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{{Infobox_gene}}
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'''Hepatitis B virus X-interacting protein''' is a [[protein]] that in humans is encoded by the ''HBXIP'' [[gene]].<ref name="pmid9499022">{{cite journal |vauthors=Melegari M, Scaglioni PP, Wands JR | title = Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication | journal = J Virol | volume = 72 | issue = 3 | pages = 1737–43 |date=Mar 1998 | pmid = 9499022 | pmc = 109461 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HBXIP hepatitis B virus x interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10542| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Hepatitis B virus x interacting protein
| HGNCid = 17955
| Symbol = HBXIP
| AltSymbols =; MGC71071; XIP
| OMIM = 608521
| ECnumber = 
| Homologene = 4668
| MGIid = 1915826
| GeneAtlas_image1 = PBB_GE_HBXIP_202299_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HBXIP_202300_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}} {{GNF_GO|id=GO:0043154 |text = negative regulation of caspase activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10542
    | Hs_Ensembl = ENSG00000134248
    | Hs_RefseqProtein = NP_006393
    | Hs_RefseqmRNA = NM_006402
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 110745394
    | Hs_GenLoc_end = 110752087
    | Hs_Uniprot = O43504
    | Mm_EntrezGene = 68576
    | Mm_Ensembl = ENSMUSG00000043469
    | Mm_RefseqmRNA = XM_909856
    | Mm_RefseqProtein = XP_914949
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 154928888
    | Mm_GenLoc_end = 154929163
    | Mm_Uniprot = Q9D1L9
  }}
}}
'''Hepatitis B virus x interacting protein''', also known as '''HBXIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HBXIP hepatitis B virus x interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10542| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.<ref name="entrez">{{cite web | title = Entrez Gene: HBXIP hepatitis B virus x interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10542| accessdate = }}</ref>
| summary_text = This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.<ref name="entrez" />
}}
}}
==Interactions==
HBXIP has been shown to [[Protein-protein interaction|interact]] with [[NCOA6]].<ref name=pmid14578865>{{cite journal |last=Kong |first=Hee Jeong |authorlink= |author2=Park Min Jung |author3=Hong SunHwa |author4=Yu Hyun Jung |author5=Lee Young Chul |author6=Choi Young Hyun |author7=Cheong JaeHun  |date=Nov 2003 |title=Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 |journal=Hepatology |volume=38 |issue=5 |pages=1258–66 |publisher= |location = United States| issn = 0270-9139| pmid = 14578865 |doi = 10.1053/jhep.2003.50451 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|30em}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Melegari M, Scaglioni PP, Wands JR |title=Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. |journal=J. Virol. |volume=72 |issue= 3 |pages= 1737-43 |year= 1998 |pmid= 9499022 |doi=  }}
*{{cite journal  | author=Shamay M |title=Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9982–8 |year= 2002 |pmid= 11788598 |doi= 10.1074/jbc.M111354200 |name-list-format=vanc| author2=Barak O  | author3=Doitsh G  | display-authors=3  | last4=Ben-Dor  | first4=I  | last5=Shaul  | first5=Y }}
*{{cite journal  | author=Shamay M, Barak O, Doitsh G, ''et al.'' |title=Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9982-8 |year= 2002 |pmid= 11788598 |doi= 10.1074/jbc.M111354200 }}
*{{cite journal  |vauthors=Li Y, Lu YY |title=Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 213–6 |year= 2002 |pmid= 11925594 |doi=  }}
*{{cite journal  | author=Li Y, Lu YY |title=Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells. |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 213-6 |year= 2002 |pmid= 11925594 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Marusawa H |title=HBXIP functions as a cofactor of survivin in apoptosis suppression |journal=EMBO J. |volume=22 |issue= 11 |pages= 2729–40 |year= 2003 |pmid= 12773388 |doi= 10.1093/emboj/cdg263 | pmc=156760  |name-list-format=vanc| author2=Matsuzawa S  | author3=Welsh K  | display-authors=3  | last4=Zou  | first4=H  | last5=Armstrong  | first5=R  | last6=Tamm  | first6=I  | last7=Reed  | first7=JC }}
*{{cite journal  | author=Marusawa H, Matsuzawa S, Welsh K, ''et al.'' |title=HBXIP functions as a cofactor of survivin in apoptosis suppression. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2729-40 |year= 2003 |pmid= 12773388 |doi= 10.1093/emboj/cdg263 }}
*{{cite journal  | author=Kong HJ |title=Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2 |journal=Hepatology |volume=38 |issue= 5 |pages= 1258–66 |year= 2003 |pmid= 14578865 |doi= 10.1053/jhep.2003.50451 |name-list-format=vanc| author2=Park MJ  | author3=Hong S  | display-authors=3  | last4=Yu  | first4=HJ  | last5=Lee  | first5=YC  | last6=Choi  | first6=YH  | last7=Cheong  | first7=J }}
*{{cite journal  | author=Kong HJ, Park MJ, Hong S, ''et al.'' |title=Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2. |journal=Hepatology |volume=38 |issue= 5 |pages= 1258-66 |year= 2003 |pmid= 14578865 |doi= 10.1053/jhep.2003.50451 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Lee SH, Park SG, Lim SO, Jung G |title=The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes |journal=Biochim. Biophys. Acta |volume=1741 |issue= 1–2 |pages= 75–84 |year= 2005 |pmid= 15955450 |doi= 10.1016/j.bbadis.2004.10.004 }}
*{{cite journal  | author=Lee SH, Park SG, Lim SO, Jung G |title=The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes. |journal=Biochim. Biophys. Acta |volume=1741 |issue= 1-2 |pages= 75-84 |year= 2005 |pmid= 15955450 |doi= 10.1016/j.bbadis.2004.10.004 }}
*{{cite journal  | author=Lee AT |title=The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage |journal=J. Biol. Chem. |volume=280 |issue= 39 |pages= 33525–35 |year= 2005 |pmid= 16055925 |doi= 10.1074/jbc.M506628200 |name-list-format=vanc| author2=Ren J  | author3=Wong ET  | display-authors=3  | last4=Ban  | first4=KH  | last5=Lee  | first5=LA  | last6=Lee  | first6=CG }}
*{{cite journal  | author=Lee AT, Ren J, Wong ET, ''et al.'' |title=The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage. |journal=J. Biol. Chem. |volume=280 |issue= 39 |pages= 33525-35 |year= 2005 |pmid= 16055925 |doi= 10.1074/jbc.M506628200 }}
*{{cite journal  | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |name-list-format=vanc| author2=Worm U  | author3=Lalowski M  | display-authors=3  | last4=Haenig  | first4=Christian  | last5=Brembeck  | first5=Felix H.  | last6=Goehler  | first6=Heike  | last7=Stroedicke  | first7=Martin  | last8=Zenkner  | first8=Martina  | last9=Schoenherr  | first9=Anke }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  |vauthors=Minczuk M, Mroczek S, Pawlak SD, Stepien PP |title=Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP |journal=FEBS J. |volume=272 |issue= 19 |pages= 5008–19 |year= 2005 |pmid= 16176273 |doi= 10.1111/j.1742-4658.2005.04910.x }}
*{{cite journal  | author=Minczuk M, Mroczek S, Pawlak SD, Stepien PP |title=Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP. |journal=FEBS J. |volume=272 |issue= 19 |pages= 5008-19 |year= 2005 |pmid= 16176273 |doi= 10.1111/j.1742-4658.2005.04910.x }}
*{{cite journal  | author=Muroyama R |title=Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma |journal=J. Hepatol. |volume=45 |issue= 6 |pages= 805–12 |year= 2007 |pmid= 17050029 |doi= 10.1016/j.jhep.2006.07.025 |name-list-format=vanc| author2=Kato N  | author3=Yoshida H  | display-authors=3  | last4=Otsuka  | first4=M  | last5=Moriyama  | first5=M  | last6=Wang  | first6=Y  | last7=Shao  | first7=R  | last8=Dharel  | first8=N  | last9=Tanaka  | first9=Y }}
*{{cite journal  | author=Muroyama R, Kato N, Yoshida H, ''et al.'' |title=Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. |journal=J. Hepatol. |volume=45 |issue= 6 |pages= 805-12 |year= 2007 |pmid= 17050029 |doi= 10.1016/j.jhep.2006.07.025 }}
*{{cite journal  |vauthors=Chen J, Siddiqui A |title=Hepatitis B Virus X Protein Stimulates the Mitochondrial Translocation of Raf-1 via Oxidative Stress |journal=J. Virol. |volume=81 |issue= 12 |pages= 6757–60 |year= 2007 |pmid= 17428866 |doi= 10.1128/JVI.00172-07 | pmc=1900104 }}
*{{cite journal  | author=Chen J, Siddiqui A |title=Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress. |journal=J. Virol. |volume=81 |issue= 12 |pages= 6757-60 |year= 2007 |pmid= 17428866 |doi= 10.1128/JVI.00172-07 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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[[Category:Hepatitis B virus]]
 
 
{{gene-1-stub}}

Revision as of 13:29, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[1][2]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[2]

Interactions

HBXIP has been shown to interact with NCOA6.[3]

References

  1. ↑ Melegari M, Scaglioni PP, Wands JR (Mar 1998). "Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication". J Virol. 72 (3): 1737–43. PMC 109461. PMID 9499022.
  2. ↑ 2.0 2.1 "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
  3. ↑ Kong, Hee Jeong; Park Min Jung; Hong SunHwa; Yu Hyun Jung; Lee Young Chul; Choi Young Hyun; Cheong JaeHun (Nov 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. United States. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. ISSN 0270-9139. PMID 14578865.

Further reading


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