EP400: Difference between revisions

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{{Infobox_gene}}
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'''E1A-binding protein p400''' is a [[protein]] that in humans is encoded by the ''EP400'' [[gene]].<ref name="pmid9225980">{{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Hum Genet | volume = 100 | issue = 1 | pages = 114–22 |date=Jul 1997 | pmid = 9225980 | pmc =  | doi =10.1007/s004390050476 }}</ref><ref name="pmid11509179">{{cite journal | vauthors = Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM | title = The p400 complex is an essential E1A transformation target | journal = Cell | volume = 106 | issue = 3 | pages = 297–307 |date=Aug 2001 | pmid = 11509179 | pmc =  | doi =10.1016/S0092-8674(01)00450-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EP400 E1A binding protein p400| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57634| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = E1A binding protein p400
| HGNCid = 11958
| Symbol = EP400
| AltSymbols =; CAGH32; DKFZP434I225; FLJ42018; FLJ45115; P400; TNRC12
| OMIM = 606265
| ECnumber =
  | Homologene = 38779
| MGIid = 1276124
| GeneAtlas_image1 = PBB_GE_EP400_212376_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57634
    | Hs_Ensembl = ENSG00000183495
    | Hs_RefseqProtein = NP_056224
    | Hs_RefseqmRNA = NM_015409
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 131000461
    | Hs_GenLoc_end = 131130958
    | Hs_Uniprot = Q96L91
    | Mm_EntrezGene = 75560
    | Mm_Ensembl = ENSMUSG00000029505
    | Mm_RefseqmRNA = NM_029337
    | Mm_RefseqProtein = NP_083613
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 110904680
    | Mm_GenLoc_end = 111010829
    | Mm_Uniprot = Q3UX42
  }}
}}
'''E1A binding protein p400''', also known as '''EP400''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EP400 E1A binding protein p400| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57634| accessdate = }}</ref>


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==Interactions==
EP400 has been shown to [[Protein-protein interaction|interact]] with [[Transformation/transcription domain-associated protein]],<ref name=pmid11509179 /> [[RuvB-like 1]]<ref name=pmid11509179/> and [[Myc]].<ref name=pmid11509179/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  | vauthors=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147–54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  | author=Margolis RL, Abraham MR, Gatchell SB, ''et al.'' |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114-22 |year= 1997 |pmid= 9225980 |doi=  }}
*{{cite journal  | vauthors=Nagase T, Kikuno R, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143–50 |year= 2000 |pmid= 10819331 |doi=10.1093/dnares/7.2.143 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi=  }}
*{{cite journal  | vauthors=Nagase T, Nakayama M, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85  |display-authors=etal}}
*{{cite journal  | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi= }}
*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal  | author=Fuchs M, Gerber J, Drapkin R, ''et al.'' |title=The p400 complex is an essential E1A transformation target. |journal=Cell |volume=106 |issue= 3 |pages= 297-307 |year= 2001 |pmid= 11509179 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | vauthors=Cai Y, Jin J, Tomomori-Sato C |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733–6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Cai Y, Jin J, Tomomori-Sato C, ''et al.'' |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733-6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 }}
*{{cite journal  | vauthors=Doyon Y, Selleck W, Lane WS |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884–96 |year= 2004 |pmid= 14966270 |doi=10.1128/MCB.24.5.1884-1896.2004  | pmc=350560 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Doyon Y, Selleck W, Lane WS, ''et al.'' |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884-96 |year= 2004 |pmid= 14966270 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Chan HM, Narita M, Lowe SW, Livingston DM |title=The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. |journal=Genes Dev. |volume=19 |issue= 2 |pages= 196–201 |year= 2005 |pmid= 15655109 |doi= 10.1101/gad.1280205 | pmc=545875 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Samuelson AV, Narita M, Chan HM |title=p400 is required for E1A to promote apoptosis. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21915–23 |year= 2005 |pmid= 15741165 |doi= 10.1074/jbc.M414564200 |display-authors=etal}}
*{{cite journal  | author=Chan HM, Narita M, Lowe SW, Livingston DM |title=The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. |journal=Genes Dev. |volume=19 |issue= 2 |pages= 196-201 |year= 2005 |pmid= 15655109 |doi= 10.1101/gad.1280205 }}
*{{cite journal  | vauthors=Tyteca S, Vandromme M, Legube G |title=Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. |journal=EMBO J. |volume=25 |issue= 8 |pages= 1680–9 |year= 2006 |pmid= 16601686 |doi= 10.1038/sj.emboj.7601066 | pmc=1440826 |display-authors=etal}}
*{{cite journal  | author=Samuelson AV, Narita M, Chan HM, ''et al.'' |title=p400 is required for E1A to promote apoptosis. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21915-23 |year= 2005 |pmid= 15741165 |doi= 10.1074/jbc.M414564200 }}
*{{cite journal  | author=Tyteca S, Vandromme M, Legube G, ''et al.'' |title=Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. |journal=EMBO J. |volume=25 |issue= 8 |pages= 1680-9 |year= 2006 |pmid= 16601686 |doi= 10.1038/sj.emboj.7601066 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:32, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E1A-binding protein p400 is a protein that in humans is encoded by the EP400 gene.[1][2][3]


Interactions

EP400 has been shown to interact with Transformation/transcription domain-associated protein,[2] RuvB-like 1[2] and Myc.[2]

References

  1. ↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980.
  2. ↑ 2.0 2.1 2.2 2.3 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (Aug 2001). "The p400 complex is an essential E1A transformation target". Cell. 106 (3): 297–307. doi:10.1016/S0092-8674(01)00450-0. PMID 11509179.
  3. ↑ "Entrez Gene: EP400 E1A binding protein p400".

Further reading



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