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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Dynein light chain roadblock-type 1''' is a [[protein]] that in humans is encoded by the ''DYNLRB1'' [[gene]].<ref name="pmid11750132">{{cite journal | vauthors = Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S | title = Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients | journal = Gene | volume = 281 | issue = 1–2 | pages = 103–13 |date=Dec 2001 | pmid = 11750132 | pmc =  | doi =10.1016/S0378-1119(01)00787-9 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83658| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_DYNLRB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y4o.
| PDB = {{PDB2|1y4o}}, {{PDB2|1z09}}, {{PDB2|2b95}}
| Name = Dynein, light chain, roadblock-type 1
| HGNCid = 15468
| Symbol = DYNLRB1
| AltSymbols =; BITH; BLP; DNCL2A; DNLC2A
| OMIM = 607167
| ECnumber = 
| Homologene = 69161
| MGIid = 1914318
| Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005868 |text = cytoplasmic dynein complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
  | Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0007632 |text = visual behavior}} {{GNF_GO|id=GO:0008090 |text = retrograde axon cargo transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83658
    | Hs_Ensembl = ENSG00000125971
    | Hs_RefseqProtein = NP_054902
    | Hs_RefseqmRNA = NM_014183
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 32567865
    | Hs_GenLoc_end = 32592423
    | Hs_Uniprot = Q9NP97
    | Mm_EntrezGene = 67068
    | Mm_Ensembl = ENSMUSG00000047459
    | Mm_RefseqmRNA = XM_976951
    | Mm_RefseqProtein = XP_982045
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 154934172
    | Mm_GenLoc_end = 154941405
    | Mm_Uniprot = P62627
  }}
}}
'''Dynein, light chain, roadblock-type 1''', also known as '''DYNLRB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83658| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.<ref name="entrez">{{cite web | title = Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83658| accessdate = }}</ref>
| summary_text = This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
*{{cite journal  | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  |display-authors=etal}}
*{{cite journal  | author=Jiang J, Yu L, Huang X, ''et al.'' |title=Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. |journal=Gene |volume=281 |issue= 1-2 |pages= 103-13 |year= 2002 |pmid= 11750132 |doi= }}
*{{cite journal  | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Susalka SJ, Nikulina K, Salata MW |title=The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32939–46 |year= 2002 |pmid= 12077152 |doi= 10.1074/jbc.M205510200 |display-authors=etal}}
*{{cite journal  | author=Susalka SJ, Nikulina K, Salata MW, ''et al.'' |title=The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32939-46 |year= 2002 |pmid= 12077152 |doi= 10.1074/jbc.M205510200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638–53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003 | pmc=196011 }}
*{{cite journal  | author=Huang YS, Carson JH, Barbarese E, Richter JD |title=Facilitation of dendritic mRNA transport by CPEB. |journal=Genes Dev. |volume=17 |issue= 5 |pages= 638-53 |year= 2003 |pmid= 12629046 |doi= 10.1101/gad.1053003 }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Saito Y, Doi K, Yamagishi N |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 396–402 |year= 2004 |pmid= 14733918 |doi=10.1016/j.bbrc.2003.12.108 |display-authors=etal}}
*{{cite journal  | author=Saito Y, Doi K, Yamagishi N, ''et al.'' |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 396-402 |year= 2004 |pmid= 14733918 |doi=  }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Campbell IG, Phillips WA, Choong DY |title=Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers |journal=Clin. Cancer Res. |volume=12 |issue= 12 |pages= 3713–5 |year= 2006 |pmid= 16778097 |doi= 10.1158/1078-0432.CCR-06-0800 }}
*{{cite journal  | author=Pfister KK, Fisher EM, Gibbons IR, ''et al.'' |title=Cytoplasmic dynein nomenclature. |journal=J. Cell Biol. |volume=171 |issue= 3 |pages= 411-3 |year= 2006 |pmid= 16260502 |doi= 10.1083/jcb.200508078 }}
*{{cite journal  | vauthors=Pérez-González A, Rodriguez A, Huarte M |title=hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator |journal=J. Mol. Biol. |volume=362 |issue= 5 |pages= 887–900 |year= 2007 |pmid= 16950395 |doi= 10.1016/j.jmb.2006.07.085 |display-authors=etal}}
*{{cite journal  | author=Campbell IG, Phillips WA, Choong DY |title=Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers. |journal=Clin. Cancer Res. |volume=12 |issue= 12 |pages= 3713-5 |year= 2006 |pmid= 16778097 |doi= 10.1158/1078-0432.CCR-06-0800 }}
*{{cite journal  | vauthors=Liu JF, Wang ZX, Wang XQ |title=Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74 |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 3 |pages= 1125–9 |year= 2006 |pmid= 16970917 |doi= 10.1016/j.bbrc.2006.08.161 |display-authors=etal}}
*{{cite journal  | author=Pérez-González A, Rodriguez A, Huarte M, ''et al.'' |title=hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. |journal=J. Mol. Biol. |volume=362 |issue= 5 |pages= 887-900 |year= 2007 |pmid= 16950395 |doi= 10.1016/j.jmb.2006.07.085 }}
*{{cite journal  | vauthors=Kang HC, Kim IJ, Kim K |title=km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers |journal=Cancer Genet. Cytogenet. |volume=175 |issue= 2 |pages= 173–4 |year= 2007 |pmid= 17556076 |doi= 10.1016/j.cancergencyto.2007.02.004 |display-authors=etal}}
*{{cite journal  | author=Liu JF, Wang ZX, Wang XQ, ''et al.'' |title=Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 3 |pages= 1125-9 |year= 2006 |pmid= 16970917 |doi= 10.1016/j.bbrc.2006.08.161 }}
*{{cite journal  | author=Kang HC, Kim IJ, Kim K, ''et al.'' |title=km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers. |journal=Cancer Genet. Cytogenet. |volume=175 |issue= 2 |pages= 173-4 |year= 2007 |pmid= 17556076 |doi= 10.1016/j.cancergencyto.2007.02.004 }}
}}
}}
*{{cite journal  | vauthors=Wanschers B, van de Vorstenbosch R, Fransen J |title=Rab6 family proteins interact with the dynein light chain protein DYNLRB1 |journal=Cell Motil. Cytoskeleton  |volume= 65 |issue= 3 |pages= 183–96 |year= 2008 |pmid= 18044744 |doi= 10.1002/cm.20254|display-authors=etal}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=83658}}
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Latest revision as of 18:47, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.[1][2][3]

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.[3]

References

  1. ↑ Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients". Gene. 281 (1–2): 103–13. doi:10.1016/S0378-1119(01)00787-9. PMID 11750132.
  2. ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  3. ↑ 3.0 3.1 "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1".

Further reading



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