M-RIP: Difference between revisions

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{{Infobox_gene}}
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'''Myosin phosphatase Rho-interacting protein''' is an [[enzyme]] that in humans is encoded by the ''MPRIP'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 6 | pages = 355–64 | date = May 1999 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23164| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Myosin phosphatase-Rho interacting protein
| HGNCid = 
| Symbol = M-RIP
| AltSymbols =; KIAA0864; RHOIP3; p116Rip
| OMIM = 
| ECnumber = 
| Homologene = 9034
| MGIid = 1349438
| GeneAtlas_image1 = PBB_GE_M-RIP_212197_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_M-RIP_214694_at_tn.png
| GeneAtlas_image3 = PBB_GE_M-RIP_214771_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23164
    | Hs_Ensembl = ENSG00000133030
    | Hs_RefseqProtein = NP_055949
    | Hs_RefseqmRNA = NM_015134
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 16886832
    | Hs_GenLoc_end = 17029612
    | Hs_Uniprot = Q6WCQ1
    | Mm_EntrezGene = 26936
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_012027
    | Mm_RefseqProtein = NP_036157
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Myosin phosphatase-Rho interacting protein''', also known as '''M-RIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23164| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
M-RIP has been shown to [[Protein-protein interaction|interact]] with [[RHOA]].<ref name=pmid9199174>{{cite journal | vauthors = Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH | title = Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology | journal = J. Cell Biol. | volume = 137 | issue = 7 | pages = 1603–13 | date = Jun 1997 | pmid = 9199174 | pmc = 2137826 | doi = 10.1083/jcb.137.7.1603 }}</ref>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery. | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH | title = Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. | journal = J. Cell Biol. | volume = 137 | issue = 7 | pages = 1603–13 | year = 1997 | pmid = 9199174 | pmc = 2137826 | doi = 10.1083/jcb.137.7.1603 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Surks HK, Richards CT, Mendelsohn ME | title = Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51484–93 | year = 2004 | pmid = 14506264 | doi = 10.1074/jbc.M305622200 }}
*{{cite journal | author=Gebbink MF, Kranenburg O, Poland M, ''et al.'' |title=Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. |journal=J. Cell Biol. |volume=137 |issue= 7 |pages= 1603-13 |year= 1997 |pmid= 9199174 |doi=  }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi= }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mulder J, Ariaens A, van den Boomen D, Moolenaar WH | title = p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. | journal = Mol. Biol. Cell | volume = 15 | issue = 12 | pages = 5516–27 | year = 2005 | pmid = 15469989 | pmc = 532030 | doi = 10.1091/mbc.E04-04-0275 }}
*{{cite journal | author=Surks HK, Richards CT, Mendelsohn ME |title=Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51484-93 |year= 2004 |pmid= 14506264 |doi= 10.1074/jbc.M305622200 }}
* {{cite journal | vauthors = Koga Y, Ikebe M | title = p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. | journal = J. Biol. Chem. | volume = 280 | issue = 6 | pages = 4983–91 | year = 2005 | pmid = 15545284 | doi = 10.1074/jbc.M410909200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
* {{cite journal | vauthors = Surks HK, Riddick N, Ohtani K | title = M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. | journal = J. Biol. Chem. | volume = 280 | issue = 52 | pages = 42543–51 | year = 2006 | pmid = 16257966 | doi = 10.1074/jbc.M506863200 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Mulder J, Ariaens A, van den Boomen D, Moolenaar WH |title=p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5516-27 |year= 2005 |pmid= 15469989 |doi= 10.1091/mbc.E04-04-0275 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry. | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Koga Y, Ikebe M |title=p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4983-91 |year= 2005 |pmid= 15545284 |doi= 10.1074/jbc.M410909200 }}
*{{cite journal | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Surks HK, Riddick N, Ohtani K |title=M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42543-51 |year= 2006 |pmid= 16257966 |doi= 10.1074/jbc.M506863200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 02:28, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene.[1][2]

Interactions

M-RIP has been shown to interact with RHOA.[3]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  2. ↑ "Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein".
  3. ↑ Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (Jun 1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7): 1603–13. doi:10.1083/jcb.137.7.1603. PMC 2137826. PMID 9199174.

Further reading


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