MARCKSL1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''MARCKS-related protein''' is a [[protein]] that in humans is encoded by the ''MARCKSL1'' [[gene]].<ref name="pmid9598313">{{cite journal |vauthors=Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ | title = Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects | journal = Genomics | volume = 49 | issue = 2 | pages = 253–64 | date = August 1998 | pmid = 9598313 | pmc =  | doi = 10.1006/geno.1998.5247 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MARCKSL1 MARCKS-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65108| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MARCKS-like 1
| HGNCid = 7142
| Symbol = MARCKSL1
| AltSymbols =; MLP1; MRP; MLP; F52; MACMARCKS
| OMIM = 602940
| ECnumber = 
| Homologene = 40748
| MGIid = 97143
| GeneAtlas_image1 = PBB_GE_MARCKSL1_200644_at_tn.png
| Function = {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 65108
    | Hs_Ensembl = ENSG00000175130
    | Hs_RefseqProtein = NP_075385
    | Hs_RefseqmRNA = NM_023009
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 32572020
    | Hs_GenLoc_end = 32574567
    | Hs_Uniprot = P49006
    | Mm_EntrezGene = 17357
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_010807
    | Mm_RefseqProtein = NP_034937
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''MARCKS-like 1''', also known as '''MARCKSL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MARCKSL1 MARCKS-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65108| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in [[cytoskeletal]] regulation, [[protein kinase C]] signaling and [[calmodulin]] signaling. The encoded protein affects the formation of [[adherens junction]]. Alternative splicing results in multiple transcript variants.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MARCKSL1 has been shown to [[Protein-protein interaction|interact]] with [[DCTN2]]<ref name=pmid10827182>{{cite journal |vauthors=Yue L, Lu S, Garces J, Jin T, Li J | title = Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23948–56 | date = August 2000 | pmid = 10827182 | doi = 10.1074/jbc.M001845200 }}</ref> and [[JNK]].<ref name=pmid22751924>{{cite journal |vauthors=Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET | title = c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells | journal = Mol Cell Biol | volume = 32 | issue = 17 | pages = 3513–26 | date = September 2012 | pmid = 22751924 | doi = 10.1128/MCB.00713-12 | pmc=3421996}}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Umekage T, Kato K | title = A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS. | journal = FEBS Lett. | volume = 286 | issue = 1–2 | pages = 147–51 | year = 1991 | pmid = 1864362 | doi = 10.1016/0014-5793(91)80961-2 }}
| citations =
*{{cite journal |vauthors=Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ | title = Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. | journal = J. Biol. Chem. | volume = 269 | issue = 12 | pages = 9361–7 | year = 1994 | pmid = 8132675 | doi =  }}
*{{cite journal | author=Umekage T, Kato K |title=A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS. |journal=FEBS Lett. |volume=286 |issue= 1-2 |pages= 147-51 |year= 1991 |pmid= 1864362 |doi= }}
*{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Verghese GM, Johnson JD, Vasulka C, ''et al.'' |title=Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 9361-7 |year= 1994 |pmid= 8132675 |doi=  }}
*{{cite journal |vauthors=Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal |vauthors=Yue L, Lu S, Garces J, Jin T, Li J | title = Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23948–56 | year = 2000 | pmid = 10827182 | doi = 10.1074/jbc.M001845200 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
*{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal  | author=Stumpo DJ, Eddy RL, Haley LL, ''et al.'' |title=Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects. |journal=Genomics |volume=49 |issue= 2 |pages= 253-64 |year= 1998 |pmid= 9598313 |doi= 10.1006/geno.1998.5247 }}
*{{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Yue L, Lu S, Garces J, ''et al.'' |title=Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23948-56 |year= 2000 |pmid= 10827182 |doi= 10.1074/jbc.M001845200 }}
*{{cite journal |vauthors=Hsia TC, Lin CC, Wang JJ, Ho ST, Kao A | title = Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression. | journal = Lung | volume = 180 | issue = 3 | pages = 173–9 | year = 2002 | pmid = 12177731 | doi = 10.1007/s004080000091 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain. | journal = Mol. Cell. Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | year = 2005 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline. | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006. | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415–8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Hsia TC, Lin CC, Wang JJ, ''et al.'' |title=Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression. |journal=Lung |volume=180 |issue= 3 |pages= 173-9 |year= 2002 |pmid= 12177731 |doi= 10.1007/s004080000091 }}
*{{cite journal |vauthors=Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V | title = Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. | journal = Nat. Genet. | volume = 38 | issue = 2 | pages = 197–202 | year = 2006 | pmid = 16429158 | doi = 10.1038/ng1727 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Jordanova A, Irobi J, Thomas FP, ''et al.'' |title=Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. |journal=Nat. Genet. |volume=38 |issue= 2 |pages= 197-202 |year= 2006 |pmid= 16429158 |doi= 10.1038/ng1727 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:09, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.[1][2]

Function

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants.[2]

Interactions

MARCKSL1 has been shown to interact with DCTN2[3] and JNK.[4]

References

  1. ↑ Stumpo DJ, Eddy RL, Haley LL, Sait S, Shows TB, Lai WS, Young WS, Speer MC, Dehejia A, Polymeropoulos M, Blackshear PJ (August 1998). "Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects". Genomics. 49 (2): 253–64. doi:10.1006/geno.1998.5247. PMID 9598313.
  2. ↑ 2.0 2.1 "Entrez Gene: MARCKSL1 MARCKS-like 1".
  3. ↑ Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". J. Biol. Chem. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.
  4. ↑ Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET (September 2012). "c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells". Mol Cell Biol. 32 (17): 3513–26. doi:10.1128/MCB.00713-12. PMC 3421996. PMID 22751924.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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