MFN1: Difference between revisions

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{{Infobox_gene}}
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'''Mitofusin-1''' is a [[protein]] that in humans is encoded by the ''MFN1'' [[gene]].<ref name="pmid8358434">{{cite journal |vauthors=Adams MD, Kerlavage AR, Fields C, Venter JC | title = 3,400 new expressed sequence tags identify diversity of transcripts in human brain | journal = Nat Genet | volume = 4 | issue = 3 | pages = 256–67 |date=Sep 1993 | pmid = 8358434 | pmc =  | doi = 10.1038/ng0793-256 }}</ref><ref name="pmid11181170">{{cite journal |vauthors=Santel A, Fuller MT | title = Control of mitochondrial morphology by a human mitofusin | journal = J Cell Sci | volume = 114 | issue = Pt 5 | pages = 867–74 |date=Feb 2001 | pmid = 11181170 | pmc =  | doi =  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitofusin 1
| HGNCid = 18262
| Symbol = MFN1
| AltSymbols =; DKFZp762F247; FLJ20693; MGC41806; hfzo1; hfzo2
| OMIM = 608506
| ECnumber =
| Homologene = 11481
| MGIid = 1914664
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019867 |text = outer membrane}}
| Process = {{GNF_GO|id=GO:0008053 |text = mitochondrial fusion}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55669
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_284941
    | Hs_RefseqmRNA = NM_033540
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end =   
    | Hs_Uniprot = 
    | Mm_EntrezGene = 67414
    | Mm_Ensembl = ENSMUSG00000027668
    | Mm_RefseqmRNA = NM_024200
    | Mm_RefseqProtein = NP_077162
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 32721043
    | Mm_GenLoc_end = 32770774
    | Mm_Uniprot = Q3URC4
  }}
}}
'''Mitofusin 1''', also known as '''MFN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MFN1 mitofusin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55669| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.<ref name="entrez">{{cite web | title = Entrez Gene: MFN1 mitofusin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55669| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a mediator of [[mitochondrial fusion]]. This protein and mitofusin 2 are homologs of the ''[[Drosophila]]'' protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.<ref name="entrez">{{cite web | title = Entrez Gene: MFN1 mitofusin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55669| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Pawlikowska P, Orzechowski A |title=[Role of transmembrane GTPases in mitochondrial morphology and activity] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 53-9 |year= 2007 |pmid= 17718388 |doi=  }}
* {{cite journal  |vauthors=Pawlikowska P, Orzechowski A |title=[Role of transmembrane GTPases in mitochondrial morphology and activity] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 53–9 |year= 2007 |pmid= 17718388 |doi=  }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fields C, Venter JC |title=3,400 new expressed sequence tags identify diversity of transcripts in human brain. |journal=Nat. Genet. |volume=4 |issue= 3 |pages= 256-67 |year= 1993 |pmid= 8358434 |doi= 10.1038/ng0793-256 }}
* {{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
* {{cite journal  |vauthors=Hales KG, Fuller MT |title=Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase |journal=Cell |volume=90 |issue= 1 |pages= 121–9 |year= 1997 |pmid= 9230308 |doi=10.1016/S0092-8674(00)80319-0 }}
*{{cite journal  | author=Hales KG, Fuller MT |title=Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. |journal=Cell |volume=90 |issue= 1 |pages= 121-9 |year= 1997 |pmid= 9230308 |doi= }}
* {{cite journal   |vauthors=Chung JG, Yeh KT, Wu SL, etal |title=Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8873–9 |year= 2002 |pmid= 11751411 |doi=  }}
*{{cite journal  | author=Santel A, Fuller MT |title=Control of mitochondrial morphology by a human mitofusin. |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 867-74 |year= 2001 |pmid= 11181170 |doi= }}
* {{cite journal  |vauthors=Rojo M, Legros F, Chateau D, Lombès A |title=Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo |journal=J. Cell Sci. |volume=115 |issue= Pt 8 |pages= 1663–74 |year= 2003 |pmid= 11950885 |doi=  }}
*{{cite journal | author=Chung JG, Yeh KT, Wu SL, ''et al.'' |title=Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display. |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8873-9 |year= 2002 |pmid= 11751411 |doi=  }}
* {{cite journal  |vauthors=Legros F, Lombès A, Frachon P, Rojo M |title=Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4343–54 |year= 2003 |pmid= 12475957 |doi= 10.1091/mbc.E02-06-0330 | pmc=138638 }}
*{{cite journal  | author=Rojo M, Legros F, Chateau D, Lombès A |title=Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. |journal=J. Cell. Sci. |volume=115 |issue= Pt 8 |pages= 1663-74 |year= 2003 |pmid= 11950885 |doi=  }}
* {{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Legros F, Lombès A, Frachon P, Rojo M |title=Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4343-54 |year= 2003 |pmid= 12475957 |doi= 10.1091/mbc.E02-06-0330 }}
* {{cite journal   |vauthors=Santel A, Frank S, Gaume B, etal |title=Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells |journal=J. Cell Sci. |volume=116 |issue= Pt 13 |pages= 2763–74 |year= 2004 |pmid= 12759376 |doi= 10.1242/jcs.00479 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Santel A, Frank S, Gaume B, ''et al.'' |title=Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 13 |pages= 2763-74 |year= 2004 |pmid= 12759376 |doi= 10.1242/jcs.00479 }}
* {{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal  |vauthors=Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L |title=OPA1 requires mitofusin 1 to promote mitochondrial fusion |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 45 |pages= 15927–32 |year= 2004 |pmid= 15509649 |doi= 10.1073/pnas.0407043101 | pmc=528769 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal   |vauthors=Cartoni R, Léger B, Hock MB, etal |title=Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise |journal=J. Physiol. |volume=567 |issue= Pt 1 |pages= 349–58 |year= 2005 |pmid= 15961417 |doi= 10.1113/jphysiol.2005.092031 | pmc=1474174 }}
*{{cite journal  | author=Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L |title=OPA1 requires mitofusin 1 to promote mitochondrial fusion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 45 |pages= 15927-32 |year= 2004 |pmid= 15509649 |doi= 10.1073/pnas.0407043101 }}
*{{cite journal | author=Cartoni R, Léger B, Hock MB, ''et al.'' |title=Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. |journal=J. Physiol. (Lond.) |volume=567 |issue= Pt 1 |pages= 349-58 |year= 2005 |pmid= 15961417 |doi= 10.1113/jphysiol.2005.092031 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 20:19, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[1][2][3]

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[3]

References

  1. ↑ Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.
  2. ↑ Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. PMID 11181170.
  3. ↑ 3.0 3.1 "Entrez Gene: MFN1 mitofusin 1".

Further reading



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