HLA-DQA2: Difference between revisions

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{{Infobox_gene}}
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'''HLA class II histocompatibility antigen, DQ(6) alpha chain''' is a [[protein]] that in humans is encoded by the ''HLA-DQA2'' [[gene]]. Also known as ''HLA-DXA'' or ''DAAP-381D23.2'', it is part of the [[human leucocyte antigen]] system.<ref name="entrez">{{cite web | title = Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3118| accessdate = }}</ref>
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The [[protein]] encoded by this gene is expressed, but unlike [[HLA-DQA1]], it apparently unable to heterodimerize with [[MHC class II|HLA class II]] beta chain [[Homology (biology)#Paralogy|paralogues]].<ref name="pmid9036956">{{cite journal |vauthors=Rudy GB, Lew AM | title = The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells | journal = J. Immunol. | volume = 158 | issue = 5 | pages = 2116–25 |date=March 1997 | pmid = 9036956 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/158/5/2116 }}</ref> The low level of HLA-DQA2 expression is apparently due to impaired [[transcription factor]] binding to the HLA-DQA2 gene [[Promoter (biology)|promoter]].<ref name="pmid11334674">{{cite journal |vauthors=Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC | title = Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions | journal = Hum. Immunol. | volume = 62 | issue = 5 | pages = 504–8 |date=May 2001 | pmid = 11334674 | doi = 10.1016/S0198-8859(01)00236-1 | url =   }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Major histocompatibility complex, class II, DQ alpha 2
| HGNCid = 4943
| Symbol = HLA-DQA2
| AltSymbols =; DQ alpha; HLA-DXA
| OMIM = 
| ECnumber = 
| Homologene = 69291
| MGIid = 
| GeneAtlas_image1 = PBB_GE_HLA-DQA2_212671_s_at_tn.png
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}  
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3118
    | Hs_Ensembl = ENSG00000204276
    | Hs_RefseqProtein = NP_064440
    | Hs_RefseqmRNA = NM_020056
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 32817141
    | Hs_GenLoc_end = 32823171
    | Hs_Uniprot = P01906
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Major histocompatibility complex, class II, DQ alpha 2''', also known as '''HLA-DQA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3118| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992. |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229-43 |year= 1993 |pmid= 1362295 |doi=  }}
*{{cite journal  |vauthors=Marsh SG, Bodmer JG |title=HLA class II nucleotide sequences, 1992. |journal=Tissue Antigens |volume=40 |issue= 5 |pages= 229–43 |year= 1993 |pmid= 1362295 |doi=10.1111/j.1399-0039.1992.tb02050.x }}
*{{cite journal | author=Kenter M, Otting N, Anholts J, ''et al.'' |title=Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles. |journal=Immunogenetics |volume=36 |issue= 2 |pages= 71-8 |year= 1992 |pmid= 1612647 |doi=  }}
*{{cite journal   |vauthors=Kenter M, Otting N, Anholts J, etal |title=Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles. |journal=Immunogenetics |volume=36 |issue= 2 |pages= 71–8 |year= 1992 |pmid= 1612647 |doi=10.1007/BF00215282 }}
*{{cite journal | author=Piatier-Tonneau D, Gastinel LN, Amblard F, ''et al.'' |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121-8 |year= 1991 |pmid= 1869305 |doi=  }}
*{{cite journal   |vauthors=Piatier-Tonneau D, Gastinel LN, Amblard F, etal |title=Interaction of CD4 with HLA class II antigens and HIV gp120. |journal=Immunogenetics |volume=34 |issue= 2 |pages= 121–8 |year= 1991 |pmid= 1869305 |doi=  10.1007/BF00211424}}
*{{cite journal  | author=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526-31 |year= 1990 |pmid= 1967269 |doi=  }}
*{{cite journal  |vauthors=Rosenstein Y, Burakoff SJ, Herrmann SH |title=HIV-gp120 can block CD4-class II MHC-mediated adhesion. |journal=J. Immunol. |volume=144 |issue= 2 |pages= 526–31 |year= 1990 |pmid= 1967269 |doi=  }}
*{{cite journal  | author=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052-6 |year= 1991 |pmid= 1978941 |doi=  }}
*{{cite journal  |vauthors=Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ |title=Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 9052–6 |year= 1991 |pmid= 1978941 |doi=10.1073/pnas.87.22.9052  | pmc=55099 }}
*{{cite journal  | author=Gyllensten UB, Erlich HA |title=Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 9986-90 |year= 1990 |pmid= 2513578 |doi= }}
*{{cite journal  |vauthors=Gyllensten UB, Erlich HA |title=Ancient roots for polymorphism at the HLA-DQ alpha locus in primates |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 9986–90 |year= 1990 |pmid= 2513578 |doi=10.1073/pnas.86.24.9986  | pmc=298627  }}
*{{cite journal  | author=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. |journal=Nature |volume=339 |issue= 6225 |pages= 548-51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 }}
*{{cite journal  |vauthors=Clayton LK, Sieh M, Pious DA, Reinherz EL |title=Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding |journal=Nature |volume=339 |issue= 6225 |pages= 548–51 |year= 1989 |pmid= 2543930 |doi= 10.1038/339548a0 }}
*{{cite journal | author=Diamond DC, Sleckman BP, Gregory T, ''et al.'' |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715-7 |year= 1988 |pmid= 2846691 |doi=  }}
*{{cite journal   |vauthors=Diamond DC, Sleckman BP, Gregory T, etal |title=Inhibition of CD4+ T cell function by the HIV envelope protein, gp120 |journal=J. Immunol. |volume=141 |issue= 11 |pages= 3715–7 |year= 1988 |pmid= 2846691 |doi=  }}
*{{cite journal | author=Jonsson AK, Hyldig-Nielsen JJ, Servenius B, ''et al.'' |title=Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes. |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8767-77 |year= 1987 |pmid= 3036828 |doi=  }}
*{{cite journal   |vauthors=Jonsson AK, Hyldig-Nielsen JJ, Servenius B, etal |title=Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8767–77 |year= 1987 |pmid= 3036828 |doi=  }}
*{{cite journal | author=Horn GT, Bugawan TL, Long CM, ''et al.'' |title=Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals. |journal=Hum. Immunol. |volume=21 |issue= 4 |pages= 249-63 |year= 1988 |pmid= 3372263 |doi=  }}
*{{cite journal   |vauthors=Horn GT, Bugawan TL, Long CM, etal |title=Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals |journal=Hum. Immunol. |volume=21 |issue= 4 |pages= 249–63 |year= 1988 |pmid= 3372263 |doi=10.1016/0198-8859(88)90034-1 }}
*{{cite journal  | author=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. |journal=AIDS research |volume=2 |issue= 3 |pages= 163-74 |year= 1986 |pmid= 3489470 |doi=  }}
*{{cite journal  |vauthors=Andrieu JM, Even P, Venet A |title=AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications |journal=AIDS research |volume=2 |issue= 3 |pages= 163–74 |year= 1986 |pmid= 3489470 |doi=  10.1089/aid.1.1986.2.163}}
*{{cite journal | author=Auffray C, Lillie JW, Korman AJ, ''et al.'' |title=Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector. |journal=Immunogenetics |volume=26 |issue= 1-2 |pages= 63-73 |year= 1987 |pmid= 3610256 |doi=  }}
*{{cite journal   |vauthors=Auffray C, Lillie JW, Korman AJ, etal |title=Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector |journal=Immunogenetics |volume=26 |issue= 1–2 |pages= 63–73 |year= 1987 |pmid= 3610256 |doi=  10.1007/bf00345456}}
*{{cite journal | author=Trowsdale J, Lee J, Carey J, ''et al.'' |title=Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 7 |pages= 1972-6 |year= 1983 |pmid= 6300884 |doi=  }}
*{{cite journal   |vauthors=Trowsdale J, Lee J, Carey J, etal |title=Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=80 |issue= 7 |pages= 1972–6 |year= 1983 |pmid= 6300884 |doi=10.1073/pnas.80.7.1972  | pmc=393734 }}
*{{cite journal | author=Auffray C, Lillie JW, Arnot D, ''et al.'' |title=Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. |journal=Nature |volume=308 |issue= 5957 |pages= 327-33 |year= 1984 |pmid= 6584734 |doi=  }}
*{{cite journal   |vauthors=Auffray C, Lillie JW, Arnot D, etal |title=Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes |journal=Nature |volume=308 |issue= 5957 |pages= 327–33 |year= 1984 |pmid= 6584734 |doi=10.1038/308327a0 }}
*{{cite journal | author=Houlgatte R, Scarmato P, el Marhomy S, ''et al.'' |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475-88 |year= 1994 |pmid= 7512597 |doi=  }}
*{{cite journal   |vauthors=Houlgatte R, Scarmato P, el Marhomy S, etal |title=HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4 |journal=J. Immunol. |volume=152 |issue= 9 |pages= 4475–88 |year= 1994 |pmid= 7512597 |doi=  }}
*{{cite journal | author=Chirmule N, McCloskey TW, Hu R, ''et al.'' |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917-24 |year= 1995 |pmid= 7541827 |doi=  }}
*{{cite journal   |vauthors=Chirmule N, McCloskey TW, Hu R, etal |title=HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71) |journal=J. Immunol. |volume=155 |issue= 2 |pages= 917–24 |year= 1995 |pmid= 7541827 |doi=  }}
*{{cite journal  | author=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473-88 |year= 1995 |pmid= 7602119 |doi=  }}
*{{cite journal  |vauthors=Rowell JF, Stanhope PE, Siliciano RF |title=Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC |journal=J. Immunol. |volume=155 |issue= 1 |pages= 473–88 |year= 1995 |pmid= 7602119 |doi=  }}
*{{cite journal  | author=Rudy G, Lew AM |title=Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer. |journal=Hum. Immunol. |volume=39 |issue= 3 |pages= 225-9 |year= 1994 |pmid= 8026991 |doi=  }}
*{{cite journal  |vauthors=Rudy G, Lew AM |title=Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer |journal=Hum. Immunol. |volume=39 |issue= 3 |pages= 225–9 |year= 1994 |pmid= 8026991 |doi=10.1016/0198-8859(94)90264-X }}
*{{cite journal | author=Chen YH, Böck G, Vornhagen R, ''et al.'' |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977-82 |year= 1994 |pmid= 8084338 |doi=  }}
*{{cite journal   |vauthors=Chen YH, Böck G, Vornhagen R, etal |title=HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41 |journal=Mol. Immunol. |volume=31 |issue= 13 |pages= 977–82 |year= 1994 |pmid= 8084338 |doi=10.1016/0161-5890(94)90092-2 }}
*{{cite journal | author=Chirmule N, Wang XP, Hu R, ''et al.'' |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169-82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110 }}
*{{cite journal   |vauthors=Chirmule N, Wang XP, Hu R, etal |title=Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help |journal=Cell. Immunol. |volume=155 |issue= 1 |pages= 169–82 |year= 1994 |pmid= 8168144 |doi= 10.1006/cimm.1994.1110 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Surface antigens}}
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{{gene-6-stub}}

Latest revision as of 02:26, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also known as HLA-DXA or DAAP-381D23.2, it is part of the human leucocyte antigen system.[1]

The protein encoded by this gene is expressed, but unlike HLA-DQA1, it apparently unable to heterodimerize with HLA class II beta chain paralogues.[2] The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.[3]


References

  1. ↑ "Entrez Gene: HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2".
  2. ↑ Rudy GB, Lew AM (March 1997). "The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells". J. Immunol. 158 (5): 2116–25. PMID 9036956.
  3. ↑ Indovina P, Megiorni F, Fontemaggi G, Coni P, Mora B, Mazzilli MC (May 2001). "Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions". Hum. Immunol. 62 (5): 504–8. doi:10.1016/S0198-8859(01)00236-1. PMID 11334674.

Further reading



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