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{{Infobox_gene}}
{{PBB_Controls
'''FUS-interacting serine-arginine-rich protein 1''' is a [[protein]] that in humans is encoded by the ''SFRS13A'' [[gene]].<ref name="pmid9774382">{{cite journal | vauthors = Yang L, Embree LJ, Tsai S, Hickstein DD | title = Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing | journal = J. Biol. Chem. | volume = 273 | issue = 43 | pages = 27761–4  | date = November 1998 | pmid = 9774382 | pmc =  | doi = 10.1074/jbc.273.43.27761 }}</ref><ref name="pmid11891055">{{cite journal | vauthors = Clinton JM, Chansky HA, Odell DD, Zielinska-Kwiatkowska A, Hickstein DD, Yang L | title = Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins | journal = Gene | volume = 284 | issue = 1-2 | pages = 141–7  | date = March 2002 | pmid = 11891055 | pmc =  | doi = 10.1016/S0378-1119(02)00382-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10772| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = FUS interacting protein (serine/arginine-rich) 1
| HGNCid = 16713
| Symbol = FUSIP1
| AltSymbols =; FUSIP2; NSSR; SFRS13; SRp38; SRrp40; TASR; TASR1; TASR2
| OMIM = 605221
| ECnumber = 
| Homologene = 87811
| MGIid = 1333805
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0031202 |text = RNA splicing factor activity, transesterification mechanism}} {{GNF_GO|id=GO:0050733 |text = RS domain binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000244 |text = assembly of spliceosomal tri-snRNP}} {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0006376 |text = mRNA splice site selection}} {{GNF_GO|id=GO:0006406 |text = mRNA export from nucleus}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016482 |text = cytoplasmic transport}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0048025 |text = negative regulation of nuclear mRNA splicing, via spliceosome}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10772
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006616
    | Hs_RefseqmRNA = NM_006625
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 14105
    | Mm_Ensembl = ENSMUSG00000028676
    | Mm_RefseqmRNA = XM_987706
    | Mm_RefseqProtein = XP_992800
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 135127823
    | Mm_GenLoc_end = 135141984
    | Mm_Uniprot = Q3UXS8
  }}
}}
'''FUS interacting protein (serine/arginine-rich) 1''', also known as '''FUSIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10772| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product is a member of the serine-arginine ([[SR protein|SR]]) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. [[Alternative splicing]] of this gene results in at least two transcript variants encoding different [[protein isoforms|isoforms]]. In addition, transcript variants utilizing alternative polyA sites exist.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.<ref name="entrez">{{cite web | title = Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10772| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
FUSIP1 has been shown to [[Protein-protein interaction|interact]] with [[FUS (gene)|FUS]].<ref name=pmid10779324>{{cite journal | vauthors = Yang L, Embree LJ, Hickstein DD | title = TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3345–54  | date = May 2000 | pmid = 10779324 | pmc = 85627 | doi = 10.1128/MCB.20.10.3345-3354.2000 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Yang L, Embree LJ, Hickstein DD | title = TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3345–54 | year = 2000 | pmid = 10779324 | pmc = 85627 | doi = 10.1128/MCB.20.10.3345-3354.2000 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Cowper AE, Cáceres JF, Mayeda A, Screaton GR | title = Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing | journal = J. Biol. Chem. | volume = 276 | issue = 52 | pages = 48908–14 | year = 2001 | pmid = 11684676 | doi = 10.1074/jbc.M103967200 }}
*{{cite journal  | author=Yang L, Embree LJ, Tsai S, Hickstein DD |title=Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 27761-4 |year= 1998 |pmid= 9774382 |doi=  }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Yang L, Embree LJ, Hickstein DD |title=TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3345-54 |year= 2000 |pmid= 10779324 |doi= }}
* {{cite journal | vauthors = Shin C, Manley JL | title = The SR protein SRp38 represses splicing in M phase cells | journal = Cell | volume = 111 | issue = 3 | pages = 407–17 | year = 2002 | pmid = 12419250 | doi = 10.1016/S0092-8674(02)01038-3 }}
*{{cite journal | author=Cowper AE, Cáceres JF, Mayeda A, Screaton GR |title=Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48908-14 |year= 2002 |pmid= 11684676 |doi= 10.1074/jbc.M103967200 }}
* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 21 | pages = 7437–47 | year = 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
* {{cite journal | vauthors = Shin C, Feng Y, Manley JL | title = Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock | journal = Nature | volume = 427 | issue = 6974 | pages = 553–8 | year = 2004 | pmid = 14765198 | doi = 10.1038/nature02288 }}
*{{cite journal  | author=Clinton JM, Chansky HA, Odell DD, ''et al.'' |title=Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. |journal=Gene |volume=284 |issue= 1-2 |pages= 141-7 |year= 2002 |pmid= 11891055 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Shin C, Manley JL |title=The SR protein SRp38 represses splicing in M phase cells. |journal=Cell |volume=111 |issue= 3 |pages= 407-17 |year= 2002 |pmid= 12419250 |doi= }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
* {{cite journal | vauthors = Shin C, Kleiman FE, Manley JL | title = Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins | journal = Mol. Cell. Biol. | volume = 25 | issue = 18 | pages = 8334–43 | year = 2005 | pmid = 16135820 | pmc = 1234314 | doi = 10.1128/MCB.25.18.8334-8343.2005 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Shin C, Feng Y, Manley JL |title=Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. |journal=Nature |volume=427 |issue= 6974 |pages= 553-8 |year= 2004 |pmid= 14765198 |doi= 10.1038/nature02288 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Shin C, Kleiman FE, Manley JL |title=Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. |journal=Mol. Cell. Biol. |volume=25 |issue= 18 |pages= 8334-43 |year= 2005 |pmid= 16135820 |doi= 10.1128/MCB.25.18.8334-8343.2005 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:58, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.[1][2][3]

Function

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[3]

Interactions

FUSIP1 has been shown to interact with FUS.[4]

References

  1. ↑ Yang L, Embree LJ, Tsai S, Hickstein DD (November 1998). "Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing". J. Biol. Chem. 273 (43): 27761–4. doi:10.1074/jbc.273.43.27761. PMID 9774382.
  2. ↑ Clinton JM, Chansky HA, Odell DD, Zielinska-Kwiatkowska A, Hickstein DD, Yang L (March 2002). "Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins". Gene. 284 (1–2): 141–7. doi:10.1016/S0378-1119(02)00382-7. PMID 11891055.
  3. ↑ 3.0 3.1 "Entrez Gene: FUSIP1 FUS interacting protein (serine/arginine-rich) 1".
  4. ↑ Yang L, Embree LJ, Hickstein DD (May 2000). "TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins". Mol. Cell. Biol. 20 (10): 3345–54. doi:10.1128/MCB.20.10.3345-3354.2000. PMC 85627. PMID 10779324.

Further reading


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