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{{Underlinked|date=August 2017}}
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{{Infobox_gene}}
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'''Vigilin''' is a [[protein]] that in humans is encoded by the ''HDLBP'' [[gene]].<ref name="pmid1318310">{{cite journal |vauthors=McKnight GL, Reasoner J, Gilbert T, Sundquist KO, Hokland B, McKernan PA, Champagne J, Johnson CJ, Bailey MC, Holly R | title = Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells | journal = J Biol Chem | volume = 267 | issue = 17 | pages = 12131–41 |date=Jul 1992 | pmid = 1318310 | pmc =  | doi =  |display-authors=etal}}</ref><ref name="pmid8390966">{{cite journal |vauthors=Xia YR, Klisak I, Sparkes RS, Oram J, Lusis AJ | title = Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37 | journal = Genomics | volume = 16 | issue = 2 | pages = 524–5 |date=Jul 1993 | pmid = 8390966 | pmc =  | doi = 10.1006/geno.1993.1221 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HDLBP high density lipoprotein binding protein (vigilin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3069| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HDLBP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vig.
| PDB = {{PDB2|1vig}}, {{PDB2|1vih}}, {{PDB2|2cte}}, {{PDB2|2ctf}}, {{PDB2|2ctj}}, {{PDB2|2ctk}}, {{PDB2|2ctl}}, {{PDB2|2ctm}}
| Name = High density lipoprotein binding protein (vigilin)
| HGNCid = 4857
| Symbol = HDLBP
| AltSymbols =; HBP; FLJ16432; VGL
| OMIM = 142695
| ECnumber =
| Homologene = 38035
| MGIid = 99256
  | GeneAtlas_image1 = PBB_GE_HDLBP_200643_at_tn.png
  | GeneAtlas_image2 = PBB_GE_HDLBP_221767_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3069
    | Hs_Ensembl = ENSG00000115677
    | Hs_RefseqProtein = NP_005327
    | Hs_RefseqmRNA = NM_005336
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 241816817
    | Hs_GenLoc_end = 241903908
    | Hs_Uniprot = Q00341
    | Mm_EntrezGene = 110611
    | Mm_Ensembl = ENSMUSG00000034088
    | Mm_RefseqmRNA = NM_133808
    | Mm_RefseqProtein = NP_598569
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 95236346
    | Mm_GenLoc_end = 95309214
    | Mm_Uniprot = A0PJE9
  }}
}}
'''High density lipoprotein binding protein (vigilin)''', also known as '''HDLBP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HDLBP high density lipoprotein binding protein (vigilin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3069| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = High density lipoprotein-binding protein, also known as vigilin, is a 110-kD protein that specifically binds HDL molecules and may function in the removal of excess cellular cholesterol.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HDLBP high density lipoprotein binding protein (vigilin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3069| accessdate = }}</ref>
| summary_text = High density lipoprotein-binding protein, also known as vigilin, is a 110-kD protein that specifically binds HDL molecules and may function in the removal of excess cellular cholesterol.[supplied by OMIM]<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi=  }}
*{{cite journal  |vauthors=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell. Proteomics |volume=1 |issue= 11 |pages= 845–67 |year= 2003 |pmid= 12488461 |doi=  10.1074/mcp.R200007-MCP200}}
*{{cite journal  | author=McKnight GL, Reasoner J, Gilbert T, ''et al.'' |title=Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. |journal=J. Biol. Chem. |volume=267 |issue= 17 |pages= 12131-41 |year= 1992 |pmid= 1318310 |doi=  }}
*{{cite journal  |vauthors=Graham DL, Oram JF |title=Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting. |journal=J. Biol. Chem. |volume=262 |issue= 16 |pages= 7439–42 |year= 1987 |pmid= 3034894 |doi=  }}
*{{cite journal  | author=Graham DL, Oram JF |title=Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting. |journal=J. Biol. Chem. |volume=262 |issue= 16 |pages= 7439-42 |year= 1987 |pmid= 3034894 |doi=  }}
*{{cite journal   |vauthors=Plenz G, Kügler S, Schnittger S, etal |title=The human vigilin gene: identification, chromosomal localization and expression pattern. |journal=Hum. Genet. |volume=93 |issue= 5 |pages= 575–82 |year= 1994 |pmid= 8168838 |doi=10.1007/BF00202827  }}
*{{cite journal | author=Plenz G, Kügler S, Schnittger S, ''et al.'' |title=The human vigilin gene: identification, chromosomal localization and expression pattern. |journal=Hum. Genet. |volume=93 |issue= 5 |pages= 575-82 |year= 1994 |pmid= 8168838 |doi=  }}
*{{cite journal   |vauthors=Neu-Yilik G, Zorbas H, Gloe TR, etal |title=Vigilin is a cytoplasmic protein. A study on its expression in primary cells and in established cell lines of different species. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 727–36 |year= 1993 |pmid= 8477745 |doi=10.1111/j.1432-1033.1993.tb17813.x }}
*{{cite journal  | author=Xia YR, Klisak I, Sparkes RS, ''et al.'' |title=Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37. |journal=Genomics |volume=16 |issue= 2 |pages= 524-5 |year= 1993 |pmid= 8390966 |doi= 10.1006/geno.1993.1221 }}
*{{cite journal   |vauthors=Kügler S, Grünweller A, Probst C, etal |title=Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus. |journal=FEBS Lett. |volume=382 |issue= 3 |pages= 330–4 |year= 1996 |pmid= 8605996 |doi=10.1016/0014-5793(96)00204-9 }}
*{{cite journal | author=Neu-Yilik G, Zorbas H, Gloe TR, ''et al.'' |title=Vigilin is a cytoplasmic protein. A study on its expression in primary cells and in established cell lines of different species. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 727-36 |year= 1993 |pmid= 8477745 |doi=  }}
*{{cite journal  |vauthors=Kügler S, Plenz G, Müller PK |title=Two additional 5' exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression. |journal=Eur. J. Biochem. |volume=238 |issue= 2 |pages= 410–7 |year= 1996 |pmid= 8681952 |doi=10.1111/j.1432-1033.1996.0410z.x }}
*{{cite journal | author=Kügler S, Grünweller A, Probst C, ''et al.'' |title=Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus. |journal=FEBS Lett. |volume=382 |issue= 3 |pages= 330-4 |year= 1996 |pmid= 8605996 |doi=  }}
*{{cite journal   |vauthors=Chiu DS, Oram JF, LeBoeuf RC, etal |title=High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=17 |issue= 11 |pages= 2350–8 |year= 1998 |pmid= 9409201 |doi=  10.1161/01.ATV.17.11.2350}}
*{{cite journal  | author=Kügler S, Plenz G, Müller PK |title=Two additional 5' exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression. |journal=Eur. J. Biochem. |volume=238 |issue= 2 |pages= 410-7 |year= 1996 |pmid= 8681952 |doi=  }}
*{{cite journal   |vauthors=Kruse C, Willkomm DK, Grünweller A, etal |title=Export and transport of tRNA are coupled to a multi-protein complex |journal=Biochem. J. |volume=346 |issue=  Pt 1|pages= 107–15 |year= 2000 |pmid= 10657246 |doi=10.1042/0264-6021:3460107  | pmc=1220829 }}
*{{cite journal | author=Chiu DS, Oram JF, LeBoeuf RC, ''et al.'' |title=High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=17 |issue= 11 |pages= 2350-8 |year= 1998 |pmid= 9409201 |doi=  }}
*{{cite journal   |vauthors=Bocharov AV, Vishnyakova TG, Baranova IN, etal |title=Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein |journal=Biochemistry |volume=40 |issue= 14 |pages= 4407–16 |year= 2001 |pmid= 11284697 |doi=10.1021/bi001503k }}
*{{cite journal | author=Kruse C, Willkomm DK, Grünweller A, ''et al.'' |title=Export and transport of tRNA are coupled to a multi-protein complex. |journal=Biochem. J. |volume=346 Pt 1 |issue=  |pages= 107-15 |year= 2000 |pmid= 10657246 |doi=  }}
*{{cite journal   |vauthors=Wistow G, Bernstein SL, Ray S, etal |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium |journal=Mol. Vis. |volume=8 |issue=  |pages= 185–95 |year= 2002 |pmid= 12107412 |doi=  }}
*{{cite journal | author=Bocharov AV, Vishnyakova TG, Baranova IN, ''et al.'' |title=Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein. |journal=Biochemistry |volume=40 |issue= 14 |pages= 4407-16 |year= 2001 |pmid= 11284697 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wistow G, Bernstein SL, Ray S, ''et al.'' |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue=  |pages= 185-95 |year= 2002 |pmid= 12107412 |doi=  }}
*{{cite journal   |vauthors=Adkins JN, Varnum SM, Auberry KJ, etal |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry |journal=Mol. Cell. Proteomics |volume=1 |issue= 12 |pages= 947–55 |year= 2003 |pmid= 12543931 |doi=  10.1074/mcp.M200066-MCP200}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Goolsby KM, Shapiro DJ |title=RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis |journal=Nucleic Acids Res. |volume=31 |issue= 19 |pages= 5644–53 |year= 2003 |pmid= 14500828 |doi=10.1093/nar/gkg768  | pmc=206468 }}
*{{cite journal | author=Adkins JN, Varnum SM, Auberry KJ, ''et al.'' |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947-55 |year= 2003 |pmid= 12543931 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Goolsby KM, Shapiro DJ |title=RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis. |journal=Nucleic Acids Res. |volume=31 |issue= 19 |pages= 5644-53 |year= 2003 |pmid= 14500828 |doi=  }}
*{{cite journal  |vauthors=Vollbrandt T, Willkomm D, Stossberg H, Kruse C |title=Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 7 |pages= 1306–18 |year= 2004 |pmid= 15109574 |doi= 10.1016/j.biocel.2003.11.006 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal  | author=Vollbrandt T, Willkomm D, Stossberg H, Kruse C |title=Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 7 |pages= 1306-18 |year= 2004 |pmid= 15109574 |doi= 10.1016/j.biocel.2003.11.006 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3069}}
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Revision as of 13:32, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vigilin is a protein that in humans is encoded by the HDLBP gene.[1][2][3]

High density lipoprotein-binding protein, also known as vigilin, is a 110-kD protein that specifically binds HDL molecules and may function in the removal of excess cellular cholesterol.[supplied by OMIM][3]

References

  1. ↑ McKnight GL, Reasoner J, Gilbert T, Sundquist KO, Hokland B, McKernan PA, Champagne J, Johnson CJ, Bailey MC, Holly R, et al. (Jul 1992). "Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells". J Biol Chem. 267 (17): 12131–41. PMID 1318310.
  2. ↑ Xia YR, Klisak I, Sparkes RS, Oram J, Lusis AJ (Jul 1993). "Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37". Genomics. 16 (2): 524–5. doi:10.1006/geno.1993.1221. PMID 8390966.
  3. ↑ 3.0 3.1 "Entrez Gene: HDLBP high density lipoprotein binding protein (vigilin)".

Further reading



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