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{{ | '''Far upstream element-binding protein 1''' is a [[protein]] that in humans is encoded by the ''FUBP1'' [[gene]].<ref name="pmid8125259">{{cite journal | vauthors = Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D | title = A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif | journal = Genes Dev | volume = 8 | issue = 4 | pages = 465–80 |date=April 1994 | pmid = 8125259 | pmc = | doi =10.1101/gad.8.4.465 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8880| accessdate = }}</ref> | ||
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| section_title = | | section_title = | ||
| summary_text = This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.<ref name="entrez" | | summary_text = This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
Far upstream element-binding protein 1 has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]]<ref name=pmid12819782>{{cite journal |last=Kim |first=Min Jung |author2=Park Bum-Joon |author3=Kang Young-Sun |author4=Kim Hyoung June |author5=Park Jae-Hyun |author6=Kang Jung Woo |author7=Lee Sang Won |author8=Han Jung Min |author9=Lee Han-Woong |author10=Kim Sunghoon |date=July 2003 |title=Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation |journal=Nat. Genet. |volume=34 |issue=3 |pages=330–6 |publisher= |location = United States| issn = 1061-4036| pmid = 12819782 |doi = 10.1038/ng1182 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[SMN1]].<ref name=pmid10734235>{{cite journal |last=Williams |first=B Y |author2=Hamilton S L |author3=Sarkar H K |date=March 2000 |title=The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain |journal=FEBS Lett. |volume=470 |issue=2 |pages=207–10 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 10734235 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(00)01320-X }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Williams BY, Hamilton SL, Sarkar HK |title=The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain |journal=FEBS Lett. |volume=470 |issue= 2 |pages= 207–10 |year= 2000 |pmid= 10734235 |doi=10.1016/S0014-5793(00)01320-X }} | ||
*{{cite journal | | *{{cite journal | vauthors=Liu J, He L, Collins I |title=The FBP interacting repressor targets TFIIH to inhibit activated transcription |journal=Mol. Cell |volume=5 |issue= 2 |pages= 331–41 |year= 2000 |pmid= 10882074 |doi=10.1016/S1097-2765(00)80428-1 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Markovtsov V, Nikolic JM, Goldman JA |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463–79 |year= 2000 |pmid= 11003644 |doi=10.1128/MCB.20.20.7463-7479.2000 | pmc=86300 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=He L, Weber A, Levens D |title=Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor |journal=Nucleic Acids Res. |volume=28 |issue= 22 |pages= 4558–65 |year= 2000 |pmid= 11071946 |doi=10.1093/nar/28.22.4558 | pmc=113884 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Vindigni A, Ochem A, Triolo G, Falaschi A |title=Identification of human DNA helicase V with the far upstream element-binding protein |journal=Nucleic Acids Res. |volume=29 |issue= 5 |pages= 1061–7 |year= 2001 |pmid= 11222755 |doi=10.1093/nar/29.5.1061 | pmc=29729 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Liu J, Akoulitchev S, Weber A |title=Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum |journal=Cell |volume=104 |issue= 3 |pages= 353–63 |year= 2001 |pmid= 11239393 |doi=10.1016/S0092-8674(01)00223-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Braddock DT, Louis JM, Baber JL |title=Structure and dynamics of KH domains from FBP bound to single-stranded DNA |journal=Nature |volume=415 |issue= 6875 |pages= 1051–6 |year= 2002 |pmid= 11875576 |doi= 10.1038/4151051a |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rappsilber J, Ryder U, Lamond AI, Mann M |title=Large-scale proteomic analysis of the human spliceosome |journal=Genome Res. |volume=12 |issue= 8 |pages= 1231–45 |year= 2002 |pmid= 12176931 |doi= 10.1101/gr.473902 | pmc=186633 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kim MJ, Park BJ, Kang YS |title=Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation |journal=Nat. Genet. |volume=34 |issue= 3 |pages= 330–6 |year= 2003 |pmid= 12819782 |doi= 10.1038/ng1182 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kouzine F, Liu J, Sanford S |title=The dynamic response of upstream DNA to transcription-generated torsional stress |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1092–100 |year= 2004 |pmid= 15502847 |doi= 10.1038/nsmb848 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Fautsch MP, Vrabel AM, Johnson DH |title=The identification of myocilin-associated proteins in the human trabecular meshwork |journal=Exp. Eye Res. |volume=82 |issue= 6 |pages= 1046–52 |year= 2006 |pmid= 16289162 |doi= 10.1016/j.exer.2005.09.016 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Liu J, Kouzine F, Nie Z |title=The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression |journal=EMBO J. |volume=25 |issue= 10 |pages= 2119–30 |year= 2006 |pmid= 16628215 |doi= 10.1038/sj.emboj.7601101 | pmc=1462968 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ko HS, Kim SW, Sriram SR |title=Identification of far upstream element-binding protein-1 as an authentic Parkin substrate |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16193–6 |year= 2006 |pmid= 16672220 |doi= 10.1074/jbc.C600041200 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=8880}} | |||
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Revision as of 05:23, 31 August 2017
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Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.[1][2]
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.[2]
Interactions
Far upstream element-binding protein 1 has been shown to interact with MAPK14[3] and SMN1.[4]
References
- ↑ Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi:10.1101/gad.8.4.465. PMID 8125259.
- ↑ 2.0 2.1 "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
- ↑ Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. United States. 34 (3): 330–6. doi:10.1038/ng1182. ISSN 1061-4036. PMID 12819782.
- ↑ Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. NETHERLANDS. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN 0014-5793. PMID 10734235.
Further reading
- Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. PMID 10734235.
- Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi:10.1016/S1097-2765(00)80428-1. PMID 10882074.
- Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
- He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC 113884. PMID 11071946.
- Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC 29729. PMID 11222755.
- Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi:10.1016/S0092-8674(01)00223-9. PMID 11239393.
- Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. doi:10.1038/4151051a. PMID 11875576.
- Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID 12819782.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID 15502847.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
- Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC 1462968. PMID 16628215.
- Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.
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