ENSA (gene): Difference between revisions

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{{Infobox_gene}}
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'''Alpha-endosulfine''' is a [[protein]] that in humans is encoded by the ''ENSA'' [[gene]].<ref name="pmid9653196">{{cite journal | vauthors = Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D | title = Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 14 | pages = 8387–91 |date=Aug 1998 | pmid = 9653196 | pmc = 20985 | doi =10.1073/pnas.95.14.8387 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ENSA endosulfine alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2029| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endosulfine alpha
| HGNCid = 3360
| Symbol = ENSA
| AltSymbols =; MGC4319; MGC78563; MGC8394
| OMIM = 603061
| ECnumber =
| Homologene = 37924
| MGIid = 1891189
| GeneAtlas_image1 = PBB_GE_ENSA_202596_at_tn.png
| GeneAtlas_image2 = PBB_GE_ENSA_221486_at_tn.png
| GeneAtlas_image3 = PBB_GE_ENSA_221487_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008200 |text = ion channel inhibitor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2029
    | Hs_Ensembl = ENSG00000143420
    | Hs_RefseqProtein = NP_004427
    | Hs_RefseqmRNA = NM_004436
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 148839951
    | Hs_GenLoc_end = 148868722
    | Hs_Uniprot = O43768
    | Mm_EntrezGene = 56205
    | Mm_Ensembl = ENSMUSG00000038619
    | Mm_RefseqmRNA = NM_001026212
    | Mm_RefseqProtein = NP_001021383
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 95710384
    | Mm_GenLoc_end = 95715897
    | Mm_Uniprot = Q5D069
  }}
}}
'''Endosulfine alpha''', also known as '''ENSA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ENSA endosulfine alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2029| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: ENSA endosulfine alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2029| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Heron L, Virsolvy A, Peyrollier K, ''et al.'' |title=Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8387-91 |year= 1998 |pmid= 9653196 |doi= }}
*{{cite journal  | author=Héron L |title=Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels |journal=Diabetes |volume=48 |issue= 9 |pages= 1873–6 |year= 1999 |pmid= 10480622 |doi=10.2337/diabetes.48.9.1873  |name-list-format=vanc| author2=Virsolvy A  | author3=Apiou F  | display-authors=3  | last4=Le Cam  | first4=A.  | last5=Bataille  | first5=D. }}
*{{cite journal  | author=Héron L, Virsolvy A, Apiou F, ''et al.'' |title=Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels. |journal=Diabetes |volume=48 |issue= 9 |pages= 1873-6 |year= 1999 |pmid= 10480622 |doi=  }}
*{{cite journal  | author=Zhang QH |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  |name-list-format=vanc| author2=Ye M  | author3=Wu XY  | display-authors=3  | last4=Ren  | first4=SX  | last5=Zhao  | first5=M  | last6=Zhao  | first6=CJ  | last7=Fu  | first7=G  | last8=Shen  | first8=Y  | last9=Fan  | first9=HY }}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal  | vauthors=Kim SH, Lubec G |title=Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 1–9 |year= 2002 |pmid= 11771735 |doi=  10.1007/978-3-7091-6262-0_1}}
*{{cite journal  | author=Kim SH, Lubec G |title=Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 1-9 |year= 2002 |pmid= 11771735 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Bataille D |title=Endosulfines: Novel regulators of insulin secretion |journal=Drug News Perspect. |volume=13 |issue= 8 |pages= 453–62 |year= 2003 |pmid= 12937617 |doi=  }}
*{{cite journal  | author=Bataille D |title=Endosulfines: Novel regulators of insulin secretion. |journal=Drug News Perspect. |volume=13 |issue= 8 |pages= 453-62 |year= 2003 |pmid= 12937617 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Wang H |title=Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 9–15 |year= 2004 |pmid= 14728986 |doi=10.1016/j.ymgme.2003.08.003  |name-list-format=vanc| author2=Craig RL  | author3=Schay J  | display-authors=3  | last4=Chu  | first4=W  | last5=Das  | first5=SK  | last6=Zhang  | first6=Z  | last7=Elbein  | first7=SC }}
*{{cite journal  | author=Wang H, Craig RL, Schay J, ''et al.'' |title=Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion. |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 9-15 |year= 2004 |pmid= 14728986 |doi=  }}
*{{cite journal  | author=Thameem F |title=The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 16–21 |year= 2004 |pmid= 14728987 |doi=10.1016/j.ymgme.2003.09.013  |name-list-format=vanc| author2=Farook VS  | author3=Yang X  | display-authors=3  | last4=Lee  | first4=YH  | last5=Permana  | first5=PA  | last6=Bogardus  | first6=C  | last7=Prochazka  | first7=M }}
*{{cite journal  | author=Thameem F, Farook VS, Yang X, ''et al.'' |title=The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 16-21 |year= 2004 |pmid= 14728987 |doi=  }}
*{{cite journal  | author=Gabrielsson BG |title=Molecular characterization of a local sulfonylurea system in human adipose tissue |journal=Mol. Cell. Biochem. |volume=258 |issue= 1–2 |pages= 65–71 |year= 2004 |pmid= 15030171 |doi=10.1023/B:MCBI.0000012837.11847.c8  |name-list-format=vanc| author2=Karlsson AC  | author3=Lönn M  | display-authors=3  | last4=Olofsson  | first4=Louise E.  | last5=Johansson  | first5=Jenny M.  | last6=Torgerson  | first6=Jarl S.  | last7=Sjöström  | first7=Lars  | last8=Carlsson  | first8=Björn  | last9=Edén  | first9=Staffan }}
*{{cite journal  | author=Gabrielsson BG, Karlsson AC, Lönn M, ''et al.'' |title=Molecular characterization of a local sulfonylurea system in human adipose tissue. |journal=Mol. Cell. Biochem. |volume=258 |issue= 1-2 |pages= 65-71 |year= 2004 |pmid= 15030171 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 00:31, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene.[1][2]

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]

References

  1. ↑ Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (Aug 1998). "Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties". Proc Natl Acad Sci U S A. 95 (14): 8387–91. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
  2. ↑ 2.0 2.1 "Entrez Gene: ENSA endosulfine alpha".

Further reading



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