GTSE1: Difference between revisions

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{{Infobox_gene}}
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'''G2 and S phase-expressed protein 1''' is an [[enzyme]] that in humans is encoded by the ''GTSE1'' [[gene]].<ref name="pmid10974554">{{cite journal |vauthors=Monte M, Collavin L, Lazarevic D, Utrera R, Dragani TA, Schneider C | title = Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene | journal = Gene | volume = 254 | issue = 1-2 | pages = 229–36 |date=Oct 2000 | pmid = 10974554 | pmc =  | doi =10.1016/S0378-1119(00)00260-2 }}</ref><ref name="pmid10984615">{{cite journal |vauthors=Collavin L, Monte M, Verardo R, Pfleger C, Schneider C | title = Cell-cycle regulation of the p53-inducible gene B99 | journal = FEBS Lett | volume = 481 | issue = 1 | pages = 57–62 |date=Oct 2000 | pmid = 10984615 | pmc = | doi =10.1016/S0014-5793(00)01969-4  }}</ref><ref name="pmid12750368">{{cite journal |vauthors=Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C | title = The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function | journal = J Biol Chem | volume = 278 | issue = 32 | pages = 30356–64 |date=Aug 2003 | pmid = 12750368 | pmc =  | doi = 10.1074/jbc.M302902200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTSE1 G-2 and S-phase expressed 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51512| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G-2 and S-phase expressed 1
| HGNCid = 13698
| Symbol = GTSE1
| AltSymbols =; B99
| OMIM = 607477
| ECnumber =
| Homologene = 8489
| MGIid = 1352755
  | GeneAtlas_image1 = PBB_GE_GTSE1_204315_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_GTSE1_204317_at_tn.png
| GeneAtlas_image3 = PBB_GE_GTSE1_204318_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005881 |text = cytoplasmic microtubule}}
| Process = {{GNF_GO|id=GO:0000085 |text = G2 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006977 |text = DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest}} {{GNF_GO|id=GO:0007017 |text = microtubule-based process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51512
    | Hs_Ensembl = ENSG00000075218
    | Hs_RefseqProtein = NP_057510
    | Hs_RefseqmRNA = NM_016426
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 45071476
    | Hs_GenLoc_end = 45108257
    | Hs_Uniprot = Q9NYZ3
    | Mm_EntrezGene = 29870
    | Mm_Ensembl = ENSMUSG00000022385
    | Mm_RefseqmRNA = NM_013882
    | Mm_RefseqProtein = NP_038910
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 85687511
    | Mm_GenLoc_end = 85704338
    | Mm_Uniprot = Q542Q3
  }}
}}
'''G-2 and S-phase expressed 1''', also known as '''GTSE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTSE1 G-2 and S-phase expressed 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51512| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: GTSE1 G-2 and S-phase expressed 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51512| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Monte M, Collavin L, Lazarevic D, ''et al.'' |title=Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene. |journal=Gene |volume=254 |issue= 1-2 |pages= 229-36 |year= 2000 |pmid= 10974554 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Collavin L, Monte M, Verardo R, ''et al.'' |title=Cell-cycle regulation of the p53-inducible gene B99. |journal=FEBS Lett. |volume=481 |issue= 1 |pages= 57-62 |year= 2000 |pmid= 10984615 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Monte M, Benetti R, Collavin L, etal |title=hGTSE-1 expression stimulates cytoplasmic localization of p53. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11744–52 |year= 2004 |pmid= 14707141 |doi= 10.1074/jbc.M311123200 }}
*{{cite journal | author=Monte M, Benetti R, Buscemi G, ''et al.'' |title=The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30356-64 |year= 2003 |pmid= 12750368 |doi= 10.1074/jbc.M302902200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Monte M, Benetti R, Collavin L, ''et al.'' |title=hGTSE-1 expression stimulates cytoplasmic localization of p53. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11744-52 |year= 2004 |pmid= 14707141 |doi= 10.1074/jbc.M311123200 }}
*{{cite journal   |vauthors=Cheng J, Kapranov P, Drenkow J, etal |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Kapranov P, Drenkow J, Cheng J, etal |title=Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. |journal=Genome Res. |volume=15 |issue= 7 |pages= 987–97 |year= 2005 |pmid= 15998911 |doi= 10.1101/gr.3455305 | pmc=1172043 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Cheng J, Kapranov P, Drenkow J, ''et al.'' |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149-54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
*{{cite journal | author=Kapranov P, Drenkow J, Cheng J, ''et al.'' |title=Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. |journal=Genome Res. |volume=15 |issue= 7 |pages= 987-97 |year= 2005 |pmid= 15998911 |doi= 10.1101/gr.3455305 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 09:09, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.[1][2][3][4]

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.[4]

References

  1. ↑ Monte M, Collavin L, Lazarevic D, Utrera R, Dragani TA, Schneider C (Oct 2000). "Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene". Gene. 254 (1–2): 229–36. doi:10.1016/S0378-1119(00)00260-2. PMID 10974554.
  2. ↑ Collavin L, Monte M, Verardo R, Pfleger C, Schneider C (Oct 2000). "Cell-cycle regulation of the p53-inducible gene B99". FEBS Lett. 481 (1): 57–62. doi:10.1016/S0014-5793(00)01969-4. PMID 10984615.
  3. ↑ Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C (Aug 2003). "The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function". J Biol Chem. 278 (32): 30356–64. doi:10.1074/jbc.M302902200. PMID 12750368.
  4. ↑ 4.0 4.1 "Entrez Gene: GTSE1 G-2 and S-phase expressed 1".

Further reading



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