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{{Infobox_gene}}
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'''Segment polarity protein dishevelled homolog DVL-3''' is a [[protein]] that in humans is encoded by the ''DVL3'' [[gene]].<ref name="pmid8817329">{{cite journal | vauthors = Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B | title = cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene | journal = Hum Mol Genet | volume = 5 | issue = 7 | pages = 953–8 |date=January 1997 | pmid = 8817329 | pmc =  | doi =10.1093/hmg/5.7.953 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1857| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DVL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1l6o.
| PDB = {{PDB2|1l6o}}, {{PDB2|2f0a}}
| Name = Dishevelled, dsh homolog 3 (Drosophila)
| HGNCid = 3087
| Symbol = DVL3
| AltSymbols =; KIAA0208
| OMIM = 601368
| ECnumber =
| Homologene = 20928
| MGIid = 108100
  | GeneAtlas_image1 = PBB_GE_DVL3_201908_at_tn.png
  | Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1857
    | Hs_Ensembl = ENSG00000161202
    | Hs_RefseqProtein = NP_004414
    | Hs_RefseqmRNA = NM_004423
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 185355978
    | Hs_GenLoc_end = 185374092
    | Hs_Uniprot = Q92997
    | Mm_EntrezGene = 13544
    | Mm_Ensembl = ENSMUSG00000003233
    | Mm_RefseqmRNA = NM_007889
    | Mm_RefseqProtein = NP_031915
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 20430525
    | Mm_GenLoc_end = 20445059
    | Mm_Uniprot = Q61062
  }}
}}
'''Dishevelled, dsh homolog 3 (Drosophila)''', also known as '''DVL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1857| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.<ref name="entrez">{{cite web | title = Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1857| accessdate = }}</ref>
| summary_text = This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.<ref name="entrez" />
}}
}}
==Interactions==
DVL3 has been shown to [[Protein-protein interaction|interact]] with [[DAB2]],<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H  |date=June 2003  |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> [[DVL1]]<ref name=pmid10330181>{{cite journal |last=Kishida |first=S |author2=Yamamoto H |author3=Hino S |author4=Ikeda S |author5=Kishida M |author6=Kikuchi A  |date=June 1999  |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue=6 |pages=4414–22 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10330181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=104400 | doi=10.1128/mcb.19.6.4414}}</ref> and [[PRPF3]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005  |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==See also==
* [[Dishevelled]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Pizzuti A, Amati F, Calabrese G, ''et al.'' |title=cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 953-8 |year= 1997 |pmid= 8817329 |doi=  }}
*{{cite journal  | vauthors=Nagase T, Seki N, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi=  }}
*{{cite journal  | vauthors=Semënov MV, Snyder M |title=Human dishevelled genes constitute a DHR-containing multigene family |journal=Genomics |volume=42 |issue= 2 |pages= 302–10 |year= 1997 |pmid= 9192851 |doi= 10.1006/geno.1997.4713 }}
*{{cite journal  | author=Semënov MV, Snyder M |title=Human dishevelled genes constitute a DHR-containing multigene family. |journal=Genomics |volume=42 |issue= 2 |pages= 302-10 |year= 1997 |pmid= 9192851 |doi= 10.1006/geno.1997.4713 }}
*{{cite journal  | vauthors=Bui TD, Beier DR, Jonssen M |title=cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 510–6 |year= 1997 |pmid= 9344861 |doi= 10.1006/bbrc.1997.7500 |display-authors=etal}}
*{{cite journal  | author=Bui TD, Beier DR, Jonssen M, ''et al.'' |title=cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 510-6 |year= 1997 |pmid= 9344861 |doi= 10.1006/bbrc.1997.7500 }}
*{{cite journal  | vauthors=Kishida S, Yamamoto H, Hino S |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414–22 |year= 1999 |pmid= 10330181 |doi=  10.1128/mcb.19.6.4414| pmc=104400  |display-authors=etal}}
*{{cite journal  | author=Kishida S, Yamamoto H, Hino S, ''et al.'' |title=DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4414-22 |year= 1999 |pmid= 10330181 |doi=  }}
*{{cite journal  | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | author=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790-7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hocevar BA, Mou F, Rennolds JL |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084–94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286 | pmc=162138 |display-authors=etal}}
*{{cite journal  | author=Hocevar BA, Mou F, Rennolds JL, ''et al.'' |title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2). |journal=EMBO J. |volume=22 |issue= 12 |pages= 3084-94 |year= 2003 |pmid= 12805222 |doi= 10.1093/emboj/cdg286 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | author=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703-13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Chan DW, Chan CY, Yam JW |title=Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1218–27 |year= 2006 |pmid= 17030191 |doi= 10.1053/j.gastro.2006.07.020 |display-authors=etal}}
*{{cite journal  | author=Chan DW, Chan CY, Yam JW, ''et al.'' |title=Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. |journal=Gastroenterology |volume=131 |issue= 4 |pages= 1218-27 |year= 2006 |pmid= 17030191 |doi= 10.1053/j.gastro.2006.07.020 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1857}}
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Revision as of 18:46, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.[1][2]

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[2]

Interactions

DVL3 has been shown to interact with DAB2,[3] DVL1[4] and PRPF3.[5]

See also

References

  1. ↑ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
  2. ↑ 2.0 2.1 "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
  3. ↑ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
  4. ↑ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. UNITED STATES. 19 (6): 4414–22. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400. PMID 10330181.
  5. ↑ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading



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