Digoxin immune fab: Difference between revisions

Revision as of 11:08, 27 February 2014

Digoxin Immune Fab
DIGIFAB^® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings
Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Digoxin Immune Fab
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]

For patient information about Digoxin immune fab, click here.

Synonyms / Brand Names: DIGIFAB ^® injection

Overview

Digoxin Immune Fab (Ovine) is the generic name for an antidote for overdose of digitalis.^[1] It is made from immunoglobin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline and the latter manufactured by Protherics, Inc.

FDA Package Insert

DIGIFAB^®

Mechanism of Action

References

↑ DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. PMID 11150387.

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6832767f-db6b-4eea-b88b-bdfc905749e1

[pmid11150387-1] DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. PMID 11150387.

[1]

@@ Line 1: / Line 1: @@
-{{CMG}}
+__NOTOC__
-{{drugbox
+{{Digoxin immune fab}}
-|IUPAC_name=Anti-digoxin antibody fragment
+{{CMG}}; {{AE}} {{AK}}
-|image=
-|CAS_number=
+'''''For patient information about Digoxin immune fab, click [[Digoxin immune fab (patient information)|here]].'''''
-|ATC_prefix=V03
-|ATC_suffix=AB24
+{{SB}}
-|ATC_supplemental=
+DIGIFAB <sup>®</sup> injection
-|PubChem=
-|DrugBank=BTD00027
-|chemical_formula=
-|C=6394|H=9908|N=1698|O=2011|S=58
-|molecular_weight=144602.257 g/mol
-|bioavailability=
-|protein_bound=
-|metabolism=
-|elimination_half-life=15 hours for DigiFab, 23 hours for Digibind
-|excretion=[[Kidney|Renal]]
-|pregnancy_AU=<!-- A / B1 / B2 / B3 / C / D / X -->
-|pregnancy_US= C
-|pregnancy_category=
-|legal_AU=<!-- Unscheduled / S2 / S4 / S8 -->
-|legal_UK=<!-- GSL / P / POM / CD -->
-|legal_US=<!-- OTC / Rx-only -->
-|legal_status=
-|routes_of_administration=[[IV infusion]], [[Injection (medicine)|injection]]
-}}
 ==Overview==
 '''Digoxin Immune Fab (Ovine)''' is the generic name for an antidote for overdose of [[digitalis]].<ref name="pmid11150387">{{cite journal |author=DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL |title=Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity |journal=J. Cardiovasc. Pharmacol. Ther. |volume=5 |issue=2 |pages=77–85 |year=2000 |pmid=11150387 |doi=}}</ref> It is made from immunoglobin fragments from [[sheep]] who have already been immunized with a digoxin derivative, [[digoxindicarboxymethoxylamine]] (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by [[GlaxoSmithKline]] and the latter manufactured by Protherics, Inc.
+==Category==
+==FDA Package Insert==
+====DIGIFAB<sup>®</sup>====
-==Pharmacology==
+'''  [[Digoxin immune fab indications and usage|Indications and Usage]]'''
-It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.
+'''| [[Digoxin immune fab dosage and administration|Dosage and Administration]]'''
+'''| [[Digoxin immune fab dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[Digoxin immune fab contraindications|Contraindications]]'''
+'''| [[Digoxin immune fab warnings and precautions|Warnings and Precautions]]'''
+'''| [[Digoxin immune fab adverse reactions|Adverse Reactions]]'''
+'''| [[Digoxin immune fab drug interactions|Drug Interactions]]'''
+'''| [[Digoxin immune fab use in specific populations|Use in Specific Populations]]'''
+'''| [[Digoxin immune fab overdosage|Overdosage]]'''
+'''| [[Digoxin immune fab description|Description]]'''
+'''| [[Digoxin immune fab clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Digoxin immune fab nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Digoxin immune fab clinical studies|Clinical Studies]]'''
+'''| [[Digoxin immune fab how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Digoxin immune fab patient counseling information|Patient Counseling Information]]'''
+'''| [[Digoxin immune fab labels and packages|Labels and Packages]]'''
-==Contraindications==
+==Mechanism of Action==
-Although no [[contraindication]]s have been noted, the patient must be closely monitored for [[anaphylactic shock]], and anyone allergic to sheep protein, [[papain]], [[bromelain]], or [[papaya]] extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.
 ==References==
-{{reflist|2}}
-==External links==
+{{Reflist|2}}
-*[http://www.drugs.com/cdi/digibind.html Drug information online]
+http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6832767f-db6b-4eea-b88b-bdfc905749e1
-*[http://www.rxlist.com/cgi/generic/digoxinfab.htm Digibind description]
+[[Category:Cardiovascular Drugs]]
-*[http://www.fda.gov/cber/label/digpro083101LB.pdf FDA - DigiFab]
+[[Category:Drugs]]
-[[de:Digitalis-Antidot]]