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{{Infobox_gene}}
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'''Histone H2B type 1-K''' is a [[protein]] that in humans is encoded by the ''HIST1H2BK'' [[gene]].<ref name="pmid12408966">{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc =  | doi =10.1016/S0888-7543(02)96850-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BK histone cluster 1, H2bk| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85236| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HIST1H2BK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1f66}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1u35}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = Histone cluster 1, H2bk
| HGNCid = 13954
| Symbol = HIST1H2BK
| AltSymbols =; H2B/S; H2BFAiii; H2BFT; MGC131989
| OMIM = 
| ECnumber = 
| Homologene = 89090
| MGIid = 
| GeneAtlas_image1 = PBB_GE_HIST1H2BK_208579_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 85236
    | Hs_Ensembl = ENSG00000197903
    | Hs_RefseqProtein = NP_542160
    | Hs_RefseqmRNA = NM_080593
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 27222129
    | Hs_GenLoc_end = 27222556
    | Hs_Uniprot = P62807
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Histone cluster 1, H2bk''', also known as '''HIST1H2BK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BK histone cluster 1, H2bk| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85236| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H2BK histone cluster 1, H2bk| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85236| accessdate = }}</ref>
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.<ref name="entrez" />
}}
}}
==Interactions==
HIST1H2BK has been shown to [[Protein-protein interaction|interact]] with [[HIRA]].<ref name=pmid9710638>{{cite journal |last=Lorain |first=S |authorlink= |author2=Quivy J P |author3=Monier-Gavelle F |author4=Scamps C |author5=Lécluse Y |author6=Almouzni G |author7=Lipinski M  |date=Sep 1998 |title=Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA |journal=Mol. Cell. Biol. |volume=18 |issue=9 |pages=5546–56 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9710638 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=109139 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dobner T, Wolf I, Mai B, Lipp M |title=A novel divergently transcribed human histone H2A/H2B gene pair. |journal=DNA Seq. |volume=1 |issue= 6 |pages= 409-13 |year= 1992 |pmid= 1768865 |doi=  }}
*{{cite journal  |vauthors=Dobner T, Wolf I, Mai B, Lipp M |title=A novel divergently transcribed human histone H2A/H2B gene pair |journal=DNA Seq. |volume=1 |issue= 6 |pages= 409–13 |year= 1992 |pmid= 1768865 |doi=10.3109/10425179109020799 }}
*{{cite journal  | author=Frohm M, Gunne H, Bergman AC, ''et al.'' |title=Biochemical and antibacterial analysis of human wound and blister fluid. |journal=Eur. J. Biochem. |volume=237 |issue= 1 |pages= 86-92 |year= 1996 |pmid= 8620898 |doi=  }}
*{{cite journal  | author=Frohm M |title=Biochemical and antibacterial analysis of human wound and blister fluid |journal=Eur. J. Biochem. |volume=237 |issue= 1 |pages= 86–92 |year= 1996 |pmid= 8620898 |doi=10.1111/j.1432-1033.1996.0086n.x |name-list-format=vanc| author2=Gunne H  | author3=Bergman AC  | display-authors=3  | last4=Agerberth  | first4=Birgitta  | last5=Bergman  | first5=Tomas  | last6=Boman  | first6=Anita  | last7=Liden | first7=Sture | last8=Jornvall  | first8=Hans  | last9=Boman  | first9=Hans G.  }}
*{{cite journal  | author=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535-44 |year= 1998 |pmid= 9566873 |doi=  }}
*{{cite journal |vauthors=El Kharroubi A, Piras G, Zensen R, Martin MA |title=Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2535–44 |year= 1998 |pmid= 9566873 |doi=  10.1128/mcb.18.5.2535| pmc=110633  }}
*{{cite journal | author=Lorain S, Quivy JP, Monier-Gavelle F, ''et al.'' |title=Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546-56 |year= 1998 |pmid= 9710638 |doi=  }}
*{{cite journal  | author=Lorain S |title=Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5546–56 |year= 1998 |pmid= 9710638 |doi=  | pmc=109139 |name-list-format=vanc| author2=Quivy JP  | author3=Monier-Gavelle F  | display-authors=3 | last4=Scamps  | first4=C  | last5=Lécluse  | first5=Y  | last6=Almouzni  | first6=G  | last7=Lipinski  | first7=M }}
*{{cite journal  | author=Albig W, Trappe R, Kardalinou E, ''et al.'' |title=The human H2A and H2B histone gene complement. |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 7-18 |year= 1999 |pmid= 10064132 |doi=  }}
*{{cite journal  | author=Albig W |title=The human H2A and H2B histone gene complement |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 7–18 |year= 1999 |pmid= 10064132 |doi=10.1515/BC.1999.002 |name-list-format=vanc| author2=Trappe R  | author3=Kardalinou E  | display-authors=3  | last4=Eick  | first4=S.  | last5=Doenecke  | first5=D. }}
*{{cite journal | author=Ahn J, Gruen JR |title=The genomic organization of the histone clusters on human 6p21.3. |journal=Mamm. Genome |volume=10 |issue= 7 |pages= 768-70 |year= 1999 |pmid= 10384058 |doi=  }}
*{{cite journal  |vauthors=Ahn J, Gruen JR |title=The genomic organization of the histone clusters on human 6p21.3 |journal=Mamm. Genome |volume=10 |issue= 7 |pages= 768–70 |year= 1999 |pmid= 10384058 |doi=10.1007/s003359901089 }}
*{{cite journal  | author=Deng L, de la Fuente C, Fu P, ''et al.'' |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. |journal=Virology |volume=277 |issue= 2 |pages= 278-95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 }}
*{{cite journal  | author=Deng L |title=Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones |journal=Virology |volume=277 |issue= 2 |pages= 278–95 |year= 2001 |pmid= 11080476 |doi= 10.1006/viro.2000.0593 |name-list-format=vanc| author2=de la Fuente C | author3=Fu P  | display-authors=3  | last4=Wang  | first4=L  | last5=Donnelly  | first5=R  | last6=Wade  | first6=JD  | last7=Lambert  | first7=P  | last8=Li  | first8=H  | last9=Lee  | first9=CG }}
*{{cite journal | author=Deng L, Wang D, de la Fuente C, ''et al.'' |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. |journal=Virology |volume=289 |issue= 2 |pages= 312-26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 }}
*{{cite journal  | author=Deng L |title=Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA |journal=Virology |volume=289 |issue= 2 |pages= 312–26 |year= 2001 |pmid= 11689053 |doi= 10.1006/viro.2001.1129 |name-list-format=vanc| author2=Wang D | author3=de la Fuente C  | display-authors=3  | last4=Wang  | first4=L  | last5=Li  | first5=H  | last6=Lee  | first6=CG  | last7=Donnelly  | first7=R  | last8=Wade  | first8=JD  | last9=Lambert | first9=P }}
*{{cite journal  | author=Kim HS, Cho JH, Park HW, ''et al.'' |title=Endotoxin-neutralizing antimicrobial proteins of the human placenta. |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2356-64 |year= 2002 |pmid= 11859126 |doi=  }}
*{{cite journal  | author=Kim HS |title=Endotoxin-neutralizing antimicrobial proteins of the human placenta |journal=J. Immunol. |volume=168 |issue= 5 |pages= 2356–64 |year= 2002 |pmid= 11859126 |doi= 10.4049/jimmunol.168.5.2356|name-list-format=vanc| author2=Cho JH | author3=Park HW  | display-authors=3  | last4=Yoon  | first4=H  | last5=Kim  | first5=MS  | last6=Kim  | first6=SC  }}
*{{cite journal  | author=Marzluff WF, Gongidi P, Woods KR, ''et al.'' |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487-98 |year= 2003 |pmid= 12408966 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Cheung WL |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase |journal=Cell |volume=113 |issue= 4 |pages= 507–17 |year= 2003 |pmid= 12757711 |doi=10.1016/S0092-8674(03)00355-6 |name-list-format=vanc| author2=Ajiro K  | author3=Samejima K  | display-authors=3  | last4=Kloc  | first4=Malgorzata  | last5=Cheung  | first5=Peter  | last6=Mizzen  | first6=Craig A.  | last7=Beeser  | first7=Alexander  | last8=Etkin  | first8=Laurence D.  | last9=Chernoff  | first9=Jonathan  }}
*{{cite journal  | author=Cheung WL, Ajiro K, Samejima K, ''et al.'' |title=Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. |journal=Cell |volume=113 |issue= 4 |pages= 507-17 |year= 2003 |pmid= 12757711 |doi=  }}
*{{cite journal  | author=Tollin M |title=Antimicrobial peptides in the first line defence of human colon mucosa |journal=Peptides |volume=24 |issue= 4 |pages= 523–30 |year= 2004 |pmid= 12860195 |doi=10.1016/S0196-9781(03)00114-1  |name-list-format=vanc| author2=Bergman P  | author3=Svenberg T  | display-authors=3  | last4=Jörnvall  | first4=Hans  | last5=Gudmundsson  | first5=Gudmundur Hrafn  | last6=Agerberth  | first6=Birgitta  }}
*{{cite journal | author=Tollin M, Bergman P, Svenberg T, ''et al.'' |title=Antimicrobial peptides in the first line defence of human colon mucosa. |journal=Peptides |volume=24 |issue= 4 |pages= 523-30 |year= 2004 |pmid= 12860195 |doi=  }}
*{{cite journal  | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055  |name-list-format=vanc| author2=Palmer SA  | author3=Sims SK  | display-authors=3  | last4=Edwards  | first4=C. A.  | last5=Ashurst  | first5=J. L.  | last6=Wilming  | first6=L.  | last7=Jones  | first7=M. C.  | last8=Horton  | first8=R.  | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550–61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631  | pmc=291826 }}
*{{cite journal | author=Lusic M, Marcello A, Cereseto A, Giacca M |title=Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6550-61 |year= 2004 |pmid= 14657027 |doi= 10.1093/emboj/cdg631 }}
*{{cite journal  |vauthors=Howell SJ, Wilk D, Yadav SP, Bevins CL |title=Antimicrobial polypeptides of the human colonic epithelium |journal=Peptides |volume=24 |issue= 11 |pages= 1763–70 |year= 2004 |pmid= 15019208 |doi= 10.1016/j.peptides.2003.07.028 }}
*{{cite journal  | author=Howell SJ, Wilk D, Yadav SP, Bevins CL |title=Antimicrobial polypeptides of the human colonic epithelium. |journal=Peptides |volume=24 |issue= 11 |pages= 1763-70 |year= 2004 |pmid= 15019208 |doi= 10.1016/j.peptides.2003.07.028 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  |vauthors=Tsunaka Y, Kajimura N, Tate S, Morikawa K |title=Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle |journal=Nucleic Acids Res. |volume=33 |issue= 10 |pages= 3424–34 |year= 2005 |pmid= 15951514 |doi= 10.1093/nar/gki663  | pmc=1150222 }}
*{{cite journal | author=Tsunaka Y, Kajimura N, Tate S, Morikawa K |title=Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle. |journal=Nucleic Acids Res. |volume=33 |issue= 10 |pages= 3424-34 |year= 2005 |pmid= 15951514 |doi= 10.1093/nar/gki663 }}
*{{cite journal  |vauthors=Golebiowski F, Kasprzak KS |title=Inhibition of core histones acetylation by carcinogenic nickel(II) |journal=Mol. Cell. Biochem. |volume=279 |issue= 1–2 |pages= 133–9 |year= 2007 |pmid= 16283522 |doi= 10.1007/s11010-005-8285-1 }}
*{{cite journal  | author=Golebiowski F, Kasprzak KS |title=Inhibition of core histones acetylation by carcinogenic nickel(II). |journal=Mol. Cell. Biochem. |volume=279 |issue= 1-2 |pages= 133-9 |year= 2007 |pmid= 16283522 |doi= 10.1007/s11010-005-8285-1 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=85236}}
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Revision as of 13:40, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.[1][2]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.[2]

Interactions

HIST1H2BK has been shown to interact with HIRA.[3]

References

  1. ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  2. ↑ 2.0 2.1 "Entrez Gene: HIST1H2BK histone cluster 1, H2bk".
  3. ↑ Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. UNITED STATES. 18 (9): 5546–56. ISSN 0270-7306. PMC 109139. PMID 9710638.

Further reading



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