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{{Infobox_gene}}
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'''Interferon alpha-4''' is a [[protein]] that in humans is encoded by the ''IFNA4'' [[gene]].<ref name="pmid1385305">{{cite journal |vauthors=Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO | title = Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia | journal = Genomics | volume = 14 | issue = 2 | pages = 437–43 |date=Dec 1992 | pmid = 1385305 | pmc =  | doi =10.1016/S0888-7543(05)80238-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFNA4 interferon, alpha 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3441| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Interferon, alpha 4
| HGNCid = 5425
| Symbol = IFNA4
| AltSymbols =; INFA4; MGC142200
| OMIM = 147564
| ECnumber =
| Homologene = 68536
| MGIid = 107668
| GeneAtlas_image1 = PBB_GE_IFNA4_207964_x_at_tn.png
  | GeneAtlas_image2 = PBB_GE_IFNA4_208182_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_IFNA4_208259_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005132 |text = interferon-alpha/beta receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3441
    | Hs_Ensembl = ENSG00000147877
    | Hs_RefseqProtein = NP_066546
    | Hs_RefseqmRNA = NM_021068
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 21176693
    | Hs_GenLoc_end = 21177670
    | Hs_Uniprot = P05014
    | Mm_EntrezGene = 15962
    | Mm_Ensembl = ENSMUSG00000070903
    | Mm_RefseqmRNA = NM_010502
    | Mm_RefseqProtein = NP_034632
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 88321318
    | Mm_GenLoc_end = 88321887
    | Mm_Uniprot = Q810G7
  }}
}}
'''Interferon, alpha 4''', also known as '''IFNA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNA4 interferon, alpha 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3441| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Olopade OI, Bohlander SK, Pomykala H, ''et al.'' |title=Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. |journal=Genomics |volume=14 |issue= 2 |pages= 437-43 |year= 1992 |pmid= 1385305 |doi=  }}
*{{cite journal  |vauthors=Mizoguchi J, Pitha PM, Raj NB |title=Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules. |journal=DNA |volume=4 |issue= 3 |pages= 221–32 |year= 1985 |pmid= 3891272 |doi=10.1089/dna.1985.4.221 }}
*{{cite journal  | author=Mizoguchi J, Pitha PM, Raj NB |title=Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules. |journal=DNA |volume=4 |issue= 3 |pages= 221-32 |year= 1985 |pmid= 3891272 |doi=  }}
*{{cite journal   |vauthors=Henco K, Brosius J, Fujisawa A, etal |title=Structural relationship of human interferon alpha genes and pseudogenes. |journal=J. Mol. Biol. |volume=185 |issue= 2 |pages= 227–60 |year= 1985 |pmid= 4057246 |doi=10.1016/0022-2836(85)90401-2 }}
*{{cite journal | author=Henco K, Brosius J, Fujisawa A, ''et al.'' |title=Structural relationship of human interferon alpha genes and pseudogenes. |journal=J. Mol. Biol. |volume=185 |issue= 2 |pages= 227-60 |year= 1985 |pmid= 4057246 |doi=  }}
*{{cite journal   |vauthors=Linnane AW, Beilharz MW, McMullen GL, etal |title=Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides. |journal=Biochem. Int. |volume=8 |issue= 5 |pages= 725–32 |year= 1984 |pmid= 6089830 |doi=  }}
*{{cite journal | author=Linnane AW, Beilharz MW, McMullen GL, ''et al.'' |title=Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides. |journal=Biochem. Int. |volume=8 |issue= 5 |pages= 725-32 |year= 1984 |pmid= 6089830 |doi=  }}
*{{cite journal   |vauthors=Tiefenbrun N, Melamed D, Levy N, etal |title=Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3934–44 |year= 1996 |pmid= 8668211 |doi= | pmc=231390 }}
*{{cite journal | author=Tiefenbrun N, Melamed D, Levy N, ''et al.'' |title=Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. |journal=Mol. Cell. Biol. |volume=16 |issue= 7 |pages= 3934-44 |year= 1996 |pmid= 8668211 |doi=  }}
*{{cite journal  |vauthors=Hussain M, Gill DS, Liao MJ |title=Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population |journal=J. Interferon Cytokine Res. |volume=17 |issue= 9 |pages= 559–66 |year= 1997 |pmid= 9335434 |doi=10.1089/jir.1997.17.559 }}
*{{cite journal  | author=Hussain M, Gill DS, Liao MJ |title=Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. |journal=J. Interferon Cytokine Res. |volume=17 |issue= 9 |pages= 559-66 |year= 1997 |pmid= 9335434 |doi=  }}
*{{cite journal  |vauthors=Nyman TA, Tölö H, Parkkinen J, Kalkkinen N |title=Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes |journal=Biochem. J. |volume=329 ( Pt 2) |issue=  Pt 2|pages= 295–302 |year= 1998 |pmid= 9425112 |doi= | pmc=1219044 }}
*{{cite journal  | author=Nyman TA, Tölö H, Parkkinen J, Kalkkinen N |title=Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. |journal=Biochem. J. |volume=329 ( Pt 2) |issue=  |pages= 295-302 |year= 1998 |pmid= 9425112 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Yokota S, Yokosawa N, Okabayashi T, etal |title=Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway |journal=J. Virol. |volume=78 |issue= 12 |pages= 6282–6 |year= 2004 |pmid= 15163721 |doi= 10.1128/JVI.78.12.6282-6286.2004 | pmc=416529 }}
*{{cite journal | author=Yokota S, Yokosawa N, Okabayashi T, ''et al.'' |title=Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway. |journal=J. Virol. |volume=78 |issue= 12 |pages= 6282-6 |year= 2004 |pmid= 15163721 |doi= 10.1128/JVI.78.12.6282-6286.2004 }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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{{Cytokine receptor modulators}}


{{gene-9-stub}}
{{gene-9-stub}}

Latest revision as of 23:39, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.[1][2]


References

  1. ↑ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
  2. ↑ "Entrez Gene: IFNA4 interferon, alpha 4".

Further reading



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