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{{Infobox_gene}}
{{PBB_Controls
'''Interleukin-18-binding protein''' is a [[protein]] that in humans is encoded by the ''IL18BP'' [[gene]].<ref name="pmid10023777">{{cite journal |vauthors=Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M | title = Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response | journal = Immunity | volume = 10 | issue = 1 | pages = 127–36 |date=Mar 1999 | pmid = 10023777 | pmc = | doi =10.1016/S1074-7613(00)80013-8  }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Interleukin 18 binding protein
| HGNCid = 5987
| Symbol = IL18BP
| AltSymbols =; IL18BPa
| OMIM = 604113
| ECnumber = 
| Homologene = 7781
| MGIid = 1333800
| GeneAtlas_image1 = PBB_GE_IL18BP_219323_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0042007 |text = interleukin-18 binding}} {{GNF_GO|id=GO:0048019 |text = receptor antagonist activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0042088 |text = T-helper 1 type immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10068
    | Hs_Ensembl = ENSG00000137496
    | Hs_RefseqProtein = NP_001034748
    | Hs_RefseqmRNA = NM_001039659
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 71387587
    | Hs_GenLoc_end = 71394409
    | Hs_Uniprot = O95998
    | Mm_EntrezGene = 16068
    | Mm_Ensembl = ENSMUSG00000070427
    | Mm_RefseqmRNA = NM_010531
    | Mm_RefseqProtein = NP_034661
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 101888895
    | Mm_GenLoc_end = 101892511
    | Mm_Uniprot = Q4FJR8
  }}
}}
'''Interleukin 18 binding protein''', also known as '''IL18BP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL18BP interleukin 18 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10068| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Three transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: IL18BP interleukin 18 binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10068| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is an inhibitor of the proinflammatory [[cytokine]] [[Interleukin 18|IL18]]. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: IL18BP interleukin 18 binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10068| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dinarello CA |title=Novel targets for interleukin 18 binding protein. |journal=Ann. Rheum. Dis. |volume=60 Suppl 3 |issue=  |pages= iii18-24 |year= 2002 |pmid= 11890646 |doi=  }}
*{{cite journal  | author=Dinarello CA |title=Novel targets for interleukin 18 binding protein |journal=Ann. Rheum. Dis. |volume=60 Suppl 3 |issue=  Suppl 3|pages= iii18–24 |year= 2002 |pmid= 11890646 |doi= 10.1136/ard.60.90003.iii18 | pmc=1766679 }}
*{{cite journal | author=Loughney K, Martins TJ, Harris EA, ''et al.'' |title=Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 796-806 |year= 1996 |pmid= 8557689 |doi= }}
*{{cite journal   |vauthors=Loughney K, Martins TJ, Harris EA, etal |title=Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 796–806 |year= 1996 |pmid= 8557689 |doi=10.1074/jbc.271.2.796  }}
*{{cite journal | author=Novick D, Kim SH, Fantuzzi G, ''et al.'' |title=Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. |journal=Immunity |volume=10 |issue= 1 |pages= 127-36 |year= 1999 |pmid= 10023777 |doi=  }}
*{{cite journal   |vauthors=Aizawa Y, Akita K, Taniai M, etal |title=Cloning and expression of interleukin-18 binding protein |journal=FEBS Lett. |volume=445 |issue= 2–3 |pages= 338–42 |year= 1999 |pmid= 10094485 |doi=10.1016/S0014-5793(99)00148-9 }}
*{{cite journal  | author=Aizawa Y, Akita K, Taniai M, ''et al.'' |title=Cloning and expression of interleukin-18 binding protein. |journal=FEBS Lett. |volume=445 |issue= 2-3 |pages= 338-42 |year= 1999 |pmid= 10094485 |doi= }}
*{{cite journal  |vauthors=Xiang Y, Moss B |title=Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus |journal=Virology |volume=257 |issue= 2 |pages= 297–302 |year= 1999 |pmid= 10329540 |doi= 10.1006/viro.1999.9676 }}
*{{cite journal | author=Xiang Y, Moss B |title=Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus. |journal=Virology |volume=257 |issue= 2 |pages= 297-302 |year= 1999 |pmid= 10329540 |doi= 10.1006/viro.1999.9676 }}
*{{cite journal   |vauthors=Kim SH, Eisenstein M, Reznikov L, etal |title=Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 3 |pages= 1190–5 |year= 2000 |pmid= 10655506 |doi=10.1073/pnas.97.3.1190  | pmc=15564  }}
*{{cite journal | author=Kim SH, Eisenstein M, Reznikov L, ''et al.'' |title=Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 3 |pages= 1190-5 |year= 2000 |pmid= 10655506 |doi=  }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal   |vauthors=Michibata H, Yanaka N, Kanoh Y, etal |title=Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 278–87 |year= 2001 |pmid= 11342109 |doi=  10.1016/s0167-4781(00)00293-1}}
*{{cite journal | author=Michibata H, Yanaka N, Kanoh Y, ''et al.'' |title=Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 278-87 |year= 2001 |pmid= 11342109 |doi=  }}
*{{cite journal   |vauthors=Paulukat J, Bosmann M, Nold M, etal |title=Expression and release of IL-18 binding protein in response to IFN-gamma |journal=J. Immunol. |volume=167 |issue= 12 |pages= 7038–43 |year= 2001 |pmid= 11739524 |doi=  10.4049/jimmunol.167.12.7038}}
*{{cite journal  | author=Paulukat J, Bosmann M, Nold M, ''et al.'' |title=Expression and release of IL-18 binding protein in response to IFN-gamma. |journal=J. Immunol. |volume=167 |issue= 12 |pages= 7038-43 |year= 2001 |pmid= 11739524 |doi=  }}
*{{cite journal  |vauthors=Fidock M, Miller M, Lanfear J |title=Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants |journal=Cell. Signal. |volume=14 |issue= 1 |pages= 53–60 |year= 2002 |pmid= 11747989 |doi=10.1016/S0898-6568(01)00207-8 }}
*{{cite journal | author=Fidock M, Miller M, Lanfear J |title=Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. |journal=Cell. Signal. |volume=14 |issue= 1 |pages= 53-60 |year= 2002 |pmid= 11747989 |doi=  }}
*{{cite journal   |vauthors=Corbaz A, ten Hove T, Herren S, etal |title=IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3608–16 |year= 2002 |pmid= 11907126 |doi=  10.4049/jimmunol.168.7.3608}}
*{{cite journal | author=Corbaz A, ten Hove T, Herren S, ''et al.'' |title=IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3608-16 |year= 2002 |pmid= 11907126 |doi=  }}
*{{cite journal   |vauthors=Bufler P, Azam T, Gamboni-Robertson F, etal |title=A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13723–8 |year= 2002 |pmid= 12381835 |doi= 10.1073/pnas.212519099 | pmc=129755 }}
*{{cite journal | author=Bufler P, Azam T, Gamboni-Robertson F, ''et al.'' |title=A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13723-8 |year= 2002 |pmid= 12381835 |doi= 10.1073/pnas.212519099 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Hurgin V, Novick D, Rubinstein M |title=The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16957–62 |year= 2003 |pmid= 12482935 |doi= 10.1073/pnas.262663399  | pmc=139251 }}
*{{cite journal | author=Hurgin V, Novick D, Rubinstein M |title=The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16957-62 |year= 2003 |pmid= 12482935 |doi= 10.1073/pnas.262663399 }}
*{{cite journal   |vauthors=Plitz T, Saint-Mézard P, Satho M, etal |title=IL-18 binding protein protects against contact hypersensitivity |journal=J. Immunol. |volume=171 |issue= 3 |pages= 1164–71 |year= 2003 |pmid= 12874202 |doi= 10.4049/jimmunol.171.3.1164}}
*{{cite journal | author=Plitz T, Saint-Mézard P, Satho M, ''et al.'' |title=IL-18 binding protein protects against contact hypersensitivity. |journal=J. Immunol. |volume=171 |issue= 3 |pages= 1164-71 |year= 2003 |pmid= 12874202 |doi= }}
*{{cite journal   |vauthors=Fantuzzi G, Banda NK, Guthridge C, etal |title=Generation and characterization of mice transgenic for human IL-18-binding protein isoform a |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 889–96 |year= 2004 |pmid= 12960225 |doi= 10.1189/jlb.0503230 }}
*{{cite journal | author=Fantuzzi G, Banda NK, Guthridge C, ''et al.'' |title=Generation and characterization of mice transgenic for human IL-18-binding protein isoform a. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 889-96 |year= 2004 |pmid= 12960225 |doi= 10.1189/jlb.0503230 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Kawashima M, Novick D, Rubinstein M, Miossec P |title=Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1800–5 |year= 2004 |pmid= 15188356 |doi= 10.1002/art.20320 }}
*{{cite journal  | author=Kawashima M, Novick D, Rubinstein M, Miossec P |title=Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1800-5 |year= 2004 |pmid= 15188356 |doi= 10.1002/art.20320 }}
*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|IL18BP}}
* {{UCSC gene details|IL18BP}}
 
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{{Interleukin receptor modulators}}
 
 
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Revision as of 23:47, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.[1][2]

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[2]

References

  1. ↑ Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777.
  2. ↑ 2.0 2.1 "Entrez Gene: IL18BP interleukin 18 binding protein".

Further reading

External links



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