GSTT2: Difference between revisions

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{{Infobox_gene}}
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'''Glutathione S-transferase theta-2''' is an [[enzyme]] that in humans is encoded by the ''GSTT2'' [[gene]].<ref name="pmid7789971">{{cite journal |vauthors=Tan KL, Webb GC, Baker RT, Board PG | title = Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22 | journal = Genomics | volume = 25 | issue = 2 | pages = 381–7 |date=Jul 1995 | pmid = 7789971 | pmc =  | doi =10.1016/0888-7543(95)80037-M  }}</ref><ref name="pmid9729470">{{cite journal |vauthors=Coggan M, Whitbread L, Whittington A, Board P | title = Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex | journal = Biochem J | volume = 334 | issue =  3| pages = 617–23 |date=Nov 1998 | pmid = 9729470 | pmc = 1219731 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GSTT2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ljr.
| PDB = {{PDB2|1ljr}}, {{PDB2|2ljr}}, {{PDB2|3ljr}}
| Name = Glutathione S-transferase theta 2
| HGNCid = 4642
| Symbol = GSTT2
| AltSymbols =; GSTT2
| OMIM = 600437
| ECnumber =
| Homologene = 37358
| MGIid = 106188
  | Function = {{GNF_GO|id=GO:0004364 |text = glutathione transferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2953
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_000845
    | Hs_RefseqmRNA = NM_000854
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =   
    | Hs_Uniprot =
    | Mm_EntrezGene = 14872
    | Mm_Ensembl = ENSMUSG00000033318
    | Mm_RefseqmRNA = NM_010361
    | Mm_RefseqProtein = NP_034491
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 75275566
    | Mm_GenLoc_end = 75278150
    | Mm_Uniprot = Q91VB0
  }}
}}
'''Glutathione S-transferase theta 2''', also known as '''GSTT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.<ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref>
| summary_text = Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.<ref name="entrez">{{cite web | title = Entrez Gene: GSTT2 glutathione S-transferase theta 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2953| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hussey AJ, Hayes JD |title=Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. |journal=Biochem. J. |volume=286 ( Pt 3) |issue=  |pages= 929-35 |year= 1992 |pmid= 1417752 |doi=  }}
*{{cite journal  |vauthors=Hussey AJ, Hayes JD |title=Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate. |journal=Biochem. J. |volume=286 |issue=  3|pages= 929–35 |year= 1992 |pmid= 1417752 |doi=  | pmc=1132992 }}
*{{cite journal  | author=Tan KL, Webb GC, Baker RT, Board PG |title=Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22. |journal=Genomics |volume=25 |issue= 2 |pages= 381-7 |year= 1995 |pmid= 7789971 |doi=  }}
*{{cite journal  |vauthors=Whittington AT, Webb GC, Baker RT, Board PG |title=Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. |journal=Genomics |volume=33 |issue= 1 |pages= 105–11 |year= 1996 |pmid= 8617493 |doi= 10.1006/geno.1996.0165 }}
*{{cite journal  | author=Whittington AT, Webb GC, Baker RT, Board PG |title=Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. |journal=Genomics |volume=33 |issue= 1 |pages= 105-11 |year= 1996 |pmid= 8617493 |doi= 10.1006/geno.1996.0165 }}
*{{cite journal  |vauthors=Webb G, Vaska V, Coggan M, Board P |title=Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). |journal=Genomics |volume=33 |issue= 1 |pages= 121–3 |year= 1996 |pmid= 8617495 |doi= 10.1006/geno.1996.0167 }}
*{{cite journal  | author=Webb G, Vaska V, Coggan M, Board P |title=Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). |journal=Genomics |volume=33 |issue= 1 |pages= 121-3 |year= 1996 |pmid= 8617495 |doi= 10.1006/geno.1996.0167 }}
*{{cite journal   |vauthors=Mainwaring GW, Williams SM, Foster JR, etal |title=The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. |journal=Biochem. J. |volume=318 |issue=  1|pages= 297–303 |year= 1996 |pmid= 8761485 |doi= | pmc=1217621 }}
*{{cite journal | author=Mainwaring GW, Williams SM, Foster JR, ''et al.'' |title=The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. |journal=Biochem. J. |volume=318 ( Pt 1) |issue=  |pages= 297-303 |year= 1996 |pmid= 8761485 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Chelvanayagam G, Wilce MC, Parker MW, etal |title=Homology model for the human GSTT2 Theta class glutathione transferase. |journal=Proteins |volume=27 |issue= 1 |pages= 118–30 |year= 1997 |pmid= 9037717 |doi=10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q }}
*{{cite journal | author=Chelvanayagam G, Wilce MC, Parker MW, ''et al.'' |title=Homology model for the human GSTT2 Theta class glutathione transferase. |journal=Proteins |volume=27 |issue= 1 |pages= 118-30 |year= 1997 |pmid= 9037717 |doi=  }}
*{{cite journal   |vauthors=Rossjohn J, McKinstry WJ, Oakley AJ, etal |title=Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. |journal=Structure |volume=6 |issue= 3 |pages= 309–22 |year= 1998 |pmid= 9551553 |doi=10.1016/S0969-2126(98)00034-3 }}
*{{cite journal | author=Rossjohn J, McKinstry WJ, Oakley AJ, ''et al.'' |title=Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site. |journal=Structure |volume=6 |issue= 3 |pages= 309-22 |year= 1998 |pmid= 9551553 |doi= }}
*{{cite journal  |vauthors=de Bruin WC, Wagenmans MJ, Board PG, Peters WH |title=Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers. |journal=Carcinogenesis |volume=20 |issue= 8 |pages= 1453–7 |year= 1999 |pmid= 10426791 |doi=10.1093/carcin/20.8.1453 }}
*{{cite journal  | author=Coggan M, Whitbread L, Whittington A, Board P |title=Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. |journal=Biochem. J. |volume=334 ( Pt 3) |issue=  |pages= 617-23 |year= 1998 |pmid= 9729470 |doi= }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=de Bruin WC, Wagenmans MJ, Board PG, Peters WH |title=Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers. |journal=Carcinogenesis |volume=20 |issue= 8 |pages= 1453-7 |year= 1999 |pmid= 10426791 |doi=  }}
*{{cite journal  |vauthors=de Bruin WC, Wagenmans MJ, Peters WH |title=Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 3 |pages= 310–6 |year= 2000 |pmid= 10760690 |doi=  10.1111/j.1349-7006.2000.tb00946.x}}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Sprenger R, Schlagenhaufer R, Kerb R, etal |title=Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. |journal=Pharmacogenetics |volume=10 |issue= 6 |pages= 557–65 |year= 2001 |pmid= 10975610 |doi=10.1097/00008571-200008000-00009 }}
*{{cite journal  | author=de Bruin WC, Wagenmans MJ, Peters WH |title=Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 3 |pages= 310-6 |year= 2000 |pmid= 10760690 |doi=  }}
*{{cite journal   |vauthors=Venter JC, Adams MD, Myers EW, etal |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal | author=Sprenger R, Schlagenhaufer R, Kerb R, ''et al.'' |title=Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. |journal=Pharmacogenetics |volume=10 |issue= 6 |pages= 557-65 |year= 2001 |pmid= 10975610 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal   |vauthors=De Maria F, Pedersen JZ, Caccuri AM, etal |title=The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42283–93 |year= 2004 |pmid= 12871945 |doi= 10.1074/jbc.M305568200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=De Maria F, Pedersen JZ, Caccuri AM, ''et al.'' |title=The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42283-93 |year= 2004 |pmid= 12871945 |doi= 10.1074/jbc.M305568200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal   |vauthors=Jang SG, Kim IJ, Kang HC, etal |title=GSTT2 promoter polymorphisms and colorectal cancer risk. |journal=BMC Cancer |volume=7|pages= 16 |year= 2007 |pmid= 17250773 |doi= 10.1186/1471-2407-7-16 | pmc=1793996 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Jang SG, Kim IJ, Kang HC, ''et al.'' |title=GSTT2 promoter polymorphisms and colorectal cancer risk. |journal=BMC Cancer |volume=7 |issue=  |pages= 16 |year= 2007 |pmid= 17250773 |doi= 10.1186/1471-2407-7-16 }}
}}
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{{PDB Gallery|geneid=2953}}
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Latest revision as of 09:07, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.[1][2][3]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]

References

  1. ↑ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.
  2. ↑ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. PMC 1219731. PMID 9729470.
  3. ↑ 3.0 3.1 "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Further reading



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