HGS (gene): Difference between revisions

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{{Infobox_gene}}
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'''Hepatocyte growth factor-regulated tyrosine kinase substrate''' is an [[enzyme]] that in humans is encoded by the ''HGS'' [[gene]].<ref name="pmid9407053">{{cite journal|last1=Asao|first1=H.|last2=Sasaki|first2=Y.|last3=Arita|first3=T.|last4=Tanaka|first4=N.|last5=Endo|first5=K.|last6=Kasai|first6=H.|last7=Takeshita|first7=T.|last8=Endo|first8=Y.|last9=Fujita|first9=T.|last10=Sugamura|first10=K.|title=Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth|journal=Journal of Biological Chemistry|volume=272|issue=52|year=1997|pages=32785–32791|issn=0021-9258|doi=10.1074/jbc.272.52.32785|pmid=9407053}}</ref><ref name="pmid9630564">{{cite journal | vauthors = Lu L, Komada M, Kitamura N | title = Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17 | journal = Gene | volume = 213 | issue = 1-2 | pages = 125–32  | date = August 1998 | pmid = 9630564 | pmc =  | doi = 10.1016/S0378-1119(98)00184-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9146| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Hepatocyte growth factor-regulated tyrosine kinase substrate
| HGNCid = 4897
| Symbol = HGS
| AltSymbols =; HRS; ZFYVE8
| OMIM = 604375
| ECnumber = 
| Homologene = 37954
| MGIid = 104681
| GeneAtlas_image1 = PBB_GE_HGS_210428_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016197 |text = endosome transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9146
    | Hs_Ensembl = ENSG00000185359
    | Hs_RefseqProtein = NP_004703
    | Hs_RefseqmRNA = NM_004712
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77261425
    | Hs_GenLoc_end = 77279548
    | Hs_Uniprot = O14964
    | Mm_EntrezGene = 15239
    | Mm_Ensembl = ENSMUSG00000025793
    | Mm_RefseqmRNA = NM_008244
    | Mm_RefseqProtein = NP_032270
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120283765
    | Mm_GenLoc_end = 120300065
    | Mm_Uniprot = Q3TLL4
  }}
}}
'''Hepatocyte growth factor-regulated tyrosine kinase substrate''', also known as '''HGS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9146| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
HGS (gene) has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CLTC]]<ref name = pmid11532964>{{cite journal | vauthors = Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H | title = Hrs recruits clathrin to early endosomes | journal = EMBO J. | volume = 20 | issue = 17 | pages = 5008–21  | date = September 2001 | pmid = 11532964 | pmc = 125612 | doi = 10.1093/emboj/20.17.5008 }}</ref>
| summary_text =  
* [[DLG4]],<ref name = pmid12151521>{{cite journal | vauthors = Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS | title = Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms | journal = J. Neurosci. | volume = 22 | issue = 15 | pages = 6415–25  | date = August 2002 | pmid = 12151521 | doi = }}</ref>
}}
* [[EPS15]],<ref name = pmid12551915/><ref name = pmid10809762>{{cite journal | vauthors = Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y | title = Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15 | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15271–8 | date = May 2000 | pmid = 10809762 | doi =  10.1074/jbc.275.20.15271}}</ref>
* [[IL2RB]],<ref name = pmid18445679>{{cite journal | vauthors = Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T | title = Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain | journal = J. Cell Sci. | volume = 121 | issue = Pt 10 | pages = 1727–38  | date = May 2008 | pmid = 18445679 | doi = 10.1242/jcs.024455 }}</ref>  
* [[Merlin (protein)|Merlin]],<ref name = pmid11285248>{{cite journal | vauthors = Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM | title = The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility | journal = Hum. Mol. Genet. | volume = 10 | issue = 8 | pages = 825–34  | date = April 2001 | pmid = 11285248 | doi =  10.1093/hmg/10.8.825}}</ref><ref name = pmid10861283>{{cite journal | vauthors = Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM | title = The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate | journal = Hum. Mol. Genet. | volume = 9 | issue = 11 | pages = 1567–74  | date = July 2000 | pmid = 10861283 | doi =  10.1093/hmg/9.11.1567}}</ref>
* [[STAM2]],<ref name = pmid12551915>{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 12513–21  | date = April 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 }}</ref><ref name = pmid16189514/>
* [[Signal transducing adaptor molecule]],<ref name = pmid9407053 /><ref name = pmid12551915/><ref name = pmid16189514/> and
* [[TSG101]].<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8  | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid12802020>{{cite journal | vauthors = Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN | title = TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 13 | pages = 7626–31  | date = June 2003 | pmid = 12802020 | pmc = 164637 | doi = 10.1073/pnas.0932599100 }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}
==Further reading==
{{Clear}}
{{refbegin | 2}}
 
{{PBB_Further_reading
== Further reading ==
| citations =
{{refbegin|35em}}
*{{cite journal | author=Comoglio PM |title=Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. |journal=EXS |volume=65 |issue=  |pages= 131-65 |year= 1993 |pmid= 8380735 |doi=  }}
* {{cite journal | vauthors = Comoglio PM | title = Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells | journal = EXS | volume = 65 | issue =  | pages = 131–65 | year = 1993 | pmid = 8380735 | doi =  }}
*{{cite journal | author=Komada M, Masaki R, Yamamoto A, Kitamura N |title=Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20538-44 |year= 1997 |pmid= 9252367 |doi= }}
* {{cite journal | vauthors = Komada M, Masaki R, Yamamoto A, Kitamura N | title = Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes | journal = J. Biol. Chem. | volume = 272 | issue = 33 | pages = 20538–44 | year = 1997 | pmid = 9252367 | doi = 10.1074/jbc.272.33.20538 }}
*{{cite journal | author=Asao H, Sasaki Y, Arita T, ''et al.'' |title=Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32785-91 |year= 1998 |pmid= 9407053 |doi= }}
* {{cite journal | vauthors = Stephens DJ, Banting G | title = Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30080–6 | year = 1999 | pmid = 10514494 | doi = 10.1074/jbc.274.42.30080 }}
*{{cite journal | author=Lu L, Komada M, Kitamura N |title=Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17. |journal=Gene |volume=213 |issue= 1-2 |pages= 125-32 |year= 1998 |pmid= 9630564 |doi= }}
* {{cite journal | vauthors = Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y | title = Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15 | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15271–8 | year = 2000 | pmid = 10809762 | doi = 10.1074/jbc.275.20.15271 }}
*{{cite journal | author=Stephens DJ, Banting G |title=Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30080-6 |year= 1999 |pmid= 10514494 |doi=  }}
* {{cite journal | vauthors = Kwong J, Roundabush FL, Hutton Moore P, Montague M, Oldham W, Li Y, Chin LS, Li L | title = Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis | journal = J. Cell Sci. | volume = 113 | issue = 12 | pages = 2273–84 | year = 2000 | pmid = 10825299 | doi =  }}
*{{cite journal | author=Bean AJ, Davanger S, Chou MF, ''et al.'' |title=Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15271-8 |year= 2000 |pmid= 10809762 |doi= }}
* {{cite journal | vauthors = Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM | title = The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate | journal = Hum. Mol. Genet. | volume = 9 | issue = 11 | pages = 1567–74 | year = 2000 | pmid = 10861283 | doi = 10.1093/hmg/9.11.1567 }}
*{{cite journal | author=Kwong J, Roundabush FL, Hutton Moore P, ''et al.'' |title=Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis. |journal=J. Cell. Sci. |volume=113 ( Pt 12) |issue= |pages= 2273-84 |year= 2000 |pmid= 10825299 |doi= }}
* {{cite journal | vauthors = Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H | title = Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells | journal = EMBO J. | volume = 19 | issue = 17 | pages = 4577–88 | year = 2000 | pmid = 10970851 | pmc = 302054 | doi = 10.1093/emboj/19.17.4577 }}
*{{cite journal | author=Scoles DR, Huynh DP, Chen MS, ''et al.'' |title=The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. |journal=Hum. Mol. Genet. |volume=9 |issue= 11 |pages= 1567-74 |year= 2000 |pmid= 10861283 |doi= }}
* {{cite journal | vauthors = Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K | title = Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA | journal = Mol. Cell. Biol. | volume = 20 | issue = 24 | pages = 9346–55 | year = 2000 | pmid = 11094085 | pmc = 102191 | doi = 10.1128/MCB.20.24.9346-9355.2000 }}
*{{cite journal | author=Gillooly DJ, Morrow IC, Lindsay M, ''et al.'' |title=Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4577-88 |year= 2000 |pmid= 10970851 |doi= 10.1093/emboj/19.17.4577 }}
* {{cite journal | vauthors = Chin LS, Raynor MC, Wei X, Chen HQ, Li L | title = Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor | journal = J. Biol. Chem. | volume = 276 | issue = 10 | pages = 7069–78 | year = 2001 | pmid = 11110793 | doi = 10.1074/jbc.M004129200 }}
*{{cite journal | author=Miura S, Takeshita T, Asao H, ''et al.'' |title=Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. |journal=Mol. Cell. Biol. |volume=20 |issue= 24 |pages= 9346-55 |year= 2001 |pmid= 11094085 |doi= }}
* {{cite journal | vauthors = Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM | title = The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility | journal = Hum. Mol. Genet. | volume = 10 | issue = 8 | pages = 825–34 | year = 2001 | pmid = 11285248 | doi = 10.1093/hmg/10.8.825 }}
*{{cite journal | author=Chin LS, Raynor MC, Wei X, ''et al.'' |title=Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 7069-78 |year= 2001 |pmid= 11110793 |doi= 10.1074/jbc.M004129200 }}
* {{cite journal | vauthors = Sasaki Y, Sugamura K | title = Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1 | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29943–52 | year = 2001 | pmid = 11397816 | doi = 10.1074/jbc.M104230200 }}
*{{cite journal | author=Gutmann DH, Haipek CA, Burke SP, ''et al.'' |title=The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility. |journal=Hum. Mol. Genet. |volume=10 |issue= 8 |pages= 825-34 |year= 2001 |pmid= 11285248 |doi=  }}
* {{cite journal | vauthors = Raiborg C, Bremnes B, Mehlum A, Gillooly DJ, D'Arrigo A, Stang E, Stenmark H | title = FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes | journal = J. Cell Sci. | volume = 114 | issue = Pt 12 | pages = 2255–63 | year = 2001 | pmid = 11493665 | doi =  }}
*{{cite journal | author=Sasaki Y, Sugamura K |title=Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29943-52 |year= 2001 |pmid= 11397816 |doi= 10.1074/jbc.M104230200 }}
* {{cite journal | vauthors = Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H | title = Hrs recruits clathrin to early endosomes | journal = EMBO J. | volume = 20 | issue = 17 | pages = 5008–21 | year = 2001 | pmid = 11532964 | pmc = 125612 | doi = 10.1093/emboj/20.17.5008 }}
*{{cite journal | author=Raiborg C, Bremnes B, Mehlum A, ''et al.'' |title=FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes. |journal=J. Cell. Sci. |volume=114 |issue= Pt 12 |pages= 2255-63 |year= 2001 |pmid= 11493665 |doi= }}
* {{cite journal | vauthors = Steen H, Kuster B, Fernandez M, Pandey A, Mann M | title = Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1031–9 | year = 2002 | pmid = 11687594 | doi = 10.1074/jbc.M109992200 }}
*{{cite journal | author=Raiborg C, Bache KG, Mehlum A, ''et al.'' |title=Hrs recruits clathrin to early endosomes. |journal=EMBO J. |volume=20 |issue= 17 |pages= 5008-21 |year= 2001 |pmid= 11532964 |doi= 10.1093/emboj/20.17.5008 }}
* {{cite journal | vauthors = Bishop N, Horman A, Woodman P | title = Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 91–101 | year = 2002 | pmid = 11916981 | pmc = 2173266 | doi = 10.1083/jcb.200112080 }}
*{{cite journal | author=Steen H, Kuster B, Fernandez M, ''et al.'' |title=Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1031-9 |year= 2002 |pmid= 11687594 |doi= 10.1074/jbc.M109992200 }}
* {{cite journal | vauthors = Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF | title = The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins | journal = Mol. Med. | volume = 8 | issue = 1 | pages = 56–64 | year = 2002 | pmid = 11984006 | pmc = 2039936 | doi =  }}
*{{cite journal  | author=Bishop N, Horman A, Woodman P |title=Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 91-101 |year= 2002 |pmid= 11916981 |doi= 10.1083/jcb.200112080 }}
* {{cite journal | vauthors = Li Y, Chin LS, Levey AI, Li L | title = Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28212–21 | year = 2002 | pmid = 12021262 | doi = 10.1074/jbc.M111612200 }}
*{{cite journal  | author=Tchernev VT, Mansfield TA, Giot L, ''et al.'' |title=The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. |journal=Mol. Med. |volume=8 |issue= 1 |pages= 56-64 |year= 2002 |pmid= 11984006 |doi=  }}
*{{cite journal | author=Li Y, Chin LS, Levey AI, Li L |title=Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28212-21 |year= 2002 |pmid= 12021262 |doi= 10.1074/jbc.M111612200 }}
}}
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Revision as of 20:02, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.[1][2][3]

Interactions

HGS (gene) has been shown to interact with:

References

  1. ↑ 1.0 1.1 Asao, H.; Sasaki, Y.; Arita, T.; Tanaka, N.; Endo, K.; Kasai, H.; Takeshita, T.; Endo, Y.; Fujita, T.; Sugamura, K. (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry. 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053.
  2. ↑ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
  3. ↑ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".
  4. ↑ Raiborg C, Bache KG, Mehlum A, Stang E, Stenmark H (September 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMC 125612. PMID 11532964.
  5. ↑ Chetkovich DM, Bunn RC, Kuo SH, Kawasaki Y, Kohwi M, Bredt DS (August 2002). "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms". J. Neurosci. 22 (15): 6415–25. PMID 12151521.
  6. ↑ 6.0 6.1 6.2 Bache KG, Raiborg C, Mehlum A, Stenmark H (April 2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi:10.1074/jbc.M210843200. PMID 12551915.
  7. ↑ Bean AJ, Davanger S, Chou MF, Gerhardt B, Tsujimoto S, Chang Y (May 2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. doi:10.1074/jbc.275.20.15271. PMID 10809762.
  8. ↑ Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008). "Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain". J. Cell Sci. 121 (Pt 10): 1727–38. doi:10.1242/jcs.024455. PMID 18445679.
  9. ↑ Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM (April 2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. doi:10.1093/hmg/10.8.825. PMID 11285248.
  10. ↑ Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (July 2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. doi:10.1093/hmg/9.11.1567. PMID 10861283.
  11. ↑ 11.0 11.1 11.2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  12. ↑ Lu Q, Hope LW, Brasch M, Reinhard C, Cohen SN (June 2003). "TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7626–31. doi:10.1073/pnas.0932599100. PMC 164637. PMID 12802020.

Further reading

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