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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ubiquitin-conjugating enzyme E2 K''' is a [[protein]] that in humans is encoded by the ''UBE2K'' [[gene]].<ref name="pmid8702625">{{cite journal | vauthors = Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR | title = Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme | journal = J Biol Chem | volume = 271 | issue = 32 | pages = 19385–94 | date = Sep 1996 | pmid = 8702625 | pmc =  | doi = 10.1074/jbc.271.32.19385 }}</ref><ref name="pmid17873885">{{cite journal | vauthors = Christensen DE, Brzovic PS, Klevit RE | title = E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages | journal = Nat Struct Mol Biol | volume = 14 | issue = 10 | pages = 941–8 | date = Oct 2007 | pmid = 17873885 | pmc =  | doi = 10.1038/nsmb1295 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[ubiquitin-conjugating enzyme]] family. It binds selectively to a large region at the N terminus of [[huntingtin]]. This interaction is not influenced by the length of the huntingtin [[polyglutamine tract]]. This protein has been implicated in the degradation of huntingtin and suppression of [[apoptosis]].<ref name="entrez"/>
{{GNF_Protein_box
| image = PBB_Protein_HIP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yla.
| PDB = {{PDB2|1yla}}, {{PDB2|2bep}}, {{PDB2|2bf8}}, {{PDB2|2o25}}
| Name = Huntingtin interacting protein 2
| HGNCid = 4914
| Symbol = HIP2
| AltSymbols =; HYPG; LIG; UBE2K
| OMIM = 602846
| ECnumber = 
| Homologene = 3903
| MGIid = 1858216
| GeneAtlas_image1 = PBB_GE_HIP2_202346_at_tn.png
| GeneAtlas_image2 = PBB_GE_HIP2_202347_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3093
    | Hs_Ensembl = ENSG00000078140
    | Hs_RefseqProtein = NP_005330
    | Hs_RefseqmRNA = NM_005339
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 39376266
    | Hs_GenLoc_end = 39457977
    | Hs_Uniprot = P61086
    | Mm_EntrezGene = 53323
    | Mm_Ensembl = ENSMUSG00000029203
    | Mm_RefseqmRNA = NM_016786
    | Mm_RefseqProtein = NP_058066
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 65816406
    | Mm_GenLoc_end = 65878063
    | Mm_Uniprot = Q3TL77
  }}
}}
'''Huntingtin interacting protein 2''', also known as '''HIP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: HIP2 huntingtin interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3093| accessdate = }}</ref>
}}


==References==
HIP2 has been shown to [[Protein-protein interaction|interact]] with [[Huntingtin]]<ref name=pmid8702625 /><ref name=pmid9700202>{{cite journal | vauthors = Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME | title = Huntingtin interacts with a family of WW domain proteins | journal = Hum. Mol. Genet. | volume = 7 | issue = 9 | pages = 1463–74 | date = Sep 1998 | pmid = 9700202 | doi = 10.1093/hmg/7.9.1463 }}</ref> and [[RNF2]].<ref name=pmid11513855>{{cite journal | vauthors = Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S | title = E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme | journal = FEBS Lett. | volume = 503 | issue = 1 | pages = 61–4 | date = Aug 2001 | pmid = 11513855 | doi = 10.1016/S0014-5793(01)02689-8 }}</ref>
{{reflist|2}}
 
==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Petersén A, Mani K, Brundin P | title = Recent advances on the pathogenesis of Huntington's disease. | journal = Exp. Neurol. | volume = 157 | issue = 1 | pages = 1–18 | year = 1999 | pmid = 10222105 | doi = 10.1006/exnr.1998.7006 }}
| citations =
* {{cite journal | vauthors = Coux O, Goldberg AL | title = Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8820–8 | year = 1998 | pmid = 9535861 | doi = 10.1074/jbc.273.15.8820 }}
*{{cite journal | author=Petersén A, Mani K, Brundin P |title=Recent advances on the pathogenesis of Huntington's disease. |journal=Exp. Neurol. |volume=157 |issue= 1 |pages= 1-18 |year= 1999 |pmid= 10222105 |doi= 10.1006/exnr.1998.7006 }}
* {{cite journal | vauthors = Whitby FG, Xia G, Pickart CM, Hill CP | title = Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. | journal = J. Biol. Chem. | volume = 273 | issue = 52 | pages = 34983–91 | year = 1999 | pmid = 9857030 | doi = 10.1074/jbc.273.52.34983 }}
*{{cite journal | author=Kalchman MA, Graham RK, Xia G, ''et al.'' |title=Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19385-94 |year= 1996 |pmid= 8702625 |doi=  }}
* {{cite journal | vauthors = Kikuchi J, Furukawa Y, Kubo N, Tokura A, Hayashi N, Nakamura M, Matsuda M, Sakurabayashi I | title = Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. | journal = Arterioscler. Thromb. Vasc. Biol. | volume = 20 | issue = 1 | pages = 128–34 | year = 2000 | pmid = 10634809 | doi = 10.1161/01.ATV.20.1.128 }}
*{{cite journal  | author=Coux O, Goldberg AL |title=Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8820-8 |year= 1998 |pmid= 9535861 |doi= }}
* {{cite journal | vauthors = Furukawa Y, Kubo N, Kikuchi J, Tokura A, Fujita N, Sakurabayashi I | title = Regulation of macrophage-specific gene expression by degenerated lipoproteins. | journal = Electrophoresis | volume = 21 | issue = 2 | pages = 338–46 | year = 2000 | pmid = 10675012 | doi = 10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9 }}
*{{cite journal | author=Whitby FG, Xia G, Pickart CM, Hill CP |title=Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34983-91 |year= 1999 |pmid= 9857030 |doi= }}
* {{cite journal | vauthors = Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S | title = E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. | journal = FEBS Lett. | volume = 503 | issue = 1 | pages = 61–4 | year = 2001 | pmid = 11513855 | doi = 10.1016/S0014-5793(01)02689-8 }}
*{{cite journal | author=Kikuchi J, Furukawa Y, Kubo N, ''et al.'' |title=Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=20 |issue= 1 |pages= 128-34 |year= 2000 |pmid= 10634809 |doi= }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Furukawa Y, Kubo N, Kikuchi J, ''et al.'' |title=Regulation of macrophage-specific gene expression by degenerated lipoproteins. |journal=Electrophoresis |volume=21 |issue= 2 |pages= 338-46 |year= 2000 |pmid= 10675012 |doi= 10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9 }}
* {{cite journal | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–65 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Lee SJ, Choi JY, Sung YM, ''et al.'' |title=E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. |journal=FEBS Lett. |volume=503 |issue= 1 |pages= 61-4 |year= 2001 |pmid= 11513855 |doi= }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Flierman D, Coleman CS, Pickart CM, Rapoport TA, Chau V | title = E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 31 | pages = 11589–94 | year = 2006 | pmid = 16868077 | pmc = 1520313 | doi = 10.1073/pnas.0605215103 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = de Pril R, Fischer DF, Roos RA, van Leeuwen FW | title = Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. | journal = Mol. Cell. Neurosci. | volume = 34 | issue = 1 | pages = 10–9 | year = 2007 | pmid = 17092742 | doi = 10.1016/j.mcn.2006.09.006 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Flierman D, Coleman CS, Pickart CM, ''et al.'' |title=E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 31 |pages= 11589-94 |year= 2006 |pmid= 16868077 |doi= 10.1073/pnas.0605215103 }}
*{{cite journal | author=de Pril R, Fischer DF, Roos RA, van Leeuwen FW |title=Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. |journal=Mol. Cell. Neurosci. |volume=34 |issue= 1 |pages= 10-9 |year= 2007 |pmid= 17092742 |doi= 10.1016/j.mcn.2006.09.006 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Christensen DE, Brzovic PS, Klevit RE |title=E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 10 |pages= 941-8 |year=  |pmid= 17873885 |doi= 10.1038/nsmb1295 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=3093}}
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{{gene-4-stub}}

Latest revision as of 13:36, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.[1][2][3]

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.[3]

Interactions

HIP2 has been shown to interact with Huntingtin[1][4] and RNF2.[5]

References

  1. ↑ 1.0 1.1 Kalchman MA, Graham RK, Xia G, Koide HB, Hodgson JG, Graham KC, Goldberg YP, Gietz RD, Pickart CM, Hayden MR (Sep 1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J Biol Chem. 271 (32): 19385–94. doi:10.1074/jbc.271.32.19385. PMID 8702625.
  2. ↑ Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat Struct Mol Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.
  3. ↑ 3.0 3.1 "Entrez Gene: HIP2 huntingtin interacting protein 2".
  4. ↑ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
  5. ↑ Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (Aug 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855.

Further reading


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