G3BP1: Difference between revisions
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{{ | '''Ras GTPase-activating protein-binding protein 1''' is an [[enzyme]] that in humans is encoded by the ''G3BP1'' [[gene]].<ref name="pmid8649363">{{cite journal |vauthors=Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B | title = A Ras-GTPase-activating protein SH3-domain-binding protein | journal = Mol Cell Biol | volume = 16 | issue = 6 | pages = 2561–9 |date=Jul 1996 | pmid = 8649363 | pmc = 231246 | doi = }}</ref><ref name="pmid9889278">{{cite journal |vauthors=Costa M, Ochem A, Staub A, Falaschi A | title = Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway | journal = Nucleic Acids Res | volume = 27 | issue = 3 | pages = 817–21 |date=Mar 1999 | pmid = 9889278 | pmc = 148252 | doi =10.1093/nar/27.3.817 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = }}</ref> | ||
}} | |||
{{ | |||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It | | summary_text = This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.<ref>{{Cite journal | ||
| pmid = 22205990 | |||
| pmc = 3242762 | |||
| year = 2011 | |||
| author1 = Annibaldi | |||
| first1 = A | |||
| title = Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1 | |||
| journal = PLoS ONE | |||
| volume = 6 | |||
| issue = 12 | |||
| pages = e29024 | |||
| last2 = Dousse | |||
| first2 = A | |||
| last3 = Martin | |||
| first3 = S | |||
| last4 = Tazi | |||
| first4 = J | |||
| last5 = Widmann | |||
| first5 = C | |||
| doi = 10.1371/journal.pone.0029024 | |||
}}</ref> Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/> | |||
}} | }} | ||
==Interactions== | |||
G3BP1 has been shown to [[Protein-protein interaction|interact]] with [[USP10]].<ref name=pmid11439350>{{cite journal |last=Soncini |first=C |authorlink= |author2=Berdo I|author3=Draetta G |date=Jun 2001 |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue=29 |pages=3869–79 |publisher= |location = England| issn = 0950-9232| pmid = 11439350 |doi = 10.1038/sj.onc.1204553 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
It also interacts with SND1[5]. | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532. | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Irvine K, Stirling R, Hume D, Kennedy D |title=Rasputin, more promiscuous than ever: a review of G3BP |journal=Int. J. Dev. Biol. |volume=48 |issue= 10 |pages= 1065–77 |year= 2005 |pmid= 15602692 |doi= 10.1387/ijdb.041893ki }} | ||
*{{cite journal | | *{{cite journal |vauthors=Onno M, Nakamura T, Hillova J, Hill M |title=Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes |journal=Oncogene |volume=7 |issue= 12 |pages= 2519–23 |year= 1993 |pmid= 1461655 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal |vauthors=Gallouzi IE, Parker F, Chebli K |title=A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3956–65 |year= 1998 |pmid= 9632780 |doi= | pmc=108980 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Kociok N, Esser P, Unfried K |title=Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 194–201 |year= 1999 |pmid= 10404389 |doi=10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M |display-authors=etal}} | ||
*{{cite journal |vauthors=Soncini C, Berdo I, Draetta G |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue= 29 |pages= 3869–79 |year= 2001 |pmid= 11439350 |doi= 10.1038/sj.onc.1204553 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Tourrière H, Gallouzi IE, Chebli K |title=RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7747–60 |year= 2001 |pmid= 11604510 |doi= 10.1128/MCB.21.22.7747-7760.2001 | pmc=99945 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Barnes CJ, Li F, Mandal M |title=Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1251–5 |year= 2002 |pmid= 11888885 |doi= |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Tourrière H, Chebli K, Zekri L |title=The RasGAP-associated endoribonuclease G3BP assembles stress granules |journal=J. Cell Biol. |volume=160 |issue= 6 |pages= 823–31 |year= 2003 |pmid= 12642610 |doi= 10.1083/jcb.200212128 | pmc=2173781 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Katsafanas GC, Moss B |title=Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52210–7 |year= 2005 |pmid= 15471883 |doi= 10.1074/jbc.M411033200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal |vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{ | ==External links== | ||
{{ | * {{UCSC genome browser|G3BP1}} | ||
* {{UCSC gene details|G3BP1}} | |||
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Revision as of 08:34, 31 August 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.[1][2][3]
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]
Interactions
G3BP1 has been shown to interact with USP10.[5] It also interacts with SND1[5].
References
- ↑ Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. PMC 231246. PMID 8649363.
- ↑ Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
- ↑ 3.0 3.1 "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
- ↑ Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLoS ONE. 6 (12): e29024. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
- ↑ Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. England. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350.
[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.
Further reading
- Irvine K, Stirling R, Hume D, Kennedy D (2005). "Rasputin, more promiscuous than ever: a review of G3BP". Int. J. Dev. Biol. 48 (10): 1065–77. doi:10.1387/ijdb.041893ki. PMID 15602692.
- Onno M, Nakamura T, Hillova J, Hill M (1993). "Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes". Oncogene. 7 (12): 2519–23. PMID 1461655.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Gallouzi IE, Parker F, Chebli K, et al. (1998). "A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability". Mol. Cell. Biol. 18 (7): 3956–65. PMC 108980. PMID 9632780.
- Kociok N, Esser P, Unfried K, et al. (1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". J. Cell. Biochem. 74 (2): 194–201. doi:10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M. PMID 10404389.
- Soncini C, Berdo I, Draetta G (2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29): 3869–79. doi:10.1038/sj.onc.1204553. PMID 11439350.
- Tourrière H, Gallouzi IE, Chebli K, et al. (2001). "RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization". Mol. Cell. Biol. 21 (22): 7747–60. doi:10.1128/MCB.21.22.7747-7760.2001. PMC 99945. PMID 11604510.
- Barnes CJ, Li F, Mandal M, et al. (2002). "Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors". Cancer Res. 62 (5): 1251–5. PMID 11888885.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tourrière H, Chebli K, Zekri L, et al. (2003). "The RasGAP-associated endoribonuclease G3BP assembles stress granules". J. Cell Biol. 160 (6): 823–31. doi:10.1083/jcb.200212128. PMC 2173781. PMID 12642610.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Katsafanas GC, Moss B (2005). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". J. Biol. Chem. 279 (50): 52210–7. doi:10.1074/jbc.M411033200. PMID 15471883.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.
External links
- G3BP1 human gene location in the UCSC Genome Browser.
- G3BP1 human gene details in the UCSC Genome Browser.
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