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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mastermind-like protein 1''' is a [[protein]] that in humans is encoded by the ''MAML1'' [[gene]].<ref name="pmid11101851">{{cite journal | vauthors = Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD | title = MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors | journal = Nat Genet | volume = 26 | issue = 4 | pages = 484–9 | date = Dec 2000 | pmid = 11101851 | pmc =  | doi = 10.1038/82644 }}</ref><ref name="pmid11390662">{{cite journal | vauthors = Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K | title = A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters | journal = Mol Cell Biol | volume = 21 | issue = 13 | pages = 4337–46 | date = Jun 2001 | pmid = 11390662 | pmc = 87094 | doi = 10.1128/MCB.21.13.4337-4346.2001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAML1 mastermind-like 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9794| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAML1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2f8x.
| PDB = {{PDB2|2f8x}}
| Name = Mastermind-like 1 (Drosophila)
| HGNCid = 13632
| Symbol = MAML1
| AltSymbols =; KIAA0200; Mam-1; Mam1
| OMIM = 605424
| ECnumber = 
| Homologene = 8845
| MGIid = 1890504
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9794
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001126853
    | Hs_RefseqmRNA = XM_001126853
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 103806
    | Mm_Ensembl = ENSMUSG00000050567
    | Mm_RefseqmRNA = NM_175334
    | Mm_RefseqProtein = NP_780543
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 50099057
    | Mm_GenLoc_end = 50135739
    | Mm_Uniprot = Q6T264
  }}
}}
'''Mastermind-like 1 (Drosophila)''', also known as '''MAML1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAML1 mastermind-like 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9794| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.<ref name="entrez">{{cite web | title = Entrez Gene: MAML1 mastermind-like 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9794| accessdate = }}</ref>
}}


==References==
Details on the activity of the N-terminal domain of Mastermind-like protein 1
{{reflist|2}}
may be found under [[MamL-1 domain|MamL-1]].
==Further reading==
 
== Interactions ==
 
MAML1 has been shown to [[Protein-protein interaction|interact]] with [[EP300]]<ref name=pmid12391150>{{cite journal | vauthors = Wallberg AE, Pedersen K, Lendahl U, Roeder RG | title = p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro | journal = Mol. Cell. Biol. | volume = 22 | issue = 22 | pages = 7812–9 | date = Nov 2002 | pmid = 12391150 | pmc = 134732 | doi = 10.1128/MCB.22.22.7812-7819.2002 }}</ref><ref name=pmid12050117>{{cite journal | vauthors = Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA | title = Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex | journal = Genes Dev. | volume = 16 | issue = 11 | pages = 1397–411 | date = Jun 2002 | pmid = 12050117 | pmc = 186317 | doi = 10.1101/gad.991602 }}</ref> and [[NOTCH1]].<ref name=pmid11101851 /><ref name=pmid12370315>{{cite journal | vauthors = Wu L, Sun T, Kobayashi K, Gao P, Griffin JD | title = Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors | journal = Mol. Cell. Biol. | volume = 22 | issue = 21 | pages = 7688–700 | date = Nov 2002 | pmid = 12370315 | pmc = 135662 | doi = 10.1128/MCB.22.21.7688-7700.2002 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Alves-Guerra MC, Ronchini C, Capobianco AJ | title = Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. | journal = Cancer Res. | volume = 67 | issue = 18 | pages = 8690–8 | year = 2007 | pmid = 17875709 | doi = 10.1158/0008-5472.CAN-07-1720 }}
| citations =
* {{cite journal | vauthors = Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V | title = The notch regulator MAML1 interacts with p53 and functions as a coactivator. | journal = J. Biol. Chem. | volume = 282 | issue = 16 | pages = 11969–81 | year = 2007 | pmid = 17317671 | doi = 10.1074/jbc.M608974200 }}
*{{cite journal | author=Alves-Guerra MC, Ronchini C, Capobianco AJ |title=Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. |journal=Cancer Res. |volume=67 |issue= 18 |pages= 8690-8 |year= 2007 |pmid= 17875709 |doi= 10.1158/0008-5472.CAN-07-1720 }}
* {{cite journal | vauthors = Nam Y, Sliz P, Song L, Aster JC, Blacklow SC | title = Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. | journal = Cell | volume = 124 | issue = 5 | pages = 973–83 | year = 2006 | pmid = 16530044 | doi = 10.1016/j.cell.2005.12.037 }}
*{{cite journal | author=Zhao Y, Katzman RB, Delmolino LM, ''et al.'' |title=The notch regulator MAML1 interacts with p53 and functions as a coactivator. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 11969-81 |year= 2007 |pmid= 17317671 |doi= 10.1074/jbc.M608974200 }}
* {{cite journal | vauthors = Fryer CJ, White JB, Jones KA | title = Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. | journal = Mol. Cell | volume = 16 | issue = 4 | pages = 509–20 | year = 2005 | pmid = 15546612 | doi = 10.1016/j.molcel.2004.10.014 }}
*{{cite journal | author=Nam Y, Sliz P, Song L, ''et al.'' |title=Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. |journal=Cell |volume=124 |issue= 5 |pages= 973-83 |year= 2006 |pmid= 16530044 |doi= 10.1016/j.cell.2005.12.037 }}
* {{cite journal | vauthors = Nam Y, Weng AP, Aster JC, Blacklow SC | title = Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. | journal = J. Biol. Chem. | volume = 278 | issue = 23 | pages = 21232–9 | year = 2003 | pmid = 12644465 | doi = 10.1074/jbc.M301567200 }}
*{{cite journal | author=Fryer CJ, White JB, Jones KA |title=Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 509-20 |year= 2005 |pmid= 15546612 |doi= 10.1016/j.molcel.2004.10.014 }}
* {{cite journal | vauthors = Wallberg AE, Pedersen K, Lendahl U, Roeder RG | title = p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. | journal = Mol. Cell. Biol. | volume = 22 | issue = 22 | pages = 7812–9 | year = 2002 | pmid = 12391150 | pmc = 134732 | doi = 10.1128/MCB.22.22.7812-7819.2002 }}
*{{cite journal | author=Nam Y, Weng AP, Aster JC, Blacklow SC |title=Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. |journal=J. Biol. Chem. |volume=278 |issue= 23 |pages= 21232-9 |year= 2003 |pmid= 12644465 |doi= 10.1074/jbc.M301567200 }}
* {{cite journal | vauthors = Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M | title = Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50612–20 | year = 2003 | pmid = 12386158 | doi = 10.1074/jbc.M209529200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA | title = Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. | journal = Genes Dev. | volume = 16 | issue = 11 | pages = 1397–411 | year = 2002 | pmid = 12050117 | pmc = 186317 | doi = 10.1101/gad.991602 }}
*{{cite journal  | author=Wallberg AE, Pedersen K, Lendahl U, Roeder RG |title=p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 7812-9 |year= 2002 |pmid= 12391150 |doi= }}
* {{cite journal | vauthors = Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J | title = SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. | journal = Mol. Cell. Biol. | volume = 21 | issue = 21 | pages = 7403–15 | year = 2001 | pmid = 11585921 | pmc = 99913 | doi = 10.1128/MCB.21.21.7403-7415.2001 }}
*{{cite journal | author=Lin SE, Oyama T, Nagase T, ''et al.'' |title=Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50612-20 |year= 2003 |pmid= 12386158 |doi= 10.1074/jbc.M209529200 }}
*{{cite journal | author=Fryer CJ, Lamar E, Turbachova I, ''et al.'' |title=Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1397-411 |year= 2002 |pmid= 12050117 |doi= 10.1101/gad.991602 }}
*{{cite journal | author=Wu G, Lyapina S, Das I, ''et al.'' |title=SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7403-15 |year= 2001 |pmid= 11585921 |doi= 10.1128/MCB.21.21.7403-7415.2001 }}
*{{cite journal  | author=Kitagawa M, Oyama T, Kawashima T, ''et al.'' |title=A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4337-46 |year= 2001 |pmid= 11390662 |doi= 10.1128/MCB.21.13.4337-4346.2001 }}
*{{cite journal  | author=Wu L, Aster JC, Blacklow SC, ''et al.'' |title=MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. |journal=Nat. Genet. |volume=26 |issue= 4 |pages= 484-9 |year= 2001 |pmid= 11101851 |doi= 10.1038/82644 }}
*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 (supplement). |journal=DNA Res. |volume=3 |issue= 1 |pages= 43-53 |year= 1996 |pmid= 8724853 |doi=  }}
*{{cite journal  | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17-24 |year= 1996 |pmid= 8724849 |doi=  }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9794}}


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Latest revision as of 06:03, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[1][2][3]

Function

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[3]

Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.

Interactions

MAML1 has been shown to interact with EP300[4][5] and NOTCH1.[1][6]

References

  1. ↑ 1.0 1.1 Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851.
  2. ↑ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC 87094. PMID 11390662.
  3. ↑ 3.0 3.1 "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)".
  4. ↑ Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
  5. ↑ Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
  6. ↑ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.

Further reading


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