MAL2 (gene): Difference between revisions

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{{Infobox_gene}}
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'''Protein MAL2''' is a [[protein]] that in humans is encoded by the ''MAL2'' [[gene]].<ref name="pmid11549320">{{cite journal |vauthors=Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA | title = Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system | journal = Genomics | volume = 76 | issue = 1–3 | pages = 81–8 |date=Sep 2001 | pmid = 11549320 | pmc =  | doi = 10.1006/geno.2001.6610 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mal, T-cell differentiation protein 2
| HGNCid = 13634
| Symbol = MAL2
| AltSymbols =;
| OMIM = 609684
| ECnumber =
| Homologene = 14167
| MGIid = 2146021
  | GeneAtlas_image1 = PBB_GE_MAL2_gnf1h01194_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAL2_gnf1h01195_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114569
    | Hs_Ensembl = ENSG00000147676
    | Hs_RefseqProtein = NP_443118
    | Hs_RefseqmRNA = NM_052886
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 120289893
    | Hs_GenLoc_end = 120327090
    | Hs_Uniprot = Q969L2
    | Mm_EntrezGene = 105853
    | Mm_Ensembl = ENSMUSG00000024479
    | Mm_RefseqmRNA = NM_178920
    | Mm_RefseqProtein = NP_849251
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 54401568
    | Mm_GenLoc_end = 54432921
    | Mm_Uniprot = Q2KHK7
  }}
}}
'''Mal, T-cell differentiation protein 2''', also known as '''MAL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.<ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref>
| summary_text = This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.<ref name="entrez">{{cite web | title = Entrez Gene: MAL2 mal, T-cell differentiation protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114569| accessdate = }}</ref>
}}
}}
==Interactions==
MAL2 (gene) has been shown to [[Protein-protein interaction|interact]] with [[TPD52]].<ref name=pmid11549320 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Marazuela M, Alonso MA |title=Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue. |journal=Histol. Histopathol. |volume=19 |issue= 3 |pages= 925-33 |year= 2004 |pmid= 15168355 |doi=  }}
*{{cite journal  |vauthors=Marazuela M, Alonso MA |title=Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue |journal=Histol. Histopathol. |volume=19 |issue= 3 |pages= 925–33 |year= 2004 |pmid= 15168355 |doi=  }}
*{{cite journal | author=Rohan S, Tu JJ, Kao J, ''et al.'' |title=Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6937-45 |year= 2007 |pmid= 17145811 |doi= 10.1158/1078-0432.CCR-06-1268 }}
*{{cite journal   |vauthors=Rohan S, Tu JJ, Kao J, etal |title=Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6937–45 |year= 2007 |pmid= 17145811 |doi= 10.1158/1078-0432.CCR-06-1268 }}
*{{cite journal  | author=Barbaric D, Byth K, Dalla-Pozza L, Byrne JA |title=Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. |journal=Leuk. Res. |volume=30 |issue= 11 |pages= 1355-63 |year= 2007 |pmid= 16620967 |doi= 10.1016/j.leukres.2006.03.009 }}
*{{cite journal  |vauthors=Barbaric D, Byth K, Dalla-Pozza L, Byrne JA |title=Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations |journal=Leuk. Res. |volume=30 |issue= 11 |pages= 1355–63 |year= 2007 |pmid= 16620967 |doi= 10.1016/j.leukres.2006.03.009 }}
*{{cite journal  | author=de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA |title=Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells. |journal=Traffic |volume=7 |issue= 1 |pages= 61-73 |year= 2006 |pmid= 16445687 |doi= 10.1111/j.1600-0854.2005.00361.x }}
*{{cite journal  |vauthors=de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA |title=Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells |journal=Traffic |volume=7 |issue= 1 |pages= 61–73 |year= 2006 |pmid= 16445687 |doi= 10.1111/j.1600-0854.2005.00361.x }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Llorente A, de Marco MC, Alonso MA |title=Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. |journal=J. Cell. Sci. |volume=117 |issue= Pt 22 |pages= 5343-51 |year= 2005 |pmid= 15466889 |doi= 10.1242/jcs.01420 }}
*{{cite journal  |vauthors=Llorente A, de Marco MC, Alonso MA |title=Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line |journal=J. Cell Sci. |volume=117 |issue= Pt 22 |pages= 5343–51 |year= 2005 |pmid= 15466889 |doi= 10.1242/jcs.01420 }}
*{{cite journal | author=Marazuela M, Acevedo A, García-López MA, ''et al.'' |title=Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia. |journal=J. Histochem. Cytochem. |volume=52 |issue= 2 |pages= 243-52 |year= 2004 |pmid= 14729876 |doi=  }}
*{{cite journal   |vauthors=Marazuela M, Acevedo A, García-López MA, etal |title=Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia |journal=J. Histochem. Cytochem. |volume=52 |issue= 2 |pages= 243–52 |year= 2004 |pmid= 14729876 |doi=  10.1177/002215540405200212}}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Marazuela M, Martín-Belmonte F, García-López MA, ''et al.'' |title=Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells. |journal=Endocrinology |volume=145 |issue= 2 |pages= 1011-6 |year= 2004 |pmid= 14576188 |doi= 10.1210/en.2003-0652 }}
*{{cite journal   |vauthors=Marazuela M, Martín-Belmonte F, García-López MA, etal |title=Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells |journal=Endocrinology |volume=145 |issue= 2 |pages= 1011–6 |year= 2004 |pmid= 14576188 |doi= 10.1210/en.2003-0652 }}
*{{cite journal  | author=Boutros R, Bailey AM, Wilson SH, Byrne JA |title=Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. |journal=J. Mol. Biol. |volume=332 |issue= 3 |pages= 675-87 |year= 2003 |pmid= 12963375 |doi=  }}
*{{cite journal  |vauthors=Boutros R, Bailey AM, Wilson SH, Byrne JA |title=Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins |journal=J. Mol. Biol. |volume=332 |issue= 3 |pages= 675–87 |year= 2003 |pmid= 12963375 |doi=10.1016/S0022-2836(03)00944-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=de Marco MC, Martín-Belmonte F, Kremer L, ''et al.'' |title=MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. |journal=J. Cell Biol. |volume=159 |issue= 1 |pages= 37-44 |year= 2002 |pmid= 12370246 |doi= 10.1083/jcb.200206033 }}
*{{cite journal   |vauthors=de Marco MC, Martín-Belmonte F, Kremer L, etal |title=MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells |journal=J. Cell Biol. |volume=159 |issue= 1 |pages= 37–44 |year= 2002 |pmid= 12370246 |doi= 10.1083/jcb.200206033  | pmc=2173496 }}
*{{cite journal | author=Wilson SH, Bailey AM, Nourse CR, ''et al.'' |title=Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. |journal=Genomics |volume=76 |issue= 1-3 |pages= 81-8 |year= 2001 |pmid= 11549320 |doi= 10.1006/geno.2001.6610 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:16, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.[1][2]

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.[2]

Interactions

MAL2 (gene) has been shown to interact with TPD52.[1]

References

  1. ↑ 1.0 1.1 Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (Sep 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
  2. ↑ 2.0 2.1 "Entrez Gene: MAL2 mal, T-cell differentiation protein 2".

Further reading



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