MCF2: Difference between revisions

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{{Infobox_gene}}
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'''Proto-oncogene DBL''' is a [[protein]] that in humans is encoded by the ''MCF2'' [[gene]].<ref name="pmid2577874">{{cite journal |vauthors=Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D | title = Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences | journal = Oncogene | volume = 3 | issue = 6 | pages = 709–15 |date=Apr 1994 | pmid = 2577874 | pmc =  | doi =  }}</ref><ref name="pmid1611909">{{cite journal |vauthors=Galland F, Stefanova M, Lafage M, Birnbaum D | title = Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23 | journal = Cytogenet Cell Genet | volume = 60 | issue = 2 | pages = 114–6 |date=Jul 1992 | pmid = 1611909 | pmc =  | doi =10.1159/000133316 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MCF.2 cell line derived transforming sequence
| HGNCid = 6940
| Symbol = MCF2
| AltSymbols =; DBL
| OMIM = 311030
| ECnumber =
| Homologene = 3917
| MGIid = 96932
  | GeneAtlas_image1 = PBB_GE_MCF2_217004_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MCF2_208017_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4168
    | Hs_Ensembl = ENSG00000101977
    | Hs_RefseqProtein = NP_005360
    | Hs_RefseqmRNA = NM_005369
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 138491595
    | Hs_GenLoc_end = 138601981
    | Hs_Uniprot = P10911
    | Mm_EntrezGene = 109904
    | Mm_Ensembl = ENSMUSG00000031139
    | Mm_RefseqmRNA = NM_133197
    | Mm_RefseqProtein = NP_573460
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 56402742
    | Mm_GenLoc_end = 56525873
    | Mm_Uniprot =   
  }}
}}
'''MCF.2 cell line derived transforming sequence''', also known as '''MCF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = }}</ref>
| summary_text = MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Galland F, Stefanova M, Lafage M, Birnbaum D |title=Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 2 |pages= 114-6 |year= 1992 |pmid= 1611909 |doi=  }}
*{{cite journal  | author=Ron D |title=A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr |journal=New Biol. |volume=3 |issue= 4 |pages= 372–9 |year= 1991 |pmid= 2065022 |doi=  |name-list-format=vanc| author2=Zannini M | author3=Lewis M | display-authors=3  | last4=Wickner  | first4=RB  | last5=Hunt  | first5=LT  | last6=Graziani  | first6=G  | last7=Tronick  | first7=SR  | last8=Aaronson  | first8=SA  | last9=Eva  | first9=A }}
*{{cite journal  | author=Ron D, Zannini M, Lewis M, ''et al.'' |title=A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr. |journal=New Biol. |volume=3 |issue= 4 |pages= 372-9 |year= 1991 |pmid= 2065022 |doi=  }}
*{{cite journal  |vauthors=Tronick SR, McBride OW, Popescu NC, Eva A |title=Chromosomal localization of DBL oncogene sequences |journal=Genomics |volume=5 |issue= 3 |pages= 546–53 |year= 1990 |pmid= 2613238 |doi=10.1016/0888-7543(89)90022-0  }}
*{{cite journal  | author=Noguchi T, Galland F, Batoz M, ''et al.'' |title=Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences. |journal=Oncogene |volume=3 |issue= 6 |pages= 709-15 |year= 1994 |pmid= 2577874 |doi= }}
*{{cite journal  | author=Ron D, Tronick SR, [[Stuart A. Aaronson|Aaronson SA]], Eva A |title=Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells |journal=EMBO J. |volume=7 |issue= 8 |pages= 2465–73 |year= 1989 |pmid= 3056717 |doi= | pmc=457116 }}
*{{cite journal  | author=Tronick SR, McBride OW, Popescu NC, Eva A |title=Chromosomal localization of DBL oncogene sequences. |journal=Genomics |volume=5 |issue= 3 |pages= 546-53 |year= 1990 |pmid= 2613238 |doi=  }}
*{{cite journal  | author=Eva A |title=The predicted DBL oncogene product defines a distinct class of transforming proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2061–5 |year= 1988 |pmid= 3281159 |doi=10.1073/pnas.85.7.2061  | pmc=279928 |name-list-format=vanc| author2=Vecchio G | author3=Rao CD | display-authors=3  | last4=Tronick  | first4=SR  | last5=Aaronson  | first5=SA  }}
*{{cite journal  | author=Ron D, Tronick SR, Aaronson SA, Eva A |title=Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells. |journal=EMBO J. |volume=7 |issue= 8 |pages= 2465-73 |year= 1989 |pmid= 3056717 |doi=  }}
*{{cite journal  |vauthors=Srivastava SK, Wheelock RH, Aaronson SA, Eva A |title=Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8868–72 |year= 1987 |pmid= 3491366 |doi=10.1073/pnas.83.23.8868  | pmc=387034 }}
*{{cite journal  | author=Eva A, Vecchio G, Rao CD, ''et al.'' |title=The predicted DBL oncogene product defines a distinct class of transforming proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2061-5 |year= 1988 |pmid= 3281159 |doi=  }}
*{{cite journal  | author=Hart MJ |title=Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 62–5 |year= 1994 |pmid= 8276860 |doi=  |name-list-format=vanc| author2=Eva A | author3=Zangrilli D  | display-authors=3  | last4=Aaronson  | first4=SA  | last5=Evans  | first5=T  | last6=Cerione  | first6=RA  | last7=Zheng  | first7=Y }}
*{{cite journal  | author=Srivastava SK, Wheelock RH, Aaronson SA, Eva A |title=Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8868-72 |year= 1987 |pmid= 3491366 |doi=  }}
*{{cite journal  |vauthors=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=10.1016/S0014-5793(99)01244-2  }}
*{{cite journal  | author=Hart MJ, Eva A, Zangrilli D, ''et al.'' |title=Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 62-5 |year= 1994 |pmid= 8276860 |doi=  }}
*{{cite journal  |vauthors=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141–7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106 }}
*{{cite journal | author=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186-90 |year= 1999 |pmid= 10518015 |doi=  }}
*{{cite journal  |vauthors=Zhu K, Debreceni B, Li R, Zheng Y |title=Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 25993–6001 |year= 2000 |pmid= 10854437 |doi= 10.1074/jbc.M003780200 }}
*{{cite journal  | author=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141-7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106 }}
*{{cite journal  | author=Palmieri G |title=Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site |journal=Gene |volume=253 |issue= 1 |pages= 107–15 |year= 2000 |pmid= 10925207 |doi=10.1016/S0378-1119(00)00212-2  |name-list-format=vanc| author2=de Franciscis V  | author3=Casamassimi A  | display-authors=3  | last4=Romano  | first4=G  | last5=Torino  | first5=A  | last6=Pingitore  | first6=P  | last7=Califano  | first7=D | last8=Santelli  | first8=G  | last9=Eva  | first9=A  }}
*{{cite journal  | author=Zhu K, Debreceni B, Li R, Zheng Y |title=Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 25993-6001 |year= 2000 |pmid= 10854437 |doi= 10.1074/jbc.M003780200 }}
*{{cite journal  |vauthors=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718–21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744 }}
*{{cite journal  | author=Palmieri G, de Franciscis V, Casamassimi A, ''et al.'' |title=Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site. |journal=Gene |volume=253 |issue= 1 |pages= 107-15 |year= 2000 |pmid= 10925207 |doi= }}
*{{cite journal  |vauthors=Zhu K, Debreceni B, Bi F, Zheng Y |title=Oligomerization of DH domain is essential for Dbl-induced transformation |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 425–37 |year= 2001 |pmid= 11134331 |doi= 10.1128/MCB.21.2.425-437.2001  | pmc=86589 }}
*{{cite journal  | author=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718-21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744 }}
*{{cite journal  | author=Vanni C |title=Regulation of proto-Dbl by intracellular membrane targeting and protein stability |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19745–53 |year= 2002 |pmid= 11907027 |doi= 10.1074/jbc.M111025200 |name-list-format=vanc| author2=Mancini P  | author3=Gao Y  | display-authors=3  | last4=Ottaviano  | first4=C  | last5=Guo  | first5=F  | last6=Salani  | first6=B  | last7=Torrisi  | first7=MR | last8=Zheng  | first8=Y  | last9=Eva  | first9=A }}
*{{cite journal  | author=Zhu K, Debreceni B, Bi F, Zheng Y |title=Oligomerization of DH domain is essential for Dbl-induced transformation. |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 425-37 |year= 2001 |pmid= 11134331 |doi= 10.1128/MCB.21.2.425-437.2001 }}
*{{cite journal  | author=Wennerberg K |title=RhoG signals in parallel with Rac1 and Cdc42 |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200  |name-list-format=vanc| author2=Ellerbroek SM  | author3=Liu RY  | display-authors=3  | last4=Karnoub  | first4=AE  | last5=Burridge  | first5=K  | last6=Der  | first6=CJ }}
*{{cite journal | author=Vanni C, Mancini P, Gao Y, ''et al.'' |title=Regulation of proto-Dbl by intracellular membrane targeting and protein stability. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19745-53 |year= 2002 |pmid= 11907027 |doi= 10.1074/jbc.M111025200 }}
*{{cite journal  | author=Komai K |title=Alternative splicing variants of the human DBL (MCF-2) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 455–8 |year= 2003 |pmid= 12445822 |doi=10.1016/S0006-291X(02)02645-1  |name-list-format=vanc| author2=Okayama R  | author3=Kitagawa M  | display-authors=3  | last4=Yagi  | first4=H  | last5=Chihara  | first5=K  | last6=Shiozawa  | first6=S  }}
*{{cite journal  | author=Wennerberg K, Ellerbroek SM, Liu RY, ''et al.'' |title=RhoG signals in parallel with Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810-7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200 }}
*{{cite journal  |vauthors=Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S |title=Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 906–9 |year= 2003 |pmid= 13679059 |doi=10.1016/j.bbrc.2003.08.088  }}
*{{cite journal  | author=Komai K, Okayama R, Kitagawa M, ''et al.'' |title=Alternative splicing variants of the human DBL (MCF-2) proto-oncogene. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 455-8 |year= 2003 |pmid= 12445822 |doi= }}
*{{cite journal  | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286  |name-list-format=vanc| author2=Grafham DV  | author3=Coffey AJ  | display-authors=3  | last4=Scherer  | first4=Steven  | last5=McLay  | first5=Kirsten  | last6=Muzny  | first6=Donna  | last7=Platzer  | first7=Matthias  | last8=Howell  | first8=Gareth R.  | last9=Burrows  | first9=Christine }}
*{{cite journal | author=Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S |title=Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 906-9 |year= 2003 |pmid= 13679059 |doi= }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 06:14, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.[1][2][3]

MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM][3]

References

  1. ↑ Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D (Apr 1994). "Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences". Oncogene. 3 (6): 709–15. PMID 2577874.
  2. ↑ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet Cell Genet. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
  3. ↑ 3.0 3.1 "Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence".

Further reading



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