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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ensconsin''' is a [[protein]] that in humans is encoded by the ''MAP7'' [[gene]].<ref name="pmid8408219">{{cite journal | vauthors = Masson D, Kreis TE | title = Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells | journal = J Cell Biol | volume = 123 | issue = 2 | pages = 357–71 | date = Nov 1993 | pmid = 8408219 | pmc = 2119845 | doi = 10.1083/jcb.123.2.357 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP7 microtubule-associated protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9053| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein 7
| HGNCid = 6869
| Symbol = MAP7
| AltSymbols =; E-MAP-115; EMAP115
| OMIM = 604108
| ECnumber = 
| Homologene = 20851
| MGIid = 1328328
| GeneAtlas_image1 = PBB_GE_MAP7_202889_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAP7_215471_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MAP7_202890_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0006970 |text = response to osmotic stress}} {{GNF_GO|id=GO:0007163 |text = establishment and/or maintenance of cell polarity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9053
    | Hs_Ensembl = ENSG00000135525
    | Hs_RefseqProtein = NP_003971
    | Hs_RefseqmRNA = NM_003980
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 136705566
    | Hs_GenLoc_end = 136913485
    | Hs_Uniprot = Q14244
    | Mm_EntrezGene = 17761
    | Mm_Ensembl = ENSMUSG00000019996
    | Mm_RefseqmRNA = NM_008635
    | Mm_RefseqProtein = NP_032661
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 19838430
    | Mm_GenLoc_end = 19967769
    | Mm_Uniprot = O88735
  }}
}}
'''Microtubule-associated protein 7''', also known as '''MAP7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP7 microtubule-associated protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9053| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: MAP7 microtubule-associated protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9053| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAP7 has been shown to [[Protein-protein interaction|interact]] with [[TRPV4]].<ref name=pmid14517216>{{cite journal | vauthors = Suzuki M, Hirao A, Mizuno A | title = Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4) | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51448–53 | date = December 2003 | pmid = 14517216 | doi = 10.1074/jbc.M308212200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Masson D, Kreis TE | title = Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation. | journal = J. Cell Biol. | volume = 131 | issue = 4 | pages = 1015–24 | year = 1996 | pmid = 7490279 | pmc = 2200015 | doi = 10.1083/jcb.131.4.1015 }}
| citations =
* {{cite journal | vauthors = Fabre-Jonca N, Viard I, French LE, Masson D | title = Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. | journal = J. Invest. Dermatol. | volume = 112 | issue = 2 | pages = 216–25 | year = 1999 | pmid = 9989799 | doi = 10.1046/j.1523-1747.1999.00500.x }}
*{{cite journal | author=Masson D, Kreis TE |title=Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation. |journal=J. Cell Biol. |volume=131 |issue= 4 |pages= 1015-24 |year= 1996 |pmid= 7490279 |doi= }}
* {{cite journal | vauthors = Bulinski JC, Odde DJ, Howell BJ, Salmon TD, Waterman-Storer CM | title = Rapid dynamics of the microtubule binding of ensconsin in vivo. | journal = J. Cell Sci. | volume = 114 | issue = Pt 21 | pages = 3885–97 | year = 2002 | pmid = 11719555 | doi =  }}
*{{cite journal  | author=Masson D, Kreis TE |title=Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. |journal=J. Cell Biol. |volume=123 |issue= 2 |pages= 357-71 |year= 1993 |pmid= 8408219 |doi=  }}
* {{cite journal | vauthors = Penttilä TL, Parvinen M, Paranko J | title = Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette. | journal = Int. J. Androl. | volume = 26 | issue = 3 | pages = 166–74 | year = 2004 | pmid = 12755995 | doi = 10.1046/j.1365-2605.2003.00406.x }}
*{{cite journal | author=Fabre-Jonca N, Viard I, French LE, Masson D |title=Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. |journal=J. Invest. Dermatol. |volume=112 |issue= 2 |pages= 216-25 |year= 1999 |pmid= 9989799 |doi= 10.1046/j.1523-1747.1999.00500.x }}
* {{cite journal | vauthors = Vanier MT, Deck P, Stutzmann J, Gendry P, Arnold C, Dirrig-Grosch S, Kedinger M, Launay JF | title = Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells. | journal = Cell Motil. Cytoskeleton | volume = 55 | issue = 4 | pages = 221–31 | year = 2004 | pmid = 12845596 | doi = 10.1002/cm.10124 }}
*{{cite journal | author=Bulinski JC, Odde DJ, Howell BJ, ''et al.'' |title=Rapid dynamics of the microtubule binding of ensconsin in vivo. |journal=J. Cell. Sci. |volume=114 |issue= Pt 21 |pages= 3885-97 |year= 2002 |pmid= 11719555 |doi=  }}
* {{cite journal | vauthors = Suzuki M, Hirao A, Mizuno A | title = Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51448–53 | year = 2004 | pmid = 14517216 | doi = 10.1074/jbc.M308212200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Sood R, Bader PI, Speer MC, Edwards YH, Eddings EM, Blair RT, Hu P, Faruque MU, Robbins CM, Zhang H, Leuders J, Morrison K, Thompson D, Schwartzberg PL, Meltzer PS, Trent JM | title = Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis. | journal = Cytogenet. Genome Res. | volume = 106 | issue = 1 | pages = 61–7 | year = 2004 | pmid = 15218243 | doi = 10.1159/000078563 }}
*{{cite journal  | author=Penttilä TL, Parvinen M, Paranko J |title=Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette. |journal=Int. J. Androl. |volume=26 |issue= 3 |pages= 166-74 |year= 2004 |pmid= 12755995 |doi= }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Vanier MT, Deck P, Stutzmann J, ''et al.'' |title=Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells. |journal=Cell Motil. Cytoskeleton |volume=55 |issue= 4 |pages= 221-31 |year= 2004 |pmid= 12845596 |doi= 10.1002/cm.10124 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Suzuki M, Hirao A, Mizuno A |title=Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51448-53 |year= 2004 |pmid= 14517216 |doi= 10.1074/jbc.M308212200 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Sood R, Bader PI, Speer MC, ''et al.'' |title=Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis. |journal=Cytogenet. Genome Res. |volume=106 |issue= 1 |pages= 61-7 |year= 2004 |pmid= 15218243 |doi= 10.1159/000078563 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:17, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ensconsin is a protein that in humans is encoded by the MAP7 gene.[1][2]

Function

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.[2]

Interactions

MAP7 has been shown to interact with TRPV4.[3]

References

  1. ↑ Masson D, Kreis TE (Nov 1993). "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells". J Cell Biol. 123 (2): 357–71. doi:10.1083/jcb.123.2.357. PMC 2119845. PMID 8408219.
  2. ↑ 2.0 2.1 "Entrez Gene: MAP7 microtubule-associated protein 7".
  3. ↑ Suzuki M, Hirao A, Mizuno A (December 2003). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.

Further reading

  • Masson D, Kreis TE (1996). "Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation". J. Cell Biol. 131 (4): 1015–24. doi:10.1083/jcb.131.4.1015. PMC 2200015. PMID 7490279.
  • Fabre-Jonca N, Viard I, French LE, Masson D (1999). "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts". J. Invest. Dermatol. 112 (2): 216–25. doi:10.1046/j.1523-1747.1999.00500.x. PMID 9989799.
  • Bulinski JC, Odde DJ, Howell BJ, Salmon TD, Waterman-Storer CM (2002). "Rapid dynamics of the microtubule binding of ensconsin in vivo". J. Cell Sci. 114 (Pt 21): 3885–97. PMID 11719555.
  • Penttilä TL, Parvinen M, Paranko J (2004). "Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette". Int. J. Androl. 26 (3): 166–74. doi:10.1046/j.1365-2605.2003.00406.x. PMID 12755995.
  • Vanier MT, Deck P, Stutzmann J, Gendry P, Arnold C, Dirrig-Grosch S, Kedinger M, Launay JF (2004). "Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells". Cell Motil. Cytoskeleton. 55 (4): 221–31. doi:10.1002/cm.10124. PMID 12845596.
  • Suzuki M, Hirao A, Mizuno A (2004). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.
  • Sood R, Bader PI, Speer MC, Edwards YH, Eddings EM, Blair RT, Hu P, Faruque MU, Robbins CM, Zhang H, Leuders J, Morrison K, Thompson D, Schwartzberg PL, Meltzer PS, Trent JM (2004). "Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis". Cytogenet. Genome Res. 106 (1): 61–7. doi:10.1159/000078563. PMID 15218243.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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