cite journal | date = Dec 2001 | vauthors = Kang ES, Park CW, Chung JH | title = Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1 | journal = Biochem. Biophys. Res. Commun. | volume = 289 | issue = 4 | pages = 862–8 | pmid = 11735126 | doi = 10.1006/bbrc.2001.6057}}</ref>  and
| OMIM = 602900
* [[UBE2I]].<ref name = pmid11735126/>
| ECnumber = 2.1.1.37
{{Div col end}}
| Homologene = 56000
 
| MGIid = 1261819
== References ==
| GeneAtlas_image1 = PBB_GE_DNMT3B_220668_s_at_tn.png
{{Reflist}}
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003886 |text = DNA (cytosine-5-)-methyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008326 |text = site-specific DNA-methyltransferase (cytosine-specific) activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}}
| Process = {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006349 |text = imprinting}} {{GNF_GO|id=GO:0031503 |text = protein complex localization}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1789
    | Hs_Ensembl = ENSG00000088305
    | Hs_RefseqProtein = NP_008823
    | Hs_RefseqmRNA = NM_006892
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 30813852
    | Hs_GenLoc_end = 30860823
    | Hs_Uniprot = Q9UBC3
    | Mm_EntrezGene = 13436
    | Mm_Ensembl = ENSMUSG00000027478
    | Mm_RefseqmRNA = XM_001003158
    | Mm_RefseqProtein = XP_001003158
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 153340894
    | Mm_GenLoc_end = 153379171
    | Mm_Uniprot = O88509
  }}
}}
'''DNA (cytosine-5-)-methyltransferase 3 beta''', also known as '''DNMT3B''', is a protein associated with [[immunodeficiency, centromere instability and facial anomalies syndrome]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text = CpG methylation is an [[epigenetics|epigenetic]] modification that is important for [[embryonic development]], [[imprinting]], and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a [[DNA methyltransferase]] which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1789| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Wijmenga C, Hansen RS, Gimelli G |title=Genetic variation in ICF syndrome: evidence for genetic heterogeneity. |journal=Hum. Mutat. |volume=16 |issue= 6 |pages= 509–17 |year= 2001 |pmid= 11102980 |doi= 10.1002/1098-1004(200012)16:6<509::AID-HUMU8>3.0.CO;2-V |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Okano M, Xie S, Li E |title=Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. |journal=Nat. Genet. |volume=19 |issue= 3 |pages= 219–20 |year= 1998 |pmid= 9662389 |doi= 10.1038/890 }}
*{{cite journal  | author=Wijmenga C, Hansen RS, Gimelli G, ''et al.'' |title=Genetic variation in ICF syndrome: evidence for genetic heterogeneity. |journal=Hum. Mutat. |volume=16 |issue= 6 |pages= 509-17 |year= 2001 |pmid= 11102980 |doi= 10.1002/1098-1004(200012)16:6<509::AID-HUMU8>3.0.CO;2-V }}
*{{cite journal  | vauthors=Robertson KD, Uzvolgyi E, Liang G |title=The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. |journal=Nucleic Acids Res. |volume=27 |issue= 11 |pages= 2291–8 |year= 1999 |pmid= 10325416 |doi=10.1093/nar/27.11.2291  | pmc=148793 |display-authors=etal}}
*{{cite journal  | author=Okano M, Xie S, Li E |title=Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. |journal=Nat. Genet. |volume=19 |issue= 3 |pages= 219-20 |year= 1998 |pmid= 9662389 |doi= 10.1038/890 }}
*{{cite journal  | vauthors=Xie S, Wang Z, Okano M |title=Cloning, expression and chromosome locations of the human DNMT3 gene family. |journal=Gene |volume=236 |issue= 1 |pages= 87–95 |year= 1999 |pmid= 10433969 |doi=10.1016/S0378-1119(99)00252-8 |display-authors=etal}}
*{{cite journal  | author=Robertson KD, Uzvolgyi E, Liang G, ''et al.'' |title=The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. |journal=Nucleic Acids Res. |volume=27 |issue= 11 |pages= 2291-8 |year= 1999 |pmid= 10325416 |doi=  }}
*{{cite journal  | vauthors=Okano M, Bell DW, Haber DA, Li E |title=DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. |journal=Cell |volume=99 |issue= 3 |pages= 247–57 |year= 1999 |pmid= 10555141 |doi=10.1016/S0092-8674(00)81656-6 }}
*{{cite journal  | author=Xie S, Wang Z, Okano M, ''et al.'' |title=Cloning, expression and chromosome locations of the human DNMT3 gene family. |journal=Gene |volume=236 |issue= 1 |pages= 87-95 |year= 1999 |pmid= 10433969 |doi=  }}
*{{cite journal  | vauthors=Hansen RS, Wijmenga C, Luo P |title=The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 25 |pages= 14412–7 |year= 2000 |pmid= 10588719 |doi=10.1073/pnas.96.25.14412  | pmc=24450 |display-authors=etal}}
*{{cite journal  | author=Okano M, Bell DW, Haber DA, Li E |title=DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. |journal=Cell |volume=99 |issue= 3 |pages= 247-57 |year= 1999 |pmid= 10555141 |doi=  }}
*{{cite journal  | vauthors=Xu GL, Bestor TH, Bourc'his D |title=Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. |journal=Nature |volume=402 |issue= 6758 |pages= 187–91 |year= 2000 |pmid= 10647011 |doi= 10.1038/46052 |display-authors=etal}}
*{{cite journal  | author=Hansen RS, Wijmenga C, Luo P, ''et al.'' |title=The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 25 |pages= 14412-7 |year= 2000 |pmid= 10588719 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Xu GL, Bestor TH, Bourc'his D, ''et al.'' |title=Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. |journal=Nature |volume=402 |issue= 6758 |pages= 187-91 |year= 2000 |pmid= 10647011 |doi= 10.1038/46052 }}
*{{cite journal  | vauthors=Fuks F, Burgers WA, Godin N |title=Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. |journal=EMBO J. |volume=20 |issue= 10 |pages= 2536–44 |year= 2001 |pmid= 11350943 |doi= 10.1093/emboj/20.10.2536 | pmc=125250 |display-authors=etal}}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Kang ES, Park CW, Chung JH |title=Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 4 |pages= 862–8 |year= 2002 |pmid= 11735126 |doi= 10.1006/bbrc.2001.6057 }}
*{{cite journal  | author=Fuks F, Burgers WA, Godin N, ''et al.'' |title=Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. |journal=EMBO J. |volume=20 |issue= 10 |pages= 2536-44 |year= 2001 |pmid= 11350943 |doi= 10.1093/emboj/20.10.2536 }}
*{{cite journal  | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
*{{cite journal  | author=Kang ES, Park CW, Chung JH |title=Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 4 |pages= 862-8 |year= 2002 |pmid= 11735126 |doi= 10.1006/bbrc.2001.6057 }}
*{{cite journal  | vauthors=Rhee I, Bachman KE, Park BH |title=DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. |journal=Nature |volume=416 |issue= 6880 |pages= 552–6 |year= 2002 |pmid= 11932749 |doi= 10.1038/416552a |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Hata K, Okano M, Lei H, Li E |title=Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. |journal=Development |volume=129 |issue= 8 |pages= 1983–93 |year= 2002 |pmid= 11934864 |doi=  }}
*{{cite journal  | author=Rhee I, Bachman KE, Park BH, ''et al.'' |title=DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. |journal=Nature |volume=416 |issue= 6880 |pages= 552-6 |year= 2002 |pmid= 11932749 |doi= 10.1038/416552a }}
*{{cite journal  | vauthors=Beaulieu N, Morin S, Chute IC |title=An essential role for DNA methyltransferase DNMT3B in cancer cell survival. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28176–81 |year= 2002 |pmid= 12015329 |doi= 10.1074/jbc.M204734200 |display-authors=etal}}
*{{cite journal  | author=Hata K, Okano M, Lei H, Li E |title=Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. |journal=Development |volume=129 |issue= 8 |pages= 1983-93 |year= 2002 |pmid= 11934864 |doi=  }}
*{{cite journal  | vauthors=Saito Y, Kanai Y, Sakamoto M |title=Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 10060–5 |year= 2002 |pmid= 12110732 |doi= 10.1073/pnas.152121799 | pmc=126624 |display-authors=etal}}
*{{cite journal  | author=Beaulieu N, Morin S, Chute IC, ''et al.'' |title=An essential role for DNA methyltransferase DNMT3B in cancer cell survival. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28176-81 |year= 2002 |pmid= 12015329 |doi= 10.1074/jbc.M204734200 }}
*{{cite journal  | vauthors=Kim GD, Ni J, Kelesoglu N |title=Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. |journal=EMBO J. |volume=21 |issue= 15 |pages= 4183–95 |year= 2002 |pmid= 12145218 |doi=10.1093/emboj/cdf401 | pmc=126147  |display-authors=etal}}
*{{cite journal  | author=Saito Y, Kanai Y, Sakamoto M, ''et al.'' |title=Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 10060-5 |year= 2002 |pmid= 12110732 |doi= 10.1073/pnas.152121799 }}
*{{cite journal  | vauthors=Deplus R, Brenner C, Burgers WA |title=Dnmt3L is a transcriptional repressor that recruits histone deacetylase. |journal=Nucleic Acids Res. |volume=30 |issue= 17 |pages= 3831–8 |year= 2002 |pmid= 12202768 |doi=10.1093/nar/gkf509  | pmc=137431 |display-authors=etal}}
*{{cite journal  | author=Kim GD, Ni J, Kelesoglu N, ''et al.'' |title=Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. |journal=EMBO J. |volume=21 |issue= 15 |pages= 4183-95 |year= 2002 |pmid= 12145218 |doi=  }}
*{{cite journal  | vauthors=Shen H, Wang L, Spitz MR |title=A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. |journal=Cancer Res. |volume=62 |issue= 17 |pages= 4992–5 |year= 2002 |pmid= 12208751 |doi=  |display-authors=etal}}
*{{cite journal  | author=Deplus R, Brenner C, Burgers WA, ''et al.'' |title=Dnmt3L is a transcriptional repressor that recruits histone deacetylase. |journal=Nucleic Acids Res. |volume=30 |issue= 17 |pages= 3831-8 |year= 2002 |pmid= 12202768 |doi=  }}
*{{cite journal  | vauthors=Shirohzu H, Kubota T, Kumazawa A |title=Three novel DNMT3B mutations in Japanese patients with ICF syndrome. |journal=Am. J. Med. Genet. |volume=112 |issue= 1 |pages= 31–7 |year= 2003 |pmid= 12239717 |doi= 10.1002/ajmg.10658 |display-authors=etal}}
*{{cite journal  | author=Shen H, Wang L, Spitz MR, ''et al.'' |title=A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. |journal=Cancer Res. |volume=62 |issue= 17 |pages= 4992-5 |year= 2002 |pmid= 12208751 |doi=  }}
*{{cite journal  | author=Shirohzu H, Kubota T, Kumazawa A, ''et al.'' |title=Three novel DNMT3B mutations in Japanese patients with ICF syndrome. |journal=Am. J. Med. Genet. |volume=112 |issue= 1 |pages= 31-7 |year= 2003 |pmid= 12239717 |doi= 10.1002/ajmg.10658 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|DNMT3b}}
* {{MeshName|DNMT3b}}
* {{EC number|2.1.1.37}}
* {{EC number|2.1.1.37}}


{{biochem-stub}}
{{PDB Gallery|geneid=1789}}
{{One carbon transferases}}
{{One carbon transferases}}
{{WikiDoc Sources}}

Revision as of 18:39, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA (cytosine-5-)-methyltransferase 3 beta, also known as DNMT3B, is a protein associated with immunodeficiency, centromere instability and facial anomalies syndrome.

Function

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.[1]

Interactions

DNMT3B has been shown to interact with:

References

  1. ↑ "Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta".
  2. ↑ 2.0 2.1 2.2 Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH (Jul 2003). "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin". Curr. Biol. 13 (14): 1192–200. doi:10.1016/s0960-9822(03)00432-9. PMID 12867029.
  3. ↑ 3.0 3.1 Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S (Aug 2002). "Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases". EMBO J. 21 (15): 4183–95. doi:10.1093/emboj/cdf401. PMC 126147. PMID 12145218.
  4. ↑ Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD. "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048.
  5. ↑ 5.0 5.1 5.2 Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD. "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
  6. ↑ 6.0 6.1 Kang ES, Park CW, Chung JH (Dec 2001). "Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1". Biochem. Biophys. Res. Commun. 289 (4): 862–8. doi:10.1006/bbrc.2001.6057. PMID 11735126.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=DNMT3B&oldid=1419459"