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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Proto-oncogene FRAT1''' is a [[protein]] that in humans is encoded by the ''FRAT1'' [[gene]].<ref name="pmid9034327">{{cite journal | vauthors = Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A | title = Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas | journal = EMBO J | volume = 16 | issue = 3 | pages = 441–50 |date=Mar 1997 | pmid = 9034327 | pmc = 1169648 | doi = 10.1093/emboj/16.3.441 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10023| accessdate = }}</ref>
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| image = PBB_Protein_FRAT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gng.
| PDB = {{PDB2|1gng}}
| Name = Frequently rearranged in advanced T-cell lymphomas
| HGNCid = 3944
| Symbol = FRAT1
| AltSymbols =;
| OMIM = 602503
| ECnumber =
| Homologene = 3999
| MGIid = 109450
| GeneAtlas_image1 = PBB_GE_FRAT1_219889_at_tn.png
| Function =
| Component =
| Process = {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10023
    | Hs_Ensembl = ENSG00000165879
    | Hs_RefseqProtein = NP_005470
    | Hs_RefseqmRNA = NM_005479
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 99069012
    | Hs_GenLoc_end = 99071662
    | Hs_Uniprot = Q92837
    | Mm_EntrezGene = 14296
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_008043
    | Mm_RefseqProtein = NP_032069
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
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'''Frequently rearranged in advanced T-cell lymphomas''', also known as '''FRAT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10023| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.<ref name="entrez">{{cite web | title = Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10023| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Jonkers J, Korswagen HC, Acton D, ''et al.'' |title=Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. |journal=EMBO J. |volume=16 |issue= 3 |pages= 441-50 |year= 1997 |pmid= 9034327 |doi= 10.1093/emboj/16.3.441 }}
*{{cite journal  | vauthors=Li L, Yuan H, Weaver CD |title=Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. |journal=EMBO J. |volume=18 |issue= 15 |pages= 4233–40 |year= 1999 |pmid= 10428961 |doi= 10.1093/emboj/18.15.4233 | pmc=1171499 |display-authors=etal}}
*{{cite journal  | author=Li L, Yuan H, Weaver CD, ''et al.'' |title=Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. |journal=EMBO J. |volume=18 |issue= 15 |pages= 4233-40 |year= 1999 |pmid= 10428961 |doi= 10.1093/emboj/18.15.4233 }}
*{{cite journal  | vauthors=Saitoh T, Katoh M |title=FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. |journal=Int. J. Oncol. |volume=19 |issue= 2 |pages= 311–5 |year= 2001 |pmid= 11445844 |doi=  10.3892/ijo.19.2.311}}
*{{cite journal  | author=Saitoh T, Katoh M |title=FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. |journal=Int. J. Oncol. |volume=19 |issue= 2 |pages= 311-5 |year= 2001 |pmid= 11445844 |doi=  }}
*{{cite journal  | vauthors=Bax B, Carter PS, Lewis C |title=The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. |journal=Structure |volume=9 |issue= 12 |pages= 1143–52 |year= 2002 |pmid= 11738041 |doi=10.1016/S0969-2126(01)00679-7 |display-authors=etal}}
*{{cite journal  | author=Bax B, Carter PS, Lewis C, ''et al.'' |title=The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. |journal=Structure |volume=9 |issue= 12 |pages= 1143-52 |year= 2002 |pmid= 11738041 |doi=  }}
*{{cite journal  | vauthors=Saitoh T, Mine T, Katoh M |title=Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. |journal=Int. J. Oncol. |volume=20 |issue= 4 |pages= 785–9 |year= 2002 |pmid= 11894125 |doi=  10.3892/ijo.20.4.785}}
*{{cite journal  | author=Saitoh T, Mine T, Katoh M |title=Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. |journal=Int. J. Oncol. |volume=20 |issue= 4 |pages= 785-9 |year= 2002 |pmid= 11894125 |doi=  }}
*{{cite journal  | vauthors=Freemantle SJ, Portland HB, Ewings K |title=Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. |journal=Gene |volume=291 |issue= 1-2 |pages= 17–27 |year= 2002 |pmid= 12095675 |doi=10.1016/S0378-1119(02)00594-2 |display-authors=etal}}
*{{cite journal  | author=Freemantle SJ, Portland HB, Ewings K, ''et al.'' |title=Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. |journal=Gene |volume=291 |issue= 1-2 |pages= 17-27 |year= 2002 |pmid= 12095675 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hino S, Michiue T, Asashima M, Kikuchi A |title=Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14066–73 |year= 2003 |pmid= 12556519 |doi= 10.1074/jbc.M213265200 }}
*{{cite journal  | author=Hino S, Michiue T, Asashima M, Kikuchi A |title=Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14066-73 |year= 2003 |pmid= 12556519 |doi= 10.1074/jbc.M213265200 }}
*{{cite journal  | vauthors=Khambata-Ford S, Liu Y, Gleason C |title=Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. |journal=Genome Res. |volume=13 |issue= 7 |pages= 1765–74 |year= 2003 |pmid= 12805274 |doi= 10.1101/gr.529803 | pmc=403750 |display-authors=etal}}
*{{cite journal  | author=Khambata-Ford S, Liu Y, Gleason C, ''et al.'' |title=Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. |journal=Genome Res. |volume=13 |issue= 7 |pages= 1765-74 |year= 2003 |pmid= 12805274 |doi= 10.1101/gr.529803 }}
*{{cite journal  | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Wang Y, Hewitt SM, Liu S |title=Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. |journal=Br. J. Cancer |volume=94 |issue= 5 |pages= 686–91 |year= 2006 |pmid= 16479254 |doi= 10.1038/sj.bjc.6602988 | pmc=2361213 |display-authors=etal}}
*{{cite journal  | author=Wang Y, Hewitt SM, Liu S, ''et al.'' |title=Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. |journal=Br. J. Cancer |volume=94 |issue= 5 |pages= 686-91 |year= 2006 |pmid= 16479254 |doi= 10.1038/sj.bjc.6602988 }}
*{{cite journal  | vauthors=Hagen T, Cross DA, Culbert AA |title=FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 35021–9 |year= 2007 |pmid= 16982607 |doi= 10.1074/jbc.M607003200 |display-authors=etal}}
*{{cite journal  | author=Hagen T, Cross DA, Culbert AA, ''et al.'' |title=FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 35021-9 |year= 2007 |pmid= 16982607 |doi= 10.1074/jbc.M607003200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|FRAT1}}
* {{UCSC gene details|FRAT1}}
 
{{PDB Gallery|geneid=10023}}
 
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Latest revision as of 04:56, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.[1][2]

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.[2]

References

  1. ↑ Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC 1169648. PMID 9034327.
  2. ↑ 2.0 2.1 "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

Further reading

External links



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