FCRL3: Difference between revisions

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{{Infobox_gene}}
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'''Fc receptor-like protein 3''' is a [[protein]] that in humans is encoded by the ''FCRL3'' [[gene]].<ref name="pmid11493702">{{cite journal | vauthors = Davis RS, Wang YH, Kubagawa H, Cooper MD | title = Identification of a family of Fc receptor homologs with preferential B cell expression | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 17 | pages = 9772–7 |date=Aug 2001 | pmid = 11493702 | pmc = 55528 | doi = 10.1073/pnas.171308498 }}</ref><ref name="pmid12014205">{{cite journal | vauthors = Davis RS, ((Dennis G Jr)), Kubagawa H, Cooper MD | title = Fc receptor homologs (FcRH1-5) extend the Fc receptor family | journal = Curr Top Microbiol Immunol | volume = 266 | issue =  | pages = 85–112 |date=May 2002 | pmid = 12014205 | pmc =  | doi =  10.1007/978-3-662-04700-2_7}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FCRL3 Fc receptor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115352| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Fc receptor-like 3
| HGNCid = 18506
| Symbol = FCRL3
| AltSymbols =; FCRH3; IFGP3; IRTA3; SPAP2
| OMIM = 606510
| ECnumber =
| Homologene = 76447
| MGIid = 3053558
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 115352
    | Hs_Ensembl = ENSG00000160856
    | Hs_RefseqProtein = NP_001019838
    | Hs_RefseqmRNA = NM_001024667
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 155912895
    | Hs_GenLoc_end = 155937399
    | Hs_Uniprot =   
    | Mm_EntrezGene = 329693
    | Mm_Ensembl = ENSMUSG00000048031
    | Mm_RefseqmRNA = NM_183222
    | Mm_RefseqProtein = NP_899045
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 87521812
    | Mm_GenLoc_end = 87543763
    | Mm_Uniprot = 
  }}
}}
'''Fc receptor-like 3''', also known as '''FCRL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FCRL3 Fc receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115352| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.<ref name="entrez">{{cite web | title = Entrez Gene: FCRL3 Fc receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115352| accessdate = }}</ref>
| summary_text = This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.<ref name="entrez" />
}}
}}
==Interactions==
FCRL3 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]].<ref name=pmid12051764>{{cite journal |last=Xu |first=Ming-jiang |author2=Zhao Runxiang |author3=Cao Hongxi |author4=Zhao Zhizhuang Joe  |date=May 2002 |title=SPAP2, an Ig family receptor containing both ITIMs and ITAMs |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue=3 |pages=1037–46 |publisher= |location = United States| issn = 0006-291X| pmid = 12051764 |doi = 10.1016/S0006-291X(02)00332-7 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Davis RS, Dennis G, Kubagawa H, Cooper MD |title=Fc receptor homologs (FcRH1-5) extend the Fc receptor family. |journal=Curr. Top. Microbiol. Immunol. |volume=266 |issue= |pages= 85-112 |year= 2002 |pmid= 12014205 |doi=  }}
*{{cite journal  | author=Miller I |title=IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells |journal=Blood |volume=99 |issue= 8 |pages= 2662–9 |year= 2002 |pmid= 11929751 |doi=10.1182/blood.V99.8.2662 |name-list-format=vanc| author2=Hatzivassiliou G | author3=Cattoretti G  | display-authors=3  | last4=Mendelsohn  | first4=C  | last5=Dalla-Favera  | first5=R  }}
*{{cite journal | author=Davis RS, Wang YH, Kubagawa H, Cooper MD |title=Identification of a family of Fc receptor homologs with preferential B cell expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9772-7 |year= 2001 |pmid= 11493702 |doi= 10.1073/pnas.171308498 }}
*{{cite journal  | vauthors=Xu MJ, Zhao R, Cao H, Zhao ZJ |title=SPAP2, an Ig family receptor containing both ITIMs and ITAMs |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1037–46 |year= 2002 |pmid= 12051764 |doi= 10.1016/S0006-291X(02)00332-7 }}
*{{cite journal  | author=Miller I, Hatzivassiliou G, Cattoretti G, ''et al.'' |title=IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. |journal=Blood |volume=99 |issue= 8 |pages= 2662-9 |year= 2002 |pmid= 11929751 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Xu MJ, Zhao R, Cao H, Zhao ZJ |title=SPAP2, an Ig family receptor containing both ITIMs and ITAMs. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1037-46 |year= 2002 |pmid= 12051764 |doi= 10.1016/S0006-291X(02)00332-7 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3 | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kochi Y |title=A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities |journal=Nat. Genet. |volume=37 |issue= 5 |pages= 478–85 |year= 2005 |pmid= 15838509 |doi= 10.1038/ng1540  | pmc=1362949  |name-list-format=vanc| author2=Yamada R | author3=Suzuki A  | display-authors=3  | last4=Harley  | first4=John B  | last5=Shirasawa  | first5=Senji  | last6=Sawada  | first6=Tetsuji  | last7=Bae  | first7=Sang-Cheol  | last8=Tokuhiro  | first8=Shinya  | last9=Chang  | first9=Xiaotian }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Simmonds MJ |title=Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 3 |pages= 1056–61 |year= 2006 |pmid= 16384851 |doi= 10.1210/jc.2005-1634 |name-list-format=vanc| author2=Heward JM  | author3=Carr-Smith J  | display-authors=3 | last4=Foxall  | first4=H  | last5=Franklyn  | first5=JA  | last6=Gough  | first6=SC }}
*{{cite journal  | author=Kochi Y, Yamada R, Suzuki A, ''et al.'' |title=A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. |journal=Nat. Genet. |volume=37 |issue= 5 |pages= 478-85 |year= 2005 |pmid= 15838509 |doi= 10.1038/ng1540 }}
*{{cite journal  | author=Eyre S |title=Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? |journal=[[Arthritis Research & Therapy]] |volume=8 |issue= 4 |pages= R117 |year= 2007 |pmid= 16859508 |doi= 10.1186/ar2006 | pmc=1779391  |name-list-format=vanc| author2=Bowes J  | author3=Potter C  | display-authors=3  | last4=Worthington  | first4=Jane  | last5=Barton  | first5=Anne }}
*{{cite journal  | author=Simmonds MJ, Heward JM, Carr-Smith J, ''et al.'' |title=Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 3 |pages= 1056-61 |year= 2006 |pmid= 16384851 |doi= 10.1210/jc.2005-1634 }}
*{{cite journal  | author=Umemura T |title=Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis |journal=Clin. Immunol. |volume=122 |issue= 3 |pages= 338–42 |year= 2007 |pmid= 17020818 |doi= 10.1016/j.clim.2006.08.012  |name-list-format=vanc| author2=Ota M  | author3=Yoshizawa K  | display-authors=3  | last4=Katsuyama  | first4=Yoshihiko  | last5=Ichijo  | first5=Tetsuya | last6=Tanaka  | first6=Eiji  | last7=Kawa  | first7=Shigeyuki  | last8=Kiyosawa  | first8=Kendo }}
*{{cite journal | author=Eyre S, Bowes J, Potter C, ''et al.'' |title=Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? |journal=Arthritis Res. Ther. |volume=8 |issue= 4 |pages= R117 |year= 2007 |pmid= 16859508 |doi= 10.1186/ar2006 }}
*{{cite journal  | author=Schäfer N |title=Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata |journal=Int. J. Immunogenet. |volume=33 |issue= 6 |pages= 393–5 |year= 2007 |pmid= 17117947 |doi= 10.1111/j.1744-313X.2006.00633.x  |name-list-format=vanc| author2=Blaumeiser B | author3=Becker T  | display-authors=3  | last4=Freudenberg-Hua  | first4=Y. | last5=Hanneken  | first5=S. | last6=Eigelshoven  | first6=S.  | last7=Schmael  | first7=C.  | last8=Lambert  | first8=J.  | last9=De Weert  | first9=J. }}
*{{cite journal  | author=Umemura T, Ota M, Yoshizawa K, ''et al.'' |title=Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis. |journal=Clin. Immunol. |volume=122 |issue= 3 |pages= 338-42 |year= 2007 |pmid= 17020818 |doi= 10.1016/j.clim.2006.08.012 }}
*{{cite journal  | author=Newman WG |title=Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3820–7 |year= 2007 |pmid= 17133579 |doi= 10.1002/art.22270  |name-list-format=vanc| author2=Zhang Q  | author3=Liu X  | display-authors=3  | last4=Walker  | first4=Erin  | last5=Ternan  | first5=Heather  | last6=Owen  | first6=Julie  | last7=Johnson  | first7=Ben  | last8=Greer  | first8=Wenda  | last9=Mosher  | first9=Dianne P. }}
*{{cite journal | author=Schäfer N, Blaumeiser B, Becker T, ''et al.'' |title=Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata. |journal=Int. J. Immunogenet. |volume=33 |issue= 6 |pages= 393-5 |year= 2007 |pmid= 17117947 |doi= 10.1111/j.1744-313X.2006.00633.x }}
*{{cite journal  | author=Choi CB |title=The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3838–41 |year= 2007 |pmid= 17133581 |doi= 10.1002/art.22248  |name-list-format=vanc| author2=Kang CP  | author3=Seong SS  | display-authors=3  | last4=Bae  | first4=Sang-Cheol  | last5=Kang  | first5=Changwon }}
*{{cite journal  | author=Newman WG, Zhang Q, Liu X, ''et al.'' |title=Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population. |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3820-7 |year= 2007 |pmid= 17133579 |doi= 10.1002/art.22270 }}
*{{cite journal  | author=Owen CJ |title=Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 3 |pages= 1106–11 |year= 2007 |pmid= 17200162 |doi= 10.1210/jc.2006-2183  |name-list-format=vanc| author2=Kelly H  | author3=Eden JA  | display-authors=3  | last4=Merriman  | first4=M. E.  | last5=Pearce  | first5=S. H. S.  | last6=Merriman  | first6=T. R. }}
*{{cite journal | author=Choi CB, Kang CP, Seong SS, ''et al.'' |title=The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans. |journal=Arthritis Rheum. |volume=54 |issue= 12 |pages= 3838-41 |year= 2007 |pmid= 17133581 |doi= 10.1002/art.22248 }}
*{{cite journal  | vauthors=Taylor AI, Gould HJ, Sutton BJ, Calvert RA |title=The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL |journal=Immunogenetics |volume=59 |issue= 4 |pages= 323–8 |year= 2007 |pmid= 17273841 |doi= 10.1007/s00251-007-0195-9 }}
*{{cite journal  | author=Owen CJ, Kelly H, Eden JA, ''et al.'' |title=Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 3 |pages= 1106-11 |year= 2007 |pmid= 17200162 |doi= 10.1210/jc.2006-2183 }}
*{{cite journal  | author=Martínez A |title=Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD |journal=Tissue Antigens |volume=69 |issue= 4 |pages= 313–7 |year= 2007 |pmid= 17389014 |doi= 10.1111/j.1399-0039.2007.00816.x  |name-list-format=vanc| author2=Núñez C  | author3=Martín MC  | display-authors=3  | last4=Mendoza  | first4=J. L.  | last5=Taxonera  | first5=C.  | last6=Díaz-Rubio  | first6=M.  | last7=De La Concha  | first7=E. G.  | last8=Urcelay  | first8=E. }}
*{{cite journal | author=Taylor AI, Gould HJ, Sutton BJ, Calvert RA |title=The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL. |journal=Immunogenetics |volume=59 |issue= 4 |pages= 323-8 |year= 2007 |pmid= 17273841 |doi= 10.1007/s00251-007-0195-9 }}
*{{cite journal  | author=Martínez A |title=FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity? |journal=J. Neuroimmunol. |volume=189 |issue= 1–2 |pages= 132–6 |year= 2007 |pmid= 17617473 |doi= 10.1016/j.jneuroim.2007.06.018  |name-list-format=vanc| author2=Mas A  | author3=de Las Heras V  | display-authors=3  | last4=Bartolome  | first4=M  | last5=Arroyo  | first5=R  | last6=Fernandezarquero  | first6=M  | last7=Delaconcha  | first7=E  | last8=Urcelay  | first8=E }}
*{{cite journal | author=Martínez A, Núñez C, Martín MC, ''et al.'' |title=Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD. |journal=Tissue Antigens |volume=69 |issue= 4 |pages= 313-7 |year= 2007 |pmid= 17389014 |doi= 10.1111/j.1399-0039.2007.00816.x }}
*{{cite journal  | author=Martínez A, Mas A, de Las Heras V, ''et al.'' |title=FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity? |journal=J. Neuroimmunol. |volume=189 |issue= 1-2 |pages= 132-6 |year= 2007 |pmid= 17617473 |doi= 10.1016/j.jneuroim.2007.06.018 }}
}}
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[[Category:Fc receptors]]
 
 
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Revision as of 04:44, 31 August 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[1][2][3]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[3]

Interactions

FCRL3 has been shown to interact with PTPN6.[4]

References

  1. ↑ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
  2. ↑ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr Top Microbiol Immunol. 266: 85–112. doi:10.1007/978-3-662-04700-2_7. PMID 12014205.
  3. ↑ 3.0 3.1 "Entrez Gene: FCRL3 Fc receptor-like 3".
  4. ↑ Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. United States. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Further reading


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