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{{Infobox_gene}}
{{PBB_Controls
'''GRIP and coiled-coil domain-containing protein 2''' is a [[protein]] that in humans is encoded by the ''GCC2'' [[gene]].<ref name="pmid12446665">{{cite journal |vauthors=Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA | title = GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network | journal = J Biol Chem | volume = 278 | issue = 6 | pages = 4216–26 |date=Feb 2003 | pmid = 12446665 | pmc = | doi = 10.1074/jbc.M210387200 }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = GRIP and coiled-coil domain containing 2
| HGNCid = 23218
| Symbol = GCC2
| AltSymbols =; GCC185; KIAA0336
| OMIM = 
| ECnumber = 
| Homologene = 45639
| MGIid = 1917547
| GeneAtlas_image1 = PBB_GE_GCC2_202832_at_tn.png
| GeneAtlas_image2 = PBB_GE_GCC2_210676_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_GCC2_212842_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9648
    | Hs_Ensembl = ENSG00000135968
    | Hs_RefseqProtein = NP_055450
    | Hs_RefseqmRNA = NM_014635
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 108432068
    | Hs_GenLoc_end = 108492286
    | Hs_Uniprot = Q4ZG46
    | Mm_EntrezGene = 70297
    | Mm_Ensembl = ENSMUSG00000038039
    | Mm_RefseqmRNA = NM_027375
    | Mm_RefseqProtein = NP_081651
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 57650883
    | Mm_GenLoc_end = 57700951
    | Mm_Uniprot = Q3UFV3
  }}
}}
'''GRIP and coiled-coil domain containing 2''', also known as '''GCC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9648| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9648| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a peripheral [[membrane protein]] localized to the [[trans-Golgi network]]. It is sensitive to [[brefeldin A]]. This encoded protein contains a [[GRIP domain]] which is thought to be used in targeting. Two alternatively spliced [[transcript variants]] encoding different [[isoforms]] have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9648| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Derby MC, Lieu ZZ, Brown D, ''et al.'' |title=The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. |journal=Traffic |volume=8 |issue= 6 |pages= 758-73 |year= 2007 |pmid= 17488291 |doi= 10.1111/j.1600-0854.2007.00563.x }}
*{{cite journal  |vauthors=Derby MC, Lieu ZZ, Brown D |title=The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. |journal=Traffic |volume=8 |issue= 6 |pages= 758–73 |year= 2007 |pmid= 17488291 |doi= 10.1111/j.1600-0854.2007.00563.x |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  |vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Reddy JV, Burguete AS, Sridevi K, ''et al.'' |title=A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4353-63 |year= 2007 |pmid= 16885419 |doi= 10.1091/mbc.E06-02-0153 }}
*{{cite journal  |vauthors=Reddy JV, Burguete AS, Sridevi K |title=A Functional Role for the GCC185 Golgin in Mannose 6-Phosphate Receptor Recycling |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4353–63 |year= 2007 |pmid= 16885419 |doi= 10.1091/mbc.E06-02-0153 | pmc=1635343 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | author=Luke MR, Houghton F, Perugini MA, Gleeson PA |title=The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers. |journal=Biochem. J. |volume=388 |issue= Pt 3 |pages= 835-41 |year= 2005 |pmid= 15654769 |doi= 10.1042/BJ20041810 }}
*{{cite journal  |vauthors=Luke MR, Houghton F, Perugini MA, Gleeson PA |title=The trans-Golgi network GRIP-domain proteins form α-helical homodimers |journal=Biochem. J. |volume=388 |issue= Pt 3 |pages= 835–41 |year= 2005 |pmid= 15654769 |doi= 10.1042/BJ20041810 | pmc=1183463 }}
*{{cite journal  | author=Derby MC, van Vliet C, Brown D, ''et al.'' |title=Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. |journal=J. Cell. Sci. |volume=117 |issue= Pt 24 |pages= 5865-74 |year= 2005 |pmid= 15522892 |doi= 10.1242/jcs.01497 }}
*{{cite journal  |vauthors=Derby MC, van Vliet C, Brown D |title=Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN |journal=J. Cell Sci. |volume=117 |issue= Pt 24 |pages= 5865–74 |year= 2005 |pmid= 15522892 |doi= 10.1242/jcs.01497 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Lu L, Hong W |title=Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi. |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3767-81 |year= 2004 |pmid= 12972563 |doi= 10.1091/mbc.E03-01-0864 }}
*{{cite journal  |vauthors=Lu L, Hong W |title=Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi |journal=Mol. Biol. Cell |volume=14 |issue= 9 |pages= 3767–81 |year= 2004 |pmid= 12972563 |doi= 10.1091/mbc.E03-01-0864 | pmc=196566 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Luke MR, Kjer-Nielsen L, Brown DL, ''et al.'' |title=GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 4216-26 |year= 2003 |pmid= 12446665 |doi= 10.1074/jbc.M210387200 }}
*{{cite journal  |vauthors=Krackhardt AM, Witzens M, Harig S |title=Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX |journal=Blood |volume=100 |issue= 6 |pages= 2123–31 |year= 2002 |pmid= 12200376 |doi= 10.1182/blood-2002-02-0513 |display-authors=etal}}
*{{cite journal  | author=Krackhardt AM, Witzens M, Harig S, ''et al.'' |title=Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. |journal=Blood |volume=100 |issue= 6 |pages= 2123-31 |year= 2002 |pmid= 12200376 |doi= 10.1182/blood-2002-02-0513 }}
*{{cite journal  |vauthors=Eichmuller S, Usener D, Dummer R |title=Serological detection of cutaneous T-cell lymphoma-associated antigens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629–34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 | pmc=14639 |display-authors=etal}}
*{{cite journal  | author=Eichmuller S, Usener D, Dummer R, ''et al.'' |title=Serological detection of cutaneous T-cell lymphoma-associated antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629-34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 }}
*{{cite journal  |vauthors=Scanlan MJ, Gordan JD, Williamson B |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 |display-authors=etal}}
*{{cite journal  | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi=  }}
*{{cite journal  |vauthors=Nagase T, Ishikawa K, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{gene-2-stub}}

Latest revision as of 19:58, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.[1][2]

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

References

  1. ↑ Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (Feb 2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J Biol Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
  2. ↑ 2.0 2.1 "Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2".

Further reading



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