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{{Infobox_gene}}
{{PBB_Controls
'''SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2''' is an [[enzyme]] that in humans is encoded by the ''INPPL1'' [[gene]].<ref name="pmid8530088">{{cite journal | vauthors = Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE | title = Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases | journal = Genomics | volume = 29 | issue = 1 | pages = 285–7 | date = February 1996 | pmid = 8530088 | pmc = | doi = 10.1006/geno.1995.1247 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3636| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Inositol polyphosphate phosphatase-like 1
| HGNCid = 6080
| Symbol = INPPL1
| AltSymbols =; SHIP2
| OMIM = 600829
| ECnumber = 
| Homologene = 1204
| MGIid = 1333787
| GeneAtlas_image1 = PBB_GE_INPPL1_201598_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004437 |text = inositol or phosphatidylinositol phosphatase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006796 |text = phosphate metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3636
    | Hs_Ensembl = ENSG00000165458
    | Hs_RefseqProtein = NP_001558
    | Hs_RefseqmRNA = NM_001567
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 71580806
    | Hs_GenLoc_end = 71627797
    | Hs_Uniprot = 
    | Mm_EntrezGene = 16332
    | Mm_Ensembl = ENSMUSG00000032737
    | Mm_RefseqmRNA = NM_010567
    | Mm_RefseqProtein = NP_034697
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 101696482
    | Mm_GenLoc_end = 101711897
    | Mm_Uniprot = 
  }}
}}
'''Inositol polyphosphate phosphatase-like 1''', also known as '''INPPL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3636| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.<ref name="entrez">{{cite web | title = Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3636| accessdate = }}</ref>
}}


==References==
INPPL1 has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[BCAR1]],<ref name = pmid11158326>{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1416–28 | date = February 2001 | pmid = 11158326 | pmc = 99593 | doi = 10.1128/MCB.21.4.1416-1428.2001 }}</ref>
==Further reading==
* [[FLNC (gene)|FLNC]],<ref name = pmid11739414>{{cite journal | vauthors = Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA | title = The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin | journal = J. Cell Biol. | volume = 155 | issue = 6 | pages = 1065–79 | date = December 2001 | pmid = 11739414 | pmc = 2150887 | doi = 10.1083/jcb.200104005 }}</ref>
* [[SHC1]],<ref name = pmid10194451>{{cite journal | vauthors = Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B | title = A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells | journal = Blood | volume = 93 | issue = 8 | pages = 2707–20 | date = April 1999 | pmid = 10194451 | doi =  }}</ref><ref name = pmid11349134>{{cite journal | vauthors = Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C | title = The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28348–55 | date = July 2001 | pmid = 11349134 | doi = 10.1074/jbc.M103537200 }}</ref><ref name = pmid9660833>{{cite journal | vauthors = Habib T, Hejna JA, Moses RE, Decker SJ | title = Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18605–9 | date = July 1998 | pmid = 9660833 | doi =  10.1074/jbc.273.29.18605}}</ref> and
* [[SORBS1]].<ref name = pmid12504111>{{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2 | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 2 | pages = 494–500 | date = January 2003 | pmid = 12504111 | doi =  10.1016/s0006-291x(02)02894-2}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Pesesse X, Deleu S, De Smedt F, Drayer L, Erneux C | title = Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 3 | pages = 697–700 | year = 1997 | pmid = 9367831 | doi = 10.1006/bbrc.1997.7538 }}
| citations =
*{{cite journal | vauthors = Habib T, Hejna JA, Moses RE, Decker SJ | title = Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein. | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18605–9 | year = 1998 | pmid = 9660833 | doi = 10.1074/jbc.273.29.18605 }}
*{{cite journal | author=Hejna JA, Saito H, Merkens LS, ''et al.'' |title=Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases. |journal=Genomics |volume=29 |issue= 1 |pages= 285-7 |year= 1996 |pmid= 8530088 |doi= 10.1006/geno.1995.1247 }}
*{{cite journal | vauthors = Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C | title = The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. | journal = FEBS Lett. | volume = 437 | issue = 3 | pages = 301–3 | year = 1998 | pmid = 9824312 | doi = 10.1016/S0014-5793(98)01255-1 }}
*{{cite journal | author=Pesesse X, Deleu S, De Smedt F, ''et al.'' |title=Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 3 |pages= 697-700 |year= 1997 |pmid= 9367831 |doi= 10.1006/bbrc.1997.7538 }}
*{{cite journal | vauthors = Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B | title = A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. | journal = Blood | volume = 93 | issue = 8 | pages = 2707–20 | year = 1999 | pmid = 10194451 | doi =  }}
*{{cite journal | author=Habib T, Hejna JA, Moses RE, Decker SJ |title=Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18605-9 |year= 1998 |pmid= 9660833 |doi= }}
*{{cite journal | vauthors = Bruyns C, Pesesse X, Moreau C, Blero D, Erneux C | title = The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes. | journal = Biol. Chem. | volume = 380 | issue = 7-8 | pages = 969–74 | year = 1999 | pmid = 10494849 | doi = 10.1515/BC.1999.120 }}
*{{cite journal | author=Pesesse X, Moreau C, Drayer AL, ''et al.'' |title=The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. |journal=FEBS Lett. |volume=437 |issue= 3 |pages= 301-3 |year= 1998 |pmid= 9824312 |doi=  }}
*{{cite journal | vauthors = Schurmans S, Carrió R, Behrends J, Pouillon V, Merino J, Clément S | title = The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. | journal = Genomics | volume = 62 | issue = 2 | pages = 260–71 | year = 2000 | pmid = 10610720 | doi = 10.1006/geno.1999.5995 }}
*{{cite journal | author=Wisniewski D, Strife A, Swendeman S, ''et al.'' |title=A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. |journal=Blood |volume=93 |issue= 8 |pages= 2707-20 |year= 1999 |pmid= 10194451 |doi= }}
*{{cite journal | vauthors = Muraille E, Bruhns P, Pesesse X, Daëron M, Erneux C | title = The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. | journal = Immunol. Lett. | volume = 72 | issue = 1 | pages = 7–15 | year = 2000 | pmid = 10789675 | doi = 10.1016/S0165-2478(00)00162-0 }}
*{{cite journal | author=Bruyns C, Pesesse X, Moreau C, ''et al.'' |title=The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes. |journal=Biol. Chem. |volume=380 |issue= 7-8 |pages= 969-74 |year= 1999 |pmid= 10494849 |doi= }}
*{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1416–28 | year = 2001 | pmid = 11158326 | pmc = 99593 | doi = 10.1128/MCB.21.4.1416-1428.2001 }}
*{{cite journal | author=Schurmans S, Carrió R, Behrends J, ''et al.'' |title=The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. |journal=Genomics |volume=62 |issue= 2 |pages= 260-71 |year= 2000 |pmid= 10610720 |doi= 10.1006/geno.1999.5995 }}
*{{cite journal | vauthors = Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M | title = Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. | journal = Mol. Cell. Biol. | volume = 21 | issue = 5 | pages = 1633–46 | year = 2001 | pmid = 11238900 | pmc = 86709 | doi = 10.1128/MCB.21.5.1633-1646.2001 }}
*{{cite journal | author=Muraille E, Bruhns P, Pesesse X, ''et al.'' |title=The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. |journal=Immunol. Lett. |volume=72 |issue= 1 |pages= 7-15 |year= 2000 |pmid= 10789675 |doi= }}
*{{cite journal | vauthors = Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C | title = The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28348–55 | year = 2001 | pmid = 11349134 | doi = 10.1074/jbc.M103537200 }}
*{{cite journal | author=Prasad N, Topping RS, Decker SJ |title=SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1416-28 |year= 2001 |pmid= 11158326 |doi= 10.1128/MCB.21.4.1416-1428.2001 }}
*{{cite journal | vauthors = Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA | title = The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. | journal = J. Cell Biol. | volume = 155 | issue = 6 | pages = 1065–79 | year = 2002 | pmid = 11739414 | pmc = 2150887 | doi = 10.1083/jcb.200104005 }}
*{{cite journal | author=Wada T, Sasaoka T, Funaki M, ''et al.'' |title=Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 5 |pages= 1633-46 |year= 2001 |pmid= 11238900 |doi= 10.1128/MCB.21.5.1633-1646.2001 }}
*{{cite journal | vauthors = Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S | title = The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. | journal = Diabetes | volume = 51 | issue = 7 | pages = 2012–7 | year = 2002 | pmid = 12086927 | doi = 10.2337/diabetes.51.7.2012 }}
*{{cite journal | author=Pesesse X, Dewaste V, De Smedt F, ''et al.'' |title=The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28348-55 |year= 2001 |pmid= 11349134 |doi= 10.1074/jbc.M103537200 }}
*{{cite journal | vauthors = Giuriato S, Blero D, Robaye B, Bruyns C, Payrastre B, Erneux C | title = SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line. | journal = Biochem. Biophys. Res. Commun. | volume = 296 | issue = 1 | pages = 106–10 | year = 2002 | pmid = 12147234 | doi = 10.1016/S0006-291X(02)00787-8 }}
*{{cite journal | author=Dyson JM, O'Malley CJ, Becanovic J, ''et al.'' |title=The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 1065-79 |year= 2002 |pmid= 11739414 |doi= 10.1083/jcb.200104005 }}
*{{cite journal | vauthors = Prasad N, Topping RS, Decker SJ | title = Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. | journal = J. Cell Sci. | volume = 115 | issue = Pt 19 | pages = 3807–15 | year = 2003 | pmid = 12235291 | doi = 10.1242/jcs.00070 }}
*{{cite journal | author=Marion E, Kaisaki PJ, Pouillon V, ''et al.'' |title=The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. |journal=Diabetes |volume=51 |issue= 7 |pages= 2012-7 |year= 2002 |pmid= 12086927 |doi= }}
*{{cite journal | vauthors = Tridandapani S, Wang Y, Marsh CB, Anderson CL | title = Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. | journal = J. Immunol. | volume = 169 | issue = 8 | pages = 4370–8 | year = 2002 | pmid = 12370370 | doi = 10.4049/jimmunol.169.8.4370 }}
*{{cite journal | author=Giuriato S, Blero D, Robaye B, ''et al.'' |title=SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 1 |pages= 106-10 |year= 2002 |pmid= 12147234 |doi= }}
*{{cite journal | vauthors = Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I | title = The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. | journal = Biochem. Biophys. Res. Commun. | volume = 300 | issue = 2 | pages = 494–500 | year = 2003 | pmid = 12504111 | doi = 10.1016/S0006-291X(02)02894-2 }}
*{{cite journal | author=Prasad N, Topping RS, Decker SJ |title=Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I. |journal=J. Cell. Sci. |volume=115 |issue= Pt 19 |pages= 3807-15 |year= 2003 |pmid= 12235291 |doi= }}
*{{cite journal | vauthors = Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC | title = Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 2 | pages = 443–8 | year = 2003 | pmid = 12522270 | pmc = 141014 | doi = 10.1073/pnas.2436191100 }}
*{{cite journal | author=Tridandapani S, Wang Y, Marsh CB, Anderson CL |title=Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells. |journal=J. Immunol. |volume=169 |issue= 8 |pages= 4370-8 |year= 2002 |pmid= 12370370 |doi= }}
*{{cite journal | vauthors = Pengal RA, Ganesan LP, Fang H, Marsh CB, Anderson CL, Tridandapani S | title = SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22657–63 | year = 2003 | pmid = 12690104 | doi = 10.1074/jbc.M302907200 }}
*{{cite journal | author=Vandenbroere I, Paternotte N, Dumont JE, ''et al.'' |title=The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 494-500 |year= 2003 |pmid= 12504111 |doi= }}
*{{cite journal | vauthors = Kaisaki PJ, Delépine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D | title = Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. | journal = Diabetes | volume = 53 | issue = 7 | pages = 1900–4 | year = 2004 | pmid = 15220217 | doi = 10.2337/diabetes.53.7.1900 }}
*{{cite journal | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal | vauthors = Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, Willoughby CE | title = Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract | journal = The American Journal of Human Genetics | volume = 89 | issue = 5 | pages = 628–33 | year = 2011 | pmid = 21996275 | pmc = 3213395 | doi = 10.1016/j.ajhg.2011.09.014 }}
*{{cite journal | author=Pengal RA, Ganesan LP, Fang H, ''et al.'' |title=SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22657-63 |year= 2003 |pmid= 12690104 |doi= 10.1074/jbc.M302907200 }}
*{{cite journal | author=Kaisaki PJ, Delépine M, Woon PY, ''et al.'' |title=Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. |journal=Diabetes |volume=53 |issue= 7 |pages= 1900-4 |year= 2004 |pmid= 15220217 |doi= }}
}}
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Latest revision as of 20:07, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2-domain containing Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 is an enzyme that in humans is encoded by the INPPL1 gene.[1][2]

INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif.[2]

Interactions

INPPL1 has been shown to interact with:

References

  1. ↑ Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE (February 1996). "Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases". Genomics. 29 (1): 285–7. doi:10.1006/geno.1995.1247. PMID 8530088.
  2. ↑ 2.0 2.1 "Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1".
  3. ↑ Prasad N, Topping RS, Decker SJ (February 2001). "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading". Mol. Cell. Biol. 21 (4): 1416–28. doi:10.1128/MCB.21.4.1416-1428.2001. PMC 99593. PMID 11158326.
  4. ↑ Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA (December 2001). "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin". J. Cell Biol. 155 (6): 1065–79. doi:10.1083/jcb.200104005. PMC 2150887. PMID 11739414.
  5. ↑ Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B (April 1999). "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells". Blood. 93 (8): 2707–20. PMID 10194451.
  6. ↑ Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C (July 2001). "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells". J. Biol. Chem. 276 (30): 28348–55. doi:10.1074/jbc.M103537200. PMID 11349134.
  7. ↑ Habib T, Hejna JA, Moses RE, Decker SJ (July 1998). "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein". J. Biol. Chem. 273 (29): 18605–9. doi:10.1074/jbc.273.29.18605. PMID 9660833.
  8. ↑ Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I (January 2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2". Biochem. Biophys. Res. Commun. 300 (2): 494–500. doi:10.1016/s0006-291x(02)02894-2. PMID 12504111.

Further reading

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