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{{Infobox_gene}}
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'''Heat shock protein 105 kDa''' is a [[protein]] that in humans is encoded by the ''HSPH1'' [[gene]].<ref name="pmid9610721">{{cite journal |vauthors=Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ | title = Characterization of human colon cancer antigens recognized by autologous antibodies | journal = Int J Cancer | volume = 76 | issue = 5 | pages = 652–8 |date=Jun 1998 | pmid = 9610721 | pmc = | doi =10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P }}</ref><ref name="pmid9931472">{{cite journal |vauthors=Ishihara K, Yasuda K, Hatayama T | title = Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105 | journal = Biochim Biophys Acta | volume = 1444 | issue = 1 | pages = 138–42 |date=Mar 1999 | pmid = 9931472 | pmc = | doi = 10.1016/s0167-4781(98)00254-1}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10808| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Heat shock 105kDa/110kDa protein 1
| HGNCid = 16969
| Symbol = HSPH1
| AltSymbols =; DKFZp686M05240; HSP105; HSP105A; HSP105B; KIAA0201; NY-CO-25
| OMIM = 610703
| ECnumber = 
| Homologene = 21322
| MGIid = 105053
| GeneAtlas_image1 = PBB_GE_HSPH1_206976_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HSPH1_208744_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0051085 |text = chaperone cofactor-dependent protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10808
    | Hs_Ensembl = ENSG00000120694
    | Hs_RefseqProtein = NP_006635
    | Hs_RefseqmRNA = NM_006644
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 30608765
    | Hs_GenLoc_end = 30634502
    | Hs_Uniprot = Q92598
    | Mm_EntrezGene = 15505
    | Mm_Ensembl = ENSMUSG00000029657
    | Mm_RefseqmRNA = NM_013559
    | Mm_RefseqProtein = NP_038587
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 149882666
    | Mm_GenLoc_end = 149904597
    | Mm_Uniprot = Q8C6H1
  }}
}}
'''Heat shock 105kDa/110kDa protein 1''', also known as '''HSPH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10808| accessdate = }}</ref>
 
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==Interactions==
HSPH1 has been shown to [[Protein-protein interaction|interact]] with [[Cofilin 1]].<ref name=pmid14733918>{{cite journal |last=Saito |first=Youhei |authorlink= |author2=Doi Kazuya |author3=Yamagishi Nobuyuki |author4=Ishihara Keiichi |author5=Hatayama Takumi  |date=Feb 2004 |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue=2 |pages=396–402 |publisher= |location = United States| issn = 0006-291X| pmid = 14733918 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/j.bbrc.2003.12.108 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
*{{cite journal |vauthors=Dawson SJ, White LA |title=Treatment of ''Haemophilus aphrophilus'' endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi= }}
*{{cite journal  |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 }}
*{{cite journal | author=Scanlan MJ, Chen YT, Williamson B, ''et al.'' |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652-8 |year= 1998 |pmid= 9610721 |doi= }}
*{{cite journal |vauthors=Hatayama T, Yasuda K, Yasuda K |title=Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 2 |pages= 395–401 |year= 1998 |pmid= 9675148 |doi= 10.1006/bbrc.1998.8979 }}
*{{cite journal | author=Hatayama T, Yasuda K, Yasuda K |title=Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 2 |pages= 395-401 |year= 1998 |pmid= 9675148 |doi= 10.1006/bbrc.1998.8979 }}
*{{cite journal |vauthors=Ishihara K, Yasuda K, Hatayama T |title=Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 927–31 |year= 2000 |pmid= 10772927 |doi= 10.1006/bbrc.2000.2541 }}
*{{cite journal | author=Ishihara K, Yasuda K, Hatayama T |title=Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. |journal=Biochim. Biophys. Acta |volume=1444 |issue= 1 |pages= 138-42 |year= 1999 |pmid= 9931472 |doi= }}
*{{cite journal |vauthors=Hylander BL, Chen X, Graf PC, Subjeck JR |title=The distribution and localization of hsp110 in brain. |journal=Brain Res. |volume=869 |issue= 1–2 |pages= 49–55 |year= 2000 |pmid= 10865058 |doi=10.1016/S0006-8993(00)02346-5 }}
*{{cite journal  | author=Ishihara K, Yasuda K, Hatayama T |title=Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and HSP105beta, by casein kinase II. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 927-31 |year= 2000 |pmid= 10772927 |doi= 10.1006/bbrc.2000.2541 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Hylander BL, Chen X, Graf PC, Subjeck JR |title=The distribution and localization of hsp110 in brain. |journal=Brain Res. |volume=869 |issue= 1-2 |pages= 49-55 |year= 2000 |pmid= 10865058 |doi= }}
*{{cite journal |vauthors=Ishihara K, Yamagishi N, Hatayama T |title=Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 917–25 |year= 2003 |pmid= 12558502 |doi= 10.1042/BJ20021331 | pmc=1223342 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Saito Y, Yamagishi N, Ishihara K, Hatayama T |title=Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system |journal=Exp. Cell Res. |volume=286 |issue= 2 |pages= 233–40 |year= 2003 |pmid= 12749852 |doi=10.1016/S0014-4827(03)00054-5 }}
*{{cite journal  | author=Ishihara K, Yamagishi N, Hatayama T |title=Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 917-25 |year= 2003 |pmid= 12558502 |doi= 10.1042/BJ20021331 }}
*{{cite journal  |vauthors=Chen WF, Huang MH, Tzang CH, etal |title=Inhibitory actions of genistein in human breast cancer (MCF-7) cells |journal=Biochim. Biophys. Acta |volume=1638 |issue= 2 |pages= 187–96 |year= 2003 |pmid= 12853125 |doi= 10.1016/s0925-4439(03)00082-6 }}
*{{cite journal  | author=Saito Y, Yamagishi N, Ishihara K, Hatayama T |title=Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system. |journal=Exp. Cell Res. |volume=286 |issue= 2 |pages= 233-40 |year= 2003 |pmid= 12749852 |doi= }}
*{{cite journal  |vauthors=Kai M, Nakatsura T, Egami H, etal |title=Heat shock protein 105 is overexpressed in a variety of human tumors |journal=Oncol. Rep. |volume=10 |issue= 6 |pages= 1777–82 |year= 2004 |pmid= 14534695 |doi= 10.3892/or.10.6.1777}}
*{{cite journal | author=Chen WF, Huang MH, Tzang CH, ''et al.'' |title=Inhibitory actions of genistein in human breast cancer (MCF-7) cells. |journal=Biochim. Biophys. Acta |volume=1638 |issue= 2 |pages= 187-96 |year= 2003 |pmid= 12853125 |doi= }}
*{{cite journal |vauthors=Piechotta K, Garbarini N, England R, Delpire E |title=Characterization of the interaction of the stress kinase SPAK with the Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>−</sup> cotransporter in the nervous system: evidence for a scaffolding role of the kinase |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52848–56 |year= 2004 |pmid= 14563843 |doi= 10.1074/jbc.M309436200 }}
*{{cite journal  | author=Kai M, Nakatsura T, Egami H, ''et al.'' |title=Heat shock protein 105 is overexpressed in a variety of human tumors. |journal=Oncol. Rep. |volume=10 |issue= 6 |pages= 1777-82 |year= 2004 |pmid= 14534695 |doi= }}
*{{cite journal  |vauthors=Saito Y, Doi K, Yamagishi N, etal |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 396–402 |year= 2004 |pmid= 14733918 |doi=10.1016/j.bbrc.2003.12.108 }}
*{{cite journal  | author=Piechotta K, Garbarini N, England R, Delpire E |title=Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52848-56 |year= 2004 |pmid= 14563843 |doi= 10.1074/jbc.M309436200 }}
*{{cite journal  |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
*{{cite journal  | author=Saito Y, Doi K, Yamagishi N, ''et al.'' |title=Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 396-402 |year= 2004 |pmid= 14733918 |doi= }}
*{{cite journal  |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal |vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal  |vauthors=Miyazaki M, Nakatsura T, Yokomine K, etal |title=DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells |journal=Cancer Sci. |volume=96 |issue= 10 |pages= 695–705 |year= 2005 |pmid= 16232202 |doi= 10.1111/j.1349-7006.2005.00093.x }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Miyazaki M, Nakatsura T, Yokomine K, ''et al.'' |title=DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells. |journal=Cancer Sci. |volume=96 |issue= 10 |pages= 695-705 |year= 2005 |pmid= 16232202 |doi= 10.1111/j.1349-7006.2005.00093.x }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 14:07, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.[1][2][3]


Interactions

HSPH1 has been shown to interact with Cofilin 1.[4]

References

  1. ↑ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
  2. ↑ Ishihara K, Yasuda K, Hatayama T (Mar 1999). "Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105". Biochim Biophys Acta. 1444 (1): 138–42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472.
  3. ↑ "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1".
  4. ↑ Saito, Youhei; Doi Kazuya; Yamagishi Nobuyuki; Ishihara Keiichi; Hatayama Takumi (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochem. Biophys. Res. Commun. United States. 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. ISSN 0006-291X. PMID 14733918.

Further reading



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