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{{ | '''InaD-like protein''' is a [[protein]] that in humans is encoded by the ''INADL'' [[gene]].<ref name="pmid9280290">{{cite journal | vauthors = Philipp S, Flockerzi V | title = Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster | journal = FEBS Lett | volume = 413 | issue = 2 | pages = 243–8 | date = Sep 1997 | pmid = 9280290 | pmc = | doi = 10.1016/S0014-5793(97)00877-6 }}</ref><ref name="pmid11374908">{{cite journal | vauthors = Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T | title = Isolation of novel heart-specific genes using the BodyMap database | journal = Genomics | volume = 74 | issue = 1 | pages = 115–20 | date = May 2001 | pmid = 11374908 | pmc = | doi = 10.1006/geno.2001.6527 }}</ref><ref name="entrez"/> | ||
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== Function == | |||
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.<ref name="entrez">{{cite web | title = Entrez Gene: INADL InaD-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10207| accessdate = }}</ref> | |||
== Interactions == | |||
}} | INADL has been shown to [[Protein-protein interaction|interact]] with [[MPP5]].<ref name=pmid11927608>{{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | date = Apr 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }}</ref> | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
*{{cite journal | vauthors = Fanning AS, Anderson JM | title = PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane | journal = J. Clin. Invest. | volume = 103 | issue = 6 | pages = 767–72 | year = 1999 | pmid = 10079096 | pmc = 408156 | doi = 10.1172/JCI6509 }} | |||
*{{cite journal | vauthors = Lennon G, Auffray C, Polymeropoulos M, Soares MB | title = The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression | journal = Genomics | volume = 33 | issue = 1 | pages = 151–2 | year = 1996 | pmid = 8617505 | doi = 10.1006/geno.1996.0177 }} | |||
*{{cite journal | *{{cite journal | vauthors = Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ | title = CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins | journal = Mol. Cell. Neurosci. | volume = 11 | issue = 3 | pages = 161–72 | year = 1998 | pmid = 9647694 | doi = 10.1006/mcne.1998.0679 }} | ||
*{{cite journal | *{{cite journal | vauthors = Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L | title = Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 42122–30 | year = 2001 | pmid = 11509564 | doi = 10.1074/jbc.M104208200 }} | ||
*{{cite journal | *{{cite journal | vauthors = Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E | title = The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16655–61 | year = 2002 | pmid = 11872753 | doi = 10.1074/jbc.M201087200 }} | ||
*{{cite journal | vauthors = Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J. Cell Biol. | volume = 157 | issue = 1 | pages = 161–72 | year = 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }} | |||
*{{cite journal | *{{cite journal | vauthors = Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A | title = hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25408–15 | year = 2002 | pmid = 11964389 | doi = 10.1074/jbc.M202196200 }} | ||
*{{cite journal | vauthors = Roh MH, Liu CJ, Laurinec S, Margolis B | title = The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions | journal = J. Biol. Chem. | volume = 277 | issue = 30 | pages = 27501–9 | year = 2002 | pmid = 12021270 | doi = 10.1074/jbc.M201177200 }} | |||
*{{cite journal | *{{cite journal | vauthors = Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B | title = Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1) | journal = Gene | volume = 302 | issue = 1–2 | pages = 21–9 | year = 2003 | pmid = 12527193 | doi = 10.1016/S0378111902010843 }} | ||
*{{cite journal | *{{cite journal | vauthors = Roh MH, Fan S, Liu CJ, Margolis B | title = The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells | journal = J. Cell Sci. | volume = 116 | issue = Pt 14 | pages = 2895–906 | year = 2004 | pmid = 12771187 | doi = 10.1242/jcs.00500 }} | ||
*{{cite journal | *{{cite journal | vauthors = Li Y, Karnak D, Demeler B, Margolis B, Lavie A | title = Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes | journal = EMBO J. | volume = 23 | issue = 14 | pages = 2723–33 | year = 2005 | pmid = 15241471 | pmc = 514954 | doi = 10.1038/sj.emboj.7600294 }} | ||
*{{cite journal | *{{cite journal | vauthors = Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A | title = PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells | journal = J. Cell Sci. | volume = 118 | issue = Pt 17 | pages = 4049–57 | year = 2005 | pmid = 16129888 | doi = 10.1242/jcs.02528 }} | ||
*{{cite journal | *{{cite journal | vauthors = Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G | title = Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays | journal = J. Am. Chem. Soc. | volume = 128 | issue = 17 | pages = 5913–22 | year = 2007 | pmid = 16637659 | pmc = 2533859 | doi = 10.1021/ja060943h }} | ||
*{{cite journal | vauthors = Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T | title = A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells | journal = Cell | volume = 125 | issue = 3 | pages = 535–48 | year = 2006 | pmid = 16678097 | doi = 10.1016/j.cell.2006.02.045 }} | |||
*{{cite journal | |||
*{{cite journal | |||
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{{refend}} | {{refend}} | ||
{{ | ==External links== | ||
{{ | * {{UCSC genome browser|INADL}} | ||
* {{UCSC gene details|INADL}} | |||
{{PDB Gallery|geneid=10207}} | |||
{{gene-1-stub}} |
Revision as of 20:06, 8 November 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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InaD-like protein is a protein that in humans is encoded by the INADL gene.[1][2][3]
Function
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[3]
Interactions
INADL has been shown to interact with MPP5.[4]
References
- ↑ Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290.
- ↑ Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
- ↑ 3.0 3.1 "Entrez Gene: INADL InaD-like (Drosophila)".
- ↑ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
Further reading
- Fanning AS, Anderson JM (1999). "PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane". J. Clin. Invest. 103 (6): 767–72. doi:10.1172/JCI6509. PMC 408156. PMID 10079096.
- Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
- Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
- Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L (2001). "Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster". J. Biol. Chem. 276 (45): 42122–30. doi:10.1074/jbc.M104208200. PMID 11509564.
- Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons". J. Biol. Chem. 277 (19): 16655–61. doi:10.1074/jbc.M201087200. PMID 11872753.
- Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
- Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". J. Biol. Chem. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
- Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
- Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
- Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
- Li Y, Karnak D, Demeler B, Margolis B, Lavie A (2005). "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes". EMBO J. 23 (14): 2723–33. doi:10.1038/sj.emboj.7600294. PMC 514954. PMID 15241471.
- Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A (2005). "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells". J. Cell Sci. 118 (Pt 17): 4049–57. doi:10.1242/jcs.02528. PMID 16129888.
- Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
- Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006). "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells". Cell. 125 (3): 535–48. doi:10.1016/j.cell.2006.02.045. PMID 16678097.
External links
- INADL human gene location in the UCSC Genome Browser.
- INADL human gene details in the UCSC Genome Browser.
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. |