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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitogen-activated protein kinase scaffold protein 1''' is a scaffold protein that in humans is encoded by the ''MAPKSP1'' [[gene]].<ref name="pmid9733512">{{cite journal | vauthors = Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ | title = MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade | journal = Science | volume = 281 | issue = 5383 | pages = 1668–71  | date = Oct 1998 | pmid = 9733512 | pmc =  | doi = 10.1126/science.281.5383.1668 }}</ref><ref name="pmid15016825">{{cite journal | vauthors = Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M | title = The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling | journal = J. Biol. Chem. | volume = 279 | issue = 22 | pages = 23422–30  | date = May 2004 | pmid = 15016825 | pmc = | doi = 10.1074/jbc.M401648200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8649| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAP2K1IP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1sko.
| PDB = {{PDB2|1sko}}, {{PDB2|1vet}}, {{PDB2|1veu}}
| Name = Mitogen-activated protein kinase kinase 1 interacting protein 1
| HGNCid = 15606
| Symbol = MAP2K1IP1
| AltSymbols =; MP1
| OMIM = 603296
| ECnumber = 
| Homologene = 10539
| MGIid = 
| GeneAtlas_image1 = PBB_GE_MAP2K1IP1_217971_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8649
    | Hs_Ensembl = ENSG00000109270
    | Hs_RefseqProtein = NP_068805
    | Hs_RefseqmRNA = NM_021970
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 101021279
    | Hs_GenLoc_end = 101034617
    | Hs_Uniprot = Q9UHA4
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Mitogen-activated protein kinase kinase 1 interacting protein 1''', also known as '''MAP2K1IP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8649| accessdate = }}</ref>. It was initially called MP1 (MEK1 binding Partner 1) when it was isolated in a yeast two hybrid screen using MEK1 as a bait <ref> MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ. Science. 1998 Sep 11;281(5383):1668-71.</ref>. Subsequently Huber and colleagues found that a late endosomal/lysosome enriched protein of 14 kDa (p14) interacted with MP1<ref>Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA. 2001.A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol. 2001 Feb 19;152(4):765-76.</ref> and this interaction is required for localizing this dimer to late endosome <ref> Teis D, Wunderlich W, Huber LA.2002. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell. 2002 Dec;3(6):803-14.</ref>. Binding of MP1 to p14 is of high affinity (~12nM)<ref>Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.2004. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9.</ref>. The crystal structure of MP1/p14 dimer has been solved by two independent groups <ref> Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M. The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. 2004 . J Biol Chem. May 28;279(22):23422-30. Epub 2004 Mar 11.</ref> <ref> Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T..2004. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9</ref>.  MP1/p14 complex appears necessary for EGF mediated activation of ERK <ref>Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.2005.The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol. 2005 Jun;25(12):5119-33</ref><ref>Teis D, Wunderlich W, Huber LA.2002. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell. 2002 Dec;3(6):803-14.</ref>.Further, MP1 is required for efficient cell spreading on fibronectin.  During acute cell spreading MP1 appears to downregulate Rho GTPase activity necessary for remodeling focal adhesions and membrane production at the leading edge<ref>Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.2005.The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol. 2005 Jun;25(12):5119-33</ref>.


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene was identified as an interacting protein that binds specifically to [[MAP kinase kinase]] [[MAP2K1|MAP2K1/MEK1]] and to [[MAP kinase]] [[MAPK2]]/[[ERK1]]. This protein enhances the activation of [[MAPK2]], and thus is thought to function as an adaptor to enhance the efficiency of the [[MAPK/ERK pathway#Kinase cascade|MAP kinase cascade]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.<ref name="entrez">{{cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8649| accessdate = }}</ref>
}}


== '''Researchers who work on MP1''' ==
== Interactions ==


Hans J-Schaeffer
MAP2K1IP1 has been shown to [[Protein-protein interaction|interact]] with [[MAP2K1]].<ref name=pmid9733512 /><ref name=pmid11266467>{{cite journal | vauthors = Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA | title = A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment | journal = J. Cell Biol. | volume = 152 | issue = 4 | pages = 765–76  | date = Feb 2001 | pmid = 11266467 | pmc = 2195784 | doi = 10.1083/jcb.152.4.765 }}</ref>
Andrew D. Catling
 
Ashok Pullikuth
== References ==
Tomas Vomastek
{{reflist}}
M. Cygler
 
D. Teis
== Further reading ==
V.V. Lunin
M.Sacher
Lukas A Huber
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K | title = Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway | journal = Exp. Hematol. | volume = 27 | issue = 10 | pages = 1542–7 | year = 1999 | pmid = 10517496 | doi = 10.1016/S0301-472X(99)00094-6 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA | title = A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment | journal = J. Cell Biol. | volume = 152 | issue = 4 | pages = 765–76 | year = 2001 | pmid = 11266467 | pmc = 2195784 | doi = 10.1083/jcb.152.4.765 }}
*{{cite journal | author=Schaeffer HJ, Catling AD, Eblen ST, ''et al.'' |title=MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. |journal=Science |volume=281 |issue= 5383 |pages= 1668-71 |year= 1998 |pmid= 9733512 |doi= }}
* {{cite journal | vauthors = Teis D, Wunderlich W, Huber LA | title = Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction | journal = Dev. Cell | volume = 3 | issue = 6 | pages = 803–14 | year = 2002 | pmid = 12479806 | doi = 10.1016/S1534-5807(02)00364-7 }}
*{{cite journal | author=Okabe S, Tauchi T, Morita H, ''et al.'' |title=Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. |journal=Exp. Hematol. |volume=27 |issue= 10 |pages= 1542-7 |year= 1999 |pmid= 10517496 |doi= }}
* {{cite journal | vauthors = Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y | title = Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 47089–97 | year = 2003 | pmid = 12975377 | doi = 10.1074/jbc.M306002200 }}
*{{cite journal | author=Wunderlich W, Fialka I, Teis D, ''et al.'' |title=A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. |journal=J. Cell Biol. |volume=152 |issue= 4 |pages= 765-76 |year= 2001 |pmid= 11266467 |doi= }}
* {{cite journal | vauthors = Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF | title = The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins | journal = Biochem. J. | volume = 378 | issue = Pt 2 | pages = 353–62 | year = 2004 | pmid = 14611647 | pmc = 1223961 | doi = 10.1042/BJ20030786 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ | title = Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 18 | pages = 6981–6 | year = 2004 | pmid = 15118098 | pmc = 406452 | doi = 10.1073/pnas.0305894101 }}
*{{cite journal | author=Teis D, Wunderlich W, Huber LA |title=Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. |journal=Dev. Cell |volume=3 |issue= 6 |pages= 803-14 |year= 2003 |pmid= 12479806 |doi= }}
* {{cite journal | vauthors = Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T | title = Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 30 | pages = 10984–9 | year = 2004 | pmid = 15263099 | pmc = 503730 | doi = 10.1073/pnas.0403435101 }}
*{{cite journal | author=Channavajhala PL, Wu L, Cuozzo JW, ''et al.'' |title=Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47089-97 |year= 2004 |pmid= 12975377 |doi= 10.1074/jbc.M306002200 }}
* {{cite journal | vauthors = Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ | title = MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling | journal = J. Cell. Biochem. | volume = 94 | issue = 4 | pages = 708–19 | year = 2005 | pmid = 15547943 | doi = 10.1002/jcb.20344 }}
*{{cite journal | author=Paces-Fessy M, Boucher D, Petit E, ''et al.'' |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353-62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786 }}
* {{cite journal | vauthors = Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD | title = The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals | journal = Mol. Cell. Biol. | volume = 25 | issue = 12 | pages = 5119–33 | year = 2005 | pmid = 15923628 | pmc = 1140582 | doi = 10.1128/MCB.25.12.5119-5133.2005 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Villegas SN, Njaine B, Linden R, Carri NG | title = Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways | journal = Brain Res. Bull. | volume = 71 | issue = 1-3 | pages = 116–26 | year = 2006 | pmid = 17113937 | doi = 10.1016/j.brainresbull.2006.08.014 }}
*{{cite journal | author=Lunin VV, Munger C, Wagner J, ''et al.'' |title=The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23422-30 |year= 2004 |pmid= 15016825 |doi= 10.1074/jbc.M401648200 }}
* {{cite journal | vauthors = Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA | title = p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis | journal = J. Cell Biol. | volume = 175 | issue = 6 | pages = 861–8 | year = 2006 | pmid = 17178906 | pmc = 2064696 | doi = 10.1083/jcb.200607025 }}
*{{cite journal | author=Vomastek T, Schaeffer HJ, Tarcsafalvi A, ''et al.'' |title=Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 6981-6 |year= 2004 |pmid= 15118098 |doi= 10.1073/pnas.0305894101 }}
* {{cite journal | vauthors = Brahma A, Dalby KN | title = Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer | journal = Arch. Biochem. Biophys. | volume = 460 | issue = 1 | pages = 85–91 | year = 2007 | pmid = 17254543 | pmc = 2853909 | doi = 10.1016/j.abb.2006.11.031 }}
*{{cite journal | author=Kurzbauer R, Teis D, de Araujo ME, ''et al.'' |title=Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 30 |pages= 10984-9 |year= 2004 |pmid= 15263099 |doi= 10.1073/pnas.0403435101 }}
* {{cite journal | vauthors = Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ | title = RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility | journal = Mol. Cell. Biol. | volume = 27 | issue = 23 | pages = 8296–305 | year = 2007 | pmid = 17908799 | pmc = 2169169 | doi = 10.1128/MCB.00598-07 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Sharma C, Vomastek T, Tarcsafalvi A, ''et al.'' |title=MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling. |journal=J. Cell. Biochem. |volume=94 |issue= 4 |pages= 708-19 |year= 2005 |pmid= 15547943 |doi= 10.1002/jcb.20344 }}
*{{cite journal  | author=Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD |title=The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. |journal=Mol. Cell. Biol. |volume=25 |issue= 12 |pages= 5119-33 |year= 2005 |pmid= 15923628 |doi= 10.1128/MCB.25.12.5119-5133.2005 }}
*{{cite journal  | author=Villegas SN, Njaine B, Linden R, Carri NG |title=Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. |journal=Brain Res. Bull. |volume=71 |issue= 1-3 |pages= 116-26 |year= 2007 |pmid= 17113937 |doi= 10.1016/j.brainresbull.2006.08.014 }}
*{{cite journal  | author=Teis D, Taub N, Kurzbauer R, ''et al.'' |title=p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. |journal=J. Cell Biol. |volume=175 |issue= 6 |pages= 861-8 |year= 2007 |pmid= 17178906 |doi= 10.1083/jcb.200607025 }}
*{{cite journal  | author=Brahma A, Dalby KN |title=Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer. |journal=Arch. Biochem. Biophys. |volume=460 |issue= 1 |pages= 85-91 |year= 2007 |pmid= 17254543 |doi= 10.1016/j.abb.2006.11.031 }}
*{{cite journal  | author=Vomastek T, Iwanicki MP, Schaeffer HJ, ''et al.'' |title=RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. |journal=Mol. Cell. Biol. |volume=27 |issue= 23 |pages= 8296-305 |year= 2007 |pmid= 17908799 |doi= 10.1128/MCB.00598-07 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8649}}
{{WikiDoc Sources}}
 
 
{{gene-4-stub}}

Latest revision as of 06:04, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.[1][2][3]

Function

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.[3]

Interactions

MAP2K1IP1 has been shown to interact with MAP2K1.[1][4]

References

  1. ↑ 1.0 1.1 Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ (Oct 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science. 281 (5383): 1668–71. doi:10.1126/science.281.5383.1668. PMID 9733512.
  2. ↑ Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M (May 2004). "The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling". J. Biol. Chem. 279 (22): 23422–30. doi:10.1074/jbc.M401648200. PMID 15016825.
  3. ↑ 3.0 3.1 "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1".
  4. ↑ Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA (Feb 2001). "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment". J. Cell Biol. 152 (4): 765–76. doi:10.1083/jcb.152.4.765. PMC 2195784. PMID 11266467.

Further reading


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