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{{Infobox_gene}}
{{PBB_Controls
'''Granzyme K''' is a [[protein]] that in humans is encoded by the ''GZMK'' [[gene]].<ref name="pmid7758581">{{cite journal |vauthors=Przetak MM, Yoast S, Schmidt BF | title = Cloning of cDNA for human granzyme 3 | journal = FEBS Lett | volume = 364 | issue = 3 | pages = 268–71 |date=Jun 1995 | pmid = 7758581 | pmc =  | doi =10.1016/0014-5793(95)00407-Z }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3003| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GZMK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mza.
| PDB = {{PDB2|1mza}}, {{PDB2|1mzd}}
| Name = Granzyme K (granzyme 3; tryptase II)
| HGNCid = 4711
| Symbol = GZMK
| AltSymbols =; TRYP2
| OMIM = 600784
| ECnumber =
| Homologene = 20485
| MGIid = 1298232
  | GeneAtlas_image1 = PBB_GE_GZMK_206666_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}}
  | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}  
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3003
    | Hs_Ensembl = ENSG00000113088
    | Hs_RefseqProtein = NP_002095
    | Hs_RefseqmRNA = NM_002104
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 54355838
    | Hs_GenLoc_end = 54366155
    | Hs_Uniprot = P49863
    | Mm_EntrezGene = 14945
    | Mm_Ensembl = ENSMUSG00000042385
    | Mm_RefseqmRNA = NM_008196
    | Mm_RefseqProtein = NP_032222
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 114292752
    | Mm_GenLoc_end = 114301775
    | Mm_Uniprot = Q9R0K0
  }}
}}
'''Granzyme K (granzyme 3; tryptase II)''', also known as '''GZMK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3003| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.<ref name="entrez">{{cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3003| accessdate = }}</ref>
| summary_text = This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Smyth MJ, O'Connor MD, Trapani JA |title=Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies. |journal=J. Leukoc. Biol. |volume=60 |issue= 5 |pages= 555-62 |year= 1996 |pmid= 8929545 |doi=  }}
*{{cite journal  |vauthors=Smyth MJ, O'Connor MD, Trapani JA |title=Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies |journal=J. Leukoc. Biol. |volume=60 |issue= 5 |pages= 555–62 |year= 1996 |pmid= 8929545 |doi=  }}
*{{cite journal  | author=Shi L, Kam CM, Powers JC, ''et al.'' |title=Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. |journal=J. Exp. Med. |volume=176 |issue= 6 |pages= 1521-9 |year= 1993 |pmid= 1460416 |doi=  }}
*{{cite journal  | author=Shi L |title=Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions |journal=J. Exp. Med. |volume=176 |issue= 6 |pages= 1521–9 |year= 1993 |pmid= 1460416 |doi=10.1084/jem.176.6.1521  | pmc=2119451  |name-list-format=vanc| author2=Kam CM  | author3=Powers JC  | display-authors=3  | last4=Aebersold  | first4=R  | last5=Greenberg  | first5=AH }}
*{{cite journal  | author=Hameed A, Lowrey DM, Lichtenheld M, Podack ER |title=Characterization of three serine esterases isolated from human IL-2 activated killer cells. |journal=J. Immunol. |volume=141 |issue= 9 |pages= 3142-7 |year= 1988 |pmid= 3262682 |doi=  }}
*{{cite journal  |vauthors=Hameed A, Lowrey DM, Lichtenheld M, Podack ER |title=Characterization of three serine esterases isolated from human IL-2 activated killer cells |journal=J. Immunol. |volume=141 |issue= 9 |pages= 3142–7 |year= 1988 |pmid= 3262682 |doi=  }}
*{{cite journal  | author=Przetak MM, Yoast S, Schmidt BF |title=Cloning of cDNA for human granzyme 3. |journal=FEBS Lett. |volume=364 |issue= 3 |pages= 268-71 |year= 1995 |pmid= 7758581 |doi=  }}
*{{cite journal  |vauthors=Baker E, Sayers TJ, Sutherland GR, Smyth MJ |title=The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases |journal=Immunogenetics |volume=40 |issue= 3 |pages= 235–7 |year= 1994 |pmid= 8039831 |doi=10.1007/BF00167085 }}
*{{cite journal  | author=Baker E, Sayers TJ, Sutherland GR, Smyth MJ |title=The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. |journal=Immunogenetics |volume=40 |issue= 3 |pages= 235-7 |year= 1994 |pmid= 8039831 |doi=  }}
*{{cite journal  | author=Sayers TJ |title=Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3 |journal=J. Leukoc. Biol. |volume=59 |issue= 5 |pages= 763–8 |year= 1996 |pmid= 8656064 |doi= |name-list-format=vanc| author2=Lloyd AR  | author3=McVicar DW  | display-authors=3  | last4=O'Connor  | first4=MD  | last5=Kelly  | first5=JM  | last6=Carter  | first6=CR  | last7=Wiltrout  | first7=TA  | last8=Wiltrout  | first8=RH  | last9=Smyth  | first9=MJ }}
*{{cite journal  | author=Sayers TJ, Lloyd AR, McVicar DW, ''et al.'' |title=Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. |journal=J. Leukoc. Biol. |volume=59 |issue= 5 |pages= 763-8 |year= 1996 |pmid= 8656064 |doi=  }}
*{{cite journal  | author=Hink-Schauer C |title=The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50923–33 |year= 2003 |pmid= 12384499 |doi= 10.1074/jbc.M207962200 |name-list-format=vanc| author2=Estébanez-Perpiñá E  | author3=Wilharm E  | display-authors=3  | last4=Fuentes-Prior  | first4=P  | last5=Klinkert  | first5=W  | last6=Bode  | first6=W  | last7=Jenne  | first7=DE }}
*{{cite journal  | author=Hink-Schauer C, Estébanez-Perpiñá E, Wilharm E, ''et al.'' |title=The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50923-33 |year= 2003 |pmid= 12384499 |doi= 10.1074/jbc.M207962200 }}
*{{cite journal  |vauthors=Fajardo I, Pejler G |title=Formation of active monomers from tetrameric human beta-tryptase |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 603–10 |year= 2003 |pmid= 12387726 |doi= 10.1042/BJ20021418 | pmc=1223112 }}
*{{cite journal  | author=Fajardo I, Pejler G |title=Formation of active monomers from tetrameric human beta-tryptase. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 603-10 |year= 2003 |pmid= 12387726 |doi= 10.1042/BJ20021418 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhao T |title=Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells |journal=Cell Death Differ. |volume=14 |issue= 3 |pages= 489–99 |year= 2007 |pmid= 17008916 |doi= 10.1038/sj.cdd.4402040 |name-list-format=vanc| author2=Zhang H  | author3=Guo Y  | display-authors=3  | last4=Zhang  | first4=Q  | last5=Hua  | first5=G  | last6=Lu  | first6=H  | last7=Hou  | first7=Q  | last8=Liu  | first8=H  | last9=Fan  | first9=Z }}
*{{cite journal  | author=Zhao T, Zhang H, Guo Y, ''et al.'' |title=Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. |journal=Cell Death Differ. |volume=14 |issue= 3 |pages= 489-99 |year= 2007 |pmid= 17008916 |doi= 10.1038/sj.cdd.4402040 }}
*{{cite journal  |vauthors=Zhao T, Zhang H, Guo Y, Fan Z |title=Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12104–11 |year= 2007 |pmid= 17308307 |doi= 10.1074/jbc.M611006200 }}
*{{cite journal  | author=Zhao T, Zhang H, Guo Y, Fan Z |title=Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12104-11 |year= 2007 |pmid= 17308307 |doi= 10.1074/jbc.M611006200 }}
*{{cite journal  | author=Rucevic M |title=Altered levels and molecular forms of granzyme k in plasma from septic patients |journal=Shock |volume=27 |issue= 5 |pages= 488–93 |year= 2007 |pmid= 17438453 |doi= 10.1097/01.shk.0000246905.24895.e5 |name-list-format=vanc| author2=Fast LD  | author3=Jay GD  | display-authors=3  | last4=Trespalcios  | first4=Flor M.  | last5=Sucov  | first5=Andrew  | last6=Siryaporn  | first6=Edward  | last7=Lim  | first7=Yow-Pin }}
*{{cite journal  | author=Rucevic M, Fast LD, Jay GD, ''et al.'' |title=Altered levels and molecular forms of granzyme k in plasma from septic patients. |journal=Shock |volume=27 |issue= 5 |pages= 488-93 |year= 2007 |pmid= 17438453 |doi= 10.1097/01.shk.0000246905.24895.e5 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3003}}
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Latest revision as of 09:12, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Granzyme K is a protein that in humans is encoded by the GZMK gene.[1][2]

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.[2]

References

  1. ↑ Przetak MM, Yoast S, Schmidt BF (Jun 1995). "Cloning of cDNA for human granzyme 3". FEBS Lett. 364 (3): 268–71. doi:10.1016/0014-5793(95)00407-Z. PMID 7758581.
  2. ↑ 2.0 2.1 "Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)".

Further reading



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