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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
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'''Granzyme H''' is a [[protein]] that in humans is encoded by the ''GZMH'' [[gene]].<ref name="pmid2049336">{{cite journal |vauthors=Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M | title = Structure and evolutionary origin of the human granzyme H gene | journal = Int Immunol | volume = 3 | issue = 1 | pages = 57–66 |date=Jul 1991 | pmid = 2049336 | pmc =  | doi =10.1093/intimm/3.1.57 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2999| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Granzyme H (cathepsin G-like 2, protein h-CCPX)
| HGNCid = 4710
| Symbol = GZMH
| AltSymbols =; CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
| OMIM = 116831
| ECnumber = 
| Homologene = 62159
| MGIid = 109253
| GeneAtlas_image1 = PBB_GE_GZMH_210321_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0019835 |text = cytolysis}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2999
    | Hs_Ensembl = ENSG00000100450
    | Hs_RefseqProtein = NP_219491
    | Hs_RefseqmRNA = NM_033423
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 24145534
    | Hs_GenLoc_end = 24148745
    | Hs_Uniprot = P20718
    | Mm_EntrezGene = 14944
    | Mm_Ensembl = ENSMUSG00000040284
    | Mm_RefseqmRNA = NM_010375
    | Mm_RefseqProtein = NP_034505
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 55110648
    | Mm_GenLoc_end = 55113650
    | Mm_Uniprot = Q4KL28
  }}
}}
'''Granzyme H (cathepsin G-like 2, protein h-CCPX)''', also known as '''GZMH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2999| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Waterhouse NJ, Trapani JA |title=H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. |journal=Trends Immunol. |volume=28 |issue= 9 |pages= 373-5 |year= 2007 |pmid= 17766182 |doi= 10.1016/j.it.2007.08.001 }}
*{{cite journal  |vauthors=Waterhouse NJ, Trapani JA |title=H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. |journal=Trends Immunol. |volume=28 |issue= 9 |pages= 373–5 |year= 2007 |pmid= 17766182 |doi= 10.1016/j.it.2007.08.001 }}
*{{cite journal  | author=Llorens C, Martres MP, Baudry M, Schwartz JC |title=Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence. |journal=Nature |volume=274 |issue= 5671 |pages= 603-5 |year= 1978 |pmid= 209336 |doi=  }}
*{{cite journal  |vauthors=Llorens C, Martres MP, Baudry M, Schwartz JC |title=Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence. |journal=Nature |volume=274 |issue= 5671 |pages= 603–5 |year= 1978 |pmid= 209336 |doi=10.1038/274603a0 }}
*{{cite journal  | author=Heusel JW, Hanson RD, Silverman GA, Ley TJ |title=Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6152-8 |year= 1991 |pmid= 2007574 |doi=  }}
*{{cite journal  |vauthors=Heusel JW, Hanson RD, Silverman GA, Ley TJ |title=Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6152–8 |year= 1991 |pmid= 2007574 |doi=  }}
*{{cite journal  | author=Haddad P, Jenne D, Tschopp J, ''et al.'' |title=Structure and evolutionary origin of the human granzyme H gene. |journal=Int. Immunol. |volume=3 |issue= 1 |pages= 57-66 |year= 1991 |pmid= 2049336 |doi=  }}
*{{cite journal  | author=Meier M |title=Cloning of a gene that encodes a new member of the human cytotoxic cell protease family |journal=Biochemistry |volume=29 |issue= 17 |pages= 4042–9 |year= 1990 |pmid= 2193684 |doi=10.1021/bi00469a003 |name-list-format=vanc| author2=Kwong PC | author3=Frégeau CJ | display-authors=3  | last4=Atkinson  | first4=E. A. | last5=Burrington  | first5=M. | last6=Ehrman  | first6=N.  | last7=Sorensen  | first7=O.  | last8=Lin  | first8=C. C.  | last9=Wilkins  | first9=J. }}
*{{cite journal  | author=Meier M, Kwong PC, Frégeau CJ, ''et al.'' |title=Cloning of a gene that encodes a new member of the human cytotoxic cell protease family. |journal=Biochemistry |volume=29 |issue= 17 |pages= 4042-9 |year= 1990 |pmid= 2193684 |doi=  }}
*{{cite journal  |vauthors=Hanson RD, Hohn PA, Popescu NC, Ley TJ |title=A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 3 |pages= 960–3 |year= 1990 |pmid= 2300587 |doi=10.1073/pnas.87.3.960  | pmc=53389 }}
*{{cite journal  | author=Hanson RD, Hohn PA, Popescu NC, Ley TJ |title=A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 3 |pages= 960-3 |year= 1990 |pmid= 2300587 |doi=  }}
*{{cite journal  |vauthors=Klein JL, Selvakumar A, Trapani JA, Dupont B |title=Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C) |journal=Tissue Antigens |volume=35 |issue= 5 |pages= 220–8 |year= 1990 |pmid= 2402757 |doi=10.1111/j.1399-0039.1990.tb01787.x }}
*{{cite journal  | author=Klein JL, Selvakumar A, Trapani JA, Dupont B |title=Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C). |journal=Tissue Antigens |volume=35 |issue= 5 |pages= 220-8 |year= 1990 |pmid= 2402757 |doi=  }}
*{{cite journal  |vauthors=MacIvor DM, Pham CT, Ley TJ |title=The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice |journal=Blood |volume=93 |issue= 3 |pages= 963–73 |year= 1999 |pmid= 9920846 |doi=  }}
*{{cite journal  | author=MacIvor DM, Pham CT, Ley TJ |title=The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. |journal=Blood |volume=93 |issue= 3 |pages= 963-73 |year= 1999 |pmid= 9920846 |doi=  }}
*{{cite journal  |vauthors=Edwards KM, Kam CM, Powers JC, Trapani JA |title=The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30468–73 |year= 1999 |pmid= 10521426 |doi=10.1074/jbc.274.43.30468 }}
*{{cite journal  | author=Edwards KM, Kam CM, Powers JC, Trapani JA |title=The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30468-73 |year= 1999 |pmid= 10521426 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ |title=Cell death induced by granzyme C |journal=Blood |volume=101 |issue= 8 |pages= 3093–101 |year= 2003 |pmid= 12515723 |doi= 10.1182/blood-2002-08-2485 }}
*{{cite journal  | author=Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ |title=Cell death induced by granzyme C. |journal=Blood |volume=101 |issue= 8 |pages= 3093-101 |year= 2003 |pmid= 12515723 |doi= 10.1182/blood-2002-08-2485 }}
*{{cite journal  | author=Sedelies KA |title=Discordant regulation of granzyme H and granzyme B expression in human lymphocytes |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26581–7 |year= 2004 |pmid= 15069086 |doi= 10.1074/jbc.M312481200 |name-list-format=vanc| author2=Sayers TJ  | author3=Edwards KM  | display-authors=3  | last4=Chen  | first4=W  | last5=Pellicci  | first5=DG  | last6=Godfrey  | first6=DI  | last7=Trapani  | first7=JA }}
*{{cite journal  | author=Sedelies KA, Sayers TJ, Edwards KM, ''et al.'' |title=Discordant regulation of granzyme H and granzyme B expression in human lymphocytes. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26581-7 |year= 2004 |pmid= 15069086 |doi= 10.1074/jbc.M312481200 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andrade F |title=Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition |journal=EMBO J. |volume=26 |issue= 8 |pages= 2148–57 |year= 2007 |pmid= 17363894 |doi= 10.1038/sj.emboj.7601650 | pmc=1852776  |name-list-format=vanc| author2=Fellows E  | author3=Jenne DE  | display-authors=3  | last4=Rosen  | first4=Antony  | last5=Young  | first5=C S H }}
*{{cite journal  | author=Andrade F, Fellows E, Jenne DE, ''et al.'' |title=Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. |journal=EMBO J. |volume=26 |issue= 8 |pages= 2148-57 |year= 2007 |pmid= 17363894 |doi= 10.1038/sj.emboj.7601650 }}
*{{cite journal  |vauthors=Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC |title=Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program |journal=Blood |volume=110 |issue= 2 |pages= 544–52 |year= 2007 |pmid= 17409270 |doi= 10.1182/blood-2006-10-051649 }}
*{{cite journal  | author=Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC |title=Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. |journal=Blood |volume=110 |issue= 2 |pages= 544-52 |year= 2007 |pmid= 17409270 |doi= 10.1182/blood-2006-10-051649 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:11, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Granzyme H is a protein that in humans is encoded by the GZMH gene.[1][2]


References

  1. ↑ Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene". Int Immunol. 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.
  2. ↑ "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=GZMH&oldid=1416589"