DPP6: Difference between revisions

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Latest revision as of 18:41, 30 August 2017

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.^[1]^[2]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

References

↑ Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A. 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689.
↑ ^2.0 ^2.1 "Entrez Gene: DPP6 dipeptidyl-peptidase 6".

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Yokotani N, Doi K, Wenthold RJ, Wada K (1993). "Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7". Hum. Mol. Genet. 2 (7): 1037–9. doi:10.1093/hmg/2.7.1037. PMID 8103397.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Kin Y, Misumi Y, Ikehara Y (2001). "Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein". J. Biochem. 129 (2): 289–95. doi:10.1093/oxfordjournals.jbchem.a002856. PMID 11173531.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nadal MS, Ozaita A, Amarillo Y, et al. (2003). "The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels". Neuron. 37 (3): 449–61. doi:10.1016/S0896-6273(02)01185-6. PMID 12575952.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Schmitt-Ulms G, Hansen K, Liu J, et al. (2005). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nat. Biotechnol. 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195.
Strop P, Bankovich AJ, Hansen KC, et al. (2004). "Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family". J. Mol. Biol. 343 (4): 1055–65. doi:10.1016/j.jmb.2004.09.003. PMID 15476821.
Zagha E, Ozaita A, Chang SY, et al. (2005). "DPP10 modulates Kv4-mediated A-type potassium channels". J. Biol. Chem. 280 (19): 18853–61. doi:10.1074/jbc.M410613200. PMID 15671030.
Radicke S, Cotella D, Graf EM, et al. (2005). "Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3". J. Physiol. 565 (Pt 3): 751–6. doi:10.1113/jphysiol.2005.087312. PMC 1464568. PMID 15890703.
Ren X, Hayashi Y, Yoshimura N, Takimoto K (2005). "Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels". Mol. Cell. Neurosci. 29 (2): 320–32. doi:10.1016/j.mcn.2005.02.003. PMID 15911355.
Jerng HH, Kunjilwar K, Pfaffinger PJ (2006). "Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties". J. Physiol. 568 (Pt 3): 767–88. doi:10.1113/jphysiol.2005.087858. PMC 1464192. PMID 16123112.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B (2006). "Differential characterization of three alternative spliced isoforms of DPPX". Brain Res. 1094 (1): 1–12. doi:10.1016/j.brainres.2006.03.106. PMID 16764835.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[pmid1729689-1] Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S (Feb 1992). "Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family". Proc Natl Acad Sci U S A. 89 (1): 197–201. doi:10.1073/pnas.89.1.197. PMC 48203. PMID 1729689.

[entrez-2] 2.0 ^2.1 "Entrez Gene: DPP6 dipeptidyl-peptidase 6".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Dipeptidyl aminopeptidase-like protein 6''' is a [[protein]] that in humans is encoded by the ''DPP6'' [[gene]].<ref name="pmid1729689">{{cite journal | vauthors = Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S | title = Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 1 | pages = 197–201 |date=Feb 1992 | pmid = 1729689 | pmc = 48203 | doi =10.1073/pnas.89.1.197  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DPP6 dipeptidyl-peptidase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1804| accessdate = }}</ref>
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- | image = PBB_Protein_DPP6_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xfd.
- | PDB = {{PDB2|1xfd}}
- | Name = Dipeptidyl-peptidase 6
- | HGNCid = 3010
- | Symbol = DPP6
- | AltSymbols =; DPPX; MGC46605
- | OMIM = 126141
- | ECnumber =
- | Homologene = 22560
- | MGIid = 94921
- | GeneAtlas_image1 = PBB_GE_DPP6_207789_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_DPP6_gnf1h05777_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004274 |text = dipeptidyl-peptidase IV activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1804
-    | Hs_Ensembl = ENSG00000130226
-    | Hs_RefseqProtein = NP_001034439
-    | Hs_RefseqmRNA = NM_001039350
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 153380839
-    | Hs_GenLoc_end = 154315627
-    | Hs_Uniprot = P42658
-    | Mm_EntrezGene = 13483
-    | Mm_Ensembl = ENSMUSG00000061576
-    | Mm_RefseqmRNA = NM_010075
-    | Mm_RefseqProtein = NP_034205
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 27148846
-    | Mm_GenLoc_end = 28056538
-    | Mm_Uniprot = Q5U4C2
-  }}
-}}
-'''Dipeptidyl-peptidase 6''', also known as '''DPP6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DPP6 dipeptidyl-peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1804| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: DPP6 dipeptidyl-peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1804| accessdate = }}</ref>
+| summary_text = This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable [[protease]] activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Wada K, Yokotani N, Hunter C, ''et al.'' |title=Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 197-201 |year= 1992 |pmid= 1729689 |doi=  }}
+*{{cite journal  | vauthors=Adams MD, Kerlavage AR, Fleischmann RD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF   |display-authors=etal}}
-*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
+*{{cite journal  | vauthors=Yokotani N, Doi K, Wenthold RJ, Wada K |title=Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 1037–9 |year= 1993 |pmid= 8103397 |doi=10.1093/hmg/2.7.1037  }}
-*{{cite journal  | author=Yokotani N, Doi K, Wenthold RJ, Wada K |title=Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 1037-9 |year= 1993 |pmid= 8103397 |doi=  }}
+*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
-*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
+*{{cite journal  | vauthors=Kin Y, Misumi Y, Ikehara Y |title=Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. |journal=J. Biochem. |volume=129 |issue= 2 |pages= 289–95 |year= 2001 |pmid= 11173531 |doi=  10.1093/oxfordjournals.jbchem.a002856}}
-*{{cite journal  | author=Kin Y, Misumi Y, Ikehara Y |title=Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. |journal=J. Biochem. |volume=129 |issue= 2 |pages= 289-95 |year= 2001 |pmid= 11173531 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Nadal MS, Ozaita A, Amarillo Y |title=The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. |journal=Neuron |volume=37 |issue= 3 |pages= 449–61 |year= 2003 |pmid= 12575952 |doi=10.1016/S0896-6273(02)01185-6  |display-authors=etal}}
-*{{cite journal  | author=Nadal MS, Ozaita A, Amarillo Y, ''et al.'' |title=The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. |journal=Neuron |volume=37 |issue= 3 |pages= 449-61 |year= 2003 |pmid= 12575952 |doi=  }}
+*{{cite journal  | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
+*{{cite journal  | vauthors=Schmitt-Ulms G, Hansen K, Liu J |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724–31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 |display-authors=etal}}
-*{{cite journal  | author=Schmitt-Ulms G, Hansen K, Liu J, ''et al.'' |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724-31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 }}
+*{{cite journal  | vauthors=Strop P, Bankovich AJ, Hansen KC |title=Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. |journal=J. Mol. Biol. |volume=343 |issue= 4 |pages= 1055–65 |year= 2004 |pmid= 15476821 |doi= 10.1016/j.jmb.2004.09.003 |display-authors=etal}}
-*{{cite journal  | author=Strop P, Bankovich AJ, Hansen KC, ''et al.'' |title=Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. |journal=J. Mol. Biol. |volume=343 |issue= 4 |pages= 1055-65 |year= 2004 |pmid= 15476821 |doi= 10.1016/j.jmb.2004.09.003 }}
+*{{cite journal  | vauthors=Zagha E, Ozaita A, Chang SY |title=DPP10 modulates Kv4-mediated A-type potassium channels. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18853–61 |year= 2005 |pmid= 15671030 |doi= 10.1074/jbc.M410613200 |display-authors=etal}}
-*{{cite journal  | author=Zagha E, Ozaita A, Chang SY, ''et al.'' |title=DPP10 modulates Kv4-mediated A-type potassium channels. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18853-61 |year= 2005 |pmid= 15671030 |doi= 10.1074/jbc.M410613200 }}
+*{{cite journal  | vauthors=Radicke S, Cotella D, Graf EM |title=Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. |journal=J. Physiol. |volume=565 |issue= Pt 3 |pages= 751–6 |year= 2005 |pmid= 15890703 |doi= 10.1113/jphysiol.2005.087312  | pmc=1464568 |display-authors=etal}}
-*{{cite journal  | author=Radicke S, Cotella D, Graf EM, ''et al.'' |title=Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. |journal=J. Physiol. (Lond.) |volume=565 |issue= Pt 3 |pages= 751-6 |year= 2005 |pmid= 15890703 |doi= 10.1113/jphysiol.2005.087312 }}
+*{{cite journal  | vauthors=Ren X, Hayashi Y, Yoshimura N, Takimoto K |title=Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. |journal=Mol. Cell. Neurosci. |volume=29 |issue= 2 |pages= 320–32 |year= 2005 |pmid= 15911355 |doi= 10.1016/j.mcn.2005.02.003 }}
-*{{cite journal  | author=Ren X, Hayashi Y, Yoshimura N, Takimoto K |title=Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. |journal=Mol. Cell. Neurosci. |volume=29 |issue= 2 |pages= 320-32 |year= 2005 |pmid= 15911355 |doi= 10.1016/j.mcn.2005.02.003 }}
+*{{cite journal  | vauthors=Jerng HH, Kunjilwar K, Pfaffinger PJ |title=Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. |journal=J. Physiol. |volume=568 |issue= Pt 3 |pages= 767–88 |year= 2006 |pmid= 16123112 |doi= 10.1113/jphysiol.2005.087858  | pmc=1464192 }}
-*{{cite journal  | author=Jerng HH, Kunjilwar K, Pfaffinger PJ |title=Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. |journal=J. Physiol. (Lond.) |volume=568 |issue= Pt 3 |pages= 767-88 |year= 2006 |pmid= 16123112 |doi= 10.1113/jphysiol.2005.087858 }}
+*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal  | vauthors=Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B |title=Differential characterization of three alternative spliced isoforms of DPPX. |journal=Brain Res. |volume=1094 |issue= 1 |pages= 1–12 |year= 2006 |pmid= 16764835 |doi= 10.1016/j.brainres.2006.03.106 }}
-*{{cite journal  | author=Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B |title=Differential characterization of three alternative spliced isoforms of DPPX. |journal=Brain Res. |volume=1094 |issue= 1 |pages= 1-12 |year= 2006 |pmid= 16764835 |doi= 10.1016/j.brainres.2006.03.106 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=1804}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-7-stub}}
-{{WikiDoc Sources}}

DPP6: Difference between revisions

Latest revision as of 18:41, 30 August 2017

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