LIN7C: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Lin-7 homolog C''' is a [[protein]] that in humans is encoded by the ''LIN7C'' [[gene]].<ref name="pmid10341223">{{cite journal | vauthors = Jo K, Derin R, Li M, Bredt DS | title = Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex | journal = J Neurosci | volume = 19 | issue = 11 | pages = 4189–99 | date = Jun 1999 | pmid = 10341223 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LIN7C lin-7 homolog C (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55327| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_LIN7C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dkr.
| PDB = {{PDB2|2dkr}}
| Name = Lin-7 homolog C (C. elegans)
| HGNCid = 17789
| Symbol = LIN7C
| AltSymbols =; FLJ11215; LIN-7-C; LIN-7C; MALS-3; VELI3
| OMIM = 
| ECnumber = 
| Homologene = 22649
| MGIid = 1330839
| GeneAtlas_image1 = PBB_GE_LIN7C_219399_at_tn.png
| GeneAtlas_image2 = PBB_GE_LIN7C_221568_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55327
    | Hs_Ensembl = ENSG00000148943
    | Hs_RefseqProtein = NP_060832
    | Hs_RefseqmRNA = NM_018362
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 27472700
    | Hs_GenLoc_end = 27484879
    | Hs_Uniprot = Q9NUP9
    | Mm_EntrezGene = 22343
    | Mm_Ensembl = ENSMUSG00000027162
    | Mm_RefseqmRNA = NM_011699
    | Mm_RefseqProtein = NP_035829
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 109691707
    | Mm_GenLoc_end = 109701815
    | Mm_Uniprot = Q3TS99
  }}
}}
'''Lin-7 homolog C (C. elegans)''', also known as '''LIN7C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LIN7C lin-7 homolog C (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55327| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
LIN7C has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[DLG1]],<ref name = pmid14960569/>
| section_title =  
* [[KCNJ12]],<ref name = pmid14960569/><ref name = pmid15024025/> and
| summary_text =  
* [[KCNJ4]].<ref name = pmid14960569>{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}</ref><ref name = pmid15024025>{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist|2}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P | title = Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach | journal = EMBO J. | volume = 21 | issue = 10 | pages = 2332–42 | year = 2002 | pmid = 12006486 | pmc = 126011 | doi = 10.1093/emboj/21.10.2332 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hori K, Konno D, Maruoka H, Sobue K | title = MALS is a binding partner of IRSp53 at cell-cell contacts | journal = FEBS Lett. | volume = 554 | issue = 1–2 | pages = 30–4 | year = 2003 | pmid = 14596909 | doi = 10.1016/S0014-5793(03)01074-3 }}
*{{cite journal  | author=Jo K, Derin R, Li M, Bredt DS |title=Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. |journal=J. Neurosci. |volume=19 |issue= 11 |pages= 4189-99 |year= 1999 |pmid= 10341223 |doi=  }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | year = 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
*{{cite journal | author=Bécamel C, Alonso G, Galéotti N, ''et al.'' |title=Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. |journal=EMBO J. |volume=21 |issue= 10 |pages= 2332-42 |year= 2002 |pmid= 12006486 |doi= 10.1093/emboj/21.10.2332 }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | year = 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA | title = A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes | journal = J. Biol. Chem. | volume = 280 | issue = 46 | pages = 38528–36 | year = 2006 | pmid = 16147993 | doi = 10.1074/jbc.M506536200 }}
*{{cite journal  | author=Hori K, Konno D, Maruoka H, Sobue K |title=MALS is a binding partner of IRSp53 at cell-cell contacts. |journal=FEBS Lett. |volume=554 |issue= 1-2 |pages= 30-4 |year= 2003 |pmid= 14596909 |doi= }}
* {{cite journal | vauthors = Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF | title = The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria | journal = J. Biol. Chem. | volume = 280 | issue = 49 | pages = 40892–900 | year = 2006 | pmid = 16192275 | doi = 10.1074/jbc.M506623200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Bohl J, Brimer N, Lyons C, Vande Pol SB | title = The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions | journal = J. Biol. Chem. | volume = 282 | issue = 13 | pages = 9392–400 | year = 2007 | pmid = 17237226 | doi = 10.1074/jbc.M610002200 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Radeke CM, ''et al.'' |title=A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19051-63 |year= 2004 |pmid= 14960569 |doi= 10.1074/jbc.M400284200 }}
* {{cite journal | vauthors = Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H | title = Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma | journal = Cancer Res. | volume = 67 | issue = 20 | pages = 9643–8 | year = 2007 | pmid = 17942893 | doi = 10.1158/0008-5472.CAN-07-1911 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Anderson S, ''et al.'' |title=Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22331-46 |year= 2004 |pmid= 15024025 |doi= 10.1074/jbc.M400285200 }}
*{{cite journal | author=Petrosky KY, Ou HD, Löhr F, ''et al.'' |title=A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38528-36 |year= 2006 |pmid= 16147993 |doi= 10.1074/jbc.M506536200 }}
*{{cite journal | author=Mendes CC, Gomes DA, Thompson M, ''et al.'' |title=The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40892-900 |year= 2006 |pmid= 16192275 |doi= 10.1074/jbc.M506623200 }}
*{{cite journal | author=Bohl J, Brimer N, Lyons C, Vande Pol SB |title=The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9392-400 |year= 2007 |pmid= 17237226 |doi= 10.1074/jbc.M610002200 }}
*{{cite journal | author=Onda T, Uzawa K, Nakashima D, ''et al.'' |title=Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma. |journal=Cancer Res. |volume=67 |issue= 20 |pages= 9643-8 |year= 2007 |pmid= 17942893 |doi= 10.1158/0008-5472.CAN-07-1911 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Latest revision as of 17:58, 2 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.[1][2]

Interactions

LIN7C has been shown to interact with:

References

  1. ↑ Jo K, Derin R, Li M, Bredt DS (Jun 1999). "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex". J Neurosci. 19 (11): 4189–99. PMID 10341223.
  2. ↑ "Entrez Gene: LIN7C lin-7 homolog C (C. elegans)".
  3. ↑ 3.0 3.1 3.2 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  4. ↑ 4.0 4.1 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P (2002). "Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach". EMBO J. 21 (10): 2332–42. doi:10.1093/emboj/21.10.2332. PMC 126011. PMID 12006486.
  • Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909.
  • Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  • Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  • Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA (2006). "A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes". J. Biol. Chem. 280 (46): 38528–36. doi:10.1074/jbc.M506536200. PMID 16147993.
  • Mendes CC, Gomes DA, Thompson M, Souto NC, Goes TS, Goes AM, Rodrigues MA, Gomez MV, Nathanson MH, Leite MF (2006). "The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria". J. Biol. Chem. 280 (49): 40892–900. doi:10.1074/jbc.M506623200. PMID 16192275.
  • Bohl J, Brimer N, Lyons C, Vande Pol SB (2007). "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions". J. Biol. Chem. 282 (13): 9392–400. doi:10.1074/jbc.M610002200. PMID 17237226.
  • Onda T, Uzawa K, Nakashima D, Saito K, Iwadate Y, Seki N, Shibahara T, Tanzawa H (2007). "Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma". Cancer Res. 67 (20): 9643–8. doi:10.1158/0008-5472.CAN-07-1911. PMID 17942893.


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